Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer
Zhang, Zhenfeng, Lee, Jae Cheol, Lin, Luping, Olivas, Victor, Au, Valerie, LaFramboise, Thomas, Abdel-Rahman, Mohamed, Wang, Xiaoqi, Levine, Alan D, Rho, Jin Kyung, Choi, Yun Jung, Choi, Chang-Min, Kim, Sang-We, Jang, Se Jin, Park, Young Soo, Kim, Woo Sung, Lee, Dae Ho, Lee, Jung-Shin, Miller, Vincent A, Arcila, Maria, Ladanyi, Marc, Moonsamy, Philicia, Sawyers, Charles, Boggon, Titus J, Ma, Patrick C, Costa, Carlota, Taron, Miquel, Rosell, Rafael, Halmos, Balazs, Bivona, Trever G·2012·Nature Genetics
DOI 10.1038/ng.2330
Cited by (1,000)
Items 601–700 of 1,000
- First-in-human phase I study of BPI-9016M, a dual MET/Axl inhibitor, in patients with non-small cell lung cancerXingsheng Hu, Xin Zheng, Sheng Yang, Lin Wang, Xuezhi Hao, Xinge Cui, Lieming Ding, Li Mao, Pei Hu, Yuankai Shi · 2020 · Journal of Hematology & Oncology
- Bimodal regulation of the PRC2 complex by USP7 underlies tumorigenesisDongxue Su, Wenjuan Wang, Yongqiang Hou, Liyong Wang, Xianfu Yi, Cheng Cao, Yuejiao Wang, Huan Fang Gao, Yue Wang, Chao Yang et al. · 2021 · Nucleic Acids Research
- Integration of liquid biopsy and pharmacogenomics for precision therapy of EGFR mutant and resistant lung cancersJill Kolesar, Keng Hee Peh, Levin Thomas, Gayathri Baburaj, Nayonika Mukherjee, Raveena Kantamneni, Shirley Christabel Lewis, Ananth Pai, Karthik Udupa, Naveena A. N. Kumar et al. · 2022 · Molecular Cancer
- The Selective Intravenous Inhibitor of the MET Tyrosine Kinase SAR125844 Inhibits Tumor Growth in MET -Amplified CancerCoumaran Égile, Mireille Kenigsberg, Christine Delaisi, Françoise Bégassat, Véronique Do-Vale, Jessica Mestadier, Fabrice Bonche, Tsiala Bénard, Jean‐Paul Nicolas, Sandrine Valence et al. · 2014 · Molecular Cancer Therapeutics
- Multi-omics analysis reveals that ornithine decarboxylase contributes to erlotinib resistance in pancreatic cancer cellsWon‐Jun Jang, Boyeon Choi, Sang-Hoon Song, Naeun Lee, Dong Joon Kim, Sooyeun Lee, Chul‐Ho Jeong · 2017 · Oncotarget
- Design, synthesis and biological evaluation of new Axl kinase inhibitors containing 1,3,4-oxadiazole acetamide moiety as novel linkerCongjun Xu, Yufei Han, Sicong Xu, Ruxin Wang, Ming Yue, Yu Tian, Xiaofan Li, Yanfang Zhao, Ping Gong · 2019 · European Journal of Medicinal Chemistry
- Resistance of Lung Cancer to EGFR-Specific Kinase Inhibitors: Activation of Bypass Pathways and Endogenous MutatorsIlaria Marrocco, Yosef Yarden · 2023 · Cancers
- The clinical development of antibody-drug conjugates for non-small cell lung cancer therapyXinlin Liu, Junwen Deng, Renshuai Zhang, Jiyao Xing, Yudong Wu, Wujun Chen, Bing Liang, Dongming Xing, Jiazhen Xu, Miao Zhang · 2023 · Frontiers in Immunology
- Histologic transformation of non‐small‐cell lung cancer in response to tyrosine kinase inhibitors: Current knowledge of genetic changes and molecular mechanismsAya Shiba‐Ishii, Noriko Takemura, Hitomi Kawai, Daisuke Matsubara · 2024 · Cancer Science
- The novel phosphoinositide 3‐kinase–mammalian target of rapamycin inhibitor, BEZ235, circumvents erlotinib resistance of epidermal growth factor receptor mutant lung cancer cells triggered by hepatocyte growth factorTakako Sano, Shinji Takeuchi, Takayuki Nakagawa, Daisuke Ishikawa, Shigeki Nanjo, Tadaaki Yamada, Takahiro Nakamura, Kunio Matsumoto, Seiji Yano · 2013 · International Journal of Cancer
