The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
Open accessAbstract
We describe an analysis of genome variation in 825 P. falciparum samples from Asia and Africa that identifies an unusual pattern of parasite population structure at the epicenter of artemisinin resistance in western Cambodia. Within this relatively small geographic area, we have discovered several distinct but apparently sympatric parasite subpopulations with extremely high levels of genetic differentiation. Of particular interest are three subpopulations, all associated with clinical resistance to artemisinin, which have skewed allele frequency spectra and high levels of haplotype homozygosity, indicative of founder effects and recent population expansion. We provide a catalog of SNPs that show high levels of differentiation in the artemisinin-resistant subpopulations, including codon variants in transporter proteins and DNA mismatch repair proteins. These data provide a population-level genetic framework for investigating the biological origins of artemisinin resistance and for defining molecular markers to assist in its elimination.
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Cites
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Self-citationEvidence of Artemisinin-Resistant Malaria in Western Cambodia
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Cited by
Spread of Artemisinin Resistance in Plasmodium falciparum Malaria
Ashley, E. A., Dhorda, M., Fairhurst, R. M., Amaratunga, C., Lim, P., Suon, S., Sreng, S., Anderson, J. M., Mao, S., Sam, B., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1314981 · Cited by 2,205
Self-citationSemi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development
Paddon, C. J., & Keasling, J. D. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3240 · Cited by 675
Antimalarial Drug Resistance: A Threat to Malaria Elimination
Menard, D., & Dondorp, A. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025619 · Cited by 499
Self-citationArtemisinin Action and Resistance in Plasmodium falciparum
Tilley, L., Straimer, J., Gnädig, N. F., Ralph, S. A., & Fidock, D. A. (2016) · Trends in Parasitology · doi:10.1016/j.pt.2016.05.010 · Cited by 359
Evolutionary analysis of the most polymorphic gene family in falciparum malaria
Otto, T. D., Assefa, S. A., Böhme, U., Sanders, M. J., Kwiatkowski, D. P., Pf3k consortium, Berriman, M., & Newbold, C. (2019) · Wellcome Open Research · doi:10.12688/wellcomeopenres.15590.1 · Cited by 90
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Metadata
- Authors
- Miotto, O., Almagro-Garcia, J., Manske, M., MacInnis, B., Campino, S., Rockett, K. A., Amaratunga, C., Lim, P., Suon, S., Sreng, S., Anderson, J. M., Duong, S., Nguon, C., Chuor, C. M., Saunders, D., Se, Y., Lon, C., Fukuda, M. M., Amenga-Etego, L., Hodgson, A. V. O., Asoala, V., Imwong, M., Takala-Harrison, S., Nosten, F., Su, X.-Z., Ringwald, P., Ariey, F., Dolecek, C., Hien, T. T., Boni, M. F., Thai, C. Q., Amambua-Ngwa, A., Conway, D. J., Djimdé, A. A., Doumbo, O. K., Zongo, I., Ouedraogo, J.-B., Alcock, D., Drury, E., Auburn, S., Koch, O., Sanders, M., Hubbart, C., Maslen, G., Ruano-Rubio, V., Jyothi, D., Miles, A., O'Brien, J., Gamble, C., Oyola, S. O., Rayner, J. C., Newbold, C. I., Berriman, M., Spencer, C. C. A., McVean, G., Day, N. P., White, N. J., Bethell, D., Dondorp, A. M., Plowe, C. V., Fairhurst, R. M., & Kwiatkowski, D. P.
- Venue
- Nature Genetics
- Published
- 2013-04-28
- Volume
- 45
- Issue
- 6
- Pages
- 648-655
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W1973603244
- Cited by
- 462
- References
- 41
- FWCI
- 70.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Miotto, O., Almagro-Garcia, J., Manske, M., MacInnis, B., Campino, S., Rockett, K. A., Amaratunga, C., Lim, P., Suon, S., Sreng, S., Anderson, J. M., Duong, S., Nguon, C., Chuor, C. M., Saunders, D., Se, Y., Lon, C., Fukuda, M. M., Amenga-Etego, L., . . . Kwiatkowski, D. P. (2013). Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia. Nature Genetics. https://doi.org/10.1038/ng.2624
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