New susceptibility locus for coronary artery disease on chromosome 3q22.3
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We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).
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Genomewide association analyses since 2007 have identified more than 50 independent loci associated with coronary artery disease risk.
“Since 2007, genomewide association analyses have identified more than 50 independent loci associated with the risk of coronary artery disease.7–15”
From Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease (2016) · cites this paper as [11]
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- Authors
- Italian Atherosclerosis, T., Erdmann, J., Myocardial Infarction Genetics Consortium, Wellcome Trust Case Control Consortium, Cardiogenics Consortium, Großhennig, A., Braund, P. S., König, I. R., Hengstenberg, C., Hall, A. S., Linsel-Nitschke, P., Kathiresan, S., Wright, B., Trégouët, D.-A., Cambien, F., Bruse, P., Aherrahrou, Z., Wagner, A. K., Stark, K., Schwartz, S. M., Salomaa, V., Elosua, R., Melander, O., Voight, B. F., O'Donnell, C. J., Peltonen, L., Siscovick, D. S., Altshuler, D., Merlini, P. A., Peyvandi, F., Bernardinelli, L., Ardissino, D., Schillert, A., Blankenberg, S., Zeller, T., Wild, P., Schwarz, D. F., Tiret, L., Perret, C., Schreiber, S., Mokhtari, N. E. E., Schäfer, A., März, W., Renner, W., Bugert, P., Klüter, H., Schrezenmeir, J., Rubin, D., Ball, S. G., Balmforth, A. J., Wichmann, H.-E., Meitinger, T., Fischer, M., Meisinger, C., Baumert, J., Peters, A., Ouwehand, W. H., Deloukas, P., Thompson, J. R., Ziegler, A., Samani, N. J., & Schunkert, H.
- Affiliations
- University of Lübeck (DE)
- University of Leicester (GB)
- University of Regensburg (DE)
- University of Leeds (GB)
- Harvard University (US)
- Inserm (FR)
- University of Washington (US)
- Municipal Institute for Medical Research (ES)
- Lund University (SE)
- National Institutes of Health (US)
- University of Milan (IT)
- University of Pavia (IT)
- Johannes Gutenberg University Mainz (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- Medical University of Graz (AT)
- Heidelberg University (DE)
- Helmholtz Munich (DE)
- University of Cambridge (GB)
- Corresponding author
- Erdmann, Jeanette
- ORCID
- Erdmann, Jeanette
- Großhennig, Anika
- Braund, Peter S
- König, Inke R
- Hall, Alistair S
- Kathiresan, Sekar
- Trégouët, David-Alexandre
- Aherrahrou, Zouhair
- Wagner, Arnika K
- Stark, Klaus
- Schwartz, Stephen M
- Salomaa, Veikko
- Melander, Olle
- Voight, Benjamin F
- Peltonen, Leena
- Siscovick, David S
- Altshuler, David
- Peyvandi, Flora
- Bernardinelli, Luisa
- Ardissino, Diego
- Schillert, Arne
- Blankenberg, Stefan
- Zeller, Tanja
- Wild, Philipp
- Schwarz, Daniel F
- Perret, Claire
- Schreiber, Stefan
- März, Winfried
- Renner, Wilfried
- Bugert, Peter
- Klüter, Harald
- Schrezenmeir, Jürgen
- Ball, Stephen G
- Wichmann, H-Erich
- Meitinger, Thomas
- Fischer, Marcus
- Meisinger, Christa
- Baumert, Jens
- Peters, Annette
- Ouwehand, Willem H
- Deloukas, Panos
- Ziegler, Andreas
- Samani, Nilesh J
- Schunkert, Heribert
- Venue
- Nature Genetics
- Published
- 2009-02-08
- Volume
- 41
- Issue
- 3
- Pages
- 280-282
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- PMC
- PMC2695543
- OpenAlex
- W2171079026
- Cited by
- 484
- References
- 16
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 7 · 2023: 10 · 2022: 8 · 2021: 11 · 2020: 16 · 2019: 14 · 2018: 30 · 2017: 30 · 2016: 23 · 2015: 38 · 2014: 34 · 2013: 40 · 2012: 57
- FWCI
- 42.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- OPUS (Augsburg University) (submittedVersion)
- OpenAgrar (submittedVersion)
- Funders
- Wellcome Trust (077011, 089061, 076113)
- British Heart Foundation
- National Institutes of Health (6u54rr020278-06)
- National Heart, Lung, and Blood Institute (R01HL087676, R01HL056931)
- National Center for Research Resources (U54-RR020278)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- coronary artery disease, mineralocorticoid receptor antagonists, single nucleotide polymorphisms, genetic susceptibility loci, myocardial infarction, genome-wide association study, replication
- MeSH terms
- Chromosomes, Human, Pair 3, Coronary Artery Disease, Germany, Humans, Case-Control Studies, ras Proteins, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Hepatocyte Nuclear Factor 1-alpha, Genome-Wide Association Study
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