Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
Open accessAbstract
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls of European ancestry with previously genotyped data of 32,255 PrCa cases and 33,202 controls of European ancestry. Our analysis identified 62 novel loci associated (P < 5.0 × 10-8) with PrCa and one locus significantly associated with early-onset PrCa (≤55 years). Our findings include missense variants rs1800057 (odds ratio (OR) = 1.16; P = 8.2 × 10-9; G>C, p.Pro1054Arg) in ATM and rs2066827 (OR = 1.06; P = 2.3 × 10-9; T>G, p.Val109Gly) in CDKN1B. The combination of all loci captured 28.4% of the PrCa familial relative risk, and a polygenic risk score conferred an elevated PrCa risk for men in the ninetieth to ninety-ninth percentiles (relative risk = 2.69; 95% confidence interval (CI): 2.55-2.82) and first percentile (relative risk = 5.71; 95% CI: 5.04-6.48) risk stratum compared with the population average. These findings improve risk prediction, enhance fine-mapping, and provide insight into the underlying biology of PrCa 1.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Polygenic risk scores alone already predict breast cancer, prostate cancer, and type 1 diabetes risk in European descent patients more accurately than current clinical models.
“For example, polygenic risk scores alone already predict breast cancer, prostate cancer, and type 1 diabetes risk in European descent patients more accurately than current clinical models2–4.”
From Clinical use of current polygenic risk scores may exacerbate health disparities (2019) · cites this paper as [3]
The paper’s Abstract reports that a polygenic risk score stratified prostate cancer risk, and Methods > Proportion of familial risk explained describes estimating scores for men of European ancestry. It does not compare the score’s predictive accuracy with current clinical models. Breast cancer and type 1 diabetes are not assessed as claims attributed specifically to this prostate cancer paper. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
Cytoscape: A software Environment for integrated models of biomolecular interaction networks
Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., Amin, N., Schwikowski, B., & Ideker, T. (2003) · Genome Research · doi:10.1101/gr.1239303 · Cited by 51,888 · see citing works
Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206 · see citing works
Siegel, R. L., Miller, K. D., & Jemal, A. (2016) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21332 · Cited by 16,003 · see citing works
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
Wang, K., Li, M., & Hakonarson, H. H. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq603 · Cited by 14,380 · see citing works
METAL: fast and efficient meta-analysis of genomewide association scans
Willer, C. J., Li, Y., & Abecasis, G. R. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq340 · Cited by 5,205 · see citing works
Howie, B. N., Donnelly, P., & Marchini, J. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000529 · Cited by 3,928 · see citing works
PANTHER: A Library of Protein Families and Subfamilies Indexed by FunctionPreprint
Thomas, P. D., Campbell, M. J., Kejariwal, A., Mi, H., Karlak, B., Daverman, R., Diemer, K., Muruganujan, A., & Karlak, B. (2003) · Genome Research · doi:10.1101/gr.772403 · Cited by 2,912 · see citing works
Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation
Merico, D., Isserlin, R., Stueker, O., Emili, A., & Bader, G. D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013984 · Cited by 2,235 · see citing works
DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer
Mateo, J., Carreira, S., Sandhu, S., Miranda, S., Mossop, H., Perez-Lopez, R., Nava Rodrigues, D., Robinson, D., Omlin, A., Tunariu, N., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1506859 · Cited by 2,185 · see citing works
