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Cited by 458

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer

Open access
Forsberg, Lars A, Rasi, Chiara, Malmqvist, Niklas, Davies, Hanna, Pasupulati, Saichand, Pakalapati, Geeta, Sandgren, Johanna, de Ståhl, Teresita Diaz, Zaghlool, Ammar, Giedraitis, Vilmantas, Lannfelt, Lars, Score, Joannah, Cross, Nicholas C P, Absher, Devin, Janson, Eva Tiensuu, Lindgren, Cecilia M, Morris, Andrew P, Ingelsson, Erik, Lind, Lars, Dumanski, Jan P·2014·Nature Genetics
DOI 10.1038/ng.2966
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Abstract

Incidence and mortality for sex-unspecific cancers are higher among men, a fact that is largely unexplained. Furthermore, age-related loss of chromosome Y (LOY) is frequent in normal hematopoietic cells, but the phenotypic consequences of LOY have been elusive. From analysis of 1,153 elderly men, we report that LOY in peripheral blood was associated with risks of all-cause mortality (hazards ratio (HR) = 1.91, 95% confidence interval (CI) = 1.17–3.13; 637 events) and non-hematological cancer mortality (HR = 3.62, 95% CI = 1.56–8.41; 132 events). LOY affected at least 8.2% of the subjects in this cohort, and median survival times among men with LOY were 5.5 years shorter. Association of LOY with risk of all-cause mortality was validated in an independent cohort (HR = 3.66) in which 20.5% of subjects showed LOY. These results illustrate the impact of post-zygotic mosaicism on disease risk, could explain why males are more frequently affected by cancer and suggest that chromosome Y is important in processes beyond sex determination. LOY in blood could become a predictive biomarker of male carcinogenesis.

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Metadata

Authors
Forsberg, L. A., Rasi, C., Malmqvist, N., Davies, H., Pasupulati, S., Pakalapati, G., Sandgren, J., de Ståhl, T. D., Zaghlool, A., Giedraitis, V., Lannfelt, L., Score, J., Cross, N. C. P., Absher, D., Janson, E. T., Lindgren, C. M., Morris, A. P., Ingelsson, E., Lind, L., & Dumanski, J. P.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2014-04-28
Volume
46
Issue
6
Pages
624-628
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng.2966
OpenAlex
W2014541905
Cited by
458
References
38
FWCI
16.84
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer. https://app.cochat.ai/papers/10.1038/ng.2966
The paper
Forsberg, L. A., Rasi, C., Malmqvist, N., Davies, H., Pasupulati, S., Pakalapati, G., Sandgren, J., de Ståhl, T. D., Zaghlool, A., Giedraitis, V., Lannfelt, L., Score, J., Cross, N. C. P., Absher, D., Janson, E. T., Lindgren, C. M., Morris, A. P., Ingelsson, E., Lind, L., & Dumanski, J. P. (2014). Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer. Nature Genetics. https://doi.org/10.1038/ng.2966

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.