Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

Kozlitina, Julia, Smagris, Eriks, Stender, Stefan, Nordestgaard, Børge G, Zhou, Heather H, Tybjærg-Hansen, Anne, Vogt, Thomas F, Hobbs, Helen H, Cohen, Jonathan C·2014·Nature Genetics

DOI 10.1038/ng.2901

Cited by (1,000)

Items 501–600 of 1,000

Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) – an 11-Year Prospective Study
Susanna Lallukka, Sanja Sädevirta, Markus T. Kallio, Panu K. Luukkonen, You Zhou, Antti Hakkarainen, Nina M I Lundbom, Marju Orho‐Melander, Hannele Yki‐Järvinen · 2017 · Scientific Reports
Cardiovascular Disease in Nonalcoholic Steatohepatitis: Screening and Management
Hersh Shroff, Lisa B. VanWagner · 2020 · Current Hepatology Reports
Structural enzymology of cholesterol biosynthesis and storage
Tao Long, Erik Debler, Xiaochun Li · 2022 · Current Opinion in Structural Biology
Updated S2k clinical practice guideline on non-alcoholic fatty liver disease (NAFLD) issued by the German society of gastroenterology, digestive and metabolic diseases (DGVS)–April 2022–AWMF Registration No.: 021–025
Authors, Collaborators: · 2022 · Zeitschrift für Gastroenterologie
Multi-system diseases and death trajectory of metabolic dysfunction-associated fatty liver disease: findings from the UK Biobank
Jia Yu, Dongze Li, Yi You, Jing Yu, Wenli Jiang, Yi Liu, Rui Zeng, Zhi Wan, Lei Yi, Xiaoyang Liao · 2023 · BMC Medicine
Genetic and epigenetic determinants of non-alcoholic fatty liver disease (NAFLD) in lean individuals: a systematic review
Basile M. Njei, Yazan A. Al‐Ajlouni, Derek Fan Ugwendum, Manasik N. Abdu, Anim Forjindam, Mouhand Faisal Hamad Mohamed · 2024 · Translational Gastroenterology and Hepatology
Differences between hepatocellular carcinoma caused by alcohol and other aetiologies
Nathalie Ganne‐Carrié, Pierre Nahon · 2024 · Journal of Hepatology
“Trust your gut”: exploring the connection between gut microbiome dysbiosis and the advancement of Metabolic Associated Steatosis Liver Disease (MASLD)/Metabolic Associated Steatohepatitis (MASH): a systematic review of animal and human studies
Wesam Bahitham, Yusra Banoun, Mutep Aljahdali, Ghufran Almuaiqly, Shahad M. Bahshwan, Linah Aljahdali, Faisal M. Sanai, Alexandre Soares Rosado, Consolato Maria Sergi · 2025 · Frontiers in Nutrition
An overview of the genetics, mechanisms and management of NAFLD and ALD
Rachel Rowell, Quentin Mark Anstee · 2015 · Clinical Medicine
Nighttime sleep duration and risk of nonalcoholic fatty liver disease: the Dongfeng-Tongji prospective study
Cheng Liu, Rong Zhong, Jiao Lou, An Pan, Yuhan Tang, Jiang Chang, Juntao Ke, Jiaoyuan Li, Jing Yuan, Youjie Wang et al. · 2016 · Annals of Medicine
Exome array analysis identifies ETFB as a novel susceptibility gene for anthracycline-induced cardiotoxicity in cancer patients
Sara Ruiz‐Pinto, Guillermo Pita, Miguel Martín, Teresa Alonso‐Gordoa, Daniel R. Barnes, María R. Alonso, Belén Herráez, Purificación García‐Miguel, Javier Alonso, Antonio Pérez‐Martínez et al. · 2017 · Breast Cancer Research and Treatment