Self-citationA linear complexity phasing method for thousands of genomes
Delaneau, O., Marchini, J., & Zagury, J.-F. (2012) · Nature Methods · doi:10.1038/nmeth.1785 · Cited by 1,850 · see citing works
PID: the Pathway Interaction Database
Schaefer, C. F., Anthony, K., Krupa, S., Buchoff, J., Day, M., Hannay, T., & Buetow, K. H. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn653 · Cited by 1,603 · see citing works
Reactome: a knowledgebase of biological pathways
Joshi-Tope, G. (2004) · Nucleic Acids Research · doi:10.1093/nar/gki072 · Cited by 1,302 · see citing works
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Yeager, M., Orr, N., Hayes, R. B., Jacobs, K. B., Kraft, P., Wacholder, S., Minichiello, M. J., Fearnhead, P., Yu, K. F., Chatterjee, N., et al. (2007) · Nature Genetics · doi:10.1038/ng2022 · Cited by 1,122 · see citing works
Self-citationMultiple loci identified in a genome-wide association study of prostate cancer
Thomas, G. D., Jacobs, K. B., Yeager, M., Kraft, P., Wacholder, S., Orr, N., Yu, K. F., Chatterjee, N., Welch, R., Hutchinson, A. A., et al. (2008) · Nature Genetics · doi:10.1038/ng.91 · Cited by 899 · see citing works
Self-citationPathway-Based Approaches for Analysis of Genomewide Association Studies
Wang, K., Li, M., & Bućan, M. (2007) · The American Journal of Human Genetics · doi:10.1086/522374 · Cited by 858 · see citing works
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
Guðmundsson, J., Sulem, P., Manolescu, A. R., Amundadottir, L. T., Gudbjartsson, D. F., Helgason, A., Rafnar, Þ., Bergþorsson, J. Þ., Agnarsson, B. A., Baker, A., et al. (2007) · Nature Genetics · doi:10.1038/ng1999 · Cited by 856 · see citing works
Self-citationMultiple newly identified loci associated with prostate cancer susceptibility
Collaborators, T. U. G. P. C. S., Eeles, R. A., Collaborators, T. U. P. S., Kote‐Jarai, Z., Giles, G. G., Olama, A. A. A., Guy, M., Jugurnauth, S. K., Mulholland, S., Leongamornlert, D. A., et al. (2008) · Nature Genetics · doi:10.1038/ng.90 · Cited by 844 · see citing works
Self-citationA common variant associated with prostate cancer in European and African populations
Amundadottir, L. T., Sulem, P., Gudmundsson, J., Helgason, A., Baker, A., Agnarsson, B. A., Sigurdsson, A., Benediktsdottir, K. R., Cazier, J.-B., Sainz, J., et al. (2006) · Nature Genetics · doi:10.1038/ng1808 · Cited by 787 · see citing works
Self-citationAnalysing biological pathways in genome-wide association studies
Wang, K., Li, M., & Hakonarson, H. H. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2884 · Cited by 767 · see citing works
Gudmundsson, J., Sulem, P., Steinthorsdottir, V., Bergthorsson, J. T., Thorleifsson, G., Manolescu, A., Rafnar, T., Gudbjartsson, D., Agnarsson, B. A., Baker, A., et al. (2007) · Nature Genetics · doi:10.1038/ng2062 · Cited by 723 · see citing works
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array
Eeles, R. A., Bioresource, T. A. P. C., Collaborators, T. U. P. (. T. F. C. A. T. S., Olama, A. A. A., Benlloch, S., Saunders, E. J., Leongamornlert, D. A., Tymrakiewicz, M., Ghoussaini, M., Luccarini, C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2560 · Cited by 542 · see citing works
Self-citationCancer biology and NuRD: a multifaceted chromatin remodelling complex
Lai, A. Y., & Wade, P. A. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3091 · Cited by 541 · see citing works
Practical aspects of imputation-driven meta-analysis of genome-wide association studies
de Bakker, P. I. W., Ferreira, M. A. R., Jia, X., Neale, B. M., Raychaudhuri, S., & Voight, B. F. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn288 · Cited by 531 · see citing works
