Receptor for activated C kinase 1 (RACK1) and Src regulate the tyrosine phosphorylation and function of the androgen receptor.

Sequence and structure-based prediction of eukaryotic protein phosphorylation sites

Blom, N., Gammeltoft, S., & Brunak, S. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.3310 · Cited by 3,197 · see citing works

Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins.

Dorit Ron, A., Chen, C., Caldwell, J., Jamieson, L., Orr, E., & Mochly‐Rosen, D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.3.839 · Cited by 723 · see citing works

Steroid‐induced androgen receptor–oestradiol receptor β–Src complex triggers prostate cancer cell proliferation

Migliaccio, A., Castoria, G., Domenico, M. D., de Falco, A., Bilancio, A., Lombardi, M., Barone, M. V., Ametrano, D., Zannini, M. S., Abbondanza, C., et al. (2000) · The EMBO Journal · doi:10.1093/emboj/19.20.5406 · Cited by 672 · see citing works

Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross‐talk with estrogen receptor

Migliaccio, A., Piccolo, D., Castoria, G., Domenico, M. D., Bilancio, A., Lombardi, M., Gong, W., Beato, M., & Auricchio, F. (1998) · The EMBO Journal · doi:10.1093/emboj/17.7.2008 · Cited by 627 · see citing works

From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells

Yeh, S., Lin, H., Kang, H., Thin, T. H., Lin, M., & Chang, C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5458 · Cited by 594 · see citing works

Progesterone Receptor Contains a Proline-Rich Motif that Directly Interacts with SH3 Domains and Activates c-Src Family Tyrosine Kinases

Boonyaratanakornkit, V., Scott, M. P., Ribon, V., Sherman, L., Anderson, S. M., Maller, J. L., Miller, W. T., & Edwards, D. P. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00304-5 · Cited by 590 · see citing works

Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation. Specificity for steroids and antihormones.

Kemppainen, J., Lane, M. V., Sar, M., & Wilson, E. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48380-9 · Cited by 430 · see citing works

Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.

Lin, H.-K., Yeh, S., Kang, H.-Y., & Chang, C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121173298 · Cited by 401 · see citing works

The RACK1 Scaffold Protein: A Dynamic Cog in Cell Response Mechanisms

McCahill, A., Warwicker, J., Bolger, G. B., Houslay, M. D., & Yarwood, S. J. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.6.1261 · Cited by 386 · see citing works

Regulation of androgen receptor activity by tyrosine phosphorylation.

Guo, Z., Dai, B., Jiang, T., Xu, K., Xie, Y., Kim, O., Nesheiwat, I., Kong, X., Melamed, J., Handratta, V. D., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.021 · Cited by 364 · see citing works

Androgen Receptor Phosphorylation

Gioeli, D. G., Ficarro, S. B., Kwiek, J. J., Aaronson, D. S., Hancock, M., Catling, A. D., White, F. M., Christian, R. E., Settlage, R. E., Shabanowitz, J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204131200 · Cited by 355 · see citing works

Rack1, a Receptor for Activated Protein Kinase C, Interacts with Integrin β Subunit

Liliental, J., & Chang, D. D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.4.2379 · Cited by 346 · see citing works

The RACK1 Signaling Scaffold Protein Selectively Interacts with the cAMP-specific Phosphodiesterase PDE4D5 Isoform

Yarwood, S. J., Steele, M. R., Scotland, G., Houslay, M. D., & Bolger, G. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.14909 · Cited by 306 · see citing works

Nuclear receptors: integration of multiple signalling pathways through phosphorylation

Rochette-Egly, C. (2003) · Cellular Signalling · doi:10.1016/s0898-6568(02)00115-8 · Cited by 291 · see citing works

Dynamics of Intracellular Movement and Nucleocytoplasmic Recycling of the Ligand-Activated Androgen Receptor in Living Cells

Tyagi, R. K., Lavrovsky, Y., Ahn, S., Song, C. S., Chatterjee, B., & Roy, A. K. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.8.0497 · Cited by 291 · see citing works

Nuclear import of the human androgen receptor

Jenster, G. W., Trapman, J., & Brinkmann, A. O. (1993) · Biochemical Journal · doi:10.1042/bj2930761 · Cited by 273 · see citing works

RACK1, a Receptor for Activated C Kinase and a Homolog of the β Subunit of G Proteins, Inhibits Activity of Src Tyrosine Kinases and Growth of NIH 3T3 Cells

Chang, B. Y., Conroy, K. B., Machleder, E. M., & Cartwright, C. A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.6.3245 · Cited by 260 · see citing works

Physiological role for the cochaperone FKBP52 in androgen receptor signaling

Cheung-Flynn, J., Prapapanich, V., Cox, M. B., Riggs, D. L., Suarez-Quian, C., & Smith, D. F. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0071 · Cited by 212 · see citing works

RACK1, an Insulin-Like Growth Factor I (IGF-I) Receptor-Interacting Protein, Modulates IGF-I-Dependent Integrin Signaling and Promotes Cell Spreading and Contact with Extracellular Matrix