- Combined inhibition of AXL, Lyn and p130Cas kinases block migration of triple negative breast cancer cellsKinga Pénzes, Christine Baumann, István Szabadkai, László Őrfi, Gÿorgý Kéri, Axel Ullrich, Robert Torka · 2014 · Cancer Biology & Therapy
- Fisetin, a dietary phytochemical, overcomes Erlotinib-resistance of lung adenocarcinoma cells through inhibition of MAPK and AKT pathways.Liang Zhang, Yi Huang, Wenlei Zhuo, Yi Zhun Zhu, Bo Zhu, Zhengtang Chen · 2016 · PubMed Central
- AXL is a marker for epithelial‑mesenchymal transition in esophageal squamous cell carcinomaGuoan Zhang, Xia Kong, Meng Wang, Hongli Zhao, Sha Han, Ronghang Hu, Jian An Huang, Wen Cui · 2017 · Oncology Letters
- Synthesis, and anti-proliferative, Pim-1 kinase inhibitors and molecular docking of thiophenes derived from estroneRafat M. Mohareb, Eman M. Samir, Peter A. Halim · 2018 · Bioorganic Chemistry
- Blockade of AXL activation overcomes acquired resistance to EGFR tyrosine kinase inhibition in non-small cell lung cancerFeng Wang, Xuewen Liu, Boris Bartholdy, Haiying Cheng, Balázs Halmos · 2019 · Translational Cancer Research
- Repositioning Aspirin to Treat Lung and Breast Cancers and Overcome Acquired Resistance to Targeted TherapyLing Li, Mengdi Hu, Tao Wang, Hongzhuan Chen, Lu Xu · 2020 · Frontiers in Oncology
- The potential role of YAP in Axl-mediated resistance to EGFR tyrosine kinase inhibitors.Sarah Saab, Olin Shih-Shin Chang, Kentaro Nagaoka, Mien‐Chie Hung, Hirohito Yamaguchi · 2019 · PubMed Central
- LncRNA MIR17HG inhibits non-small cell lung cancer by upregulating miR-142-3p to downregulate Bach-1Sen Wei, Jinghao Liu, Xin Li, Xingyu Liu · 2020 · BMC Pulmonary Medicine
- MERTK Inhibition: Potential as a Treatment Strategy in EGFR Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung CancerChao‐Ju Chen, Yu‐Peng Liu · 2021 · Pharmaceuticals
- Early Steps of Resistance to Targeted Therapies in Non-Small-Cell Lung CancerCélia Delahaye, Sarah Figarol, Anne Pradines, Gilles Favre, Julien Mazières, Olivier Calvayrac · 2022 · Cancers
- c-MET kinase inhibitors: a patent review (2011 – 2013)Kongkai Zhu, Xiangqian Kong, Dan Zhao, Zhongjie T. Liang, Cheng Luo · 2013 · Expert Opinion on Therapeutic Patents
- Transcriptomic-metabolomic reprogramming in EGFR-mutant NSCLC early adaptive drug escape linking TGFβ2-bioenergetics-mitochondrial primingPraveena Shree Thiagarajan, Xiaoliang Wu, Wei Zhang, Ivy Shi, Rakesh K. Bagai, Patrick S. Leahy, Yan Feng, Martina L. Veigl, Daniel J. Lindner, David Danielpour et al. · 2016 · Oncotarget
- Genomic and Molecular Screenings Identify Different Mechanisms for Acquired Resistance to MET Inhibitors in Lung Cancer CellsPol Giménez‐Xavier, Eva Pros, Ester Bonastre, Sebastián Morán, Ana Aza, Osvaldo Graña‐Castro, Gonzalo Goméz-López, Sophia V. Derdak, Marc Dabad, Anna Esteve‐Codina et al. · 2017 · Molecular Cancer Therapeutics
