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Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
Open accessAbstract
We carried out a meta-analysis of data from three genome-wide association (GWA) studies of type 1 diabetes (T1D), testing 305,090 SNPs in 3,561 T1D cases and 4,646 controls of European ancestry. We obtained further support for 4q27 (IL2-IL21, P = 1.9 × 10−8) and, after genotyping an additional 6,225 cases, 6,946 controls and 2,828 families, convincing evidence for four previously unknown and distinct risk loci in chromosome regions 6q15 (BACH2, P = 4.7 × 10−12), 10p15 (PRKCQ, P = 3.7 × 10−9), 15q24 (CTSH, P = 3.2 × 10−15) and 22q13 (C1QTNF6, P = 2.0 × 10−8).
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Finding the missing heritability of complex diseases
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Integrative analysis of 111 reference human epigenomes
Roadmap Epigenomics Consortium, Kundaje, A., Meuleman, W., Ernst, J., Bilenky, M., Yen, A., Heravi-Moussavi, A., Kheradpour, P., Zhang, Z., Wang, J., et al. (2015) · Nature · doi:10.1038/nature14248 · Cited by 6,368
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Self-citationGenotype imputation for genome-wide association studies
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Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies
Van Belle, T. L., Coppieters, K. T., & Von Herrath, M. G. (2011) · Physiological Reviews · doi:10.1152/physrev.00003.2010 · Cited by 1,022
Metadata
- Authors
- Cooper, J. D., Smyth, D. J., Smiles, A. M., Plagnol, V., Walker, N. M., Allen, J. E., Downes, K., Barrett, J. C., Healy, B. C., Mychaleckyj, J. C., Warram, J. H., & Todd, J. A.
- Venue
- Nature Genetics
- Published
- 2008-11-02
- Volume
- 40
- Issue
- 12
- Pages
- 1399-1401
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2024670158
- Cited by
- 531
- References
- 15
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. https://app.cochat.ai/papers/10.1038/ng.249
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- Cooper, J. D., Smyth, D. J., Smiles, A. M., Plagnol, V., Walker, N. M., Allen, J. E., Downes, K., Barrett, J. C., Healy, B. C., Mychaleckyj, J. C., Warram, J. H., & Todd, J. A. (2008). Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nature Genetics. https://doi.org/10.1038/ng.249
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