The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Meta-analysis identifies six new susceptibility loci for atrial fibrillation
Open accessAbstract
Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death. We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 × 10(-8)). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The AF-GRS comprised 12 SNPs that had been previously shown to be associated with AF at genome-wide significance.”
From Twelve-single nucleotide polymorphism genetic risk score identifies individuals at increased risk for future atrial fibrillation and stroke (2014) · cites this paper as [23]
Experimental — accuracy not yet measuredIn the citing paper
“These are all the SNPs that have been reported to be associated with AF at a genome-wide significance level (P<5×10−8), including 4 SNPs at PITX2 locus.18-23”
From Twelve-single nucleotide polymorphism genetic risk score identifies individuals at increased risk for future atrial fibrillation and stroke (2014) · cites this paper as [23]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Principal components analysis corrects for stratification in genome-wide association studies
Price, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A., & Reich, D. (2006) · Nature Genetics · doi:10.1038/ng1847 · Cited by 10,248
The International HapMap Project
†The International HapMap Consortium, Genotyping centres: Baylor College of Medicine and ParAllele BioScience, Gibbs, R. A., Belmont, J. W., Hardenbol, P., Willis, T. D., Yu, F., Chinese HapMap Consortium, Yang, H., Ch'ang, L.-Y., et al. (2003) · Nature · doi:10.1038/nature02168 · Cited by 6,057
Self-citationFuster, V., Rydén, L. E., Cannom, D. S., Crijns, H. J., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Le Heuzey, J.-Y., Kay, G. N., Lowe, J. E., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.177292 · Cited by 2,805
SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap
Johnson, A. D., Handsaker, R. E., Pulit, S. L., Nizzari, M. M., O’Donnell, C. J., & de Bakker, P. I. W. (2008) · Bioinformatics · doi:10.1093/bioinformatics/btn564 · Cited by 1,339
Population genomics of human gene expression
Stranger, B. E., Nica, A. C., Forrest, M. S., Dimas, A. S., Bird, C., Beazley, C., Ingle, C., Dunning, M., Flicek, P., Koller, D., et al. (2007) · Nature Genetics · doi:10.1038/ng2142 · Cited by 1,153
Variants conferring risk of atrial fibrillation on chromosome 4q25
Gudbjartsson, D. F., Arnar, D. O., Helgadottir, A., Gretarsdottir, S., Holm, H., Sigurdsson, A., Jonasdottir, A., Baker, A., Thorleifsson, G., Kristjansson, K., et al. (2007) · Nature · doi:10.1038/nature06007 · Cited by 955
Self-citationZhang, Q., Bethmann, C., Worth, N. F., Davies, J. D., Wasner, C., Feuer, A., Ragnauth, C. D., Yi, Q., Mellad, J. A., Warren, D. T., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm238 · Cited by 556
Identification of a Genetic Locus for Familial Atrial Fibrillation
Brugada, R., Tapscott, T., Czernuszewicz, G. Z., Marian, A. J., Iglesias, A., Mont, L., Brugada, J., Girona, J. M., Domingo, A., Bachinski, L. L., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199703273361302 · Cited by 554
Practical aspects of imputation-driven meta-analysis of genome-wide association studies
de Bakker, P. I. W., Ferreira, M. A. R., Jia, X., Neale, B. M., Raychaudhuri, S., & Voight, B. F. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn288 · Cited by 531
Self-citationA sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke
Gudbjartsson, D. F., Holm, H., Gretarsdottir, S., Thorleifsson, G., Walters, G. B., Thorgeirsson, G., Gulcher, J., Mathiesen, E. B., Njølstad, I., Nyrnes, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.417 · Cited by 489
Self-citation
Cited by
Sorted by citations
Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000485 · Cited by 12,591
Self-citationHeart disease and stroke statistics-2018 update: a report from the american heart association
Benjamin, E. J., Virani, S. S., Callaway, C. W., Chamberlain, A. M., Chang, A. R., Cheng, S., Chiuve, S. E., Cushman, M., Delling, F. N., Deo, R., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000558 · Cited by 7,146
Self-citation2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation
January, C. T., Wann, L. S., Alpert, J. S., Calkins, H. G., Cigarroa, J. E., Cleveland, J. C., CONTI, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000041 · Cited by 7,145
Self-citationHeart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., Das, S. R., de Ferranti, S., Després, J.-P., Fullerton, H. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000350 · Cited by 6,596
Self-citation2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P. F., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castellà, M., Diener, H., Heidbüchel, H., Hendriks, J., et al. (2016) · EP Europace · doi:10.1093/europace/euw295 · Cited by 6,438
Metadata
- Authors
- Ellinor, P. T., Lunetta, K. L., Albert, C. M., Glazer, N. L., Ritchie, M. D., Smith, A. V., Arking, D. E., Müller-Nurasyid, M., Krijthe, B. P., Lubitz, S. A., Bis, J. C., Chung, M. K., Dörr, M., Ozaki, K., Roberts, J. D., Smith, J. G., Pfeufer, A., Sinner, M. F., Lohman, K., Ding, J., Smith, N. L., Smith, J. D., Rienstra, M., Rice, K. M., Van Wagoner, D. R., Magnani, J. W., Wakili, R., Clauss, S., Rotter, J. I., Steinbeck, G., Launer, L. J., Davies, R. W., Borkovich, M., Harris, T. B., Lin, H., Völker, U., Völzke, H., Milan, D. J., Hofman, A., Boerwinkle, E., Chen, L. Y., Soliman, E. Z., Voight, B. F., Li, G., Chakravarti, A., Kubo, M., Tedrow, U. B., Rose, L. M., Ridker, P. M., Conen, D., Tsunoda, T., Furukawa, T., Sotoodehnia, N., Xu, S., Kamatani, N., Levy, D., Nakamura, Y., Parvez, B., Mahida, S., Furie, K. L., Rosand, J., Muhammad, R., Psaty, B. M., Meitinger, T., Perz, S., Wichmann, H.-E., Witteman, J. C. M., Kao, W. H. L., Kathiresan, S., Roden, D. M., Uitterlinden, A. G., Rivadeneira, F., McKnight, B., Sjögren, M., Newman, A. B., Liu, Y., Gollob, M. H., Melander, O., Tanaka, T., Stricker, B. H. C., Felix, S. B., Alonso, A., Darbar, D., Barnard, J., Chasman, D. I., Heckbert, S. R., Benjamin, E. J., Gudnason, V., & Kääb, S.