Computational prediction of human metabolic pathways from the complete human genome
Romero, P. R., Wagg, J., GREEN, M. L., Kaiser, D., Krummenacker, M., & Karp, P. D. (2004) · Genome biology · doi:10.1186/gb-2004-6-1-r2 · Cited by 512 · see citing works
NetPath: a public resource of curated signal transduction pathways
Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugopal, A. K., Telikicherla, D., Navarro, J. D., Mathivanan, S., Pecquet, C., et al. (2010) · Genome biology · doi:10.1186/gb-2010-11-1-r3 · Cited by 506 · see citing works
Prevention and early detection of prostate cancer
Cuzick, J. M., Thorat, M. A., Andriole, G. L., Brawley, O. W., Brown, P. H., Čulig, Z., Eeles, R. A., Ford, L. G., Hamdy, F. C., Holmberg, L., et al. (2014) · The Lancet Oncology · doi:10.1016/s1470-2045(14)70211-6 · Cited by 495 · see citing works
Self-citationA meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer
Olama, A. A. A., Kote‐Jarai, Z., Berndt, S. I., Conti, D. V., Schumacher, F. R., Han, Y., Benlloch, S., Hazelett, D. J., Wang, Z., Saunders, E. J., et al. (2014) · Nature Genetics · doi:10.1038/ng.3094 · Cited by 452 · see citing works
Self-citationSastre‐Garau, X., Jouve, M., Asselain, B. J. R., Vincent‐Salomon, A., Beuzeboc, P., Dorval, T., Durand, J. C., Fourquet, A., & Pouillart, P. (1996) · Cancer · doi:10.1002/(sici)1097-0142(19960101)77:1 · Cited by 422 · see citing works
PD ‐1 as a potential target in cancer therapy
McDermott, D. F., & Atkins, M. B. (2013) · Cancer Medicine · doi:10.1002/cam4.106 · Cited by 418 · see citing works
Eeles, R. A., Collaborators, T. U. P. S., Kote‐Jarai, Z., Olama, A. A. A., Giles, G. G., Guy, M., Severi, G., Muir, K. R., Hopper, J. L., Henderson, B. E., et al. (2009) · Nature Genetics · doi:10.1038/ng.450 · Cited by 418 · see citing works
Self-citationCommon sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer
Guðmundsson, J., Sulem, P., Rafnar, Þ., Bergþorsson, J. Þ., Manolescu, A. R., Gudbjartsson, D. F., Agnarsson, B. A., Sigurðsson, Á., Benediktsdóttir, K. R., Blöndal, T., et al. (2008) · Nature Genetics · doi:10.1038/ng.89 · Cited by 370 · see citing works
Self-citationGuðmundsson, J., Sulem, P., Gudbjartsson, D. F., Blöndal, T., Gylfason, A., Agnarsson, B. A., Benediktsdóttir, K. R., Magnúsdóttir, D. N., Orlygsdottir, G., Jakobsdottir, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.448 · Cited by 351 · see citing works
Self-citationThe OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers
Amos, C. I., Dennis, J., Wang, Z., Byun, J., Schumacher, F. R., Gayther, S. A., Casey, G., Hunter, D. J., Sellers, T. A., Gruber, S. B., et al. (2016) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-16-0106 · Cited by 337 · see citing works
Self-citationWissmann, C., Wild, P. J., Kaiser, S., Roepcke, S., Stoehr, R., Woenckhaus, M., Kristiansen, G., Hsieh, J.-C., Hofstaedter, F., Hartmann, A., et al. (2003) · The Journal of Pathology · doi:10.1002/path.1449 · Cited by 333 · see citing works
Multiple loci on 8q24 associated with prostate cancer susceptibility
Olama, A. A. A., Collaborators, T. U. P. T. F. C. A. T. S. (. S., Kote‐Jarai, Z., Giles, G. G., Guy, M., Morrison, J., Severi, G., Leongamornlert, D. A., Tymrakiewicz, M., Jhavar, S. G., et al. (2009) · Nature Genetics · doi:10.1038/ng.452 · Cited by 295 · see citing works
Self-citationSeven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study
Kote‐Jarai, Z., The UK ProtecT Study Collaborators, T. A. P. C. B., Olama, A. A. A., Giles, G. G., Severi, G., Schleutker, J., Weischer, M., Campa, D., Ríboli, E., Key, T. J., et al. (2011) · Nature Genetics · doi:10.1038/ng.882 · Cited by 289 · see citing works
Self-citationTakata, R., Akamatsu, S., Kubo, M., Takahashi, A., Hosono, N., Kawaguchi, T., Tsunoda, T., Inazawa, J., Kamatani, N., Ogawa, O., et al. (2010) · Nature Genetics · doi:10.1038/ng.635 · Cited by 280 · see citing works