- Polyphyllin VII increases sensitivity to gefitinib by modulating the elevation of P21 in acquired gefitinib resistant non-small cell lung cancerHonggang Wang, Zhenghua Fei, Hao Jiang · 2017 · Journal of Pharmacological Sciences
- Combined effect of cabozantinib and gefitinib in crizotinib‐resistant lung tumors harboring ROS 1 fusionsYuka Kato, Kiichiro Ninomiya, Kadoaki Ohashi, Shuta Tomida, Go Makimoto, Hiromi Watanabe, Kenichiro Kudo, Shingo Matsumoto, Shigeki Umemura, Kōichi Goto et al. · 2018 · Cancer Science
- Cooperation and Interplay between EGFR Signalling and Extracellular Vesicle Biogenesis in CancerLaura C. Zanetti-Domingues, Scott E. Bonner, R. Sumanth Iyer, Marisa L. Martin-Fernandez, Veronica Huber · 2020 · Cells
- First-line therapy for advanced non-small cell lung cancer with activating EGFR mutation: is combined EGFR-TKIs and chemotherapy a better choice?Shuyun Wang, Aiqin Gao, Jie Liu, Yuping Sun · 2018 · Cancer Chemotherapy and Pharmacology
- Phenotypic chemical screening using zebrafish neural crest reporters identifies retinoid acid as an inhibitor of epithelial morphogenesisLaura Jiménez, Jindong Wang, Monique A. Morrison, Clifford J. Whatcott, Katherine K. Soh, Steven L. Warner, David J. Bearss, Cicely A. Jette, Rodney A. Stewart · 2016 · Disease Models & Mechanisms
- Advances in Circulating Tumor DNA AnalysisSamantha O. Perakis, Martina Auer, Jelena Belic, Ellen Heitzer · 2017 · Advances in clinical chemistry
- The Tumor-Suppressor Protein OPCML Potentiates Anti–EGFR- and Anti–HER2-Targeted Therapy in HER2-Positive Ovarian and Breast CancerElisa Zanini, Louay S. Louis, Jane Antony, Evdoxia Karali, Imoh Sunday Okon, Arthur B. McKie, Sebastian Vaughan, Mona A El-Bahrawy, Justin Stebbing, Chiara Recchi et al. · 2017 · Molecular Cancer Therapeutics
- Liquid biopsy uncovers distinct patterns of DNA methylation and copy number changes in NSCLC patients with different EGFR-TKI resistant mutationsHoai‐Nghia Nguyen, Ngoc-Phuong Thi Cao, Thien-Chi Van Nguyen, Khang Nguyen Duy Le, Dat Nguyen, Quynh‐Tho Thi Nguyen, Thai-Hoa Thi Nguyen, Chu Van Nguyen, Ha Thu Le, Trieu Vu Nguyen et al. · 2021 · Scientific Reports
- Pancreatic Cancer: Pathogenesis and Clinical StudiesKexun Zhou, Yingping Liu, Chuanyun Tang, Hong Zhu · 2025 · MedComm
- AUY922 Effectively Overcomes MET- and AXL-Mediated Resistance to EGFR-TKI in Lung Cancer CellsYun Jung Choi, Seon Ye Kim, Kwang Sup So, In‐Jeoung Baek, Woo Sung Kim, Sehoon Choi, Jae Cheol Lee, Trever Grant Bivona, Jin Kyung Rho, Chang‐Min Choi · 2015 · PLoS ONE
- An improved CTC isolation scheme for pairing with downstream genomics: Demonstrating clinical utility in metastatic prostate, lung and pancreatic cancerGayatri Premasekharan, Elizabeth Gilbert, Ross A. Okimoto, Ashiya Hamirani, Karla J. Lindquist, Vy Ngo, Ritu Roy, Jeffrey Hough, Matthew Edwards, Rosa Paz et al. · 2016 · Cancer Letters
- A novel human anti‐AXL monoclonal antibody attenuates tumour cell migrationYanting Duan, Longlong Luo, Chunxia Qiao, Xinying Li, Jing Wang, Hao Liu, Tingting Zhou, Beifen Shen, Ming Lv, Jiannan Feng · 2019 · Scandinavian Journal of Immunology
- Research progress on the relationship between lung cancer drug-resistance and microRNAsXuan Ma, Ai-Ling Liang, Yongjun Liu · 2019 · Journal of Cancer
