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Meta-analysis identifies six new susceptibility loci for atrial fibrillation
Open accessAbstract
Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death. We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 × 10(-8)). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.
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“The AF-GRS comprised 12 SNPs that had been previously shown to be associated with AF at genome-wide significance.”
From Twelve-single nucleotide polymorphism genetic risk score identifies individuals at increased risk for future atrial fibrillation and stroke (2014) · cites this paper as [23]
In the citing paper
“These are all the SNPs that have been reported to be associated with AF at a genome-wide significance level (P<5×10−8), including 4 SNPs at PITX2 locus.18-23”
From Twelve-single nucleotide polymorphism genetic risk score identifies individuals at increased risk for future atrial fibrillation and stroke (2014) · cites this paper as [23]
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BackgroundSelf-citationGenetic Variants Related to Height and Risk of Atrial Fibrillation
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“Although both candidate gene studies and unbiased approaches, such as genome-wide association studies, have identified single-nucleotide polymorphisms (SNPs) associated with risk of AF (14), other approaches may provide additional insight.”
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Self-citationA meta-analysis of the impact of TOE adoption on smart agriculture SMEs performance
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Self-citationThe role of common genetic variants in atrial fibrillation
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Self-citationThe role of transcription factors in atrial fibrillation.
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“The association between rs3903239 in paired-related homeobox gene 1 (PRRX1) on 1q24 and AF was reported in a GWAS study which contained a large number of Europeans and Japanese (40).”
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“Some of the important associations include PITX2, PRRX1, SCN5A, SCN10A, KCNN3 and CAV-1.”
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“Unravelling the mechanisms conveying the genetic basis of atrial fibrillation (Benjamin et al., 2009; Ellinor et al., 2012; Gudbjartsson et al., 2007) is a promising and relatively new avenue to novel preventive and therapeutic targets.”
BackgroundPark, J., Lee, J., Yang, P., Kim, T., Shin, E., Park, J., Uhm, J., Joung, B., Lee, M., & Pak, H. (2016) · Journal of Cardiology · doi:10.1016/j.jjcc.2016.04.017 · Cited by 23
“We genotyped the six SNPs associated with AF based on previous GWAS (Table 3) [13,14].”
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“Finally, subsequent to the initiation of this study, SNPs in other genetic loci have been reported to be associated with AF, although with smaller effects.(34,35) The association of these polymorphisms with AF in the context of HF remains to be determined.”
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“Four of the currently known nine AF susceptibility loci (chromosomes 1q24, 4q25, 7q31, and 16q22) were also found to be associated with AF in Japanese individuals [14].”
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“in 2012 (6) demonstrated through meta-analysis that genetic variants in SYNE2, a gene encoding a nuclear outer membrane protein that binds cytoplasmic F-actin and is involved in the maintenance of the structural integrity of the nucleus, were significantly associated with atrial fibrillation in European descendants.”
BackgroundSelf-citationNaser, N., Kulić, M., Dilić, M., Džubur, A., Durak-Nalbantić, A., Pepic, E., Smajić, E., & Kušljugić, Z. (2017) · Medical Archives · doi:10.5455/medarh.2017.71.316-319 · Cited by 23
“This information may be helpful in determining the conditions associated with AF, the risk for recurrent AF following cardioversion, and the hemodynamic benefit of maintaining sinus rhythm, also identification of patients at increased risk for thromboembolic complications of AF before cardioversion and in patients wit…”
BackgroundWeeke, P. E., Parvez, B., Blair, M. A., Short, L. L., Ingram, C., Kucera, G., Stubblefield, T., Roden, D. M., & Darbar, D. (2013) · Heart Rhythm · doi:10.1016/j.hrthm.2013.10.025 · Cited by 21
“, KCNQ1).(8,13) In brief, coding and flanking regions were amplified by polymerase chain reaction using primers designed to obtain fragments of appropriate size for each gene.”
MethodSelf-citationZaw, K. T. T., Sato, N., Ikeda, S., Thu, K. S., Mieno, M., Arai, T., Mori, S., Furukawa, T., Sasano, T., Sawabe, M., et al. (2016) · Journal of Cardiology · doi:10.1016/j.jjcc.2016.11.005 · Cited by 20
Self-citationIntegrative Analysis Reveals Key Circular RNA in Atrial Fibrillation
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“This mechanism is further supported by a recent genome wide association study that linked KCNN3 to AF.(13) The KCNN3 encodes subtype 3 of the small conductance calcium activated K (SK) channels.”