The genetic epidemiology of prostate cancer and its clinical implications
Eeles, R. A., Goh, C. L., Castro, E., Bancroft, E. K., Guy, M., Olama, A. A. A., Easton, D. F., & Kote‐Jarai, Z. (2013) · Nature Reviews Urology · doi:10.1038/nrurol.2013.266 · Cited by 260 · see citing works
Self-citationDuggan, D. J., Zheng, S. L., Knowlton, M., Benitez, D. S., Dimitrov, L., Wiklund, F., Robbins, C. M., Isaacs, S. D., Cheng, Y., Li, G., et al. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djm250 · Cited by 254 · see citing works
Self-citationHaiman, C. A., Chen, G. K., Blot, W. J., Strom, S. S., Berndt, S. I., Kittles, R. A., Rybicki, B. A., Isaacs, W. B., Ingles, S. A., Stanford, J. L., et al. (2011) · Nature Genetics · doi:10.1038/ng.839 · Cited by 222 · see citing works
Self-citationGene set analysis of genome-wide association studies: Methodological issues and perspectives
Wang, L., Jia, P., Wolfinger, R. D., Chen, X., & Zhao, Z. (2011) · Genomics · doi:10.1016/j.ygeno.2011.04.006 · Cited by 207 · see citing works
Allen, H. F., Wade, P. A., & Kutateladze, T. G. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1256-2 · Cited by 205 · see citing works
Hiltunen, M., Alhonen, L. I., Koıstınaho, J., Myöhänen, S., Pääkkönen, M. E., Marin, S., Kosma, V.-M., & Jänne, J. (1997) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19970317)70:6 · Cited by 192 · see citing works
The nucleosome remodeling and deacetylase complex in development and disease
Basta, J., & Rauchman, M. (2015) · Translational Research · doi:10.1016/j.trsl.2014.05.003 · Cited by 191 · see citing works
An Epidemiological Reappraisal of the Familial Aggregation of Prostate Cancer: A Meta-Analysis
Kiciński, M., Vangronsveld, J., & Nawrot, T. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027130 · Cited by 180 · see citing works
Bunker, C. H., Patrick, A. L., Konety, B. R., Dhir, R., Brufsky, A., Vivas, C., Becich, M. J., Trump, D. L., & Kuller, L. H. (2002) · PubMed · Cited by 172 · see citing works
Genome-wide association study identifies new prostate cancer susceptibility loci
Schumacher, F. R., Berndt, S. I., Siddiq, A., Jacobs, K. B., Wang, Z., Lindström, S., Stevens, V. L., Chen, C., Mondul, A. M., Travis, R. C., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr295 · Cited by 171 · see citing works
Self-citationEvidence for two independent prostate cancer risk–associated loci in the HNF1B gene at 17q12
Sun, J., Zheng, S. L., Wiklund, F. E., Isaacs, S. D., Purcell, L. D., Gao, Z., Hsu, F. C., Kim, S., Liu, W., Zhu, Y., et al. (2008) · Nature Genetics · doi:10.1038/ng.214 · Cited by 166 · see citing works
Self-citationBias-reduced estimators and confidence intervals for odds ratios in genome-wide association studies
Zhong, H., & Prentice, R. L. (2008) · Biostatistics · doi:10.1093/biostatistics/kxn001 · Cited by 161 · see citing works
Collaborators, T. U., Leongamornlert, D. A., Saunders, E. J., Dadaev, T., Tymrakiewicz, M., Goh, C. L., Jugurnauth-Little, S., Kozarewa, I., Fenwick, K., Assiotis, I., et al. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.30 · Cited by 157 · see citing works
Self-citationStanford, J. L., & Ostrander, E. A. (2001) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a000789 · Cited by 137 · see citing works
Self-citationRASSF tumor suppressor gene family: Biological functions and regulation
Volodko, N. V., Gordon, M., Salla, M., Ghazaleh, H. A., & Baksh, S. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.02.041 · Cited by 135 · see citing works
Olama, A. A. A., Kote-Jarai, Z., Schumacher, F. R., Wiklund, F., Berndt, S. I., Benlloch, S., Giles, G. G., Severi, G., Neal, D. E., Hamdy, F. C., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds425 · Cited by 133 · see citing works
