Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

Zhang, Zhenfeng, Lee, Jae Cheol, Lin, Luping, Olivas, Victor, Au, Valerie, LaFramboise, Thomas, Abdel-Rahman, Mohamed, Wang, Xiaoqi +22 more·2012·Nature Genetics

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  96. The role of phenotypic plasticity in the escape of cancer cells from targeted therapy
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  100. Redundant kinase activation and resistance of EGFR-tyrosine kinase inhibitors.
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