The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion
Open accessAbstract
Androgen deprivation therapy remains a critical component of treatment for men with advanced prostate cancer, and data support its use in metastatic disease and in conjunction with surgery or radiation in specific settings. Alternatives to standard androgen deprivation therapy, such as intermittent androgen suppression and estrogen therapy, hold the potential to improve toxicity profiles while maintaining clinical benefit. Current androgen deprivation strategies seem to incompletely suppress androgen levels and androgen-receptor-mediated effects at the tissue level. Advances in the understanding of mechanisms that contribute to castration-resistant prostate cancer are leading to rationally designed therapies targeting androgen metabolism and the androgen receptor. The results of large trials investigating the optimization of primary androgen deprivation therapy, including evaluation of intermittent androgen suppression and phase III studies of novel androgen synthesis inhibitors, such as abiraterone acetate, are eagerly awaited.
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Cites
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Feldman, B. J., & Feldman, D. (2001) · Nature reviews. Cancer · doi:10.1038/35094009 · Cited by 2,326
Molecular determinants of resistance to antiandrogen therapy
Chen, C. D., Welsbie, D. S., Tran, C., Baek, S. H., Chen, R., Vessella, R., Rosenfeld, M. G., & Sawyers, C. L. (2004) · Nature Medicine · doi:10.1038/nm972 · Cited by 2,278
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The Androgen Axis in Recurrent Prostate Cancer
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Self-citationManagement of Complications of Prostate Cancer Treatment
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Cited by
PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer
Raina, K., Lu, J., Qian, Y., Altieri, M., Gordon, D., Rossi, A. M. K., Wang, J., Chen, X., Dong, H., Siu, K., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521738113 · Cited by 852
Han, X., Zhao, L., Xiang, W., Qin, C., Miao, B., McEachern, D., Wang, Y., Metwally, H., Wang, L., Matvekas, A., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00882 · Cited by 170
Trop2 is a driver of metastatic prostate cancer with neuroendocrine phenotype via PARP1
Hsu, E.-C., Rice, M. A., Bermudez, A., Marques, F. J. G., Aslan, M., Liu, S., Ghoochani, A., Zhang, C. A., Chen, Y.-S., Zlitni, A., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1905384117 · Cited by 146
Triggiani, L., Mazzola, R., Magrini, S. M., Ingrosso, G., Borghetti, P., Trippa, F., Lancia, A., Detti, B., Francolini, G., Matrone, F., et al. (2019) · World Journal of Urology · doi:10.1007/s00345-019-02717-7 · Cited by 96
FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells
Maeda, K., Habara, M., Kawaguchi, M., Matsumoto, H., Hanaki, S., Masaki, T., Sato, Y., Matsuyama, H., Kunieda, K., Nakagawa, H., et al. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13030 · Cited by 32
Metadata
- Authors
- Harris, W. P., Mostaghel, E. A., Nelson, P. S., & Montgomery, B.
- Venue
- Nature Clinical Practice Urology
- Published
- 2009-02
- Volume
- 6
- Issue
- 2
- Pages
- 76-85
- ISSN
- 1743-4270 (ISSN-L)
- 1743-4289
- OpenAlex
- W2005958584
- Cited by
- 877
- References
- 7
- FWCI
- 18.04
- Type
- journal article
- Language
- en
- Open access
- green
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- Harris, W. P., Mostaghel, E. A., Nelson, P. S., & Montgomery, B. (2009). Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion. Nature Clinical Practice Urology. https://doi.org/10.1038/ncpuro1296
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