Hermanto, U., Zong, C. S., Li, W., & Wang, L. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.7.2345-2365.2002 · Cited by 204 · see citing works

Trafficking of the androgen receptor in living cells with fused green fluorescent protein–androgen receptor

Georget, V., Lobaccaro, J. A., Térouanne, B., Mangeat, P. H., Nicolas, J., & Sultan, C. (1997) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(97)04034-3 · Cited by 193 · see citing works

Binding Specificity for RACK1 Resides in the V5 Region of βII Protein Kinase C

Stebbins, E. G., & Mochly‐Rosen, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101044200 · Cited by 183 · see citing works

The Interaction of Src and RACK1 Is Enhanced by Activation of Protein Kinase C and Tyrosine Phosphorylation of RACK1

Chang, B. Y., Chiang, M., & Cartwright, C. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101375200 · Cited by 177 · see citing works

Characterization of the Interactions of Estrogen Receptor and MNAR in the Activation of cSrc

Barletta, F., Wong, C.-W., McNally, C., Komm, B. S., Katzenellenbogen, B. S., & Cheskis, B. J. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0335 · Cited by 175 · see citing works

Stress Kinase Signaling Regulates Androgen Receptor Phosphorylation, Transcription, and Localization

Gioeli, D. G., Black, B. E., Gordon, V. L., Spencer, A., Kesler, C. T., Eblen, S. T., Paschal, B. M., & Weber, M. J. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0351 · Cited by 175 · see citing works

Contribution of the Androgen Receptor to Prostate Cancer Predisposition and Progression

Buchanan, G., Irvine, R. A., Coetzee, G. A., & Tilley, W. D. (2001) · Cancer and Metastasis Reviews · doi:10.1023/a:1015531326689 · Cited by 165 · see citing works

Recent advances in androgen receptor action

Lee, H.-J., & Chang, C. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-2309-3 · Cited by 162 · see citing works

Hsp90 as a therapeutic target in prostate cancer

Solit, D. (2003) · Seminars in Oncology · doi:10.1016/s0093-7754(03)00346-4 · Cited by 140 · see citing works

RACK1 Regulates Integrin-mediated Adhesion, Protrusion, and Chemotactic Cell Migration via Its Src-binding Site

Cox, E. A., Bennin, D. A., Doan, A. T., O’Toole, T. E., & Anna Huttenlocher, A. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-03-0142 · Cited by 139 · see citing works

Androgen Receptor Cross-talk with Cell Signalling Pathways

Čulig, Z. (2004) · Growth Factors · doi:10.1080/08977190412331279908 · Cited by 137 · see citing works

RACK1 IS UP‐REGULATED IN ANGIOGENESIS AND HUMAN CARCINOMAS

Berns, H., Humar, R., Hengerer, B., Kiefer, F. N., & Battegay, E. J. (2000) · The FASEB Journal · doi:10.1096/fj.99-1038com · Cited by 119 · see citing works

Signal transduction in prostate cancer progression

Gioeli, D. G. (2005) · Clinical Science · doi:10.1042/cs20040329 · Cited by 116 · see citing works

Estradiol-Binding Mechanism and Binding Capacity of the Human Estrogen Receptor Is Regulated by Tyrosine Phosphorylation

Arnold, S. F., Melamed, M., Vorojeikina, D. P., Notides, A. C., & Sasson, S. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.1.9876 · Cited by 110 · see citing works

Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists

Vomastek, T., Schaeffer, H. J., Tarcsafalvi, A., Smolkin, M. E., Bissonette, E. A., & Weber, M. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305894101 · Cited by 109 · see citing works

The WD protein Rack1 mediates protein kinase C and integrin-dependent cell migration

Buensuceso, C. S., Woodside, D. G., Huff, J. L., Plopper, G. E., & O’Toole, T. E. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.9.1691 · Cited by 108 · see citing works

The WD Motif-containing Protein Receptor for Activated Protein Kinase C (RACK1) Is Required for Recruitment and Activation of Signal Transducer and Activator of Transcription 1 through the Type I Interferon Receptor

Усачева, А. М., Smith, R. L., Minshall, R. D., Baida, G. E., Seng, S., Croze, E., & Colamonici, O. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100087200 · Cited by 88 · see citing works

RACK1 Regulates G1/S Progression by Suppressing Src Kinase Activity

Mamidipudi, V., Zhang, J., Lee, K. C., & Cartwright, C. A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.15.6788-6798.2004 · Cited by 77 · see citing works

The Scaffolding Protein RACK1 Interacts with Androgen Receptor and Promotes Cross-talk through a Protein Kinase C Signaling Pathway

Rigas, A. C., Ozanne, D. M., Neal, D. E., & Robson, C. N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306219200 · Cited by 64 · see citing works

Phosphotryptic Peptide Analysis of the Human Androgen Receptor: Detection of a Hormone-Induced Phosphopeptide

Kuiper, G. G. J. M., & Brinkmann, A. O. (1995) · Biochemistry · doi:10.1021/bi00006a005 · Cited by 59 · see citing works

