Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

Kozlitina, Julia, Smagris, Eriks, Stender, Stefan, Nordestgaard, Børge G, Zhou, Heather H, Tybjærg-Hansen, Anne, Vogt, Thomas F, Hobbs, Helen H, Cohen, Jonathan C·2014·Nature Genetics

DOI 10.1038/ng.2901

Cited by (1,000)

Items 801–900 of 1,000

Alkoholos májbetegség: a genetikai-epigenetikai tényezők szerepe és az absztinencia hatása
Alajos Pár, Gabriella Pár · 2019 · Orvosi Hetilap
From fatty hepatocytes to impaired bile flow: Matching model systems for liver biology and disease
Roni F. Kunst, Marije Niemeijer, Luc J. W. van der Laan, Bart Spee, Stan F.J. van de Graaf · 2020 · Biochemical Pharmacology
The diagnostic conundrum in non-alcoholic fatty liver disease
Valerio Rosato, Mario Masarone, Andrea Aglitti, Marcello Persico · 2020 · Exploration of Medicine
The interplay between host cellular and gut microbial metabolism in NAFLD development and prevention
Simin Yu, Lei Xu · 2021 · Journal of Applied Microbiology
Perturbation of TM6SF2 Expression Alters Lipid Metabolism in a Human Liver Cell Line
Asmita Pant, Yue Chen, Annapurna Kuppa, Xiaomeng Du, Brian D. Halligan, Elizabeth K. Speliotes · 2021 · International Journal of Molecular Sciences
Hepatocellular carcinoma in patients with metabolic dysfunction-associated fatty liver disease: Can we stratify at-risk populations?
E. Fassio, F. Barreyro, M. S. Perez, Diana Dávila, G. Landeira, Gisela Gualano, Gabriela Ruffillo · 2022 · World Journal of Hepatology
Generation of a Diet-Induced Mouse Model of Nonalcoholic Fatty Liver Disease
Amon Asgharpour, Arun Jayant Sanyal · 2022 · Methods in molecular biology
A rare genetic variant in the manganese transporter SLC30A10 and elevated liver enzymes in the general population
Anne-Sofie Seidelin, Børge Grønne Nordestgaard, Anne Tybjærg‐Hansen, Hanieh Yaghootkar, Stefan Stender · 2022 · Hepatology International
TM6SF2/PNPLA3/MBOAT7 loss-of-function genetic variants impact on NAFLD development and progression both in patients and in in vitro models
M. Longo, M. Meroni, Veronica Erconi, Fabrizia Carli, Chiara Macchi, Francesco Fortunato, Dario Ronchi, Silvia Sabatini, Erika Paolini, Emilia Rita De Caro et al. · 2021 · Digestive and Liver Disease
Reversing Advanced Hepatic Fibrosis in NASH: Clearly Possible, but Widely at Hand?
Stephen Hugh Caldwell, Curtis Kent Argo · 2015 · Digestive Diseases and Sciences
Recurrence of fatty liver disease following liver transplantation for NAFLD-related cirrhosis: Current status and challenges.
Arash Dooghaie Moghadam, Pegah Eslami, Niloofar Razavi-Khorasani, Bobak Moazzami, Farbod Zahedi Tajrishi, Ermia Farokhi, Kamyab Makhdoomi Sharabiani, Alireza Mansour-Ghanaei, Azim Mehrvar, Morteza Aghajanpoor Pasha et al. · 2020 · PubMed Central
New Glance at the Role of TM6SF2 in Lipid Metabolism and Liver Cancer
Xiaoxiao Jiang, Hui Qian, Wen‐Xing Ding · 2021 · Hepatology
A nem alkoholos zsírmájbetegség és a 2-es típusú cukorbetegség.
