The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Eos Mediates Foxp3-Dependent Gene Silencing in CD4 + Regulatory T Cells
Open accessAbstract
T reg Responses to Eos: CD4 + regulatory T cells (T regs ) are critical for keeping our immune system in check: They prevent immune responses from getting out of hand and keep autoimmunity at bay. By activating the expression of some genes and turning off expression of others, the master regulatory transcription factor of T regs , Foxp3, endows these cells with the appropriate gene expression program to mediate their suppressive effects. Pan et al. (p. 1142 , published online 20 August) now demonstrate that the transcription factor Eos is selectively required for Foxp3-mediated gene suppression in mice. Genes normally suppressed by Foxp3 in T regs remained “on” when Eos expression was suppressed, whereas genes activated by Foxp3 were unaffected. T reg function was also affected by Eos suppression. With half their genetic program disrupted, these cells resembled an intermediate between T regs and conventional CD4 + T cells—unable to suppress immune responses properly and partially responsive to T cell–activating stimulation.
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Cites
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
Powrie, F., Leach, M. W., Mauze, S., Caddie, L. B., & Coffman, R. L. (1993) · International Immunology · doi:10.1093/intimm/5.11.1461 · Cited by 1,078
Foxp3 occupancy and regulation of key target genes during T-cell stimulation
Marson, A., Kretschmer, K., Frampton, G. M., Jacobsen, E. S., Polansky, J. K., MacIsaac, K. D., Levine, S. S., Fraenkel, E., von Boehmer, H., & Young, R. A. (2007) · Nature · doi:10.1038/nature05478 · Cited by 724
Hu, R., Sharma, S. M., Bronisz, A., Srinivasan, R., Sankar, U., & Ostrowski, M. C. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01839-06 · Cited by 86
Self-citation
Cited by
Differentiation of Effector CD4 T Cell Populations
Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
Dang, E. V., Barbi, J., Yang, H.-Y., Jinasena, D., Yu, H., Zheng, Y., Bordman, Z., Fu, J., Kim, Y., Yen, H.-R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.07.033 · Cited by 1,595
Self-citationThornton, A. M., Korty, P. E., Tran, D. Q., Wohlfert, E. A., Murray, P. E., Belkaid, Y., & Shevach, E. M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904028 · Cited by 1,382
Impact of Genetic Polymorphisms on Human Immune Cell Gene Expression
Schmiedel, B. J., Singh, D., Madrigal, A., Valdovino-Gonzalez, A. G., White, B. M., Zapardiel-Gonzalo, J., Ha, B., Altay, G., Greenbaum, J. A., McVicker, G., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.022 · Cited by 867
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity
Petukhova, L., Duvic, M., Hordinsky, M., Norris, D., Price, V., Shimomura, Y., Kim, H., Singh, P., Lee, A., Chen, W. V., et al. (2010) · Nature · doi:10.1038/nature09114 · Cited by 830
Metadata
- Authors
- Pan, F., Yu, H., Dang, E. V., Barbi, J., Pan, X., Grosso, J. F., Jinasena, D., Sharma, S. M., McCadden, E. M., Getnet, D., Drake, C. G., Liu, J. O., Ostrowski, M. C., & Pardoll, D. M.
- Venue
- Science
- Published
- 2009-08-28
- Volume
- 325
- Issue
- 5944
- Pages
- 1142-1146
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2057373464
- Cited by
- 334
- References
- 4
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Pan, F., Yu, H., Dang, E. V., Barbi, J., Pan, X., Grosso, J. F., Jinasena, D., Sharma, S. M., McCadden, E. M., Getnet, D., Drake, C. G., Liu, J. O., Ostrowski, M. C., & Pardoll, D. M. (2009). Eos Mediates Foxp3-Dependent Gene Silencing in CD4 + Regulatory T Cells. Science. https://doi.org/10.1126/science.1176077
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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