The Modulator of Nongenomic Actions of the Estrogen Receptor (MNAR) Regulates Transcription-Independent Androgen Receptor-Mediated Signaling: Evidence that MNAR Participates in G Protein-Regulated Meiosis in Xenopus laevis Oocytes

Haas, D., White, S., Lutz, L. B., Rasar, M., & Hammes, S. R. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0531 · Cited by 59 · see citing works

RACK1 regulates Src-mediated Sam68 and p190RhoGAP signaling

Miller, L. D., Lee, K. C., Mochly‐Rosen, D., & Cartwright, C. A. (2004) · Oncogene · doi:10.1038/sj.onc.1207735 · Cited by 41 · see citing works

Characterization of MNAR expression

Greger, J., Guo, Y., Henderson, R. A., Ross, J. F., & Cheskis, B. J. (2005) · Steroids · doi:10.1016/j.steroids.2005.09.016 · Cited by 31 · see citing works

Androgen receptor: structure, role in prostate cancer and drug discovery

Tan, M.-H., Li, J., Xu, H. E., Melcher, K., & Yong, E. (2014) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.18 · Cited by 958 · see citing works

Molecular genetics of prostate cancer: new prospects for old challengesPreprint

Shen, M. M., & Abate-Shen, C. T. (2010) · Genes & Development · doi:10.1101/gad.1965810 · Cited by 949 · see citing works

Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion

Harris, W. P., Mostaghel, E. A., Nelson, P. S., & Montgomery, B. (2009) · Nature Clinical Practice Urology · doi:10.1038/ncpuro1296 · Cited by 880 · see citing works

Androgen Receptor (AR) Coregulators: A Diversity of Functions Converging on and Regulating the AR Transcriptional Complex

Heemers, H. V., & Tindall, D. J. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0019 · Cited by 753 · see citing works

Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity

Berglund, E., Maaskola, J., Schultz, N., Friedrich, S., Marklund, M., Bergenstråhle, J., Tarish, F., Tanoglidi, A., Vicković, S., Larsson, L., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04724-5 · Cited by 550 · see citing works

Androgen receptor signaling in prostate cancer development and progression

Tindall, D. J., & Lonergan, P. E. (2011) · Journal of Carcinogenesis · doi:10.4103/1477-3163.83937 · Cited by 544 · see citing works

RACK1, A multifaceted scaffolding protein: Structure and function

Adams, D. R., Dorit Ron, A., & Kiely, P. A. (2011) · Cell Communication and Signaling · doi:10.1186/1478-811x-9-22 · Cited by 467 · see citing works

Androgen receptors in hormone-dependent and castration-resistant prostate cancer

Shafi, A. A., Yen, A. E., & Weigel, N. L. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.07.003 · Cited by 422 · see citing works

Targeting the androgen receptor pathway in prostate cancer

Chen, Y., Sawyers, C. L., & Scher, H. I. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.07.005 · Cited by 393 · see citing works

Androgen receptor functions in castration-resistant prostate cancer and mechanisms of resistance to new agents targeting the androgen axis

Yuan, X., Cai, C., Chen, S., Chen, S., Yu, Z., & Balk, S. P. (2013) · Oncogene · doi:10.1038/onc.2013.235 · Cited by 367 · see citing works

Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation.

Mahajan, N. P., Liu, Y., Majumder, S., Warren, M. R., Parker, C. E., Mohler, J. L., Earp, H. S., & Whang, Y. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700420104 · Cited by 274 · see citing works

Mechanisms mediating androgen receptor reactivation after castration

Yuan, X., & Balk, S. P. (2008) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2008.03.021 · Cited by 204 · see citing works

Steroid Receptor Phosphorylation: A Key Modulator of Multiple Receptor Functions

Weigel, N. L., & Moore, N. L. T. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0101 · Cited by 196 · see citing works

RACK1, a versatile hub in cancer

Li, J., & Xie, D. (2014) · Oncogene · doi:10.1038/onc.2014.127 · Cited by 182 · see citing works

Minireview: Alternative Activation Pathways for the Androgen Receptor in Prostate Cancer

Lamont, K. R., & Tindall, D. J. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0469 · Cited by 150 · see citing works

miR-30 as a tumor suppressor connects EGF/Src signal to ERG and EMT

Kao, C.-J., Martiniez, A., Shi, X.-B., Yang, J. C., Evans, C. P., Dobi, A., White, R. D., & Kung, H.-J. (2013) · Oncogene · doi:10.1038/onc.2013.200 · Cited by 147 · see citing works

Androgen deprivation of prostate cancer: Leading to a therapeutic dead end

Katzenwadel, A., & Wolf, P. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.06.021 · Cited by 140 · see citing works

Regulation of the androgen receptor by post-translational modifications

Coffey, K., & Robson, C. N. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0238 · Cited by 137 · see citing works

Post-translational modification of the androgen receptor

Gioeli, D. G., & Paschal, B. M. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.07.004 · Cited by 136 · see citing works