- Enhanced Sensitivity of Nonsmall Cell Lung Cancer with Acquired Resistance to Epidermal Growth Factor Receptor‐Tyrosine Kinase Inhibitors to Phenformin: The Roles of a Metabolic Shift to Oxidative Phosphorylation and Redox BalanceSuntae Kim, Ji Hye Im, Wankyu Kim, Young Jae Choi, Ji Yoon Lee, Sang Kyum Kim, Sun Jo Kim, Sung Won Kwon, Keon Wook Kang · 2021 · Oxidative Medicine and Cellular Longevity
- STAT3 mediated upregulation of C-MET signaling acts as a compensatory survival mechanism upon EGFR family inhibition in chemoresistant breast cancer cellsYuying Zhu, He Zhang, Xingxing Han, Zhiyong Wang, Yanfen Cui, Ran Tian, Zhaosong Wang, Baoai Han, Jianfei Tian, Fei Zhang et al. · 2021 · Cancer Letters
- AXL antibody and AXL-ADC mediate antitumor efficacy via targeting AXL in tumor-intrinsic epithelial-mesenchymal transition and tumor-associated M2-like macrophageJinpeng Pei, Yue Wang, Lanping Ma, Xin Wang, Liang Liu, Yu Zhang, Rui Jin, Zhiqiang Ren, Yan Deng, Jingkang Shen et al. · 2023 · Acta Pharmacologica Sinica
- Pharmacogenomics of EGFR-targeted therapies in non–small cell lung cancer: EGFR and beyondChristopher D. Delaney, Samuel Frank, R. Stephanie Huang · 2015 · 癌症:英文版
- A role for the pseudokinase HER3 in the acquired resistance against EGFR- and HER2-directed targeted therapyJeroen Claus, Gargi Surendra Patel, Tony Ng, Peter J. Parker · 2014 · Biochemical Society Transactions
- Secrets of Drug Resistance in NSCLC Exposed by New Molecular Definition of EMTDana S. Neel, Trever Grant Bivona · 2012 · Clinical Cancer Research
- Omega-3 Fatty Acid-Enriched Fish Oil and Selenium Combination Modulates Endoplasmic Reticulum Stress Response Elements and Reverses Acquired Gefitinib Resistance in HCC827 Lung Adenocarcinoma CellsChien-Huang Liao, Yu-Tien Tzeng, Gi‐Ming Lai, Chia-Lun Chang, Ming-Hung Hu, Wei-Lun Tsai, Yun‐Ru Liu, Simon Hsia, Shuang‐En Chuang, Tzeon-Jye Chiou et al. · 2020 · Marine Drugs
- New apoptotic anti-triple-negative breast cancer theobromine derivative inhibiting EGFRWT and EGFRT790M: in silico and in vitro evaluationIbrahim H. Eissa, Reda G. Yousef, Hazem Elkady, Aisha A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Nehal M. El‐Deeb, Ahmed M. A. Kenawy, Wagdy Mohamed Eldehna, Eslam B. Elkaeed et al. · 2023 · Molecular Diversity
- MET Gene Amplification and MET Receptor Activation Are Not Sufficient to Predict Efficacy of Combined MET and EGFR Inhibitors in EGFR TKI-Resistant NSCLC CellsDario Presutti, Simonetta Santini, Beatrice Cardinali, Giuliana Papoff, Cristiana Lalli, Simone Samperna, Valentina Fustaino, Giuseppe Giannini, Giovina Ruberti · 2015 · PLoS ONE
- Electrochemical immunosensor for receptor tyrosine kinase AXL using poly(pyrrolepropionic acid)-modified disposable electrodesVerónica Serafín, Rebeca Magnolia Torrente-Rodríguez, M. Batlle, Pablo Garcı́a de Frutos, Susana Campuzano, Paloma Yáñez‐Sedeño, José Manuel Pingarrón · 2016 · Sensors and Actuators B Chemical
- Clinical strategies for acquired epidermal growth factor receptor tyrosine kinase inhibitor resistance in non-small-cell lung cancer patientsLijun Dong, Dan Lei, Haijun Zhang · 2017 · Oncotarget
- Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseasesNaoya Fujino, Oliver J. Brand, David J. Morgan, Toshifumi Fujimori, Aleksander M. Grabiec, Christopher P. Jagger, Rose A. Maciewicz, Mitsuhiro Yamada, Koji Itakura, Hisatoshi Sugiura et al. · 2019 · The Journal of Experimental Medicine
- AXL, an Important Host Factor for DENV and ZIKV ReplicationShengda Xie, Huiru Zhang, Zhenjie Liang, Xingmiao Yang, Ruibing Cao · 2021 · Frontiers in Cellular and Infection Microbiology
- AXL/CDCP1/SRC axis confers acquired resistance to osimertinib in lung cancerYûichi Murakami, Daiki Kusakabe, Kosuke Watari, Akihiko Kawahara, Koichi Azuma, Jun Akiba, Masahiko Taniguchi, Michihiko Kuwano, Mayumi Ono · 2022 · Scientific Reports
- JNK Pathway Activation Modulates Acquired Resistance to EGFR/HER2–Targeted TherapiesSimin Manole, Edward J. Richards, Aaron S. Meyer · 2016 · Cancer Research
- Deep-proteome mapping of WM-266-4 human metastatic melanoma cells: From oncogenic addiction to druggable targetsEumorphia G. Konstantakou, Athanassios D. Velentzas, Athanasios K. Anagnostopoulos, Zoi I. Litou, Ourania A. Konstandi, Aikaterini F. Giannopoulou, Ema Anastasiadou, Gerassimos E. Voutsinas, George Th. Tsangaris, Dimitrios J. Stravopodis · 2017 · PLoS ONE
- A Vesicular Stomatitis Virus‐Inspired DNA Nanocomplex for Ovarian Cancer TherapyWei Zhao, Yuping Yang, Lingling Song, Tianyi Kang, Ting Du, Yujiao Wu, Meimei Xiong, Li Luo, Jianlin Long, Ke Men et al. · 2017 · Advanced Science
- Treatment of Non-small Cell Lung Carcinoma after Failure of Epidermal Growth Factor Receptor Tyrosine Kinase InhibitorJae Cheol Lee, Seung Hun Jang, Kye Young Lee, Young‐Chul Kim · 2013 · Cancer Research and Treatment
- Novel molecular targets for the treatment of lung cancerRafael Rosell, Niki Karachaliou, Oscar G. Arrieta · 2019 · Current Opinion in Oncology
- Regulation of the Receptor Tyrosine Kinase AXL in Response to Therapy and Its Role in Therapy Resistance in GlioblastomaLea Scherschinski, Markus Prem, Irina Kremenetskaia, Ingeborg Tinhofer, Peter Vajkoczy, Anna-Gila Karbe, Julia Onken · 2022 · International Journal of Molecular Sciences
- Research Progress on Therapeutic Targeting of Cancer-Associated Fibroblasts to Tackle Treatment-Resistant NSCLCChenxin Li, Yusong Qiu, Yong Zhang · 2022 · Pharmaceuticals
- AXL – a new player in resistance to HER2 blockadeAnna Adam‐Artigues, Enrique Javier Arenas, Joaquín Arribas, Aleix Prat, Juan Miguel Cejalvo · 2023 · Cancer Treatment Reviews
- Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agentsW-B Tsai, Y Long, J-R Park, Jeffrey T. Chang, Hui Liu, Jaime Rodriguez‐Canales, Niramol Savaraj, Lynn G. Feun, Michael A. Davies, Ignacio Ivan Wistuba et al. · 2015 · Oncogene
- Prediction of signaling cross-talks contributing to acquired drug resistance in breast cancer cells by Bayesian statistical modelingAKM Azad, Alfons Lawen, Jonathan Macgregor Keith · 2015 · BMC Systems Biology
- Insights into the roles of hnRNP A2/B1 and AXL in non-small cell lung cancerXiaohan Qu, Jinlu Liu, Xinwen Zhong, Xi Li, Qigang Zhang · 2015 · Oncology Letters
- Upregulation of Bcl2 in NSCLC with acquired resistance to EGFR‑TKIHio Teng Cheong, Fei Xu, Chi Tung Choy, Connie Wun Chun Hui, Tony S.K. Mok, Chi Hang Wong · 2017 · Oncology Letters