Alajos Pár, István Wittmann, Gabriella Pár · 2022 · Orvosi Hetilap
Food Network Analysis in Non-Obese Patients with or without Steatosis
Rossella Donghia, Pasqua Letizia Pesole, Sergio Coletta, Caterina Bonfiglio, Giovanni De Pergola, Sara De Nucci, Roberta Rinaldi, Gianluigi Giannelli · 2023 · Nutrients
Circulating transthyretin and retinol binding protein 4 levels among middle-age V122I TTR carriers in the general population
NICHOLAS S. HENDREN, James A. de Lemos, Jarett D. Berry, Julia Kozlitina, Lorena Saelices, Alan X. Ji, Zhili Shao, Chia‐Feng Liu, Sonia Garg, MARYJANE A. FARR et al. · 2024 · Amyloid
Steatotic liver disease in the context of hematological malignancies and anti-neoplastic chemotherapy
Charalampos G. Pontikoglou, Theodosios D. Filippatos, Angelos Matheakakis, Helen Α. Papadaki · 2024 · Metabolism
Identification of Interactive Genetic Loci Linked to Insulin Resistance in Metabolic Syndrome—An Update
Imadeldin Elfaki, Rashid Mir, Mohamed E. Elnageeb, Abdullah Hamadi, Zeyad M. Alharbi, Ruqaiah I. Bedaiwi, Jamsheed Javid, Tariq Alrasheed, Dalal Alatawi, Basmah M. Alrohaf et al. · 2025 · Medicina
Metabolic dysfunction-associated steatotic liver disease in people with HIV
Arijeet K. Gattu, Lindsay T. Fourman · 2025 · Current Opinion in HIV and AIDS
MAFLD: a ferroptotic disease
Cui, Shaojie, Ye, Jin · 2026 · Trends in Molecular Medicine
PNPLA3-I148M is a neomorph that interferes with two primary hepatic triglyceride clearance pathways
David J. Sherman, Lei Liu, Edward L. LaGory, Preston Fordstrom, Danielle Pruitt, Jose Barreda, Joy G. Cagmat, Jiansong Xie, John Ferbas, Ingrid C. Rulifson et al. · 2025 · Cell Reports
Genomic Signatures of MASLD: How Genomics Is Redefining Our Understanding of Metabolic Liver Disease
Peter Saliba‐Gustafsson, Jennifer Härdfeldt, Matteo Pedrelli, Paolo Parini · 2025 · International Journal of Molecular Sciences
Associations between type 2 diabetes mellitus and chronic liver diseases: evidence from a Mendelian randomization study in Europeans and East Asians
Yue Zhao, Di Li, Hanyu Shi, Wei Liu, Jiaojiao Qiao, Shanfu Wang, Yiwei Geng, Ruiying Liu, Han Feng, Jia Li et al. · 2024 · Frontiers in Endocrinology
Associations between metabolic dysfunction-associated fatty liver disease and atherosclerotic cardiovascular disease
Wen Wen, Huahao Fan, Shenghui Zhang, Siqi Hu, Chen Chen, Jiake Tang, Yao You, Chunyi Wang, Jie Li, Lin Luo et al. · 2024 · The American Journal of the Medical Sciences
Pathogenesis of NAFLD and NASH
Jacquelyn J. Maher · 2015 · Springer eBooks
Association of Bright Liver with the PNPLA3 I148M Gene Variant in 1-year-old Toddlers
Giorgio Bedogni, Giuseppe De Matteis, Marta Fabrizi, Anna Alisi, Annalisa Crudele, Fabrizio Pizzolante, Fabrizio Signore, Bruno Dallapiccola, Valério Nobili, Melania Manco · 2019 · The Journal of Clinical Endocrinology & Metabolism
High-Risk Groups for Non-alcoholic Fatty Liver and Non-alcoholic Steatohepatitis Development and Progression
Yedidya Saiman, Royce Hooks, Rotonya M. Carr · 2020 · Current Hepatology Reports
Relationships among N,N-dimethylformamide exposure, CYP2E1 and TM6SF2 genes, and non-alcoholic fatty liver disease