ResultGenetic basis of atrial fibrillation
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Karoshi May Be a Consequence of Overwork-Related Malignant Arrhythmia
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“Significant associations of Cav1 variants with increased risk of cardiac arrhythmias have been proven by human genome-wide association studies [27,28].”
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“Atrial fibrillation Ellinor et al.(5) European ancestry 59 133 (6 707) Log odds ratio Coronary heart disease CARDIoGRAMplusC4D(6) Predominantly European (77%) 184 305 (60 801) Log odds ratio”
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Self-citationHasebe, H., Yoshida, K., Iida, M., Hatano, N., Muramatsu, T., Nogami, A., & Aonuma, K. (2017) · EP Europace · doi:10.1093/europace/eux051 · Cited by 20
“Among several genomic regions associated with familial AF, intergenic variations such as the single nucleotide polymorphism on chromosome 4q25, close to the PITX2 transcription gene, have been identified in both European and Japanese individuals.(13) Insufficiency of PITX2 impairs sodium and potassium channel expressi…”
BackgroundSigurdsson, M. I., Saddic, L., Heydarpour, M., Chang, T.-W., Shekar, P., Aranki, S. F., Couper, G. S., Shernan, S. K., Muehlschlegel, J. D., & Body, S. C. (2017) · BMC Medical Genomics · doi:10.1186/s12920-017-0270-5 · Cited by 21
“The genotype of rs3740293 has previously been associated with the expression of the MYOZ1 gene in left and right atrial tissue [24], and this SNP is in high linkage disequilibrium (LD) with rs10824026, which has also been associated with AF [24, 25].”
BackgroundSupraventricular Arrhythmias in Athletes: Basic Mechanisms and New Directions
D’Souza, A., Trussell, T., Morris, G. M., Dobrzynski, H., & Boyett, M. R. (2019) · Physiology · doi:10.1152/physiol.00009.2019 · Cited by 20
Genetics and pharmacogenetics in the diagnosis and therapy of cardiovascular diseases.
Krasi, G., Precone, V., Paolacci, S., Stuppia, L., Nodari, S., Romeo, F., Perrone, M. A., Bushati, V., Dautaj, A., & Bertelli, M. (2019) · Acta bio-medica dell'Ateneo parmense/Acta biomedica · doi:10.23750/abm.v90i10-s.8748 · Cited by 21
“Familial atrial fibrillation KCNQ1, KCNE2, NPPA, KCNA5, KCNJ2, SCN5A, GJA5, ABCC9, SCN1B, SCN2B, SCN3B, SCN4B, MYL4, GATA4, GATA5, GATA6, PITX2, TBX5, NKX2-5, KCND3, KCNE1, KCNH2, LMNA, PRKAG2, RYR2, ZFHX3, SHOX2, PRRX1, KCNN3, NUP155 (23-40)”
Rahm, A., Wieder, T., Gramlich, D., Müller, M. E., Wunsch, M. N., Tahry, F. A. E., Heimberger, T., Weis, T., Most, P., Katus, H. A., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118892 · Cited by 20
Lubitz, S. A., Bauer, K. A., Benjamin, E. J., Besdine, R. W., Forman, D. E., Gurol, M. E., Reddy, V. Y., & Singer, D. E. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12456 · Cited by 20
“Genetic variants associated with AF implicate cardiac ion channels, transcription factors involved in cardiopulmonary development, and signaling molecules in the pathogenesis of AF.(26) Elucidating the mechanisms linking most common variants to AF presents an opportunity for biological investigation.”
BackgroundSelf-citationIdentification of rare variants in TNNI3 with atrial fibrillation in a Chinese GeneID population
Wang, C., Wu, M., Qian, J., Li, B., Tu, X., Xu, C., Li, S., Chen, S., Zhao, Y., Huang, Y., et al. (2015) · Molecular Genetics and Genomics · doi:10.1007/s00438-015-1090-y · Cited by 20
Atrial Fibrillation and Heart Failure: Cause or Effect?