Self-citationYee, D. S., Tang, Y., Li, X., Liu, Z., Guo, Y., Ghaffar, S., McQueen, P., Dash, A., Xie, J., Simoneau, A. R., et al. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-162 · Cited by 132 · see citing works
Prostate cancer risk prediction based on complete prostate cancer family history
Albright, F. S., Stephenson, R. A., Agarwal, N., Teerlink, C. C., Lowrance, W. T., Farnham, J. M., & Cannon‐Albright, L. (2014) · The Prostate · doi:10.1002/pros.22925 · Cited by 127 · see citing works
Self-citationGoh, C. L., Schumacher, F. R., Easton, D. F., Muir, K. R., Henderson, B. E., Kote‐Jarai, Z., & Eeles, R. A. (2012) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2012.02511.x · Cited by 99 · see citing works
Self-citationOlama, A. A. A., Benlloch, S., Antoniou, A. C., Giles, G. G., Severi, G., Neal, D. E., Hamdy, F. C., Donovan, J., Muir, K. R., Schleutker, J., et al. (2015) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-14-0317 · Cited by 71 · see citing works
Self-citationThe Augmin Connection in the Geometry of Microtubule Networks
Sánchez-Huertas, C., & Lüders, J. (2015) · Current Biology · doi:10.1016/j.cub.2015.02.006 · Cited by 71 · see citing works
Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer
Wang, M., Takahashi, A., Liu, F., Ye, D., Ding, Q., Qin, C., Yin, C., Zhang, Z., Matsuda, K., Kubo, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms9469 · Cited by 60 · see citing works
Self-citationMatikainen, M., Pukkala, E., Schleutker, J., Tammela, T., Koivisto, P., Sankila, R., & Kallioniemi, O. (2001) · Cancer Causes and Control · doi:10.1023/a:1011283123610 · Cited by 53 · see citing works
Self-citationThe RASSF3 Candidate Tumor Suppressor Induces Apoptosis and G1–S Cell-Cycle Arrest via p53
Kudo, T., Ikeda, M., Nishikawa, M., Yang, Z., Ohno, K., Nakagawa, K., & Hata, Y. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0572 · Cited by 52 · see citing works
ATM missense variant P1054R predisposes to prostate cancer
Meyer, A. A., Wilhelm, B., Dörk, T., Bremer, M., Baumann, R., Karstens, J. H., & Machtens, S. A. (2007) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2007.04.029 · Cited by 41 · see citing works
Altekruse, S. F., Huang, L., Cucinelli, J. E., McNeel, T. S., Wells, K. M., & Oliver, M. N. (2010) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-1310 · Cited by 34 · see citing works
Familial prostate cancer in Sweden : a nationwide register cohort study.
Gro`Nberg, & Damber (1996) · Cancer · Cited by 20 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [7]Ghadirian P, Howe GR, Hislop TG & Maisonneuve P Family history of prostate cancer: a multi-center case-control study in Canada. Int. J. Cancer 70, 679– 681 (1997). 9096649
Cited by
Sorted by citations
Clinical use of current polygenic risk scores may exacerbate health disparities
Martin, A. R., Kanai, M., Kamatani, Y., Okada, Y., Neale, B. M., & Daly, M. J. (2019) · Nature Genetics · doi:10.1038/s41588-019-0379-x · Cited by 2,831 · see citing works
2022 Update on Prostate Cancer Epidemiology and Risk Factors—A Systematic Review
Bergengren, O., Pekala, K. R., Matsoukas, K., Fainberg, J. S., Mungovan, S. F., Ola Bratt, A., Bray, F., Brawley, O. W., Luckenbaugh, A. N., Mucci, L. A., et al. (2023) · European Urology · doi:10.1016/j.eururo.2023.04.021 · Cited by 882 · see citing works
Self-citationGenetics and biology of prostate cancerPreprint
Wang, G., Zhao, D., Spring, D. J., & DePinho, R. A. (2018) · Genes & Development · doi:10.1101/gad.315739.118 · Cited by 758 · see citing works
Self-citationLDpred2: better, faster, stronger
Privé, F., Arbel, J., & Vilhjálmsson, B. J. (2021) · Bioinformatics · doi:10.1093/bioinformatics/btaa1029 · Cited by 726 · see citing works