Ziqi Zhou, Lingli Sang, Jin Wang, Lin Song, Lejia Zhu, Yangmei Wang, Jing Xiao, Yulong Lian · 2021 · Ecotoxicology and Environmental Safety
A minority of somatically mutated genes in pre‐existing fatty liver disease have prognostic importance in the development of NAFLD
Jake Peter Mann, Matthew Hoare · 2022 · Liver International
PNPLA3 and TM6SF2 genetic variants and hepatic fibrosis and cirrhosis in Pakistani chronic hepatitis C patients: a genetic association study
Bisma Rauff, Badr Alzahrani, Shafiq Ahmad Chudhary, Bilal Nasir, Saqib Mahmood, Munir Ahmad Bhinder, Muhammad Qaiser Faheem, Ali Amar · 2022 · BMC Gastroenterology
Myeloid TM6SF2 Deficiency Inhibits Atherosclerosis
Wenzhen Zhu, Wenying Liang, Haocheng Lu, Lin Chang, Jifeng Zhang, Y. Eugene Chen, Yanhong Guo · 2022 · Cells
The association of non‐alcoholic fatty liver disease between parents and adolescent children
Yewan Park, Dong Hyun Sinn, Kyunga Kim, Geum‐Youn Gwak · 2022 · Alimentary Pharmacology & Therapeutics
Dietary Recommendations for the Management of Non-alcoholic Fatty Liver Disease (NAFLD): A Nutritional Geometry Perspective
Manuel Romero‐Gómez, R. Aller, Franz Martı́n · 2022 · Seminars in Liver Disease
Prognostication in NAFLD: physiological bases, clinical indicators, and newer biomarkers
Francesca Terracciani, Andrea Falcomatà, Paolo Gallo, Antonio Picardi, Umberto Vespasiani Gentilucci · 2022 · Journal of Physiology and Biochemistry
Genetic Markers Predisposing to Nonalcoholic Steatohepatitis
Aalam Sohal, Hunza Chaudhry, Kris V. Kowdley · 2023 · Clinics in Liver Disease
Personalizing Care for Nonalcoholic Fatty Liver Disease Patients: What are the Research Priorities?
Silvia C. Sookoian, Carlos Jose Pirola · 2014 · Personalized Medicine
Genetic Aspects of Non-Alcoholic Fatty Liver Disease
Pavel Bogomolov, Kseniya Yu. Kokina, Alexander Yur'evich Mayorov, Ekaterina Е. Mishina · 2019 · Вопросы современной педиатрии
Sekundäre Ursachen der Fettleber – Neues zur Pathogenese, rationalen Diagnostik und Therapie
Verena Keitel, Stephan vom Dahl, Dieter Häussinger · 2020 · DMW - Deutsche Medizinische Wochenschrift
Epidemiology, Natural History, and Evaluation of Nonalcoholic Fatty Liver Disease
Quentin Mark Anstee, Christopher Paul Day · 2018 · Elsevier eBooks
Validating candidate biomarkers for different stages of non-alcoholic fatty liver disease
Reem B Alqarni, Muhammad Darwesh Iqbal, Maram Alotaibi, Faisal Al-Saif, Assim Abdulaziz Alfadda, Hisham Alkhalidi, Fahad Y. Bamehriz, Mazen M. Hassanain · 2020 · Medicine
Experimental Biology for the Identification of Causal Pathways in Atherosclerosis
Yanhong Guo, Minerva T. Garcia-Barrio, Laiyuan Wang, Yanxing Chen · 2016 · Cardiovascular Drugs and Therapy
Genetic predisposition to hepatocellular carcinoma in alcoholic cirrhosis: The NCAN-PNPLA3-lipid connection?
Jean‐Charles Nault, Pierre Nahon · 2014 · Journal of Hepatology
Non‐alcoholic fatty liver disease
Stephen Hugh Caldwell, Curtis Kent Argo · 2016
Editorial: new insights into the relationship between the intestine and non‐alcoholic fatty liver—is “fatty gut” involved in disease progression?