Collagen Formation Assessed by N‐Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography
Cyrielle Caussy, Meera Bhargava, Ida Falk Villesen, Natasja Stæhr Gudmann, Diana Julie Leeming, M.A. Karsdal, Claire Faulkner, Denny Bao, Amy Liu, Min‐Tzu Lo et al. · 2019 · Hepatology
GLP-1 mimetics as a potential therapy for nonalcoholic steatohepatitis
Yan Chen, Ying-na Xu, Chen-yu Ye, Wenbo Feng, Qingtong Zhou, Dehua Yang, Ming‐Wei Wang · 2021 · Acta Pharmacologica Sinica
Integrative network-based analysis on multiple Gene Expression Omnibus datasets identifies novel immune molecular markers implicated in non-alcoholic steatohepatitis
Junjie Zhang, Yan Shen, Xiao-yuan Chen, Man-lei Jiang, Feng-hua Yuan, Shui-lian Xie, Jie Zhang, Fei Xu · 2023 · Frontiers in Endocrinology
The role of platelets in non-alcoholic fatty liver disease: From pathophysiology to therapeutics
Navya Malladi, Md Jahangir Alam, Subir Kumar Maulik, S. Banerjee · 2023 · Prostaglandins & Other Lipid Mediators
Drivers of cardiovascular disease in metabolic dysfunction-associated steatotic liver disease: the threats of oxidative stress
Erika T. Minetti, Naomi M. Hamburg, Reiko Matsui · 2024 · Frontiers in Cardiovascular Medicine
The Effects of Hepatic Steatosis on the Natural History of HBV Infection
Idrees Suliman, Noha Abdelgelil, Farah Kassamali, Tarek Hassanein · 2019 · Clinics in Liver Disease
Characterization of essential domains in HSD17B13 for cellular localization and enzymatic activity
Yanling Ma, Suman Karki, Philip M. Brown, Dennis D. Lin, Maren Catherina Podszun, Wenchang Zhou, Olga V. Belyaeva, Natalia Y. Kedishvili, Yaron Rotman · 2020 · Journal of Lipid Research
Phenotypic Differences Between Polygenic and Monogenic Hypobetalipoproteinemia
Antoine Rimbert, Xavier Vanhoye, Dramane Coulibaly, Marie Marrec, Matthieu Pichelin, Sybil Charrière, Noël Peretti, René Valéro, Matthieu Wargny, Alain Carrié et al. · 2020 · Arteriosclerosis Thrombosis and Vascular Biology
PNPLA3, TM6SF2, and MBOAT7 Influence on Nutraceutical Therapy Response for Non-alcoholic Fatty Liver Disease: A Randomized Controlled Trial
Marcello Dallio, Mario Masarone, Mario Romeo, Concetta Tuccillo, Filomena Morisco, Marcello Persico, C. Loguercio, Alessandro Federico · 2021 · Frontiers in Medicine
Genetics in non-alcoholic fatty liver disease: The role of risk alleles through the lens of immune response
Silvia C. Sookoian, Carlos Jose Pirola · 2022 · Clinical and Molecular Hepatology
Genome‐Wide Association Study of Liver Fat: The Multiethnic Cohort Adiposity Phenotype Study
So‐Hyun Park, Yuqing Li, Xin Sheng, Victor Hom, Lucy Y. Xia, Kechen Zhao, Loreall Pooler, Veronica Wendy Setiawan, Unhee Lim, Kristine R. Monroe et al. · 2020 · Hepatology Communications
NAFLD Fibrosis Progression and Type 2 Diabetes: The Hepatic–Metabolic Interplay
Simona Cernea · 2024 · Life
A Comprehensive Review of Metabolic Dysfunction-Associated Steatotic Liver Disease: Its Mechanistic Development Focusing on Methylglyoxal and Counterbalancing Treatment Strategies
Izabela Berdowska, M. Matusiewicz, Izabela Fecka · 2025 · International Journal of Molecular Sciences