Wang, L., Lu, B., He, M., Wang, Y., Wang, Z., & Du, L. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.811044 · Cited by 670 · see citing works
Ishigaki, K., Akiyama, M., Kanai, M., Takahashi, A., Kawakami, E., Sugishita, H., Sakaue, S., Matoba, N., Low, S.-K., Okada, Y., et al. (2020) · Nature Genetics · doi:10.1038/s41588-020-0640-3 · Cited by 508 · see citing works
FinnGen, Mars, N., Koskela, J. T., Ripatti, P., Kiiskinen, T., Havulinna, A. S., Lindbohm, J. V., Ahola‐Olli, A., Kurki, M., Karjalainen, J. M., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0800-0 · Cited by 486 · see citing works
Conti, D. V., Darst, B. F., Moss, L. C., Saunders, E. J., Sheng, X., Chou, A., Schumacher, F. R., Olama, A. A. A., Benlloch, S., Dadaev, T., et al. (2021) · Nature Genetics · doi:10.1038/s41588-020-00748-0 · Cited by 467 · see citing works
Self-citationCausal relationship between gut microbiota and cancers: a two-sample Mendelian randomisation study
Long, Y., Tang, L., Zhou, Y., Zhao, S., & Zhu, H. (2023) · BMC Medicine · doi:10.1186/s12916-023-02761-6 · Cited by 401 · see citing works
Kar, S. P., Quiros, P. M., Gu, M., Jiang, T., Mitchell, J., Langdon, R., Iyer, V., Barcena, C., Vijayabaskar, M. S., Fabre, M. A., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01121-z · Cited by 377 · see citing works
Melzer, D. R., Pilling, L. C., & Ferrucci, L. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0183-6 · Cited by 371 · see citing works
Privé, F., Aschard, H., Carmi, S., Folkersen, L., Hoggart, C. J., O’Reilly, P. F., & Vilhjálmsson, B. J. (2022) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2021.11.008 · Cited by 336 · see citing works
Genetic predisposition to mosaic Y chromosome loss in blood
Thompson, D. J., The Kidney Cancer GWAS Meta-Analysis Project, Genovese, G., Halvardson, J., Ulirsch, J. C., Wright, D. J., Terao, C. C., Davidsson, O. B., Day, F. R., Sulem, P., et al. (2019) · Nature · doi:10.1038/s41586-019-1765-3 · Cited by 340 · see citing works
Self-citationCuomo, A. S. E., Seaton, D. D., McCarthy, D. J., Martinez, I., Bonder, M. J., Garcia-Bernardo, J., Amatya, S., Madrigal, P., Isaacson, A., Buettner, F., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14457-z · Cited by 331 · see citing works
Can the impact of childhood adiposity on disease risk be reversed? A Mendelian randomization study.
Richardson, T. G., Sanderson, E., Elsworth, B., Tilling, K., & Davey Smith, G. (2019) · doi:10.1101/19008011 · Cited by 321 · see citing works
Inflammation-Induced Tumorigenesis and Metastasis
Hibino, S., Kawazoe, T., Kasahara, H., Itoh, S., Ishimoto, T., Sakata‐Yanagimoto, M., & Taniguchi, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115421 · Cited by 303 · see citing works
Epidemiology and genomics of prostate cancer in Asian men
Zhu, Y., Mo, M., Yu, W., Wu, J., Pan, J. G., Freedland, S. J., Zheng, Y., & Ye, D. (2021) · Nature Reviews Urology · doi:10.1038/s41585-021-00442-8 · Cited by 286 · see citing works
Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts
Rashkin, S. R., Graff, R. E., Kachuri, L., Thai, K. K., Alexeeff, S., Blatchins, M. A., Cavazos, T. B., Corley, D. A., Emami, N. C., Hoffman, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18246-6 · Cited by 278 · see citing works
Giri, V. N., Knudsen, K. E., Kelly, W. K., Cheng, H. H., Cooney, K. A., Cookson, M. S., Dahut, W. L., Weissman, S. M., Soule, H. R., Petrylak, D. P., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.20.00046 · Cited by 278 · see citing works
Self-citationTinganelli, W., & Durante, M. (2020) · Cancers · doi:10.3390/cancers12103022 · Cited by 271 · see citing works
Prostate cancer reactivates developmental epigenomic programs during metastatic progression