CDK9 Regulates AR Promoter Selectivity and Cell Growth through Serine 81 Phosphorylation

Gordon, V. L., Bhadel, S., Wunderlich, W., Zhang, J., Ficarro, S. B., Mollah, S., Shabanowitz, J., Hunt, D. F., Xénarios, I., Hahn, W. C., et al. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0238 · Cited by 134 · see citing works

Posttranslational Modification of the Androgen Receptor in Prostate Cancer

der Steen, T. V., Tindall, D. J., & Huang, H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140714833 · Cited by 133 · see citing works

Molecular pathways and targets in prostate cancer

Shtivelman, E., Beer, T. M., & Evans, C. P. (2014) · Oncotarget · doi:10.18632/oncotarget.2406 · Cited by 115 · see citing works

SUMO-Specific Protease 1 (SENP1) Reverses the Hormone-Augmented SUMOylation of Androgen Receptor and Modulates Gene Responses in Prostate Cancer Cells

Kaikkonen, S., Jääskeläinen, T. J., Karvonen, U., Rytinki, M. M., Makkonen, H., Gioeli, D. G., Paschal, B. M., & Palvimo, J. J. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0219 · Cited by 114 · see citing works

Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases.

Liu, Y., Karaca, M., Zhang, Z., Gioeli, D., Earp, H. S., & Whang, Y. E. (2010) · Oncogene · doi:10.1038/onc.2010.103 · Cited by 106 · see citing works

Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets

Fontana, F., Raimondi, M., Marzagalli, M., Domizio, A. D., & Limonta, P. (2020) · Cells · doi:10.3390/cells9020460 · Cited by 105 · see citing works

Phosphorylation of RACK1 on Tyrosine 52 by c-Abl Is Required for Insulin-like Growth Factor I-mediated Regulation of Focal Adhesion Kinase

Kiely, P. A., Baillie, G. S., Barrett, R., Buckley, D. A., Adams, D. R., Houslay, M. D., & O’Connor, R. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.017640 · Cited by 102 · see citing works

Berberine Suppresses Androgen Receptor Signaling in Prostate Cancer

Li, J., Cao, B., Liu, X., Fu, X., Xiong, Z., Chen, L., Sartor, O. A., Dong, Y., & Zhang, H. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-10-0985 · Cited by 102 · see citing works

Invasive Prostate Carcinoma Driven by c-Src and Androgen Receptor Synergy

Cai, H., Babić, I., Wei, X. X., Huang, J., & Witte, O. N. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1605 · Cited by 96 · see citing works

Differential transformation capacity of Src family kinases during the initiation of prostate cancer

Cai, H., Smith, D. A., Memarzadeh, S., Lowell, C. A., Cooper, J. A., & Witte, O. N. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103904108 · Cited by 89 · see citing works

Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity.

Mahajan, K., Challa, S., Coppola, D., Lawrence, H., Luo, Y., Gevariya, H., Zhu, W., Chen, Y. A., Lawrence, N. J., & Mahajan, N. P. (2010) · The Prostate · doi:10.1002/pros.21163 · Cited by 86 · see citing works

RACK1: A superior independent predictor for poor clinical outcome in breast cancer

Cao, X., Xu, J., Liu, X., Xu, J., Wang, W., Li, Q., Chen, Q., Xu, Z., & Liu, X. (2009) · International Journal of Cancer · doi:10.1002/ijc.25120 · Cited by 84 · see citing works

Minireview: Tipping the Balance: Ligand-Independent Activation of Steroid Receptors

Bennesch, M. A., & Picard, D. (2015) · Molecular Endocrinology · doi:10.1210/me.2014-1315 · Cited by 80 · see citing works

CCR5 Receptor Antagonists Block Metastasis to Bone of v-Src Oncogene–Transformed Metastatic Prostate Cancer Cell Lines

Sicoli, D., Jiao, X., Ju, X., Velasco-Velázquez, M. A., Ertel, A., Addya, S., Li, Z., Andò, S., Fatatis, A., Paudyal, B., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0612 · Cited by 79 · see citing works

RACK1 promotes tumorigenicity of colon cancer by inducing cell autophagy

Xiao, T., Zhu, W., Huang, W., Lu, S., Li, X., Xiao, Z., & Yi, H. L. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1113-9 · Cited by 74 · see citing works

Kinases and protein phosphorylation as regulators of steroid hormone action

Weigel, N. L., & Moore, N. L. (2007) · Nuclear Receptor Signaling · doi:10.1621/nrs.05005 · Cited by 72 · see citing works

Androgen receptor‐related diseases: what do we know?