Interactions between lipid droplets and mitochondria in metabolic diseases
Guoxin Wang, Bin Sun, Huimin Liu, Min Hu, Huan Xu, Hongtao Li, Xijin Wang, Mingfu Tong · 2025 · Lipids in Health and Disease
Patatin‐like phospholipase domain containing 3 variants differentially impact metabolic traits in individuals at high risk for cardiovascular events
Sabrina Rüschenbaum, Katharina Maria Schwarzkopf, Mireen Friedrich‐Rust, Florian Hartmut Seeger, Fabian Schoelzel, Yolanda Martinez, Stefan Zeuzem, Jörg Bojunga, Christian Markus Lange · 2018 · Hepatology Communications
Interaction of TM6SF2 E167K and PNPLA3 I148M variants in NAFLD in northeast China
Min Xu, Yiling Li, Shuang Zhang, Xinyi Wang, Jianhua Shen, Shuwen Zhang · 2019 · Annals of Hepatology
The roles of transmembrane 6 superfamily member 2 rs58542926 polymorphism in chronic liver disease: A meta‐analysis of 24,147 subjects
Xinpei Chen, Pengcheng Zhou, De Luo, Bo Li, Song Su · 2019 · Molecular Genetics & Genomic Medicine
Association between body size-metabolic phenotype and nonalcoholic steatohepatitis and significant fibrosis
Donghee Kim, Won Kyum Kim, Sae Kyung Joo, Jimin Han, Jung Ho Kim, Stephen A. Harrison, Zobair M. Younossi, Aijaz Ahmed · 2019 · Journal of Gastroenterology
Genetic Susceptibility to Chronic Liver Disease in Individuals from Pakistan
Asad Mehmood Raja, Ester Ciociola, Imran Ahmad, Faisal Saud Dar, Syed Naqvi, Muhammad Moaeen-ud-Din, Ghazala Kaukab Raja, Stefano Romeo, Rosellina Margherita Mancina · 2020 · International Journal of Molecular Sciences
Genetic variant rs72613567 of HSD17B13 gene reduces alcohol‐related liver disease risk in Chinese Han population
Haizhen Chen, Yanfang Zhang, Tongsheng Guo, Funing Yang, Yuanli Mao, Liubing Li, Chenxi Liu, Haidi Gao, Yuting Jin, Yuanyuan Che et al. · 2020 · Liver International
Beyond the Paradigm of Weight Loss in Non-Alcoholic Fatty Liver Disease: From Pathophysiology to Novel Dietary Approaches
Angelo Armandi, Jörn Markus Schattenberg · 2021 · Nutrients
The role of PCSK9 in NAFLD/NASH and therapeutic implications of PCSK9 inhibition
Amir Abbas Momtazi‐Borojeni, Maciej Banach, Massimiliano Ruscica, Amirhossein Sahebkar · 2022 · Expert Review of Clinical Pharmacology
Genetic Polymorphisms and Diversity in Nonalcoholic Fatty Liver Disease (NAFLD): A Mini Review
Siti Aishah Sulaiman, Vicneswarry Dorairaj, Muhammad Nafiz Haidi Adrus · 2022 · Biomedicines
Fatty Liver Disease, Metabolism and Alcohol Interplay: A Comprehensive Review
Aitor Odriozola, Álvaro Santos‐Laso, María Del Barrio, Joaquín Cabezas, Paula Iruzubieta, M. Arias, Coral Rivas, Juan Carlos Rodríguez Duque, Ángela Antón, Emilio Fábrega et al. · 2023 · International Journal of Molecular Sciences
Liver fat as risk factor of hepatic and cardiometabolic diseases
Münevver Demir, Stefan Richard Bornstein, Christos Socrates Mantzoros, Nikolaos Perakakis · 2023 · Obesity Reviews
Therapeutic targets for metabolic dysfunction-associated steatohepatitis: a personalized approach to disease management