Luca V. C. Valenti, Stefano Romeo · 2017 · Alimentary Pharmacology & Therapeutics
Nonalcoholic Fatty Liver Disease
Marie Boyle, Quentin Mark Anstee · 2019 · Wiley eBooks
Serum Concentrations of Cartilage Intermediate Layer Protein 2 Were Higher in Overweight and Obese Subjects
Qinge Li, Danlan Pu, Xuyun Xia, Hua Liu, Ling Li · 2022 · BioMed Research International
Fatty Liver Disease
DINA G. TINIAKOS, Quentin Mark Anstee, Elizabeth M. Brunt, Alastair D. Burt · 2023 · Elsevier eBooks
Exploring the impact of lipid droplets on the evolution and progress of hepatocarcinoma
Samantha Maurotti, Nadia Geirola, Miriam Frosina, Angela Mirarchi, Francesca Scionti, Rosario Mare, Tiziana Montalcini, Arturo Pujia, Luca Tirinato · 2024 · Frontiers in Cell and Developmental Biology
Interaction Between PNPLA3 and SIRT5 Genetic Variants in Association with Liver Fibrosis Severity in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease
Kamonchanok Moonlisarn, Pornjira Somnark, Bootsakorn Boonkaew, Chalermrat Bunchorntavakul, Pisit Tangkijvanich · 2024 · Genes
TM6SF2-rs58542926 Genotype Has Opposing Effects on Incidence of Hepatic and Cardiac Events in a Community Cohort
Vincent Lingzhi Chen, Antonino Oliveri, Chinmay Raut, Yanhua Chen, Kelly C. Cushing, Elizabeth K. Speliotes · 2024 · The American Journal of Gastroenterology
Gene-based therapies for steatotic liver disease
Viktoriia Iakovleva, Ype P. de Jong · 2025 · Molecular Therapy
VLDL lipidomics reveals hepatocellular lipidome changes in metabolic dysfunction–associated steatotic liver disease
David F. Guardamino Ojeda, Yusuf Yalcin, Yered H. Pita-Juárez, Aaron Hakim, Susmita Bhattarai, Zsu‐Zsu Chen, John M. Asara, Margery A. Connelly, Melissa R. Miller, Michelle Lai et al. · 2025 · Hepatology Communications
Early Insights from Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Patients: An Observational Study on Polygenic Risk and Liver Biomarkers
Pietro Torre, Benedetta Maria Motta, Tommaso Sarcina, Michelina Festa, Mario Masarone, Marcello Persico · 2025 · International Journal of Molecular Sciences
Liver Steatosis‐Related Polygenic Risk Score Predicts Hepatocellular Carcinoma Risk After Hepatitis C Virus Eradication
Yu‐Sheng Lin, Ying‐Cheng Lin, Yun‐Yu Chen, Yi‐Ming Arthur Chen, I-Chieh Chen, Hsin‐Ju Tsai, C H. Chen, Shou‐Wu Lee, Hwai‐I Yang, Teng‐Yu Lee · 2026 · Alimentary Pharmacology & Therapeutics
Sex Differences in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Epidemiology, Pathophysiology, and Clinical Implications
Kanica Kaushal, Smriti Singh, Ankita Anand, Gayatri Ramakrishna, Pratibha Ramchandra Kale, Rishabh Sharma, Bharat Bhushan Rewari, Shiv Kumar Sarin · 2026 · Journal of Clinical and Experimental Hepatology
Biological and mechanistic pathways of cardiometabolic multiple long-term conditions
Lee-Ling Lim, Alicia Jenkins, Dorairaj Prabhakaran, Silvia C. Sookoian, Raveendhara R. Bannuru, Kamlesh K. Khunti · 2026 · The Lancet
Lipid droplets as the genetic nexus of fatty liver
Jake Peter Mann, Stefano Romeo, Luca V. C. Valenti · 2022 · Liver International
