The DOI matches its Crossref record; 81 of the 82 references it cites were found in a registry or an index.
Drug Insight: the role of leptin in human physiology and pathophysiology—emerging clinical applications
Abstract
Leptin is an adipocyte-secreted hormone with a key role in energy homeostasis. Studies in animal models, in humans with congenital complete leptin deficiency, and observational and interventional studies in humans with relative leptin deficiency (lower than normal leptin levels) have all indicated that leptin regulates multiple physiological functions, primarily in states of energy deficiency. This information led to proof-of-concept clinical trials involving leptin administration to individuals with relative or complete leptin deficiency. These conditions include congenital complete leptin deficiency, due to mutations in the leptin gene, and states of relative leptin deficiency including lipoatrophy and some forms of hypothalamic amenorrhea. Leptin, in replacement doses, normalizes neuroendocrine, metabolic and immune function in patients with these conditions, but further clinical studies are required to determine its long-term efficacy and safety. Management of leptin-deficient states with replacement doses of leptin holds promise as a therapeutic option. In addition, elucidation of the mechanisms underlying leptin resistance, which characterizes hyperleptinemic states such as human obesity and diabetes, might provide novel therapeutic targets for these prevalent clinical problems.
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In the citing paper
“Leptin concentrations are positively correlated with the amount of body fat (4-10).”
From Leptin in humans: lessons from translational research (2009) · cites this paper as [6]
In the citing paper
“However, although obese subjects are hyperleptinemic compared with lean persons (11), they appear either to be tolerant or resistant to the central hypothalamic effects of leptin.”
From Leptin in humans: lessons from translational research (2009) · cites this paper as [6]
In the citing paper
“Leptin has been shown to have several effects on the innate immune system in leptin-deficient states: It exerts direct effects on macrophages by up-regulating the phagocytic activity, stimulates the secretion of proinflammatory cytokines, and stimulates chemotaxis in polymorphonuclear cells (6).”
From Leptin in humans: lessons from translational research (2009) · cites this paper as [6]
In the citing paper
“Similar to congenital leptin deficiency, relative leptin deficiency because of long-term energy deprivation is associated with defects in immunologic variables that may be corrected with exogenous r-metHuLeptin administration: Leptin replacement therapy alters circulating cytokine concentrations in women with hypothalamic amenorrhea who present with chronic relative leptin deficiency resulting”
From Leptin in humans: lessons from translational research (2009) · cites this paper as [6]
In the citing paper
“These disturbances can be completely reversed by leptin administration (6).”
From Leptin in humans: lessons from translational research (2009) · cites this paper as [6]
In the citing paper
“A significant role of leptin in the regulation of the hypothalamicpituitary-thyroid axis has been well established in humans (6)(7)(8).”
From Leptin in humans: lessons from translational research (2009) · cites this paper as [6]
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
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Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
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Leptin and the regulation of body weight in mammals
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Role of leptin in the neuroendocrine response to fasting
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Self-citationLeptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
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Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
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Leptin Inhibits Bone Formation through a Hypothalamic Relay
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Flagged first, then by citations
1 of the 82 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Hollander P et al. (2000) A randomized double-blinded placebo-controlled study to determine the effects of subcutaneous recombinant methionyl human leptin on glycemic control in obese subjects with diet-treated type 2 diabetes mellitus. Abstract from the 60th Scientific Sessions of the American Diabetes Association: 2000 June 9–13; San Antonio, TX, USA
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Cited by
Sorted by citations
Adverse metabolic and cardiovascular consequences of circadian misalignment
Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351
Self-citationLeptin in Human Physiology and Pathophysiology
Mantzoros, C. S., Magkos, F., Brinkoetter, M., Sienkiewicz, E., Dardeno, T. A., Kim, S.-Y., Hamnvik, O.-P. R., & Koniaris, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00315.2011 · Cited by 593
Self-citationEstrogen: A master regulator of bioenergetic systems in the brain and body
Rettberg, J. R., Yao, J., & Brinton, R. D. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.08.001 · Cited by 534
Bays, H. E., González-Campoy, J. M., Bray, G. A., Kitabchi, A. E., Bergman, D. A., Schorr, A. B., Rodbard, H. W., & Henry, R. R. (2008) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.6.3.343 · Cited by 543
Fasting and cancer: molecular mechanisms and clinical application
Nencioni, A., Caffa, I., Cortellino, S., & Longo, V. D. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0061-0 · Cited by 518
Metadata
- Authors
- Brennan, A. M., & Mantzoros, C. S.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Mantzoros, Christos S
- Venue
- Nature Clinical Practice Endocrinology & Metabolism
- Published
- 2006-06
- Volume
- 2
- Issue
- 6
- Pages
- 318-327
- ISSN
- 1745-8366 (ISSN-L)
- 1745-8374
- OpenAlex
- W2036849525
- Semantic Scholar
- 39b64b226bdfa1ea79a07f8c094fba198c51d618
- Cited by
- 374
- References
- 82
- Citations by year
- 2025: 8 · 2024: 6 · 2023: 17 · 2022: 19 · 2021: 23 · 2020: 27 · 2019: 20 · 2018: 19 · 2017: 28 · 2016: 26 · 2015: 21 · 2014: 27 · 2013: 31 · 2012: 28
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Clinical Practice Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alexander von Humboldt-Stiftung
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 58785)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin, leptin resistance, leptin deficiency, congenital leptin deficiency, lipoatrophy, hypothalamic amenorrhea, obesity, diabetes mellitus, energy homeostasis, leptin replacement therapy, neuroendocrine function, immune function
- MeSH terms
- Animals, Energy Metabolism, Humans, Immunity, Models, Biological, Neurosecretory Systems, Obesity, Leptin
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