Shukla, G. C., Plaga, A. R., Shankar, E., & Gupta, S. (2016) · Andrology · doi:10.1111/andr.12167 · Cited by 72 · see citing works

Differential Regulation of Androgen Receptor by PIM-1 Kinases via Phosphorylation-dependent Recruitment of Distinct Ubiquitin E3 Ligases

Linn, D. E., Yang, X., Xie, Y., Alfano, A., Deshmukh, D., Wang, X., Shimelis, H., Chen, H., Li, W., Xu, K., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.338350 · Cited by 64 · see citing works

Human Rhomboid Family-1 Suppresses Oxygen-Independent Degradation of Hypoxia-Inducible Factor-1α in Breast Cancer

Zhou, Z., Liu, F., Zhang, Z.-S., Shu, F., Zheng, Y., Fu, L., & Li, L.-Y. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-1027 · Cited by 61 · see citing works

p66Shc as a switch in bringing about contrasting responses in cell growth: implications on cell proliferation and apoptosis

Bhat, S. S., Anand, D., & Khanday, F. A. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0354-9 · Cited by 59 · see citing works

The Neuroendocrine-Derived Peptide Parathyroid Hormone–Related Protein Promotes Prostate Cancer Cell Growth by Stabilizing the Androgen Receptor

DaSilva, J. O., Gioeli, D. G., Weber, M. J., & Parsons, S. J. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4687 · Cited by 57 · see citing works

Stxbp4 Regulates ΔNp63 Stability by Suppression of RACK1-Dependent Degradation

Li, Y., Peart, M. J., & Prives, C. L. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00449-09 · Cited by 52 · see citing works

Oncogenic activation of androgen receptor

Kung, H.-J., & Evans, C. P. (2008) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2008.06.002 · Cited by 52 · see citing works

Androgen Receptor Expression in Prostate Cancer Cells Is Suppressed by Activation of Epidermal Growth Factor Receptor and ErbB2

Cai, C., Portnoy, D. C., Wang, H., Jiang, X., Chen, S., & Balk, S. P. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0026 · Cited by 51 · see citing works

Targeting the androgen receptor signalling axis in castration‐resistant prostate cancer (CRPC)

Tsao, C., Galsky, M. D., Small, A., Yee, T., & Oh, W. K. (2012) · British Journal of Urology · doi:10.1111/j.1464-410x.2012.11445.x · Cited by 51 · see citing works

Identification of Kinases Regulating Prostate Cancer Cell Growth Using an RNAi Phenotypic Screen

Whitworth, H., Bhadel, S., Ivey, M. L., Conaway, M. R., Spencer, A., Hernan, R. A., Holemon, H., & Gioeli, D. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038950 · Cited by 50 · see citing works

Targeting Tyrosine Kinases and Autophagy in Prostate Cancer

Kung, H.-J. (2010) · Hormones and Cancer · doi:10.1007/s12672-010-0053-3 · Cited by 50 · see citing works

Molecular processes leading to aberrant androgen receptor signaling and castration resistance in prostate cancer

Hu, R., Denmeade, S. R., & Luo, J. (2010) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.10.49 · Cited by 49 · see citing works

p66Shc—a longevity redox protein in human prostate cancer progression and metastasis

Rajendran, M., Thomes, P. G., Zhang, L., Veeramani, S., & Lin, M. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9213-8 · Cited by 48 · see citing works

Dissecting major signaling pathways in prostate cancer development and progression: Mechanisms and novel therapeutic targets

Ramalingam, S., Ramamurthy, V. P., & Njar, V. C. O. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.07.006 · Cited by 48 · see citing works

Non-genomic signaling of steroid receptors in cancer

Thiébaut, C., Vlaeminck‐Guillem, V., Trédan, O., Poulard, C., & Romancer, M. L. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111453 · Cited by 47 · see citing works

Src: Marker or Actor in Prostate Cancer Aggressiveness

Vlaeminck‐Guillem, V., Gillet, G., & Rimokh, R. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00222 · Cited by 46 · see citing works

UGT2B17 Expedites Progression of Castration-Resistant Prostate Cancers by Promoting Ligand-Independent AR Signaling

Li, H., Xie, N., Chen, R., Verreault, M., Fazli, L., Gleave, M. E., Barbier, O., & Dong, X. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-1518 · Cited by 43 · see citing works

High Mobility Group B Proteins, Their Partners, and Other Redox Sensors in Ovarian and Prostate Cancer

Barreiro-Alonso, A., Maceiras, M. L., Rodriguez-Belmonte, E. M., Vizoso‐Vázquez, Á., Quindós, M., & Cerdán, M. E. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/5845061 · Cited by 41 · see citing works

Male hormones activate EphA2 to facilitate Kaposi’s sarcoma-associated herpesvirus infection: Implications for gender disparity in Kaposi’s sarcoma

Wang, X., Zou, Z., Deng, Z., Liang, D., Zhou, X., Sun, R., & Lan, K. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006580 · Cited by 48 · see citing works

A novel role of Shc adaptor proteins in steroid hormone-regulated cancers

Alam, S. M., Rajendran, M., Ouyang, S., Veeramani, S., Zhang, L., & Lin, M.-F. (2008) · Endocrine Related Cancer · doi:10.1677/erc-08-0179 · Cited by 39 · see citing works

Non-Coding RNAs in Castration-Resistant Prostate Cancer: Regulation of Androgen Receptor Signaling and Cancer Metabolism