Identification of key target genes and pathway analysis in nonalcoholic fatty liver disease via integrated bioinformatics analysis
Xi Chen, Lian Zhang, Yubin Wang, Rujie Li, Ming Yang, Lei Gao · 2022 · Balkan Journal of Medical Genetics
G-quadruplex forming regions in GCK and TM6SF2 are targets for differential DNA methylation in metabolic disease and hepatocellular carcinoma patients
Angelika Lahnsteiner, Victoria Ellmer, Anna Oberlercher, Zita Liutkevičiūtė, Esther Schönauer, Bernhard Paulweber, Elmar Stephan Aigner, Angela Risch · 2024 · Scientific Reports
TM6SF2 E167K Variant Overexpression Promotes Expression of Inflammatory Cytokines in the HCC Cell Line HEPA 1-6
Shui-Xian Du, Songling Liao, Shousheng Liu, Yongning Xin · 2019 · Journal of Clinical and Translational Hepatology
In vitro analysis of hepatic stellate cell activation influenced by transmembrane 6 superfamily 2 polymorphism
Songyao Liu, Eisuke Murakami, Takashi Nakahara, Kazuki Ohya, Yuji Teraoka, Grace Naswa Makokha, Takuro Uchida, Kei Morio, Hatsue Fujino, Atsushi Ono et al. · 2020 · Molecular Medicine Reports
Variations in TM6SF2, PCSK9 and PCSK7 genes and risk of hepatic steatosis after liver transplantation: a cross-sectional study
Ahad Eshraghian, Elham Moasser, Negar Azarpira, Mohammad Reza Fattahi, Saman Nikeghbalian, Seyed Ali Malek‐Hosseini, Bita Geramizadeh · 2021 · BMC Gastroenterology
Molecular mechanisms of liver carcinogenesis related to metabolic syndrome
C. Campani, J. Nault · 2022 · Hepatoma Research
The potential of soluble CD14 in discriminating nonalcoholic steatohepatitis from nonalcoholic fatty liver disease
Akihisa Nakamura, Koji Yamamoto, Rei Takeda, Ren Yamada, Akinori Kubo, Kenichi Morikawa, Sayaka Ando, Tomoe Shimazaki, Takaaki Izumi, Machiko Umemura et al. · 2022 · Hepatology Research
Evolution of Non-alcoholic Fatty Liver Disease to Liver Cancer: Insights from Genome-wide Association Studies
Sathish Kumar Mungamuri, Yogendra Kumar Gupta, Padaki Nagaraja Rao, Bagepally Ravishankar · 2023 · Gene Expression
Association of the IGF1 gene with fasting insulin levels
Sara M. Willems, Belinda K. Cornes, Jennifer A. Brody, Alanna C. Morrison, Leonard Lipovich, Marco Dauriz, Yuning Chen, Ching‐Ti Liu, Denis V. Rybin, Richard A. Gibbs et al. · 2016 · European Journal of Human Genetics
Újabb adatok a nem alkoholos zsírmáj patogeneziséhez
Alajos Pár, Gabriella Pár · 2017 · Orvosi Hetilap
Genome-Based Nutrition in Chronic Liver Disease
S. Roman, Ingrid Rivera-Iñiguez, Claudia Ojeda-Granados, Maricruz Sepúlveda-Villegas, A. Panduro · 2019 · Dietary Interventions in Liver Disease
Genetic Variants Associated with Non-Alcoholic Fatty Liver Disease Do Not Associate with Measures of Sub-Clinical Atherosclerosis: Results from the IMPROVE Study
Luigi Castaldo, Federica Laguzzi, Rona J. Strawbridge, Damiano Baldassarre, Fabrizio Veglia, Lorenzo Vigo, Elena Tremoli, Ulf dé Fairé, Per Olof Eriksson, Andries Jan Smit et al. · 2020 · Genes
Nonalcoholic Fatty Liver Disease
Carolin Lackner · 2018 · Elsevier eBooks
Nonalcoholic fatty liver disease in lean subjects: is it all metabolic-associated fatty liver disease?
