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Cited by 353

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo

Open access
Jin, Ying, Birlea, Stanca A, Fain, Pamela R, Ferrara, Tracey M, Ben, Songtao, Riccardi, Sheri L, Cole, Joanne B, Gowan, Katherine, Holland, Paulene J, Bennett, Dorothy C, Luiten, Rosalie M, Wolkerstorfer, Albert, van der Veen, J P Wietze, Hartmann, Anke, Eichner, Saskia, Schuler, Gerold, van Geel, Nanja, Lambert, Jo, Kemp, E Helen, Gawkrodger, David J, Weetman, Anthony P, Taïeb, Alain, Jouary, Thomas, Ezzedine, Khaled, Wallace, Margaret R, McCormack, Wayne T, Picardo, Mauro, Leone, Giovanni, Overbeck, Andreas, Silverberg, Nanette B, Spritz, Richard A·2012·Nature Genetics
DOI 10.1038/ng.2272
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Abstract

We previously reported a genome-wide association study (GWAS) identifying 14 susceptibility loci for generalized vitiligo. We report here a second GWAS (450 individuals with vitiligo (cases) and 3,182 controls), an independent replication study (1,440 cases and 1,316 controls) and a meta-analysis (3,187 cases and 6,723 controls) identifying 13 additional vitiligo-associated loci. These include OCA2-HERC2 (combined P = 3.80 × 10−8), MC1R (P = 1.82 × 10−13), a region near TYR (P = 1.57 × 10−13), IFIH1 (P = 4.91 × 10−15), CD80 (P = 3.78 × 10−10), CLNK (P = 1.56 × 10−8), BACH2 (P = 2.53 × 10−8), SLA (P = 1.58 × 10−8), CASP7 (P = 3.56 × 10−8), CD44 (P = 1.78 × 10−9), IKZF4 (P = 2.75 × 10−14), SH2B3 (P = 3.54 × 10−18) and TOB2 (P = 6.81 × 10−10). Most vitiligo susceptibility loci encode immunoregulatory proteins or melanocyte components that likely mediate immune targeting and the relationships among vitiligo, melanoma, and eye, skin and hair coloration.

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Metadata

Authors
Jin, Y., Birlea, S. A., Fain, P. R., Ferrara, T. M., Ben, S., Riccardi, S. L., Cole, J. B., Gowan, K., Holland, P. J., Bennett, D. C., Luiten, R. M., Wolkerstorfer, A., van der Veen, J. P. W., Hartmann, A., Eichner, S., Schuler, G., van Geel, N., Lambert, J., Kemp, E. H., Gawkrodger, D. J., Weetman, A. P., Taïeb, A., Jouary, T., Ezzedine, K., Wallace, M. R., McCormack, W. T., Picardo, M., Leone, G., Overbeck, A., Silverberg, N. B., & Spritz, R. A.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2012-05-06
Volume
44
Issue
6
Pages
676-680
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng.2272
OpenAlex
W2073062251
Cited by
353
References
59
FWCI
13.56
Type
journal article
Language
en
Open access
bronze

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