Luong, C. L., Barnes, M. E., & Tsang, T. S. M. (2014) · Current Heart Failure Reports · doi:10.1007/s11897-014-0229-1 · Cited by 19
Kolek, M. J., Parvez, B., Muhammad, R., Shoemaker, M. B., Blair, M. A., Stubblefield, T., Kucera, G., Denny, J. C., Roden, D. M., & Darbar, D. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2013.08.045 · Cited by 19
Self-citationThe genetics of atrial fibrillation
Hayashi, K., Tada, H., & Yamagishi, M. (2016) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000356 · Cited by 19
Genetics update: Monogenetics, polygene disorders and the quest for modifying genes
Symonds, J. D., & Zuberi, S. M. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.10.013 · Cited by 19
Weng, L.-C. C., Lunetta, K. L., Müller‐Nurasyid, M., Smith, A. V., Thériault, S., Weeke, P., Barnard, J., Bis, J. C., Lyytikäinen, L., Kleber, M. E., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-09396-7 · Cited by 20
Self-citationAndreasen, L. J., Bertelsen, L., Ghouse, J., Lundegaard, P. R., Ahlberg, G., Refsgaard, L., Rasmussen, T. B., Eiskjær, H., Haunsø, S., Vejlstrup, N. G., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-66671-w · Cited by 19
Diagnosing Paroxysmal Atrial Fibrillation: Are Biomarkers the Solution to This Elusive Arrhythmia?
Howlett, P. J., Hatch, F., Alexeenko, V., Jabr, R. I., Leatham, E. W., & Fry, C. H. (2015) · BioMed Research International · doi:10.1155/2015/910267 · Cited by 19
Bress, A. P., Han, J., Patel, S., Desai, A. A., Mansour, I. N., Groo, V. L., Progar, K., Shah‐Williams, E., Stamos, T. D., Wing, C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071268 · Cited by 20
“Finally, contribution by variants not interrogated in this study is also possible, as there may be other, unobserved, polymorphisms in or near CYP11B2 that may be functionally important [34,63,64].”
BackgroundWeigl, I., Geschwill, P., Reiss, M., Bruehl, C., Draguhn, A., Koenen, M., Sedaghat‐Hamedani, F., Meder, B., Thomas, D., Katus, H. A., et al. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.08.150 · Cited by 19
The developing heart: from The Wizard of Oz to congenital heart disease
Bruneau, B. G. (2020) · Development · doi:10.1242/dev.194233 · Cited by 19
“Of the several polymorphisms associated with altered function of the condition system of the heart, and of a rhythm disturbance called atrial fibrillation, those near NKX2-5 and TBX5 were repeatedly found (den Hoed et al., 2013; Ellinor et al., 2012; Pfeufer et al., 2010).”
BackgroundDetection of Paroxysmal Atrial Fibrillation in Stroke/Tia Patients
Khan, M., & Miller, D. J. (2013) · Stroke Research and Treatment · doi:10.1155/2013/840265 · Cited by 18
“These genes mostly encode for proteins important in the integrity of cardiacmyocyte structure and normal physiology [35].”
BackgroundTomomori, S., Nakano, Y., Ochi, H., Onohara, Y., Sairaku, A., Tokuyama, T., Motoda, C., Matsumura, H., Amioka, M., Hironobe, N., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0203281 · Cited by 18
Open Access Integrated Therapeutic and Diagnostic Platforms for Personalized Cardiovascular Medicine
Gladding, P. A., Cave, A., Zareian, M., Smith, K. K., Hussan, J. R., Hunter, P. J., Erogbogbo, F., Aguilar, Z. P., Martin, D. O., Chan, E., et al. (2013) · Journal of Personalized Medicine · doi:10.3390/jpm3030203 · Cited by 19
“Common variants in chromosomes, 4q25, 1q21 and 16q22, have all been associated with atrial fibrillation in genome-wide association studies (GWAS) [54].”
BackgroundThe Role of Pharmacogenetics in Atrial Fibrillation Therapeutics
Darbar, D. (2015) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000280 · Cited by 18
“Eight additional AF susceptibility loci were identified and replicated when a meta-analysis of AF GWAS was performed in 2012 (Table 2).(78) More recently, 5 additional novel AF genes were uncovered by a large consortium of investigators.”