- Affiliations
- Massachusetts General Hospital (US)
- Boston University (US)
- Brigham and Women's Hospital (US)
- University of Washington (US)
- Pennsylvania State University (US)
- University of Iceland (IS)
- Johns Hopkins University (US)
- Erasmus MC (NL)
- Cleveland Clinic (US)
- Universität Greifswald (DE)
- RIKEN (JP)
- Ottawa Heart Institute (CA)
- Broad Institute (US)
- TUM Klinikum (DE)
- Wake Forest University Health Sciences (US)
- Group Health Cooperative (US)
- University Medical Center Groningen (NL)
- Ludwig-Maximilians-Universität München (DE)
- Cedars-Sinai Medical Center (US)
- National Institutes of Health (US)
- The University of Texas Health Science Center at Houston (US)
- University of Minnesota (US)
- University Hospital of Basel (CH)
- Tokyo Medical and Dental University (JP)
- Institute of Medical Science, The University of Tokyo (JP)
- Vanderbilt University (US)
- Harvard University (US)
- Helmholtz Munich (DE)
- München Klinik (DE)
- Lund University (SE)
- University of Pittsburgh (US)
- Corresponding author
- Ellinor, Patrick T
- Kääb, Stefan
- ORCID
- Ellinor, Patrick T
- Lunetta, Kathryn L
- Albert, Christine M
- Glazer, Nicole L
- Ritchie, Marylyn D
- Smith, Albert V
- Arking, Dan E
- Lubitz, Steven A
- Bis, Joshua C
- Chung, Mina K
- Dörr, Marcus
- Ozaki, Kouichi
- Roberts, Jason D
- Sinner, Moritz F
- Ding, Jingzhong
- Smith, Nicholas L
- Smith, Jonathan D
- Rienstra, Michiel
- Rice, Kenneth M
- Magnani, Jared W
- Wakili, Reza
- Clauss, Sebastian
- Rotter, Jerome I
- Steinbeck, Gerhard
- Launer, Lenore J
- Harris, Tamara B
- Lin, Honghuang
- Völker, Uwe
- Völzke, Henry
- Milan, David J
- Boerwinkle, Eric
- Chen, Lin Y
- Soliman, Elsayed Z
- Voight, Benjamin F
- Chakravarti, Aravinda
- Kubo, Michiaki
- Tedrow, Usha B
- Rose, Lynda M
- Ridker, Paul M
- Conen, David
- Tsunoda, Tatsuhiko
- Furukawa, Tetsushi
- Kamatani, Naoyuki
- Levy, Daniel
- Nakamura, Yusuke
- Mahida, Saagar
- Furie, Karen L
- Rosand, Jonathan
- Psaty, Bruce M
- Meitinger, Thomas
- Wichmann, H-Erich
- Kao, W H Linda
- Kathiresan, Sekar
- Roden, Dan M
- Rivadeneira, Fernando
- Newman, Anne B
- Liu, Yongmei
- Gollob, Michael H
- Melander, Olle
- Tanaka, Toshihiro
- Stricker, Bruno H Ch
- Felix, Stephan B
- Darbar, Dawood
- Barnard, John
- Chasman, Daniel I
- Heckbert, Susan R
- Benjamin, Emelia J
- Gudnason, Vilmundur
- Kääb, Stefan
- Venue
- Nature Genetics
- Published
- 2012-04-29
- Volume
- 44
- Issue
- 6
- Pages
- 670-675
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- PMC
- PMC3366038
- OpenAlex
- W2149665587
- Cited by
- 601
- References
- 32
- Citations by year
- 2026: 17 · 2025: 20 · 2024: 28 · 2023: 25 · 2022: 19 · 2021: 33 · 2020: 53 · 2019: 35 · 2018: 41 · 2017: 64 · 2016: 62 · 2015: 56 · 2014: 61 · 2013: 64 · 2012: 22
- FWCI
- 41.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Site cant be reached (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- National Institutes of Health (UL1TR000124)
- Japan Society for the Promotion of Science (23390205, 23659413)
- National Heart, Lung, and Blood Institute (U19HL065962, L30 HL097675, R01HL104156, R01HL092217, R01HL105756, R01HL090620, K24HL105780, R21HL106092)
- National Institute on Drug Abuse (R21DA027021)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- atrial fibrillation, genetic susceptibility loci, genome-wide association study, European ancestry, transcription factors, cardiac ion channels, signaling molecules, cardiac arrhythmias
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Atrial Fibrillation, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Risk Factors, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, White People, Asian People, Genome-Wide Association Study, Young Adult, Genetic Loci
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