Shih, J.-W., Wang, L., Hung, C.-L., Kung, H.-J., & Hsieh, C. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226138 · Cited by 36 · see citing works

PvRACK1 Loss-of-Function Impairs Cell Expansion and Morphogenesis in Phaseolus vulgaris L. Root Nodules

Islas‐Flores, T., Guillén, G., Alvarado-Affantranger, X., Lara-Flores, M., Sánchez, F., & Villanueva, M. A. (2011) · Molecular Plant-Microbe Interactions · doi:10.1094/mpmi-11-10-0261 · Cited by 34 · see citing works

Androgen Receptor Activation in Castration-Recurrent Prostate Cancer: The Role of Src-Family and Ack1 Tyrosine Kinases

Gelman, I. H. (2014) · International Journal of Biological Sciences · doi:10.7150/ijbs.8264 · Cited by 33 · see citing works

Downregulation of receptor for activated C‐kinase 1 (RACK1) suppresses tumor growth by inhibiting tumor cell proliferation and tumor‐associated angiogenesis

Wang, F., Osawa, T., Tsuchida, R., Yuasa, Y., & Shibuya, M. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.02065.x · Cited by 31 · see citing works

v-Src Oncogene Induces Trop2 Proteolytic Activation via Cyclin D1

Ju, X., Jiao, X., Ertel, A., Casimiro, M. C., Sante, G. D., Deng, S., Li, Z., Rocco, A. D., Zhan, T., Hawkins, A., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-3327 · Cited by 29 · see citing works

A label-free electrochemical biosensor for direct detection of RACK 1 by using disposable, low-cost and reproducible ITO based electrode

Törer, H., Aydın, E. B., & Sezgintürk, M. K. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2018.04.031 · Cited by 27 · see citing works

Label-free, ITO-based immunosensor for the detection of a cancer biomarker: Receptor for Activated C Kinase 1

Bahadır, E. B., & Sezgintürk, M. K. (2016) · The Analyst · doi:10.1039/c6an00694a · Cited by 26 · see citing works

The RNA-binding protein SERBP1 interacts selectively with the signaling protein RACK1

Bolger, G. B. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.03.001 · Cited by 26 · see citing works

Profiling Human Androgen Receptor Mutations Reveals Treatment Effects in a Mouse Model of Prostate Cancer

O’Mahony, O. A., Steinkamp, M. P., Albertelli, M. A., Brogley, M. A., Rehman, H., & Robins, D. M. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0273 · Cited by 25 · see citing works

RACK1 facilitates breast cancer progression by competitively inhibiting the binding of β-catenin to PSMD2 and enhancing the stability of β-catenin

Tian, R., Tian, J., Zuo, X., Ren, S., Zhang, H., Liu, H., Wang, Z., Cui, Y., Niu, R., & Zhang, F. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06191-3 · Cited by 24 · see citing works

Genistein combined polysaccharide enhances activity of docetaxel, bicalutamide and Src kinase inhibition in androgen‐dependent and independent prostate cancer cell lines

Burich, R. A., Holland, W. S., Vinall, R. L., Tepper, C. G., White, R. D., & Mack, P. C. (2008) · British Journal of Urology · doi:10.1111/j.1464-410x.2008.07826.x · Cited by 23 · see citing works

Randomized Phase II Trial of Abiraterone Alone or With Dasatinib in Men With Metastatic Castration-resistant Prostate Cancer (mCRPC)

Dorff, T. B., Quinn, D. I., Pinski, J., Goldkorn, A., Sadeghi, S., Tsao-Wei, D. D., Groshen, S. G., Kühn, P., & Gross, M. E. (2019) · Clinical Genitourinary Cancer · doi:10.1016/j.clgc.2019.02.010 · Cited by 20 · see citing works

Enhanced Prediction of Src Homology 2 (SH2) Domain Binding Potentials Using a Fluorescence Polarization-derived c-Met, c-Kit, ErbB, and Androgen Receptor Interactome

Leung, K. K., Hause, R. J., Barkinge, J. L., Ciaccio, M. F., Chuu, C., & Jones, R. B. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.034876 · Cited by 20 · see citing works

Experimental varicocoele in rats affects mechanisms that control expression and function of the androgen receptor

Soares, T., Fernandes, S. A. F., Lima, M. L. S., Stumpp, T., Schoorlemmer, G. H. M., Lazari, M. F. M., & Porto, C. S. (2013) · Andrology · doi:10.1111/j.2047-2927.2013.00103.x · Cited by 18 · see citing works

Targeting Key Players of Neuroendocrine Differentiation in Prostate Cancer

Zamora, I., Freeman, M. R., Encı́o, I., & Rotinen, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813673 · Cited by 18 · see citing works

2,2-Bis(4-Chlorophenyl)-1,1-Dichloroethylene Stimulates Androgen Independence in Prostate Cancer Cells through Combinatorial Activation of Mutant Androgen Receptor and Mitogen-Activated Protein Kinase Pathways