BackgroundSelf-citationNorby, F. L., Eryd, S. A., Niemeijer, M. N., Rose, L. M., Smith, A. V., Yin, X., Agarwal, S. K., Arking, D. E., Chasman, D. I., Chen, L. Y., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151932 · Cited by 18
“[17,18] We used these lipid gene scores as instrumental variables to examine the association between lipid levels and incident AF in 7 US and European prospective cohort studies participating in the AF Genetics (AFGen) consortium.[19]”
MethodSelf-citationMora-García, G., Gómez‐Camargo, D., Alario, Á., & Gómez, C. (2018) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2018.0004 · Cited by 17
“A fraction of that diversity underlies common genetic variations, such CAV1 SNPs, which have been found to be prevalent in the general population but with a different distribution among subjects with metabolic disorders and cardiovascular diseases.(19,20,31,44,61) In the present study an association between a SNP loca…”
BackgroundBai, J., Zhu, Y., Lo, A. D., Gao, M. Y., Lu, Y., Zhao, J., & Zhang, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031265 · Cited by 17
“Furthermore, a meta-analysis of multiple well-phenotyped GWASs identified six new susceptibility loci for fAF, including 1q24 (PRRX1), 7q3 (CAV1), 14q23 (SYNE2), 9q22 (FBP1 and FBP2), 15q24 (HCN4), and 10q22 (upstream of SYNPO2L and MYOZ1) [5].”
BackgroundFenner, M. F., Gatta, G., Sattler, S. M., Kuiper, M., Hesselkilde, E. M., Adler, D. M. T., Smerup, M., Schotten, U., Sørensen, U. S., Diness, J. G., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.614483 · Cited by 18
Subati, T., Kim, K., Yang, Z., Murphy, M. B., Amburg, J. C. V., Christopher, I. L., Dougherty, O. P., Woodall, K. K., Smart, C. D., Johnson, J. E., et al. (2025) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.124.013199 · Cited by 18
A large genome-wide association study of QT interval length utilizing electronic health records
Hoffmann, T. J., Lü, M., Oni‐Orisan, A., Lee, C., RISCH, N. J., & Iribarren, C. (2022) · Genetics · doi:10.1093/genetics/iyac157 · Cited by 17
Kukendrarajah, K., Farmaki, A., Lambiase, P. D., SCHILLING, R. J., Finan, C., Schmidt, A. F., & Providencia, R. A. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105194 · Cited by 18
Z-disc protein CHAPb induces cardiomyopathy and contractile dysfunction in the postnatal heart
van Eldik, W. M., den Adel, B., Monshouwer‐Kloots, J., Salvatori, D. C. F., Maas, S., van der Made, I., Creemers, E. E., Frank, D., Frey, N., Boontje, N. M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0189139 · Cited by 17
“An independent genome-wide association study (GWAS) in individuals of European ancestry identified a SNP (rs10824026) upstream of CHAP gene as a novel AF locus[10].”
BackgroundAtrial fibrillation in the elderly: the potential contribution of reactive oxygen species
Kurt, J. S., & Patel, V. V. (2013) · 老年心脏病学杂志：英文版 · doi:10.3724/sp.j.1263.2012.08141 · Cited by 17
Prunotto, A., Stevenson, B. J., Berthonneche, C., Schüpfer, F., Beckmann, J. S., Maurer, F., & Bergmann, S. (2016) · BMC Genomics · doi:10.1186/s12864-016-3059-6 · Cited by 17
“Synpo2l encodes a cytoskeletal, heart-enriched, actin-associated protein; knockdown in zebrafish causes aberrant cardiac and skeletal muscle development and function [29], whereas human variants are associated with atrial fibrillation [30].”
BackgroundKirchhoff, J. E., Diness, J. G., Abildgaard, L., Sheykhzade, M., Grunnet, M., & Jespersen, T. (2016) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-016-1883-9 · Cited by 17
“Single-nucleotide polymorphisms in the KCNN3 gene encoding SK3 channels have been associated with AF risk, directly linking SK channels to clinical AF [3, 9, 10].”
