The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Genome-wide analysis of the human p53 transcriptional network unveils a lncRNA tumour suppressor signature
Open accessAbstract
Despite the inarguable relevance of p53 in cancer, genome-wide studies relating endogenous p53 activity to the expression of lncRNAs in human cells are still missing. Here, by integrating RNA-seq with p53 ChIP-seq analyses of a human cancer cell line under DNA damage, we define a high-confidence set of 18 lncRNAs that are p53 transcriptional targets. We demonstrate that two of the p53-regulated lncRNAs are required for the efficient binding of p53 to some of its target genes, modulating the p53 transcriptional network and contributing to apoptosis induction by DNA damage. We also show that the expression of p53-lncRNAs is lowered in colorectal cancer samples, constituting a tumour suppressor signature with high diagnostic power. Thus, p53-regulated lncRNAs establish a positive regulatory feedback loop that enhances p53 tumour suppressor activity. Furthermore, the signature defined by p53-regulated lncRNAs supports their potential use in the clinic as biomarkers and therapeutic targets.
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Self-citationDifferential analysis of gene regulation at transcript resolution with RNA-seq
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Cited by
Gene regulation by long non-coding RNAs and its biological functions
Statello, L., Guo, C.-J., Chen, L.-L., & Huarte, M. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00315-9 · Cited by 4,991
Self-citationThe emerging role of lncRNAs in cancer
Huarte, M. (2015) · Nature Medicine · doi:10.1038/nm.3981 · Cited by 2,702
Self-citationNon-coding RNA regulatory networks
Panni, S., Lovering, R. C., Porras, P., & Orchard, S. (2020) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2019.194417 · Cited by 479
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The bright side of dark matter: lncRNAs in cancer
Evans, J. R., Feng, F. Y., & Chinnaiyan, A. M. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84421 · Cited by 451
Metadata
- Authors
- Sánchez, Y., Segura, V., Marín-Béjar, O., Athie, A., Marchese, F. P., González, J., Bujanda, L., Guo, S., Matheu, A., & Huarte, M.
- Venue
- Nature Communications
- Published
- 2014-12-19
- Volume
- 5
- Issue
- 1
- Pages
- 5812-5812
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2019155483
- Cited by
- 192
- References
- 12
- FWCI
- 5.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Sánchez, Y., Segura, V., Marín-Béjar, O., Athie, A., Marchese, F. P., González, J., Bujanda, L., Guo, S., Matheu, A., & Huarte, M. (2014). Genome-wide analysis of the human p53 transcriptional network unveils a lncRNA tumour suppressor signature. Nature Communications. https://doi.org/10.1038/ncomms6812
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