The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia
Open accessAbstract
We have extensively characterized the DNA methylomes of 139 patients with chronic lymphocytic leukemia (CLL) with mutated or unmutated IGHV and of several mature B-cell subpopulations through the use of whole-genome bisulfite sequencing and high-density microarrays. The two molecular subtypes of CLL have differing DNA methylomes that seem to represent epigenetic imprints from distinct normal B-cell subpopulations. DNA hypomethylation in the gene body, targeting mostly enhancer sites, was the most frequent difference between naive and memory B cells and between the two molecular subtypes of CLL and normal B cells. Although DNA methylation and gene expression were poorly correlated, we identified gene-body CpG dinucleotides whose methylation was positively or negatively associated with expression. We have also recognized a DNA methylation signature that distinguishes new clinico-biological subtypes of CLL. We propose an epigenomic scenario in which differential methylation in the gene body may have functional and clinical implications in leukemogenesis.
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Cites
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Cited by
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Metadata
- Authors
- Kulis, M., Heath, S., Bibikova, M., Queirós, A. C., Navarro, A., Clot, G., Martínez-Trillos, A., Castellano, G., Brun-Heath, I., Pinyol, M., Barberán-Soler, S., Papasaikas, P., Jares, P., Beà, S., Rico, D., Ecker, S., Rubio, M., Royo, R., Ho, V., Klotzle, B., Hernández, L., Conde, L., López-Guerra, M., Colomer, D., Villamor, N., Aymerich, M., Rozman, M., Bayes, M., Gut, M., Gelpí, J. L., Orozco, M., Fan, J.-B., Quesada, V., Puente, X. S., Pisano, D. G., Valencia, A., López-Guillermo, A., Gut, I., López-Otín, C., Campo, E., & Martín-Subero, J. I.
- Venue
- Nature Genetics
- Published
- 2012-10-14
- Volume
- 44
- Issue
- 11
- Pages
- 1236-1242
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2029742174
- Cited by
- 578
- References
- 12
- FWCI
- 20.13
- Type
- journal article
- Language
- en
- Open access
- green
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- Kulis, M., Heath, S., Bibikova, M., Queirós, A. C., Navarro, A., Clot, G., Martínez-Trillos, A., Castellano, G., Brun-Heath, I., Pinyol, M., Barberán-Soler, S., Papasaikas, P., Jares, P., Beà, S., Rico, D., Ecker, S., Rubio, M., Royo, R., Ho, V., . . . Martín-Subero, J. I. (2012). Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia. Nature Genetics. https://doi.org/10.1038/ng.2443
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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