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Cited by 462

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

Open access
Miotto, Olivo, Almagro-Garcia, Jacob, Manske, Magnus, MacInnis, Bronwyn, Campino, Susana, Rockett, Kirk A, Amaratunga, Chanaki, Lim, Pharath, Suon, Seila, Sreng, Sokunthea, Anderson, Jennifer M, Duong, Socheat, Nguon, Chea, Chuor, Char Meng, Saunders, David, Se, Youry, Lon, Chantap, Fukuda, Mark M, Amenga-Etego, Lucas, Hodgson, Abraham V O, Asoala, Victor, Imwong, Mallika, Takala-Harrison, Shannon, Nosten, François, Su, Xin-zhuan, Ringwald, Pascal, Ariey, Frédéric, Dolecek, Christiane, Hien, Tran Tinh, Boni, Maciej F, Thai, Cao Quang, Amambua-Ngwa, Alfred, Conway, David J, Djimdé, Abdoulaye A, Doumbo, Ogobara K, Zongo, Issaka, Ouedraogo, Jean-Bosco, Alcock, Daniel, Drury, Eleanor, Auburn, Sarah, Koch, Oliver, Sanders, Mandy, Hubbart, Christina, Maslen, Gareth, Ruano-Rubio, Valentin, Jyothi, Dushyanth, Miles, Alistair, O'Brien, John, Gamble, Chris, Oyola, Samuel O, Rayner, Julian C, Newbold, Chris I, Berriman, Matthew, Spencer, Chris C A, McVean, Gilean, Day, Nicholas P, White, Nicholas J, Bethell, Delia, Dondorp, Arjen M, Plowe, Christopher V, Fairhurst, Rick M, Kwiatkowski, Dominic P·2013·Nature Genetics
DOI 10.1038/ng.2624
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Abstract

We describe an analysis of genome variation in 825 P. falciparum samples from Asia and Africa that identifies an unusual pattern of parasite population structure at the epicenter of artemisinin resistance in western Cambodia. Within this relatively small geographic area, we have discovered several distinct but apparently sympatric parasite subpopulations with extremely high levels of genetic differentiation. Of particular interest are three subpopulations, all associated with clinical resistance to artemisinin, which have skewed allele frequency spectra and high levels of haplotype homozygosity, indicative of founder effects and recent population expansion. We provide a catalog of SNPs that show high levels of differentiation in the artemisinin-resistant subpopulations, including codon variants in transporter proteins and DNA mismatch repair proteins. These data provide a population-level genetic framework for investigating the biological origins of artemisinin resistance and for defining molecular markers to assist in its elimination.

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Authors
Miotto, O., Almagro-Garcia, J., Manske, M., MacInnis, B., Campino, S., Rockett, K. A., Amaratunga, C., Lim, P., Suon, S., Sreng, S., Anderson, J. M., Duong, S., Nguon, C., Chuor, C. M., Saunders, D., Se, Y., Lon, C., Fukuda, M. M., Amenga-Etego, L., Hodgson, A. V. O., Asoala, V., Imwong, M., Takala-Harrison, S., Nosten, F., Su, X.-Z., Ringwald, P., Ariey, F., Dolecek, C., Hien, T. T., Boni, M. F., Thai, C. Q., Amambua-Ngwa, A., Conway, D. J., Djimdé, A. A., Doumbo, O. K., Zongo, I., Ouedraogo, J.-B., Alcock, D., Drury, E., Auburn, S., Koch, O., Sanders, M., Hubbart, C., Maslen, G., Ruano-Rubio, V., Jyothi, D., Miles, A., O'Brien, J., Gamble, C., Oyola, S. O., Rayner, J. C., Newbold, C. I., Berriman, M., Spencer, C. C. A., McVean, G., Day, N. P., White, N. J., Bethell, D., Dondorp, A. M., Plowe, C. V., Fairhurst, R. M., & Kwiatkowski, D. P.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2013-04-28
Volume
45
Issue
6
Pages
648-655
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng.2624
OpenAlex
W1973603244
Cited by
462
References
41
FWCI
70.90
Type
journal article
Language
en
Open access
green

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