Mary Eugenia Rinella, Silvia C. Sookoian · 2026 · Nature Reviews Gastroenterology & Hepatology
The common PNPLA 3 variant p.I148M is associated with liver fat contents as quantified by controlled attenuation parameter ( CAP )
Anita Arslanow, Caroline S. Stokes, Susanne Nicole Weber, F Grünhage, Frank Lammert, Marcin Jan Krawczyk · 2015 · Liver International
TM6SF2 Promotes Lipidation and Secretion of Hepatitis C Virus in Infected Hepatocytes
Audrey Boyer, Seung Bum Park, Ynto S. de Boer, Qisheng Li, T. Jake Liang · 2018 · Gastroenterology
Donor PNPLA3 and TM6SF2 Variant Alleles Confer Additive Risks for Graft Steatosis After Liver Transplantation
Irena Míková, Magdaléna Neřoldová, Jaroslav Alois Hubacek, Dana Dlouhá, Milan Jirsa, Eva Honsová, Eva Sticová, Věra Lánská, Julius Špičák, Pavel Trunečka · 2019 · Transplantation
Genome‐Wide Association Study of Lean Nonalcoholic Fatty Liver Disease Suggests Human Leukocyte Antigen as a Novel Candidate Locus
Ken Yoshida, Kazuha Yokota, Yukinobu Kutsuwada, Kazuhiro Nakayama, Kazuhisa Watanabe, Ayumi Matsumoto, Hiroshi Miyashita, Seik‐Soon Khor, Katsushi Tokunaga, Yosuke Kawai et al. · 2020 · Hepatology Communications
Validating a non-invasive, ALT-based non-alcoholic fatty liver phenotype in the million veteran program
Marina Serper, Marijana Vujković, David Edward Kaplan, Rotonya M. Carr, Kyung Min Lee, Qing Shao, Donald R. Miller, Peter D. Reaven, Lawrence S. Phillips, Christopher J. O’Donnell et al. · 2020 · PLoS ONE
Sex and Menopause Modify the Effect of Single Nucleotide Polymorphism Genotypes on Fibrosis in NAFLD
Kara Wegermann, Melanie E. Garrett, Jiayin Zheng, Andrea D. Coviello, Cynthia A. Moylan, Manal F. Abdelmalek, Shein‐Chung Chow, Cynthia D. Guy, Anna Mae Diehl, Allison E. Ashley‐Koch et al. · 2021 · Hepatology Communications
Heterozygosity of the Alpha 1‐Antitrypsin Pi*Z Allele and Risk of Liver Disease
Aaron Hakim, Matthew R. Moll, Dandi Qiao, Jiangyuan Liu, Jessica Ann Lasky-Su, Edwin K. Silverman, Sílvia Vilarinho, Zhenghui Gordon Jiang, Brian D. Hobbs, Michael H. Cho · 2021 · Hepatology Communications
The lipidome in nonalcoholic fatty liver disease: actionable targets
Carlos Jose Pirola, Silvia C. Sookoian · 2021 · Journal of Lipid Research
Genetics, Immunity and Nutrition Boost the Switching from NASH to HCC
Paola Dongiovanni, Marica Meroni, Miriam Longo, Silvia Rossana Fargion, Anna Ludovica Fracanzani · 2021 · Biomedicines
Pediatric Nonalcoholic Fatty Liver Disease: the Rise of a Lethal Disease Among Mexican American Hispanic Children
Monica M. Betancourt-Garcia, Armando Arguelles, Jorge Montes, Ambrosio Hernandez, Manish Kumar Singh, Robert Armour Forse · 2016 · Obesity Surgery
Metabolic disease as a risk of hepatocellular carcinoma
Naoshi Nishida · 2020 · Clinical and Molecular Hepatology
Human genetics of steatotic liver disease: insights into insulin resistance and lipid metabolism
Rosellina Margherita Mancina, Luca V. C. Valenti, Stefano Romeo · 2025 · Nature Metabolism
Obesity and Metabolic Dysfunction‐Associated Steatotic Liver Disease ( MASLD ): A Literature Review on Pathophysiology and Treatment
