The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi
Open accessAbstract
Isolates of Salmonella enterica serovar Typhi (Typhi), a human-restricted bacterial pathogen that causes typhoid, show limited genetic variation. We generated whole-genome sequences for 19 Typhi isolates using 454 (Roche) and Solexa (Illumina) technologies. Isolates, including the previously sequenced CT18 and Ty2 isolates, were selected to represent major nodes in the phylogenetic tree. Comparative analysis showed little evidence of purifying selection, antigenic variation or recombination between isolates. Rather, evolution in the Typhi population seems to be characterized by ongoing loss of gene function, consistent with a small effective population size. The lack of evidence for antigenic variation driven by immune selection is in contrast to strong adaptive selection for mutations conferring antibiotic resistance in Typhi. The observed patterns of genetic isolation and drift are consistent with the proposed key role of asymptomatic carriers of Typhi as the main reservoir of this pathogen, highlighting the need for identification and treatment of carriers.
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Versatile and open software for comparing large genomes
Kurtz, S., Phillippy, A., Delcher, A. L., Smoot, M., Shumway, M., Antonescu, C., & Salzberg, S. L. (2004) · Genome Biology · doi:10.1186/gb-2004-5-2-r12 · Cited by 5,254
Massive gene decay in the leprosy bacillus.
Cole, S. T., Eiglmeier, K., Parkhill, J., James, K. D., Thomson, N. R., Wheeler, P. R., Honoré, N., Garnier, T., Churcher, C., Harris, D., et al. (2001) · Nature · doi:10.1038/35059006 · Cited by 1,777
Self-citationParry, C. M., Hien, T. T., Dougan, G., White, N. J., & Farrar, J. J. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020201 · Cited by 1,112
Self-citationParkhill, J., Sebaihia, M., Preston, A., Murphy, L. D., Thomson, N., Harris, D. E., Holden, M. T. G., Churcher, C. M., Bentley, S. D., Mungall, K. L., et al. (2003) · Nature Genetics · doi:10.1038/ng1227 · Cited by 1,037
Self-citationSalmonella, the host and disease: a brief review
Coburn, B., Grassl, G. A., & Finlay, B. B. (2007) · Immunology & Cell Biology · doi:10.1038/sj.icb.7100007 · Cited by 690
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Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
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Sequencing technologies – the next generation
Metzker, M. L. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2626 · Cited by 7,066
Croucher, N. J., Page, A. J., Connor, T. R., Delaney, A. J., Keane, J. A., Bentley, S. D., Parkhill, J., & Harris, S. R. (2015) · Nucleic Acids Research · doi:10.1093/nar/gku1196 · Cited by 2,741
Self-citationBIGSdb: Scalable analysis of bacterial genome variation at the population level
Jolley, K. A., & Maiden, M. C. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-595 · Cited by 2,368
Crump, J. A., Sjölund-Karlsson, M., Gordon, M. A., & Parry, C. M. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00002-15 · Cited by 1,156
Metadata
- Authors
- Holt, K. E., Parkhill, J., Mazzoni, C. J., Roumagnac, P., Weill, F.-X., Goodhead, I., Rance, R., Baker, S., Maskell, D. J., Wain, J., Dolecek, C., Achtman, M., & Dougan, G.
- Venue
- Nature Genetics
- Published
- 2008-07-27
- Volume
- 40
- Issue
- 8
- Pages
- 987-993
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2110397906
- Cited by
- 497
- References
- 5
- FWCI
- 82.45
- Type
- journal article
- Language
- en
- Open access
- green
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- Holt, K. E., Parkhill, J., Mazzoni, C. J., Roumagnac, P., Weill, F.-X., Goodhead, I., Rance, R., Baker, S., Maskell, D. J., Wain, J., Dolecek, C., Achtman, M., & Dougan, G. (2008). High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi. Nature Genetics. https://doi.org/10.1038/ng.195
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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