- Results of a Phase II Placebo-controlled Randomized Discontinuation Trial of Cabozantinib in Patients with Non–small-cell Lung CarcinomaBeth A. Hellerstedt, Nicholas J. Vogelzang, Harriet M. Kluger, Christopher A. Yasenchak, Dana T. Aftab, David Albert Ramies, Michael S. Gordon, Primo N. Lara · 2018 · Clinical Lung Cancer
- Adrenergic Blockade Promotes Maintenance of Dormancy in Prostate Cancer Through Upregulation of GAS6Ann M. Decker, Joseph T. Decker, Younghun Jung, Frank Cameron Cackowski, Stephanie Daignault‐Newton, Todd Matthew Morgan, Lonnie D. Shea, Russell S. Taichman · 2020 · Translational Oncology
- Identification of novel bioactive molecules from garlic bulbs: A special effort to determine the anticancer potential against lung cancer with targeted drugsRAMAKRISHNAN PADMINI, V. Uma Maheshwari, Parameswaran Saravanan, Keun Woo Lee, M. Razia, Mona S. Alwahibi, Balasubramani Ravindran, Mohamed Soliman Elshikh, Young Ock Kim, Hyungsuk Kim et al. · 2020 · Saudi Journal of Biological Sciences
- Efficacy of the CDK7 Inhibitor on EMT-Associated Resistance to 3rd Generation EGFR-TKIs in Non-Small Cell Lung Cancer Cell LinesWonjun Ji, Yun Jung Choi, Myoung Hee Kang, Ki Jung Sung, Dong Ha Kim, Sangyong Jung, Chang‐Min Choi, Jae Cheol Lee, Jin Kyung Rho · 2020 · Cells
- Treatment of EGFR T790M-Positive Non-Small Cell Lung CancerJoan Rou-En Choo, Chee‐Seng Tan, Ross Andrew Soo · 2018 · Targeted Oncology
- Overcoming Resistance to AC0010, a Third Generation of EGFR Inhibitor, by Targeting c-MET and BCL-2Xu, Wanhong, Tang, Wei, Li, Tingting, Zhang, Xiaoying, Sun, Yi · 2019 · Neoplasia
- Single cell lineage tracing reveals clonal dynamics of anti-EGFR therapy resistance in triple negative breast cancerSimona Pellecchia, Melania Franchini, Gaetano Viscido, Riccardo Arnese, Gennaro Gambardella · 2024 · Genome Medicine
- MET: A New Promising Biomarker in Non-Small-Cell Lung CarcinomaCristina Pérez-Ramírez, Marisa Cañadas‐Garre, Enrique Jiménez‐Varo, María José Faus-Dáder, Miguel Ángel Calleja‐Hernández · 2015 · Pharmacogenomics
- MiR-30 Family Potentially Targeting PI3K-SIAH2 Predicted Interaction Network Represents a Novel Putative Theranostic Panel in Non-small Cell Lung CancerLawrence Chan, Fengfeng Wang, Fei Meng, Lili Wang, Sze Chuen Cesar Wong, Joseph S. K. Au, Sijun Yang, William C. S. Cho · 2017 · Frontiers in Genetics
- Management of Egfr-Mutated Non-Small-Cell Lung Cancer: Practical Implications from a Clinical and Pathology PerspectiveMichael Cabanero, Randeep S. Sangha, Brandon S. Sheffield, Mahadeo A. Sukhai, Mini Pakkal, Suzanne Kamel‐Reid, Aly Karsan, Diana N. Ionescu, Rosalyn Anne Juergens, Charles Andrew Butts et al. · 2017 · Current Oncology
- High expression of NEK2 promotes lung cancer progression and drug resistance and is regulated by mutant EGFRChuanhui Chen, Shanshan Peng, Penghui Li, Lin Ma, Xin Gan · 2020 · Molecular and Cellular Biochemistry
- Integrated Omics Analysis of Non-Small-Cell Lung Cancer Cells Harboring the EGFR C797S Mutation Reveals the Potential of AXL as a Novel Therapeutic Target in TKI-Resistant Lung CancerTong‐Hong Wang, Chih‐Ching Wu, Kuo‐Yen Huang, Yann‐Lii Leu, Shuenn‐Chen Yang, Ci‐Ling Chen, Chi‐Yuan Chen · 2020 · Cancers