BackgroundHerrera, N. T., Zhang, X., Ni, H., Maleckar, M. M., Heijman, J., Dobrev, D., Grandi, E., & Morotti, S. (2023) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00362.2023 · Cited by 16
Targeted Deep Sequencing Reveals No Definitive Evidence for Somatic Mosaicism in Atrial Fibrillation
Roberts, J. D., Longoria, J., Poon, A., Gollob, M. H., Dewland, T. A., Kwok, P., Olgin, J. E., Deo, R. C., & Marcus, G. M. (2014) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.114.000650 · Cited by 16
Self-citationGene-gene Interaction Analyses for Atrial Fibrillation
Lin, H., Müller‐Nurasyid, M., Smith, A. V., Arking, D. E., Barnard, J., Bartz, T. M., Lunetta, K. L., Lohman, K., Kleber, M. E., Lubitz, S. A., et al. (2016) · Scientific Reports · doi:10.1038/srep35371 · Cited by 17
Self-citationBiomarkers Associated with Stroke Risk in Atrial Fibrillation
Ioannou, A., Παπαγεωργίου, Ν., Falconer, D., Rehal, O., Sewart, E., Zacharia, E. M., Toutouzas, K. P., Vlachopoulos, C. V., Siasos, G., Tsioufis, C. P., et al. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170718120651 · Cited by 16
Genetic modulation of atrial fibrillation risk in a Hispanic/Latino cohort
Chalazan, B., Mol, D., Sridhar, A., Alzahrani, Z., Darbar, S. D., Ornelas-Loredo, A., Farooqui, A., Argos, M., Daviglus, M. L., Konda, S., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194480 · Cited by 16
Self-citationBrundel, B. J. J. M., Ai, X., Hills, M. T., Kuipers, M. F., Lip, G. Y. H., & de Groot, N. M. S. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.17 · Cited by 18
Roberts, J. D., Hsu, J. C., Aouizerat, B. E., Pullinger, C. R., Malloy, M. J., Kane, J. P., Olgin, J. E., & Marcus, G. M. (2013) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12317 · Cited by 16
Self-citationFerrán, A., Alegret, J. M., Subirana, I., Aragonès, G., Lluís-Ganella, C., Romero‐Menor, C., Planas, F., Joven, J., & Elosúa, R. (2014) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2013.12.019 · Cited by 16
Eryd, S. A., Sjögren, M., Smith, J. G., Nilsson, P. M., Melander, O., Hedblad, B., & Engström, G. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12144 · Cited by 16
Self-citationPITX2: a master regulator of cardiac channelopathy in atrial fibrillation?
Li, N., Dobrev, D., & Wehrens, X. H. T. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw008 · Cited by 16
Genetic heterogeneity of atrial fibrillation susceptibility loci across racial or ethnic groups
Huang, H. D., & Darbar, D. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx289 · Cited by 16
“Prior GWASs conducted in mostly white patients of European ancestry have identified 14 AF susceptibility loci (Table 1).(6,7)”
BackgroundSelf-citation
Metadata
- Authors
- Ellinor, P. T., Lunetta, K. L., Albert, C. M., Glazer, N. L., Ritchie, M. D., Smith, A. V., Arking, D. E., Müller-Nurasyid, M., Krijthe, B. P., Lubitz, S. A., Bis, J. C., Chung, M. K., Dörr, M., Ozaki, K., Roberts, J. D., Smith, J. G., Pfeufer, A., Sinner, M. F., Lohman, K., Ding, J., Smith, N. L., Smith, J. D., Rienstra, M., Rice, K. M., Van Wagoner, D. R., Magnani, J. W., Wakili, R., Clauss, S., Rotter, J. I., Steinbeck, G., Launer, L. J., Davies, R. W., Borkovich, M., Harris, T. B., Lin, H., Völker, U., Völzke, H., Milan, D. J., Hofman, A., Boerwinkle, E., Chen, L. Y., Soliman, E. Z., Voight, B. F., Li, G., Chakravarti, A., Kubo, M., Tedrow, U. B., Rose, L. M., Ridker, P. M., Conen, D., Tsunoda, T., Furukawa, T., Sotoodehnia, N., Xu, S., Kamatani, N., Levy, D., Nakamura, Y., Parvez, B., Mahida, S., Furie, K. L., Rosand, J., Muhammad, R., Psaty, B. M., Meitinger, T., Perz, S., Wichmann, H.-E., Witteman, J. C. M., Kao, W. H. L., Kathiresan, S., Roden, D. M., Uitterlinden, A. G., Rivadeneira, F., McKnight, B., Sjögren, M., Newman, A. B., Liu, Y., Gollob, M. H., Melander, O., Tanaka, T., Stricker, B. H. C., Felix, S. B., Alonso, A., Darbar, D., Barnard, J., Chasman, D. I., Heckbert, S. R., Benjamin, E. J., Gudnason, V., & Kääb, S.
