The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Therapy Insight: adipocytokines in metabolic syndrome and related cardiovascular disease
Abstract
Abdominal fat accumulation has been shown to play crucial roles in the development of metabolic syndrome. Visceral fat accumulation particularly is closely correlated to the development of cardiovascular disease and obesity-related disorders such as diabetes mellitus, hyperlipidemia and hypertension. Given these clinical findings, the functions of adipocytes have been intensively investigated in the past 10 years, and have been revealed to act as endocrine cells that secrete various bioactive substances termed adipocytokines. Among adipocytokines, tumor-necrosis factor-alpha, plasminogen activator inhibitor type 1 and heparin-binding epidermal growth factor-like growth factor are produced in adipocytes as well as other organs, and contribute to the development of vascular diseases. Visfatin has been identified as a visceral-fat-specific protein that might be involved in the development of obesity-related diseases, such as diabetes mellitus and cardiovascular disease. In contrast to these adipocytokines, adiponectin, which is an adipose-tissue-specific, collagen-like protein, has been noted as an important antiatherogenic and antidiabetic protein, or as an anti-inflammatory protein. The functions of adipocytokine secretion might be regulated dynamically by nutritional state. Visceral fat accumulation causes dysregulation of adipocyte functions, including oversecretion of tumor-necrosis factor-alpha, plasminogen activator inhibitor type 1 and heparin-binding epidermal growth factor-like growth factor, and hyposecretion of adiponectin, which results in the development of a variety of metabolic and circulatory diseases. In this review, the importance of adipocytokines, particularly adiponectin, is discussed with respect to cardiovascular diseases.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Witham et al. (751) provided 100 000 IU (2500 mg) vitamin D 2 or placebo to elderly patients with systolic heart failure at study entry (week 0) and after 10 weeks and found no effect on plasma TNF-a at 10 or 20 weeks.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [751]
Citations
Cites
1 retracted
Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2005) · Science · doi:10.1126/science.1097243 · Cited by 1,906
Self-citationRetractedRole of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856
Self-citationDeFronzo, R. A., & Ferrannini, E. (1991) · Diabetes Care · doi:10.2337/diacare.14.3.173 · Cited by 4,555
Banting lecture 1988. Role of insulin resistance in human disease.
Reaven, G. (1988) · Diabetes · doi:10.2337/diabetes.37.12.1595 · Cited by 3,801
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., et al. (2003) · Nature · doi:10.1038/nature01705 · Cited by 3,176
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133
Self-citationAdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity
Hu, E., Liang, P., & Spiegelman, B. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10697 · Cited by 2,261
Protection from obesity-induced insulin resistance in mice lacking TNF-α function
Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234
Cited by
Sorted by citations
Items 401–434 of 434
Obesity associated colon tumorigenesis: An assessment of tumor phenotype
Saxena, S. (2006) · UWSpace (University of Waterloo)
Zaghloul, S. I., Megahed, A. A. Y., Mahmoud, R. S. G., & Mohamed, E. A. (2015) · Zagazig University Medical Journal
Neves, K. B. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.60.2016.tde-05102016-091840
Tayyem, R., Hijjawi, N., Bawadi, H. A., Nimer, N. A., Agraib, L. M., Allehdan, S., & Al‐Radaideh, A. (2017) · Clinical Practice · doi:10.4172/clinical-practice.1000388
Acyl-ghrelin mediated lipid retention and inflammation within in vitro and ex vivo adipose depots
Churm, R. (2018) · Cronfa (Swansea University) · doi:10.23889/suthesis.40925
Investigating the Influence of Metabolic Syndrome on Cancer Immunotherapy