Shah, S., Hess-Wilson, J. K., Webb, S. L., Daly, H. K., Godoy‐Tundidor, S., Kim, J. I., Boldison, J., Daaka, Y., & Knudsen, K. E. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-2166 · Cited by 16 · see citing works

Silencing the receptor of activated C-kinase 1 (RACK1) suppresses tumorigenicity in epithelial ovarian cancer in vitro and in vivo

Yang, L., Cui, M., Teng, H., WANG, F., YU, W., & Xu, T. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2274 · Cited by 15 · see citing works

Simultaneous inhibition of aryl hydrocarbon receptor (AhR) and Src abolishes androgen receptor signaling

Ghotbaddini, M., Cisse, K., Carey, A. E., & Powell, J. B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179844 · Cited by 15 · see citing works

Kindlin-2 promotes Src-mediated tyrosine phosphorylation of androgen receptor and contributes to breast cancer progression

Ma, L., Tian, Y., Tao, Q., Li, W., Liu, C., Chu, B., Kong, Q., Cai, R., Bai, P., Ma, L., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04945-z · Cited by 14 · see citing works

Androgen-Sensitive Microsomal Signaling Networks Coupled to the Proliferation and Differentiation of Human Prostate Cancer Cells

Martinez, H. D., Hsiao, J. J., Jasavala, R. J., Hinkson, I. V., Eng, J. K., & Wright, M. E. (2011) · Genes & Cancer · doi:10.1177/1947601912436422 · Cited by 14 · see citing works

Interaction of the Mineralocorticoid Receptor With RACK1 and Its Role in Aldosterone Signaling

Kuppusamy, M., Gómez-Sánchez, E. P., Beloate, L. N., Plonczynski, M. W., Náray‐Fejes‐Tóth, A., Fejes‐Tóth, G., & Gómez-Sánchez, C. E. (2017) · Endocrinology · doi:10.1210/en.2017-00095 · Cited by 14 · see citing works

Unveiling RACK1: a key regulator of the PI3K/AKT pathway in prostate cancer development

Lyu, C., Vaddi, P. K., Elshafae, S. M., Pradeep, A., Ma, D., & Chen, S. (2024) · Oncogene · doi:10.1038/s41388-024-03224-9 · Cited by 13 · see citing works

Downregulation of c-SRC kinase CSK promotes castration resistant prostate cancer and pinpoints a novel disease subclass

Yang, C.-C., Fazli, L., Loguercio, S., Zharkikh, I. L., Aza‐Blanc, P., Gleave, M. E., & Wolf, D. A. (2015) · Oncotarget · doi:10.18632/oncotarget.4279 · Cited by 12 · see citing works

Constitutive Aryl Hydrocarbon Receptor Signaling in Prostate Cancer Progression

Powell, J. B. (2018) · Journal of Cancer Treatment and Diagnosis · doi:10.29245/2578-2967/2018/5.1136 · Cited by 12 · see citing works

Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen

Silva, D. D., Zhang, Z., Liu, Y., Parker, J. S., Xu, C., Cai, L., Wang, G. G., Earp, H. S., & Whang, Y. E. (2019) · Scientific Reports · doi:10.1038/s41598-019-55057-2 · Cited by 12 · see citing works

Stabilization of CCDC102B by Loss of RACK1 Through the CMA Pathway Promotes Breast Cancer Metastasis via Activation of the NF-κB Pathway

Si, J., Guo, R., Xiu, B., Chi, W., Zhang, Q., Hou, J., Su, Y., Chen, J., Xue, J., Shao, Z., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.927358 · Cited by 11 · see citing works

Interaction of protein inhibitor of activated STAT 2 (PIAS2) with receptor of activated C kinase 1, RACK1

Zheng, Y., Zhang, L., Jia, X., Wang, H., & Hu, Y. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.12.013 · Cited by 11 · see citing works

A label-free immunosensor for sensitive detection of RACK 1 cancer biomarker based on conjugated polymer modified ITO electrode

Aydın, E. B., Aydın, M., & Sezgintürk, M. K. (2020) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2020.113517 · Cited by 11 · see citing works

Prosaposin is an AR‐target gene and its neurotrophic domain upregulates AR expression and activity in prostate stromal cells

Koochekpour, S., Lee, T. ‐., Sun, Y., Hu, S., Grabowski, G. A., Liu, Z., & Garay, J. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21786 · Cited by 11 · see citing works

Cancer-Associated Fibroblasts Promote Imatinib Resistance in Gastrointestinal Stromal Tumors through PGK1-Mediated Metabolic Reprogramming

Li, C., Teng, T., Lin, X.-J., Sun, X., Yi, T., Wang, H., Gao, X., & Shen, K. (2025) · Cancer Research · doi:10.1158/0008-5472.can-25-1404 · Cited by 8 · see citing works

A Duality of Function: An Integrative Model of RACK1 as a Switch Between Translational and Signaling Hubs

Kolosov, P. M., Biziaev, N., & Alkalaeva, E. Z. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262311733 · Cited by 8 · see citing works

Associations of saposin C, Src, and androgen receptor upregulate the expression and function of androgen receptor in human prostate cancer cells