Michael Romanos, Juan Martin Garcia Cordova, Jose L. Villamarin, Juan Diego Pazmino Zurita, Andres Acosta · 2026 · Diabetes Obesity and Metabolism
Genetics of non-alcoholic fatty liver disease: From susceptibility and nutrient interactions to management
Vishnubhotla Venkata Ravi Kanth, Mitnala Sasikala, Mithun Sharma, Padaki Nagaraja Rao, D. Nageshwar Reddy · 2016 · World Journal of Hepatology
Genetics and epigenetics purpose in nonalcoholic fatty liver disease
Alan Eduardo Botello-Manilla, Norberto Carlos Chávez-Tapia, Misael Uribe, Natalia Nuño‐Lámbarri · 2020 · Expert Review of Gastroenterology & Hepatology
The Other Side of Malnutrition in Inflammatory Bowel Disease (IBD): Non-Alcoholic Fatty Liver Disease
Giulia Gibiino, Alessandro Sartini, Stefano Gitto, Cecilia Binda, Monica Sbrancia, Chiara Coluccio, Vittorio Sambri, Carlo Fabbri · 2021 · Nutrients
Review article: current and emerging therapies for acute alcohol‐associated hepatitis
Puru Rattan, Vijay H. Shah · 2022 · Alimentary Pharmacology & Therapeutics
Association of TM6SF2 rs58542926 gene polymorphism with the risk of non-alcoholic fatty liver disease and colorectal adenoma in Chinese Han population
Yuan Li, Shousheng Liu, Yuqiang Gao, Huan Ma, Shu-Hui Zhan, Yan Yang, Yongning Xin, Shiying Xuan · 2019 · BMC Biochemistry
TRIB1 rs17321515 gene polymorphism increases the risk of coronary heart disease in general population and non-alcoholic fatty liver disease patients in Chinese Han population
Qun Liu, Shousheng Liu, Zhenzhen Zhao, B T Zhao, Shui-Xian Du, Wenwen Jin, Yongning Xin · 2019 · Lipids in Health and Disease
Cellular endo‐lysosomal dysfunction in the pathogenesis of non‐alcoholic fatty liver disease
Jiang Du, Yu Ji, Liang Qiao, Yanli Liu, Juntang Lin · 2019 · Liver International
Evaluation of the efficacy of mitochondrial fission inhibitor (Mdivi-1) using non-alcoholic steatohepatitis (NASH) liver organoids
Mohamed Elbadawy, Kiwamu Tanabe, Haru Yamamoto, Yusuke Ishihara, Maria Mochizuki, Amira Abugomaa, Hideyuki Yamawaki, Masahiro Kaneda, Tatsuya Usui, Kazuaki Sasaki · 2023 · Frontiers in Pharmacology
A data-driven approach to decode metabolic dysfunction-associated steatotic liver disease
Maria Jiménez Ramos, Timothy James Kendall, Ignat A. Drozdov, Jonathan Andrew Fallowfield · 2023 · Annals of Hepatology
Intersecting Pathways: Nonalcoholic Fatty Liver Disease and Psoriasis Duet—A Comprehensive Review
Daniel Octavian Costache, Horia Blejan, Damian L. Cojocaru, Georgiana Ioniță, Marcela Poenaru, María Magdalena Constantin, Andrei C. Costache, Constantin Căruntu, Daniel Vasile Balaban, Raluca Simona Costache · 2024 · International Journal of Molecular Sciences
TM6SF2 E167K variant decreases PNPLA3-mediated PUFA transfer to promote hepatic steatosis and injury in MASLD
Baokai Sun, Xiaoqian Ding, Jie Tan, Jie Zhang, Xueru Chu, Shuimi Zhang, Shousheng Liu, Zhenzhen Zhao, Shiying Xuan, Yongning Xin et al. · 2024 · Clinical and Molecular Hepatology
Genetics in PBC: What Do the “Risk Genes” Teach Us?
