The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss
Open accessAbstract
Immunglobulin G (IgG) sialylation represents a key checkpoint that determines the engagement of pro- or anti-inflammatory Fcγ receptors (FcγR) and the direction of the immune response. Whether IgG sialylation influences osteoclast differentiation and subsequently bone architecture has not been determined yet, but may represent an important link between immune activation and bone loss. Here we demonstrate that desialylated, but not sialylated, immune complexes enhance osteoclastogenesis in vitro and in vivo. Furthermore, we find that the Fc sialylation state of random IgG and specific IgG autoantibodies determines bone architecture in patients with rheumatoid arthritis. In accordance with these findings, mice treated with the sialic acid precursor N-acetylmannosamine (ManNAc), which results in increased IgG sialylation, are less susceptible to inflammatory bone loss. Taken together, our findings provide a novel mechanism by which immune responses influence the human skeleton and an innovative treatment approach to inhibit immune-mediated bone loss.
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1 retracted
Amara, K., Steen, J., Murray, F., Morbach, H., Fernandez-Rodriguez, B. M., Joshua, V., Engström, M., Snir, O., Israelsson, L., Catrina, A. I., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20121486 · Cited by 195
Self-citationRetractedRantapää‐Dahlqvist, S., de Jong, B. A. W., Berglin, E., Hallmans, G., Wadell, G., Stenlund, H., Sundin, U., & van Venrooij, W. J. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11223 · Cited by 1,953
Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation
Kaneko, Y., Nimmerjahn, F., & Ravetch, J. V. (2006) · Science · doi:10.1126/science.1129594 · Cited by 1,754
Self-citationThe Impact of Glycosylation on the Biological Function and Structure of Human Immunoglobulins
Arnold, J. N., Wormald, M. R., Sim, R. B., Rudd, P. M., & Dwek, R. A. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141702 · Cited by 1,307
Boutroy, S., Bouxsein, M. L., Munoz, F., & Delmas, P. D. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1258 · Cited by 1,192
Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG Fc
Anthony, R. M., Nimmerjahn, F., Ashline, D. J., Reinhold, V. N., Paulson, J. C., & Ravetch, J. V. (2008) · Science · doi:10.1126/science.1154315 · Cited by 849
Self-citationCostimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
Koga, T., Inui, M., Inoue, K., Kim, S., Suematsu, A., Kobayashi, E., Iwata, T., Ohnishi, H., Matozaki, T., Kodama, T., et al. (2004) · Nature · doi:10.1038/nature02444 · Cited by 828
Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin
Harre, U., Georgess, D., Bang, H., Bozec, A., Axmann, R., Ossipova, E., Jakobsson, P.-J., Baum, W., Nimmerjahn, F., Szarka, E., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60975 · Cited by 736
Self-citationArthritis Critically Dependent on Innate Immune System Players
Ji, H., Ohmura, K., Mahmood, U., Lee, D. M., Hofhuis, F. M. A., Boackle, S. A., Takahashi, K., Holers, V. M., Walport, M., Gerard, C., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00275-3 · Cited by 693
van Gaalen, F. A., Linn‐Rasker, S. P., van Venrooij, W. J., de Jong, B. A., Breedveld, F. C., Verweij, C. L., Toes, R. E. M., & Huizinga, T. W. J. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20044 · Cited by 639
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Cited by
Osteoimmunology: evolving concepts in bone–immune interactions in health and disease
Tsukasaki, M., & Takayanagi, H. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0178-8 · Cited by 771
Osteoimmunology: The conceptual framework unifying the immune and skeletal systems
Okamoto, K., Nakashima, T., Shinohara, M., Negishi-Koga, T., Komatsu, N., Terashima, A., Sawa, S., Nitta, T., & Takayanagi, H. (2017) · Physiological Reviews · doi:10.1152/physrev.00036.2016 · Cited by 534
Mechanisms of joint destruction in rheumatoid arthritis — immune cell–fibroblast–bone interactions
Komatsu, N., & Takayanagi, H. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00793-5 · Cited by 527
Glycosylation: mechanisms, biological functions and clinical implications
He, M., Zhou, X., & Wang, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01886-1 · Cited by 499
Mechanisms of Autoantibody-Induced Pathology
Ludwig, R. J., Vanhoorelbeke, K., Leypoldt, F., Kaya, Z., Bieber, K., McLachlan, S. M., Komorowski, L., Luo, J., Cabral-Marques, O., Hammers, C. M., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00603 · Cited by 469
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Metadata
- Authors
- Harre, U., Lang, S. C., Pfeifle, R., Rombouts, Y., Frühbeißer, S., Amara, K., Bang, H., Lux, A., Koeleman, C. A., Baum, W., Dietel, K., Gröhn, F., Malmström, V., Klareskog, L., Krönke, G., Kocijan, R., Nimmerjahn, F., Toes, R. E. M., Herrmann, M., Scherer, H. U., & Schett, G.
- Venue
- Nature Communications
- Published
- 2015-03-31
- Volume
- 6
- Issue
- 1
- Pages
- 6651-6651
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2062566352
- Cited by
- 261
- References
- 35
- FWCI
- 11.71
- Type
- journal article
- Language
- en
- Open access
- gold
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- Harre, U., Lang, S. C., Pfeifle, R., Rombouts, Y., Frühbeißer, S., Amara, K., Bang, H., Lux, A., Koeleman, C. A., Baum, W., Dietel, K., Gröhn, F., Malmström, V., Klareskog, L., Krönke, G., Kocijan, R., Nimmerjahn, F., Toes, R. E. M., Herrmann, M., . . . Schett, G. (2015). Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss. Nature Communications. https://doi.org/10.1038/ncomms7651
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
