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Cited by 455

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

Open access
The Breast and Prostate Cancer Cohort Consortium (BPC3), Al Olama, Ali Amin, The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, The COGS (Collaborative Oncological Gene-environment Study) Consortium, The GAME-ON/ELLIPSE Consortium, Kote-Jarai, Zsofia, Berndt, Sonja I, Conti, David V, Schumacher, Fredrick, Han, Ying, Benlloch, Sara, Hazelett, Dennis J, Wang, Zhaoming, Saunders, Ed, Leongamornlert, Daniel, Lindstrom, Sara, Jugurnauth-Little, Sara, Dadaev, Tokhir, Tymrakiewicz, Malgorzata, Stram, Daniel O, Rand, Kristin, Wan, Peggy, Stram, Alex, Sheng, Xin, Pooler, Loreall C, Park, Karen, Xia, Lucy, Tyrer, Jonathan, Kolonel, Laurence N, Le Marchand, Loic, Hoover, Robert N, Machiela, Mitchell J, Yeager, Merideth, Burdette, Laurie, Chung, Charles C, Hutchinson, Amy, Yu, Kai, Goh, Chee, Ahmed, Mahbubl, Govindasami, Koveela, Guy, Michelle, Tammela, Teuvo L J, Auvinen, Anssi, Wahlfors, Tiina, Schleutker, Johanna, Visakorpi, Tapio, Leinonen, Katri A, Xu, Jianfeng, Aly, Markus, Donovan, Jenny, Travis, Ruth C, Key, Tim J, Siddiq, Afshan, Canzian, Federico, Khaw, Kay-Tee, Takahashi, Atsushi, Kubo, Michiaki, Pharoah, Paul, Pashayan, Nora, Weischer, Maren, Nordestgaard, Borge G, Nielsen, Sune F, Klarskov, Peter, Røder, Martin Andreas, Iversen, Peter, Thibodeau, Stephen N, McDonnell, Shannon K, Schaid, Daniel J, Stanford, Janet L, Kolb, Suzanne, Holt, Sarah, Knudsen, Beatrice, Coll, Antonio Hurtado, Gapstur, Susan M, Diver, W Ryan, Stevens, Victoria L, Maier, Christiane, Luedeke, Manuel, Herkommer, Kathleen, Rinckleb, Antje E, Strom, Sara S, Pettaway, Curtis, Yeboah, Edward D, Tettey, Yao, Biritwum, Richard B, Adjei, Andrew A, Tay, Evelyn, Truelove, Ann, Niwa, Shelley, Chokkalingam, Anand P, Cannon-Albright, Lisa, Cybulski, Cezary, Wokołorczyk, Dominika, Kluźniak, Wojciech, Park, Jong, Sellers, Thomas, Lin, Hui-Yi, Isaacs, William B, Partin, Alan W, Brenner, Hermann, Dieffenbach, Aida Karina, Stegmaier, Christa, Chen, Constance, Giovannucci, Edward L, Ma, Jing, Stampfer, Meir, Penney, Kathryn L, Mucci, Lorelei, John, Esther M, Ingles, Sue A, Kittles, Rick A, Murphy, Adam B, Pandha, Hardev, Michael, Agnieszka, Kierzek, Andrzej M, Blot, William, Signorello, Lisa B, Zheng, Wei, Albanes, Demetrius, Virtamo, Jarmo, Weinstein, Stephanie, Nemesure, Barbara, Carpten, John, Leske, Cristina, Wu, Suh-Yuh, Hennis, Anselm, Kibel, Adam S, Rybicki, Benjamin A, Neslund-Dudas, Christine, Hsing, Ann W, Chu, Lisa, Goodman, Phyllis J, Klein, Eric A, Zheng, S Lilly, Batra, Jyotsna, Clements, Judith, Spurdle, Amanda, Teixeira, Manuel R, Paulo, Paula, Maia, Sofia, Slavov, Chavdar, Kaneva, Radka, Mitev, Vanio, Witte, John S, Casey, Graham, Gillanders, Elizabeth M, Seminara, Daniella, Riboli, Elio, Hamdy, Freddie C, Coetzee, Gerhard A, Li, Qiyuan, Freedman, Matthew L, Hunter, David J, Muir, Kenneth, Gronberg, Henrik, Neal, David E, Southey, Melissa, Giles, Graham G, Severi, Gianluca, Cook, Michael B, Nakagawa, Hidewaki, Wiklund, Fredrik, Kraft, Peter, Chanock, Stephen J, Henderson, Brian E, Easton, Douglas F, Eeles, Rosalind A, Haiman, Christopher A·2014·Nature Genetics
DOI 10.1038/ng.3094
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Abstract

Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of >10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10−8; 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.