- Upfront admixing antibodies and EGFR inhibitors preempts sequential treatments in lung cancer modelsIlaria Marrocco, Donatella Romaniello, Itay Vaknin, Diana Drago Garcia, Roni Oren, Mary Luz Uribe, Nishanth Belugali Nataraj, Soma Ghosh, Raya Eilam, Tomer‐Meir Salame et al. · 2021 · EMBO Molecular Medicine
- Therapeutic Targeting of the Anaplastic Lymphoma Kinase (ALK) in Neuroblastoma—A Comprehensive UpdateAnnette K. Brenner, Maria Winther Gunnes · 2021 · Pharmaceutics
- Current therapy and development of therapeutic agents for lung cancerZilai Wang, Jiyeon Kim, Pin Zhang, Jazmin Galván Achi, Yuwei Jiang, Lijun Rong · 2022 · Cell Insight
- Utilising the EGFR interactome to identify mechanisms of drug resistance in non-small cell lung cancer – Proof of concept towards a systems pharmacology approachHisham Saafan, Sarah Foerster, Zinnia Patricia Parra-Guillen, Elke Hammer, Martin Michaelis, Jindrich Jr. Cinatl, Uwe Völker, Holger Fröhlich, Charlotte Kloft, Christoph Alexander Ritter · 2016 · European Journal of Pharmaceutical Sciences
- Marsdenia tenacissima extract overcomes Axl- and Met-mediated erlotinib and gefitinib cross-resistance in non-small cell lung cancer cellsShu-Yan Han, Wei Zhao, Hai-Bo Han, Hong Sun, Dong Xue, Yan-Na Jiao, Xi-Ran He, Shan-Tong Jiang, Pingping Li · 2017 · Oncotarget
- Resistance to epidermal growth factor receptor inhibition in non-small cell lung cancerNele Van Der Steen, Elisa Giovannetti, Daniela Carbone, Alessandro Leonetti, Christian Diego Rolfo, Godefridus J. Peters · 2018 · Cancer Drug Resistance
- Applications of liquid biopsy in lung cancer-diagnosis, prognosis prediction, and disease monitoring.Wenna Luo, Mingliang Rao, Jiayao Qu, Dixian Luo · 2018 · Europe PMC (PubMed Central)
- Axl receptor tyrosine kinase is a novel target of apigenin for the inhibition of cell proliferationKYUNG-CHAN KIM, Eun Ha Choi, ChuHee Lee · 2014 · International Journal of Molecular Medicine
- AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast CancerMauricio Marquez-Palencia, Luis Reza Herrera, Pravat Kumar Parida, Suvranil Ghosh, Kangsan Kim, Nikitha M. Das, Paula I. González Ericsson, Melinda E. Sanders, Bret C. Mobley, Sebastian Diegeler et al. · 2024 · Cancer Research
- Multiplexed Analysis for Anti-Epidermal Growth Factor Receptor Tumor Cell Growth Inhibition Based on Quantum Dot ProbesDahai Ren, Yiqiu Xia, Bin Wang, Zheng You · 2016 · Analytical Chemistry
- Guidance of Signaling Activations by Cadherins and Integrins in Epithelial Ovarian Cancer CellsFrancesca Roggiani, Delia Mezzanzanica, Katia Rea, Antonella Tomassetti · 2016 · International Journal of Molecular Sciences
- Treatment Options for EGFR T790M-Negative EGFR Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung CancerCorallo, Salvatore, D’Argento, Ettore, Strippoli, Antonia, Basso, Michele, Monterisi, Santa, Rossi, Sabrina, Cassano, Alessandra, Barone, Carlo M. · 2017 · Targeted Oncology
- Targeting AXL in NSCLCAubhishek Zaman, Trever Grant Bivona · 2021 · Lung Cancer Targets and Therapy
- Targeting Oncogenic KRAS in Non-Small-Cell Lung CancerNoriaki Sunaga, Yosuke Miura, Norimitsu Kasahara, Reiko Sakurai · 2021 · Cancers