Mariana Verdelho Machado · 2020 · Hepatoma Research
NR1H4 rs35724 G>C variant modulates liver damage in nonalcoholic fatty liver disease
Stefania Grimaudo, Paola Dongiovanni, Jussi Pihlajamäki, Mohammed Eslam, Hannele Yki‐Järvinen, Rosaria Maria Pipitone, Guido Baselli, Calogero Cammà, Vito Di Marco, Marco Enea et al. · 2021 · Liver International
Nonalcoholic Fatty Liver Disease
Christopher Paul Day, Quentin Mark Anstee · 2015 · Seminars in Liver Disease
Variants in MARC1 and HSD17B13 reduce severity of NAFLD in children, perturb phospholipid metabolism, and suppress fibrotic pathways
Christian A. Hudert, Anna Alisi, Quentin Mark Anstee, Annalisa Crudele, Laura G. Draijer, EU-PNAFLD investigators, Samuel Furse, Jan Georg Hengstler, Benjamin Jenkins, Kylie Karnebeek et al. · 2020 · medRxiv
Rewriting the MASLD ‐associated hepatocellular carcinoma script: Targeting epigenetics and metabolism
Chiara Aiello, Éric Felli, Teresa Musarra, Lorenzo Nevi, Annamaria Altomare, Jordi Gracia‐Sancho, Andrea Baiocchini, Simone Carotti · 2025 · International Journal of Cancer
Toxins to treatments: Impact of environmental pollutants, gut microbiota, and natural compounds on non-alcoholic fatty liver disease progression
Tanvi Sharma, Naveen Kaushal, Roobee Garla · 2025 · World Journal of Hepatology
Germline mutations and somatic mosaicism in steatotic liver diseases and related liver carcinogenesis
Eric Trépo, Jessica Zucman‐Rossi, Jean‐Charles Nault · 2026 · Nature Reviews Gastroenterology & Hepatology
EASL position paper on preclinical models of steatotic liver disease
Suchira Gallage, Rui E. Castro, Jennifer L. Estall, Ira A. Tabas, Quentin Mark Anstee, DINA G. TINIAKOS, Gyöngyi Szabó, Jun Yu, Chantal Desdouets, Frank Tacke et al. · 2026 · Journal of Hepatology
Genetic predisposition to nonalcoholic fatty liver disease: insights from ANGPTL8 gene variants in Iranian adults
Samira Saghafi, Elham Chamani, Fatemeh Salmani, Reza Fadaei, Efat Shafiei, Nariman Moradi, Tahmine Tavakoli · 2023 · Lipids in Health and Disease
Shared genetic architecture and causal relationship between liver and heart disease
Ziyi Fang, Sixiang Jia, Xuanting Mou, Zhe Li, Tianli Hu, Yiting Tu, Jianqiang Zhao, Tianlong Zhang, Wenting Lin, Yile Lu et al. · 2024 · iScience
Metabolic-associated fatty liver disease and pregnancy complications: new challenges and clinical perspectives
Yang Zhang, Yifan Bu, Rui Zhao, Cheng Han · 2024 · Therapeutic Advances in Endocrinology and Metabolism
Management of non-alcoholic fatty liver disease-associated hepatocellular carcinoma
Peijun Xu, Maoyun Liu, Miao Liu, Ai Shen · 2024 · BioScience Trends
Recent advances in MASLD genetics: Insights into disease mechanisms and the next frontiers in clinical application
Vincent Lingzhi Chen, Graham F. Brady · 2025 · Hepatology Communications
RETRACTED: The OMICs Window into Nonalcoholic Fatty Liver Disease (NAFLD)
Lucia Carulli, Giulia Zanca, Filippo Schepis, Erica Villa · 2019 · Metabolites · Retracted
Nonalcoholic Fatty Liver Disease
Nora V. Bergasa · 2021 · Springer eBooks
Metabolic-associated fatty liver disease from childhood to adulthood: State of art and future directions
Francesca Lanzaro, Stefano Guarino, Elisabetta D’Addio, Alessandra Salvatori, Josè Alberto D’Anna, Pierluigi Marzuillo, Emanuele Miraglia del Giudice, Anna Di Sessa · 2022 · World Journal of Hepatology
Molecular Screening via Sanger Sequencing of the Genetic Variants in Non-Alcoholic Fatty Liver Disease Subjects in the Saudi Population: A Hospital-Based Study