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Metadata

Authors
The Breast and Prostate Cancer Cohort Consortium (BPC3), Al Olama, A. A., The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, The COGS (Collaborative Oncological Gene-environment Study) Consortium, The GAME-ON/ELLIPSE Consortium, Kote-Jarai, Z., Berndt, S. I., Conti, D. V., Schumacher, F., Han, Y., Benlloch, S., Hazelett, D. J., Wang, Z., Saunders, E., Leongamornlert, D., Lindstrom, S., Jugurnauth-Little, S., Dadaev, T., Tymrakiewicz, M., Stram, D. O., Rand, K., Wan, P., Stram, A., Sheng, X., Pooler, L. C., Park, K., Xia, L., Tyrer, J., Kolonel, L. N., Le Marchand, L., Hoover, R. N., Machiela, M. J., Yeager, M., Burdette, L., Chung, C. C., Hutchinson, A., Yu, K., Goh, C., Ahmed, M., Govindasami, K., Guy, M., Tammela, T. L. J., Auvinen, A., Wahlfors, T., Schleutker, J., Visakorpi, T., Leinonen, K. A., Xu, J., Aly, M., Donovan, J., Travis, R. C., Key, T. J., Siddiq, A., Canzian, F., Khaw, K.-T., Takahashi, A., Kubo, M., Pharoah, P., Pashayan, N., Weischer, M., Nordestgaard, B. G., Nielsen, S. F., Klarskov, P., Røder, M. A., Iversen, P., Thibodeau, S. N., McDonnell, S. K., Schaid, D. J., Stanford, J. L., Kolb, S., Holt, S., Knudsen, B., Coll, A. H., Gapstur, S. M., Diver, W. R., Stevens, V. L., Maier, C., Luedeke, M., Herkommer, K., Rinckleb, A. E., Strom, S. S., Pettaway, C., Yeboah, E. D., Tettey, Y., Biritwum, R. B., Adjei, A. A., Tay, E., Truelove, A., Niwa, S., Chokkalingam, A. P., Cannon-Albright, L., Cybulski, C., Wokołorczyk, D., Kluźniak, W., Park, J., Sellers, T., Lin, H.-Y., Isaacs, W. B., Partin, A. W., Brenner, H., Dieffenbach, A. K., Stegmaier, C., Chen, C., Giovannucci, E. L., Ma, J., Stampfer, M., Penney, K. L., Mucci, L., John, E. M., Ingles, S. A., Kittles, R. A., Murphy, A. B., Pandha, H., Michael, A., Kierzek, A. M., Blot, W., Signorello, L. B., Zheng, W., Albanes, D., Virtamo, J., Weinstein, S., Nemesure, B., Carpten, J., Leske, C., Wu, S.-Y., Hennis, A., Kibel, A. S., Rybicki, B. A., Neslund-Dudas, C., Hsing, A. W., Chu, L., Goodman, P. J., Klein, E. A., Zheng, S. L., Batra, J., Clements, J., Spurdle, A., Teixeira, M. R., Paulo, P., Maia, S., Slavov, C., Kaneva, R., Mitev, V., Witte, J. S., Casey, G., Gillanders, E. M., Seminara, D., Riboli, E., Hamdy, F. C., Coetzee, G. A., Li, Q., Freedman, M. L., Hunter, D. J., Muir, K., Gronberg, H., Neal, D. E., Southey, M., Giles, G. G., Severi, G., Cook, M. B., Nakagawa, H., Wiklund, F., Kraft, P., Chanock, S. J., Henderson, B. E., Easton, D. F., Eeles, R. A., & Haiman, C. A.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2014-09-14
Volume
46
Issue
10
Pages
1103-1109
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng.3094
OpenAlex
W1992891812
Cited by
455
References
4
FWCI
8.18
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. https://app.cochat.ai/papers/10.1038/ng.3094
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The Breast and Prostate Cancer Cohort Consortium (BPC3), Al Olama, A. A., The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, The COGS (Collaborative Oncological Gene-environment Study) Consortium, The GAME-ON/ELLIPSE Consortium, Kote-Jarai, Z., Berndt, S. I., Conti, D. V., Schumacher, F., Han, Y., Benlloch, S., Hazelett, D. J., Wang, Z., Saunders, E., Leongamornlert, D., Lindstrom, S., Jugurnauth-Little, S., Dadaev, T., Tymrakiewicz, M., . . . Haiman, C. A. (2014). A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. Nature Genetics. https://doi.org/10.1038/ng.3094

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