Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer
Zhang, Zhenfeng, Lee, Jae Cheol, Lin, Luping, Olivas, Victor, Au, Valerie, LaFramboise, Thomas, Abdel-Rahman, Mohamed, Wang, Xiaoqi, Levine, Alan D, Rho, Jin Kyung, Choi, Yun Jung, Choi, Chang-Min, Kim, Sang-We, Jang, Se Jin, Park, Young Soo, Kim, Woo Sung, Lee, Dae Ho, Lee, Jung-Shin, Miller, Vincent A, Arcila, Maria, Ladanyi, Marc, Moonsamy, Philicia, Sawyers, Charles, Boggon, Titus J, Ma, Patrick C, Costa, Carlota, Taron, Miquel, Rosell, Rafael, Halmos, Balazs, Bivona, Trever G·2012·Nature Genetics
DOI 10.1038/ng.2330
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- The role of epithelial to mesenchymal transition in resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancerKristine Raaby Jakobsen, Christina Demuth, Boe Sandahl Sørensen, Anders Lade Nielsen · 2016 · Translational Lung Cancer Research
- Third generation EGFR TKIs in EGFR-mutated NSCLC: Where are we now and where are we goingAlessandro Russo, Tindara Franchina, Giuseppina Rosaria Rita Ricciardi, Valeria Smiroldo, M. Picciotto, Mariangela Zanghì, Christian Diego Rolfo, Vincenzo Adamo · 2017 · Critical Reviews in Oncology/Hematology
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- CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistanceMonique B. Nilsson, Yan Yang, Simon Heeke, Sonia A. Patel, Alissa Poteete, Hibiki Udagawa, Yasir Y. Elamin, César A. Moran, Yukie Kashima, Thiruvengadam Arumugam et al. · 2023 · Cancer Cell
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