Analysis of DNA methylation in cancer: location revisited
Abstract
Changes in DNA methylation in cancer have been heralded as promising targets for the development of powerful diagnostic, prognostic, and predictive biomarkers. Despite the existence of more than 14,000 scientific publications describing DNA methylation-based biomarkers and their clinical associations in cancer, only 14 of these biomarkers have been translated into a commercially available clinical test. Methodological and experimental obstacles are both major causes of this disparity, but the genomic location of a DNA methylation-based biomarker is an intrinsic and essential property that also has an important and often overlooked role. Here, we examine the importance of the location of DNA methylation for the development of cancer biomarkers, and take a detailed look at the genomic location and other relevant characteristics of the various biomarkers with commercially available tests. We also emphasize the value of publicly available databases for the development of DNA methylation-based biomarkers and the importance of accurate reporting of the full methodological details of research findings.
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Transposable elements have a fundamental role in development and disease.
“Although evolutionarily diverse, these elements have a fundamental role in development and disease 216 .”
From The roles of DNA, RNA and histone methylation in ageing and cancer (2019) · cites this paper as [216]
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- Authors
- Koch, A., Joosten, S. C., Feng, Z., de Ruijter, T. C., Draht, M. X., Melotte, V., Smits, K. M., Veeck, J., Herman, J. G., Van Neste, L., Van Criekinge, W., De Meyer, T., & van Engeland, M.
- Affiliations
- Maastricht University Medical Centre (NL)
- UPMC Hillman Cancer Center (US)
- Venue
- Nature Reviews Clinical Oncology
- Published
- 2018-04-17
- Volume
- 15
- Issue
- 7
- Pages
- 459-466
- ISSN
- 1759-4774 (ISSN-L)
- 1759-4782
- OpenAlex
- W2800289222
- Cited by
- 710
- References
- 81
- Citations by year
- 2026: 37 · 2025: 71 · 2024: 84 · 2023: 124 · 2022: 129 · 2021: 146 · 2020: 56 · 2019: 53 · 2018: 9 · 2013: 1
- FWCI
- 6.71
- Type
- journal article
- Language
- en
- Update notices
- correction (2018-04-30)
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- DNA methylation, tumor markers, genomic location, diagnostic biomarkers, prognostic factors, epigenetic biomarkers, clinical translation, methodological reporting
- MeSH terms
- Humans, Neoplasms, Biomarkers, Tumor, Genome, Human, DNA Methylation, Epigenesis, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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