Gideon Morris Hirschfield, Katherine A. Siminovitch · 2014 · Clinical Reviews in Allergy & Immunology
How Useful Are Monogenic Rodent Models for the Study of Human Non-Alcoholic Fatty Liver Disease?
Jake Peter Mann, Robert K. Semple, Matthew James Armstrong · 2016 · Frontiers in Endocrinology
IRGMGene Variants Modify the Relationship Between Visceral Adipose Tissue and NAFLD in Patients With Crohn’s Disease
Tracey G. Simon, Kimberley W. J. van der Sloot, Samantha B Chin, Amit D. Joshi, Paul J. Lochhead, Ashwin N. Ananthakrishnan, Ramnik J. Xavier, Raymond T. Chung, Hamed Khalili · 2018 · Inflammatory Bowel Diseases
New insights into genetic predisposition and novel therapeutic targets for nonalcoholic fatty liver disease
Mary Barbara, Andrea Leah Scott, Naim Alkhouri · 2018 · HepatoBiliary Surgery and Nutrition
Emerging risk factors for nonalcoholic fatty liver disease associated hepatocellular carcinoma
Jihane N. Benhammou, Jonathan Lin, Shehnaz K. Hussain, Mohamed M. El-Kabany · 2020 · Hepatoma Research
The impact of genetic risk on liver fibrosis in non‐alcoholic fatty liver disease as assessed by magnetic resonance elastography
Veeral H. Ajmera, Amy Y Liu, Ricki Bettencourt, Debanjan Dhar, Lisa Richards, Rohit Seth Loomba · 2021 · Alimentary Pharmacology & Therapeutics
Significance of genetic polymorphisms in patients with nonalcoholic fatty liver disease
Hisamitsu Miyaaki, Kazuhiko Nakao · 2017 · Clinical Journal of Gastroenterology
Genetics of Non-Alcoholic Fatty Liver and Cardiovascular Disease: Implications for Therapy?
Karthik H. Chandrasekharan, William Alazawi · 2020 · Frontiers in Pharmacology
Alterations in Lysosome Homeostasis in Lipid-Related Disorders: Impact on Metabolic Tissues and Immune Cells
Cabrera-Reyes, Fernanda, Parra-Ruiz, Claudia, Yuseff, María Isabel, Zanlungo, Silvana · 2021 · Frontiers in Cell and Developmental Biology
The TM6SF2 Variants, Novel Genetic Predictors for Nonalcoholic Steatohepatitis
Yoon‐Seok Roh, Rohit Seth Loomba, Ekihiro Seki · 2014 · Gastroenterology
Non-alcoholic fatty liver disease–a chronic disease of the 21st century
Peter P. Metrakos, Nilsson Tommy · 2017 · Journal of Biomedical Research
The role of PNPLA3 and TM6SF2 polymorphisms on liver fibrosis and metabolic abnormalities in Brazilian patients with chronic hepatitis C
Arthur Ivan Nobre Oliveira, Fernanda de Mello Malta, Patrícia Momoyo Zitelli, Ana Paula Moreira Salles, Michele Soares Gomes‐Gouvêa, Ana Catharina de Seixas Santos Nastri, João Renato Rebello Pinho, Flair José Carrilho, Claudia Pinto Marques Souza de Oliveira, Maria Cássia Mendes-Corrêa et al. · 2021 · BMC Gastroenterology
Inborn and acquired risk factors for severe liver disease in Europeans with type 2 diabetes from the UK Biobank
Federica Tavaglione, Antonio De Vincentis, Oveis Jamialahmadi, Roberta Pujia, Rocco Spagnuolo, Antonio Picardi, Susanna Morano, Luca V. C. Valenti, Stefano Romeo, Umberto Vespasiani Gentilucci · 2021 · JHEP Reports
Nonalcohol fatty liver disease: balancing supply and utilization of triglycerides