- Affiliations
- Massachusetts General Hospital (US)
- Boston University (US)
- Brigham and Women's Hospital (US)
- University of Washington (US)
- Pennsylvania State University (US)
- University of Iceland (IS)
- Johns Hopkins University (US)
- Erasmus MC (NL)
- Cleveland Clinic (US)
- Universität Greifswald (DE)
- RIKEN (JP)
- Ottawa Heart Institute (CA)
- Broad Institute (US)
- TUM Klinikum (DE)
- Wake Forest University Health Sciences (US)
- Group Health Cooperative (US)
- University Medical Center Groningen (NL)
- Ludwig-Maximilians-Universität München (DE)
- Cedars-Sinai Medical Center (US)
- National Institutes of Health (US)
- The University of Texas Health Science Center at Houston (US)
- University of Minnesota (US)
- University Hospital of Basel (CH)
- Tokyo Medical and Dental University (JP)
- Institute of Medical Science, The University of Tokyo (JP)
- Vanderbilt University (US)
- Harvard University (US)
- Helmholtz Munich (DE)
- München Klinik (DE)
- Lund University (SE)
- University of Pittsburgh (US)
- Corresponding author
- Ellinor, Patrick T
- Kääb, Stefan
- ORCID
- Ellinor, Patrick T
- Lunetta, Kathryn L
- Albert, Christine M
- Glazer, Nicole L
- Ritchie, Marylyn D
- Smith, Albert V
- Arking, Dan E
- Lubitz, Steven A
- Bis, Joshua C
- Chung, Mina K
- Dörr, Marcus
- Ozaki, Kouichi
- Roberts, Jason D
- Sinner, Moritz F
- Ding, Jingzhong
- Smith, Nicholas L
- Smith, Jonathan D
- Rienstra, Michiel
- Rice, Kenneth M
- Magnani, Jared W
- Wakili, Reza
- Clauss, Sebastian
- Rotter, Jerome I
- Steinbeck, Gerhard
- Launer, Lenore J
- Harris, Tamara B
- Lin, Honghuang
- Völker, Uwe
- Völzke, Henry
- Milan, David J
- Boerwinkle, Eric
- Chen, Lin Y
- Soliman, Elsayed Z
- Voight, Benjamin F
- Chakravarti, Aravinda
- Kubo, Michiaki
- Tedrow, Usha B
- Rose, Lynda M
- Ridker, Paul M
- Conen, David
- Tsunoda, Tatsuhiko
- Furukawa, Tetsushi
- Kamatani, Naoyuki
- Levy, Daniel
- Nakamura, Yusuke
- Mahida, Saagar
- Furie, Karen L
- Rosand, Jonathan
- Psaty, Bruce M
- Meitinger, Thomas
- Wichmann, H-Erich
- Kao, W H Linda
- Kathiresan, Sekar
- Roden, Dan M
- Rivadeneira, Fernando
- Newman, Anne B
- Liu, Yongmei
- Gollob, Michael H
- Melander, Olle
- Tanaka, Toshihiro
- Stricker, Bruno H Ch
- Felix, Stephan B
- Darbar, Dawood
- Barnard, John
- Chasman, Daniel I
- Heckbert, Susan R
- Benjamin, Emelia J
- Gudnason, Vilmundur
- Kääb, Stefan
- Venue
- Nature Genetics
- Published
- 2012-04-29
- Volume
- 44
- Issue
- 6
- Pages
- 670-675
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- PMC
- PMC3366038
- OpenAlex
- W2149665587
- Cited by
- 601
- References
- 32
- Citations by year
- 2026: 17 · 2025: 20 · 2024: 28 · 2023: 25 · 2022: 19 · 2021: 33 · 2020: 53 · 2019: 35 · 2018: 41 · 2017: 64 · 2016: 62 · 2015: 56 · 2014: 61 · 2013: 64 · 2012: 22
- FWCI
- 41.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Site cant be reached (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- National Institutes of Health (UL1TR000124)
- Japan Society for the Promotion of Science (23390205, 23659413)
- National Heart, Lung, and Blood Institute (U19HL065962, L30 HL097675, R01HL104156, R01HL092217, R01HL105756, R01HL090620, K24HL105780, R21HL106092)
- National Institute on Drug Abuse (R21DA027021)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- atrial fibrillation, genetic susceptibility loci, genome-wide association study, European ancestry, transcription factors, cardiac ion channels, signaling molecules, cardiac arrhythmias
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Atrial Fibrillation, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Risk Factors, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, White People, Asian People, Genome-Wide Association Study, Young Adult, Genetic Loci
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