The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer
Open accessAbstract
The androgen receptor (AR) plays a central role in establishing an oncogenic cascade that drives prostate cancer progression. Some prostate cancers escape androgen dependence and are often associated with an aggressive phenotype. The oestrogen receptor alpha (ERα) is expressed in prostate cancers, independent of AR status. However, the role of ERα remains elusive. Using a combination of chromatin immunoprecipitation (ChIP) and RNA-sequencing data, we identified an ERα-specific non-coding transcriptome signature. Among putatively ERα-regulated intergenic long non-coding RNAs (lncRNAs), we identified nuclear enriched abundant transcript 1 (NEAT1) as the most significantly overexpressed lncRNA in prostate cancer. Analysis of two large clinical cohorts also revealed that NEAT1 expression is associated with prostate cancer progression. Prostate cancer cells expressing high levels of NEAT1 were recalcitrant to androgen or AR antagonists. Finally, we provide evidence that NEAT1 drives oncogenic growth by altering the epigenetic landscape of target gene promoters to favour transcription.
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Cites
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Cited by
Gene regulation by long non-coding RNAs and its biological functions
Statello, L., Guo, C.-J., Chen, L.-L., & Huarte, M. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00315-9 · Cited by 4,991
The emerging role of lncRNAs in cancer
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The role of non-coding RNAs in oncology
Slack, F. J., & Chinnaiyan, A. M. (2019) · Cell · doi:10.1016/j.cell.2019.10.017 · Cited by 1,619
Cooke, P. S., Nanjappa, M. K., Ko, C., Prins, G. S., & Hess, R. A. (2017) · Physiological Reviews · doi:10.1152/physrev.00018.2016 · Cited by 466
The bright side of dark matter: lncRNAs in cancer
Evans, J. R., Feng, F. Y., & Chinnaiyan, A. M. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84421 · Cited by 451
Metadata
- Authors
- Chakravarty, D., Sboner, A., Nair, S. S., Giannopoulou, E., Li, R., Hennig, S., Mosquera, J. M., Pauwels, J., Park, K., Kossai, M., MacDonald, T. Y., Fontugne, J., Erho, N., Vergara, I. A., Ghadessi, M., Davicioni, E., Jenkins, R. B., Palanisamy, N., Chen, Z., Nakagawa, S., Hirose, T., Bander, N. H., Beltran, H., Fox, A. H., Elemento, O., & Rubin, M. A.
- Venue
- Nature Communications
- Published
- 2014-11-21
- Volume
- 5
- Issue
- 1
- Pages
- 5383-5383
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2124826140
- Cited by
- 621
- References
- 11
- FWCI
- 17.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Chakravarty, D., Sboner, A., Nair, S. S., Giannopoulou, E., Li, R., Hennig, S., Mosquera, J. M., Pauwels, J., Park, K., Kossai, M., MacDonald, T. Y., Fontugne, J., Erho, N., Vergara, I. A., Ghadessi, M., Davicioni, E., Jenkins, R. B., Palanisamy, N., Chen, Z., . . . Rubin, M. A. (2014). The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer. Nature Communications. https://doi.org/10.1038/ncomms6383
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