Leinys S. Santos‐Báez, Henry N. Ginsberg · 2021 · Current Opinion in Lipidology
Hemostatic alterations linked to body fat distribution, fatty liver, and insulin resistance
Sebastian Hörber, Rainer Lehmann, Norbert Stefan, Jürgen Machann, Andreas L. Birkenfeld, Robert J. Wagner, Martin Heni, Hans‐Ulrich Häring, Andreas Fritsche, Andreas Peter · 2021 · Molecular Metabolism
Is HSD17B13 Genetic Variant a Protector for Liver Dysfunction? Future Perspective as a Potential Therapeutic Target
Takashi Motomura, Sriram Amirneni, Ricardo Díaz‐Aragon, Lanuza A.P. Faccioli, Michelle R. Malizio, Michael C. Coard, Zehra N. Kocas‐Kilicarslan, Carla Frau, Nils Haep, Alina Ostrowska et al. · 2021 · Journal of Personalized Medicine
Effects of PNPLA3 , TM6SF2 and SAMM50 on the development and severity of non‐alcoholic fatty liver disease in children
Kyung Jae Lee, Jin Soo Moon, Nan Young Kim, Jae Sung Ko · 2021 · Pediatric Obesity
Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Liénard, An Verrijken, Eveline Lia Dirinck, Luisa Vonghia, Eloïse Woitrain et al. · 2022 · Hepatology
Genetic Factors Associated with Response to Vitamin E Treatment in NAFLD
Mehtap Civelek, Maren Catherina Podszun · 2022 · Antioxidants
MBOAT7 in liver and extrahepatic diseases
Andrea Marco Caddeo, Rocco Spagnuolo, Samantha Maurotti · 2023 · Liver International
Destined to develop NAFLD? The predictors of fatty liver from birth to adulthood
Luca V. C. Valenti, Stefano Romeo · 2016 · Journal of Hepatology
Constitutional and functional genetics of human alcohol‐related hepatocellular carcinoma
Pierre Nahon, Jean‐Charles Nault · 2017 · Liver International
Digital liver biopsy: Bio-imaging of fatty liver for translational and clinical research
Marcello Mancini, Paul Eugene Summers, Francesco Faita, Maurizia Rossana Brunetto, Francesco Callea, Andrea De Nicola, Nicole Di Lascio, Fabio Farinati, Amalia Gastaldelli, Bruno G. Gridelli et al. · 2018 · World Journal of Hepatology
Non-alcoholic fatty liver disease (NAFLD) in non-obese individuals
Meaghan M. Phipps, Julia J. Wattacheril · 2019 · Frontline Gastroenterology
Inhibition of Grb14, a negative modulator of insulin signaling, improves glucose homeostasis without causing cardiac dysfunction
Xunshan Ding, Rugmani Padmanabhan Iyer, Christopher A. Novotny, Daniel Metzger, Heather H. Zhou, Gordon Ian Smith, Mihoko Yoshino, Jun Yoshino, Samuel Klein, Gayathri Swaminath et al. · 2020 · Scientific Reports
Disease classification, diagnostic challenges, and evolving clinical trial design in MASLD
Mette Munk Lauridsen, Kim Ravnskjær, Lise Lotte Gluud, Arun Jayant Sanyal · 2025 · Journal of Clinical Investigation
Virtual Screening for Ligand Discovery at the σ1 Receptor
Daniel A. Greenfield, Hayden R. Schmidt, Meredith A. Skiba, Michael D. Mandler, Jacob R. Anderson, Piotr Sliz A, Andrew C. Kruse · 2020 · ACS Medicinal Chemistry Letters
Genetics of Type 2 Diabetes: Opportunities for Precision Medicine
Daniel Seung Kim, Anna L. Gloyn, Joshua W. Knowles · 2021 · Journal of the American College of Cardiology