Faisal Khalid Alsaif, Waleed Al-hamoudi, Maram Alotaiby, Amani Alsadoon, Mohammad Almayouf, Hadeel Almadany, Jawahir M. Abuhaimed, Noman Ghufran, Ahmed Merajuddin, Imran Ali Khan · 2022 · Metabolites
Nutrigenetic Interaction Between Apolipoprotein C3 Polymorphism and Fat Intake in People with Nonalcoholic Fatty Liver Disease
Reina Yamamoto, Yumie Takeshita, Hiromasa Tsujiguchi, Takayuki Kannon, Takehiro K. Sato, Kazuyoshi Hosomichi, Keita Suzuki, Yuki Kita, Takeo Tanaka, Hisanori Goto et al. · 2023 · Current Developments in Nutrition
PNPLA3 genotypes modify the adverse effect of the total energy intake on high-risk nonalcoholic steatohepatitis development
Heejun Son, Bo Kyung Koo, Sae Kyung Joo, Dong Hyeon Lee, Heejoon Jang, Jeong Hwan Park, Mee Soo Chang, Won Kyum Kim · 2023 · American Journal of Clinical Nutrition
Effects of TM6SF2 rs58542926 polymorphism on hepatocellular lipids and insulin resistance in early type 2 diabetes
Kálmán Benedikt Bódis, Maria Bombrich, Martin Schön, Birgit Knebel, Oana‐Patricia Zaharia, Gidon Josia Bönhof, Yanislava Karusheva, Klaus Straßburger, Yuliya Kupriyanova, Jörg Kotzka et al. · 2023 · Nutrition Metabolism and Cardiovascular Diseases
SAMM50-rs2073082, -rs738491 and -rs3761472 Interactions Enhancement of Susceptibility to Non-Alcoholic Fatty Liver Disease
Jinhan Zhao, Xiaoyi Xu, Xinhuan Wei, Shuang Zhang, Hangfei Xu, Xiaodie Wei, Yang Zhang, Jing Zhang · 2023 · Biomedicines
Causal association of nonalcoholic fatty liver disease with 22 extrahepatic cancers: A Mendelian randomization study
Jiarong Xie, Huizhi Gao, Cenqin Liu, Yue Pan, Chengfu Xu, Lei Xu · 2023 · Hepatology Research
Key points of etiopathogenesis of non-alcoholic fatty liver disease
Игорь Иванович Жирков, А. В. Гордиенко, Dmitry Yu. Serdyukov, G. Yu. Dorokhov · 2019 · Bulletin of the Russian Military Medical Academy
Metabolic dysfunction-associated fatty liver disease in obese youth with insulin resistance and type 2 diabetes
Concetta Mastromauro, Nella Polidori, Cosimo Giannini · 2022 · Current Opinion in Pediatrics
947 Shared Genetic Effects Between Hepatic Steatosis and Fibrosis: A Prospective Twin Study
Jeffrey Y. Cui, Chi‐Hua Chen, Min‐Tzu Lo, Nicholas J. Schork, Ricki Bettencourt, Archana Bhatt, Jonathan C. Hooker, Karen E. Nelson, Michelle T. Long, David A. Brenner et al. · 2016 · Gastroenterology
Hepatocellular Carcinoma in Obesity: Finding a Needle in the Haystack?
György Baffy · 2018 · Advances in experimental medicine and biology
Hepatocellular Carcinoma Risk Stratification by Genetic Profiling in Patients with Cirrhosis
Naoto Fujiwara, Yujin Hoshida · 2019 · Seminars in Liver Disease
Genetic architecture of 11 abdominal organ traits derived from abdominal MRI using deep learning
Yi Liu, Nicolas Basty, Brandon J. Whitcher, Jimmy David Bell, Elena P. Sorokin, Nick van Bruggen, Elizabeth Louise Thomas, Madeleine Cule · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
TM6SF2 Determines Both the Degree of Lipidation and the Number of VLDL Particles Secreted by the Liver
Reyes-Soffer, Gissette, Liu, Jing, Thomas, Tiffany, Matveyenko, Anastasiya, Seid, Heather, Ramakrishnan, Rajasekhar, Holleran, Steve, Zaghloul, Norann, Sztalryd-Woodle, Carole, Pollin, Toni et al. · 2023
Dual targeting of hepatocyte DGAT2 and stellate cell FASN alleviates nonalcoholic steatohepatitis in mice
Batuhan Yenilmez, Shauna M. Harney, Chloe DiMarzio, Mark Kelly, Kyounghee Min, Dimas Echeverria, Brianna M. Bramato, Samuel O. Jackson, Keith R. Reddig, Jason K. Kim et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
MASLD, diabetes and PMOS across the female life stages
Elisabet Stener‐Victorin, Sofia Carlsson, Hannes Hagström, Nayere Taebnia · 2026 · Diabetologia