Woodall, M. J. (2020) · Otago University Research Archive (University of Otago)
Coria, A. M., Estrada-Cruz, N. A., Ordoñez, M. I. P., Montes-Cortes, D. H., & Manuel‐Apolinar, L. (2020) · BMC Endocrine Disorders · doi:10.1186/s12902-020-00603-7
Barros, P. R. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2020.tde-24012020-115232
Effects of Adipokine Retnla on the Regulation of High-Density Lipoprotein Metabolism
Lee, M. (2016) · Journal of the Korea Society of Computer and Information · doi:10.9708/jksci.2016.21.12.139
Abdominal Obesity, Metabolic Syndrome, and Risk of Cardiovascular Disease
Marzo, J. (2008) · CRC Press eBooks · doi:10.3109/9781420060850-5
ADIPOKINES BETWEEN OBESITY AND OSTEOARTHRITIS
Nicolau, M.-A. (2015) · Romanian Journal of Rheumatology · doi:10.37897/rjr.2015.1.2
Potentials of Chenpi on Metabolic Syndrome: A Review
Lee, Y.-N., An, Y.-M., Kim, J., & Baek, K.-M. (2021) · The Journal of Internal Korean Medicine · doi:10.22246/jikm.2021.42.4.645
Adipose Tissue Remodeling and Malfunctioning in Obesity Revealed by in vivo Molecular Imaging
Nishimura, S., Manabe, I., Nagasaki, M., Hosoya, Y., Kadowaki, T., Nagai, R., & Sugiura, S. (2007) · doi:10.11169/bioimages.15.9
Health promotion through Shokuiku: health in adult life
Matsuzawa, Y. (2010) · 医と食
Self-citationAbdominal Obesity, Metabolic Syndrome and Risk of Cardiovascular Disease
(2008) · CRC Press eBooks · doi:10.3109/9781420060850-2
Duraj, V., & Recka, G. (2022) · GSC Advanced Research and Reviews · doi:10.30574/gscarr.2022.11.3.0152
Personalized epigenetic management of diabetes
Sapehia, D., Bhardwaj, N., Goyal, H., Mahajan, A., Singh, P., & Kaur, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23802-4.00017-x
Smiljić, L., Radunović, M., Muratović, M., & Smilić, T. (2009) · Praxis medica · doi:10.70949/pramed200902311s
Chincholikar, S. Z., Sakalecha, A. K., Kumar, G. S. H., Sawkar, S., & R, V. (2025) · Cureus · doi:10.7759/cureus.86144
Katsuya, S., Kawata, Y., Kawamura, J., Goto, T., Takara, T., & Tsubota, J. (2025) · International Summit on Diabetes, Endocrinology and Metabolic Disorders · doi:10.3390/obesities5040082
Assoumou, N., & Assoumou, H.-G. N. (2010)
Prevention of the aging process of the eye
Danese, C., & Lanzetta, P. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13983-3.00019-5
Kuchař, M., Morávek, A., Rejtar, P., & Henyš, P. (2021) · Clinical Osteology · doi:10.36290/clo.2021.026
Wang, J., Zheng, X., Jiang, S., Ding, M., Wang, D., An, H., & Tao, N. (2026) · BMC Public Health · doi:10.1186/s12889-026-26197-8
Begey, A.-L. (2018) · theses.fr (ABES) · doi:10.70675/d27994bbz9ea0z4727za8f5zbb789d22105d
Rôle des facteurs anthropométriques et métaboliques dans la survenue du cancer de la prostate
Lavalette, C. (2020) · theses.fr (ABES) · doi:10.70675/afc69a1dza5ffz410ezb787z0ab4a6f99163
The Adipose Tissue, Leptin Signaling, and Adiponectin in Obesity and Type 2 Diabetes Mellitus
Rashev, T. R., & Trifonov, S. (2026) · Archives of Biotechnology and Biomedicine · doi:10.29328/journal.abb.1001050
Metadata
- Authors
- Matsuzawa, Y.
- Venue
- Nature Clinical Practice Cardiovascular Medicine
- Published
- 2006-01
- Volume
- 3
- Issue
- 1
- Pages
- 35-42
- ISSN
- 1743-4297 (ISSN-L)
- 1743-4300
- OpenAlex
- W2060823593
- Cited by
- 434
- References
- 60
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 7 · 2022: 9 · 2021: 7 · 2020: 12 · 2019: 13 · 2018: 9 · 2017: 19 · 2016: 15 · 2015: 24 · 2014: 30 · 2013: 25 · 2012: 33
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Clinical Practice Cardiovascular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- adipokines, metabolic syndrome, cardiovascular disease, adiponectin, TNF-α, plasminogen activator inhibitor-1, HB-EGF, visfatin, visceral fat, obesity, diabetes mellitus, atherosclerosis, anti-inflammatory activity
- MeSH terms
- Adipose Tissue, Cardiovascular Diseases, Humans, Risk Factors, Cytokines, Metabolic Syndrome, Adiponectin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