Oral-Gut Microbiome Analysis in Patients With Metabolic-Associated Fatty Liver Disease Having Different Tongue Image Feature
Chenxia Lu, Hui Zhu, Dan Zhao, Jia Zhang, Kai Yang, Yi Lv, Peng Miao, Xi Xu, Jingjing Huang, Zuoyu Shao et al. · 2022 · Frontiers in Cellular and Infection Microbiology
Complex effects of sequence variants on lipid levels and coronary artery disease
Auðunn Skúta Snæbjarnarson, Anna Helgadóttir, Gudny Anna Arnadottir, Erna V. Ivarsdottir, Guðmar Þorleifsson, Egil Ferkingstad, Guðmundur Einarsson, Garðar Sveinbjörnsson, Thorgeir Elís Thorgeirsson, Magnus Orn Ulfarsson et al. · 2023 · Cell
A review of experimental and clinical studies on the therapeutic effects of pomegranate ( Punica granatum ) on non‐alcoholic fatty liver disease: Focus on oxidative stress and inflammation
Mohammad Yasin Zamanian, Mehraveh Sadeghi Ivraghi, Lusine Khachatryan, Diana E. Vadiyan, Hanie Yavarpour‐Bali, Maryam Golmohammadi · 2023 · Food Science & Nutrition
Navigating nonalcoholic fatty liver disease (NAFLD): Exploring the roles of estrogens, pharmacological and medical interventions, and life style
Qianying Zuo, Nicole Hwajin Park, Jenna Kathryn Lee, Ashlie Santaliz Casiano, Zeynep Madak‐Erdogan · 2023 · Steroids
Associations between metabolic hyperferritinaemia, fibrosis‐promoting alleles and clinical outcomes in steatotic liver disease
Deepika Suresh, Ashley Li, Matthew J. Miller, Karn Wijarnpreecha, Vincent Lingzhi Chen · 2023 · Liver International
Meta-analysis of the influence of TM6SF2 E167K variant on Plasma Concentration of Aminotransferases across different Populations and Diverse Liver Phenotypes
Silvia C. Sookoian, Carlos Jose Pirola · 2016 · Scientific Reports
High frequency of the PNPLA3 rs738409 [G] single‐nucleotide polymorphism in Hmong individuals as a potential basis for a predisposition to chronic liver disease
Clifford G. Tepper, Julie H. T. Dang, SUSAN LEROY STEWART, Dao Moua Fang, Kimberly A. Wong, Stephenie Y. Liu, Ryan R. Davis, Doan Y Dao, Jeffrey P. Gregg, Natalie Julia Torok et al. · 2018 · Cancer
Magnitude of Nonalcoholic Fatty Liver Disease: Eastern Perspective
Becky Ching-Yeung Yu, Deborah Kwok, Vincent Wai‐Sun Wong · 2019 · Journal of Clinical and Experimental Hepatology
The PNPLA3 rs738409 GG genotype is associated with poorer prognosis in 239 patients with autoimmune hepatitis
Young‐Seon Mederacke, Martha Maria Kirstein, Anika Großhennig, Silke Marhenke, Frauke Metzler, Michael Peter Manns, Arndt Vogel, Ingmar Mederacke · 2020 · Alimentary Pharmacology & Therapeutics
Racial Disparities in Liver Disease Mortality Trends Among Black and White Populations in the United States, 1999–2020: An Analysis of CDC WONDER Database
Yichen Wang, Yuting Huang, Samuel O. Antwi, C. Burcin Taner, Liu Yang · 2023 · The American Journal of Gastroenterology
Immunological dynamics in MASH: from landscape analysis to therapeutic intervention
Lawan Rabiu, Pengchao Zhang, Lukman Olalekan Afolabi, Muhammad Auwal Saliu, Salisu Mansur Dabai, Rabiatu Bako Suleiman, Khalid Idris Gidado, Mark Akinola Ige, Abdulrahman Ibrahim, Guizhong Zhang et al. · 2024 · Journal of Gastroenterology