Ding, Y., Wang, X., Xu, A., Xu, X., Tian, K., Young, C. Y. F., & Yuan, H. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22977 · Cited by 8 · see citing works

Monitoring cellular accumulation of 3′-deoxy-3′-fluorothymidine (FLT) and its monophosphate metabolite (FLT-MP) by LC–MS/MS as a measure of cell proliferation in vitro

Li, W., Araya, M., Elliott, M., Kang, X., Gerk, P. M., Halquist, M. S., Karnes, H. T., Zhang, C., & O'Brien, P. J. (2011) · Journal of Chromatography B · doi:10.1016/j.jchromb.2011.08.024 · Cited by 6 · see citing works

Inhibition of Fam114A1 protects melanocytes from apoptosis through higher RACK1 expression

Zhou, M., Lin, F., Wu, X., Ping, Z., Xu, W., Jin, R., & Xu, A. (2021) · Aging · doi:10.18632/aging.203712 · Cited by 4 · see citing works

Convergence of EGF Receptor and Src Family Signaling Networks in Cancer

Pritchard, J. E., Jablonski, A. B., & Parsons, S. J. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-356-1_9 · Cited by 4 · see citing works

Androgens Receptor Expression and Steroid Action in Bone

Wiren, K. M. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373884-4.00062-8 · Cited by 4 · see citing works

Cell Biology of Prostate Cancer and Molecular Targets

Gleave, M. E., Cox, M., & Wang, Y. Z. (2010) · Springer eBooks · doi:10.1007/978-1-60327-829-4_1 · Cited by 3 · see citing works

RACK1: A multifunctional scaffold protein involved in signal transduction, ribosomal regulation, and Cancer pathogenesis

Yang, J.-C., Du, Y.-Y., Zuo, W., Yao, J.-Y., Ma, K., Liang, Y. J., Zhao, M., & Li, Z.-M. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112519 · Cited by 2 · see citing works

Cooperative Interactions Between c-Src, Estrogen Receptors and Receptor Tyrosine Kinases in Breast Cancer

Parsons, S. J., Pritchard, J. E., Fox, E. M., & Shupnik, M. A. (2011) · Springer eBooks · doi:10.1007/978-1-4614-1764-4_3 · Cited by 2 · see citing works

Molecular mechanism of prostate cancer cell apoptosis induced by busulfan via adjustment of androgen receptor phosphatization.

Liu, J., Jiang, G., Yang, A., Yang, G., Yang, W., & Fang, Y. (2016) · PubMed Central · Cited by 2 · see citing works

Androgen Action in Bone: Basic Cellular and Molecular Aspects

Wiren, K. M. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-459-9_16 · Cited by 2 · see citing works

Molecular mechanisms of RACK1-driven metastasis in pancreatic ductal adenocarcinoma revealed by single-cell RNA sequencing

Liu, H., Wang, T., Cui, Y., Zhang, B., Shang, D., & Song, H. (2025) · Discover Oncology · doi:10.1007/s12672-025-03679-6 · Cited by 1 · see citing works

The Role of Cyclic AMP in Regulating the Androgen Receptor

Sadar, M. D. (2009) · Springer eBooks · doi:10.1007/978-0-387-69179-4_21 · Cited by 1 · see citing works

Role of androgen receptor co-repressor SLIRP in cell cycle regulation

De Silva, D. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/b7zq-dn70 · Cited by 1 · see citing works

Role of Cortisol and Dehydroepiandrosterone on RACK1/PKC Signalling and Consequences in Immunosenescence

Buoso, E., Serafini, M., Galasso, M., Ronfani, M., Poloni, L. M., Lanni, C., Corsini, E., & Racchi, M. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_116 · Cited by 1 · see citing works

The Scaffolding Protein RACK1 Interacts with Androgen Receptor and Promotes Cross-talk through a Protein Kinase C Signaling Pathway

Rigas, A. C., Ozanne, D. M., Neal, D. E., & Robson, C. N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306219200 · Cited by 64 · see citing works

Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation.

Mahajan, N. P., Liu, Y., Majumder, S., Warren, M. R., Parker, C. E., Mohler, J. L., Earp, H. S., & Whang, Y. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700420104 · Cited by 274 · see citing works

Regulation of androgen receptor activity by tyrosine phosphorylation.

Guo, Z., Dai, B., Jiang, T., Xu, K., Xie, Y., Kim, O., Nesheiwat, I., Kong, X., Melamed, J., Handratta, V. D., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.021 · Cited by 364 · see citing works

Src kinase potentiates androgen receptor transactivation function and invasion of androgen-independent prostate cancer C4-2 cells.

Asim, M., Siddiqui, I. A., Hafeez, B. B., Baniahmad, A., & Mukhtar, H. (2008) · Oncogene · doi:10.1038/sj.onc.1211016 · Cited by 101 · see citing works

Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases. Oncogene (2010

Liu, Y., Karaca, M., Zhang, Z., Gioeli, D. G., Earp, H. S., & Whang, Y. E. (2016)