- Heterogeneity of glutamine metabolism in acquired-EGFR-TKI-resistant lung cancerSuntae Kim, Jang Su Jeon, Yong June Choi, Ga Hee Baek, Sang Kyum Kim, Keon Wook Kang · 2022 · Life Sciences
- High levels of AXL expression in untreated EGFR ‐mutated non‐small cell lung cancer negatively impacts the use of osimertinibAkihiro Yoshimura, Tadaaki Yamada, Masakuni Serizawa, Hisanori Uehara, Keiko Tanimura, Yusuke Okuma, Akito Fukuda, Satoshi Watanabe, Naoya Nishioka, Takayuki Takeda et al. · 2022 · Cancer Science
- Unraveling the Impact of Intratumoral Heterogeneity on EGFR Tyrosine Kinase Inhibitor Resistance in EGFR-Mutated NSCLCKeigo Kobayashi, Aaron C. Tan · 2023 · International Journal of Molecular Sciences
- Intermittent high-dose treatment with erlotinib enhances therapeutic efficacy in EGFR-mutant lung cancerJakob Schöttle, Sampurna Chatterjee, Caroline Volz, Maike Siobal, Alexandra Florin, Dennis Rokitta, Yvonne Hinze, Felix Dietlein, Dennis Plenker, Katharina König et al. · 2015 · Oncotarget
- NF-κB activation is an early event of changes in gene regulation for acquiring drug resistance in human adenocarcinoma PC-9 cellsMasashi Fukuoka, Katsuji Yoshioka, Hirohiko Hohjoh · 2018 · PLoS ONE
- Ion Channels in Lung CancerEtmar Bulk, Luca Matteo Todesca, Albrecht Schwab · 2020 · Reviews of physiology, biochemistry and pharmacology
- Axl inhibition: a potential road to a novel acute myeloid leukemia therapy?Melanie Janning, Isabel Ben Batalla, Sonja Loges · 2015 · Expert Review of Hematology
- Advances in Lung Cancer Basic and Translational Research in 2025 – Overview and Perspectives Focusing on NSCLCCéline Mascaux, Triparna Sen, Montse Sánchez‐Céspedes, Sandra Ortiz‐Cuaran, Yohan Bossé, Floris F. Dammeijer, Milena R. Cavic, Martin P. Barr, Surein Arulananda, Ricardo Armisén et al. · 2025 · Journal of Thoracic Oncology
- Coexpression of receptor tyrosine kinase AXL and EGFR in human primary lung adenocarcinomasZhenzhou Wu, Fan Bai, Liyun Fan, Wenshuai Pang, Ruiyu Han, Juan Wang, Yueping Liu, Yan Xia, Huijun Duan, Lingxiao Xing · 2015 · Human Pathology
- Synthesis and antiproliferative activity of pyrrolo[2,3-b]pyridine derivatives bearing the 1,8-naphthyridin-2-one moietyQidong Tang, Yongli Duan, Linxiao Wang, Min Wang, Yiqiang Ouyang, Caolin Wang, Mei Han, Sheng Tang, Yinhua Xiong, Pengwu Zheng et al. · 2017 · European Journal of Medicinal Chemistry
- Intrinsic Differences in Spatiotemporal Organization and Stromal Cell Interactions Between Isogenic Lung Cancer Cells of Epithelial and Mesenchymal Phenotypes Revealed by High-Dimensional Single-Cell Analysis of Heterotypic 3D Spheroid ModelsMaria Lie Lotsberg, Gro Vatne Røsland, Austin J. Rayford, Sissel E. Dyrstad, Camilla Tvedt Ekanger, Ning Lü, Kirstine Frantz, Linda E. B. Stuhr, Henrik J. Ditzel, Jean Paul Thiery et al. · 2022 · Frontiers in Oncology
- AXL regulates neuregulin1 expression leading to cetuximab resistance in head and neck cancerMari Iida, Nellie K. McDaniel, Kourtney L. Kostecki, Noah B. Welke, Carlene A. Kranjac, Peng Liu, Colin A. Longhurst, Justine Y. Bruce, Seungpyo Hong, Ravi Salgia et al. · 2022 · BMC Cancer