Pomerantz, M. M., Qiu, X., Zhu, Y., Takeda, D. Y., Pan, W., Baca, S. C., Gusev, A., Korthauer, K. D., Severson, T., Ha, G., et al. (2020) · Nature Genetics · doi:10.1038/s41588-020-0664-8 · Cited by 266 · see citing works
Genetic Risk Scores for Diabetes Diagnosis and Precision Medicine
Udler, M. S., McCarthy, M. I., Florez, J. C., & Mahajan, A. (2019) · Endocrine Reviews · doi:10.1210/er.2019-00088 · Cited by 302 · see citing works
Association analyses identify 31 new risk loci for colorectal cancer susceptibility
Law, P., Timofeeva, M. N., Fernández–Rozadilla, C., Broderick, P., Studd, J. B., Fernandez-Tajes, J. J., Farrington, S. M., Svinti, V., Palles, C., Orlando, G., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09775-w · Cited by 253 · see citing works
Self-citationProstate Cancer Risks for Male BRCA1 and BRCA2 Mutation Carriers: A Prospective Cohort Study
Nyberg, T., Frost, D., Barrowdale, D., Evans, D. G., Bancroft, E. K., Adlard, J., Ahmed, M., Barwell, J., Brady, A. F., Brewer, C., et al. (2019) · European Urology · doi:10.1016/j.eururo.2019.08.025 · Cited by 250 · see citing works
Self-citationDepression and prostate cancer risk: A Mendelian randomization study
Chen, X., Kong, J., Diao, X., Cai, J., Zheng, J., Xie, W., Qin, H., Huang, J., & Lin, T. (2020) · Cancer Medicine · doi:10.1002/cam4.3493 · Cited by 245 · see citing works
Wu, L., Yang, Y., Guo, X., Shu, X., Cai, Q., Shu, X., Li, B., Tao, R., Wu, C., Nikas, J. B., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17673-9 · Cited by 244 · see citing works
Self-citationFernández–Rozadilla, C., Timofeeva, M. N., Chen, Z., Law, P., Thomas, M., Schmit, S. L., Díez‐Obrero, V., Hsu, L., Fernandez-Tajes, J. J., Palles, C., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01222-9 · Cited by 230 · see citing works
Self-citationRay, D., & Chatterjee, N. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1009218 · Cited by 236 · see citing works
Prostate carcinogenesis: inflammatory storms
Bono, J. S. D., Guo, C. W., Gürel, B., Marzo, A. M. D., Sfanos, K. S., Mani, R. S., Gil, J., Drake, C. G., & Alimonti, A. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0267-9 · Cited by 231 · see citing works
Jones, G., Trajanoska, K., Santanasto, A. J., Stringa, N., Kuo, C., Atkins, J. L., Lewis, J. R., Duong, T., Hong, S., Biggs, M. L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-20918-w · Cited by 222 · see citing works
Making the Most of Clumping and Thresholding for Polygenic Scores
Privé, F., Vilhjálmsson, B. J., Aschard, H., & Blum, M. G. B. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.11.001 · Cited by 199 · see citing works
Causal Inference in Cancer Epidemiology: What Is the Role of Mendelian Randomization?
Yarmolinsky, J., Wade, K. H., Richmond, R. C., Langdon, R., Bull, C. J., Tilling, K. M., Relton, C. L., Lewis, S. J., Smith, G. D., & Martin, R. M. (2018) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-17-1177 · Cited by 186 · see citing works
Self-citationDevelopment of a clinical polygenic risk score assay and reporting workflow
Hao, L., Kraft, P., Berriz, G. F., Hynes, E. D., Koch, C., Kumar, P. K. V., Parpattedar, S. S., Steeves, M. A., Yu, W., Antwi, A. A., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01767-6 · Cited by 180 · see citing works
Self-citationLarsson, S. C., Carter, P., Kar, S., Vithayathil, M. K., Mason, A. M., Michaëlsson, K., & Burgess, S. (2020) · PLoS Medicine · doi:10.1371/journal.pmed.1003178 · Cited by 189 · see citing works
Improved genetic prediction of complex traits from individual-level data or summary statistics
Zhang, Q., Privé, F., Vilhjálmsson, B. J., & Speed, D. (2021) · Nature Communications · doi:10.1038/s41467-021-24485-y · Cited by 175 · see citing works
Transcriptional mediators of treatment resistance in lethal prostate cancer
He, M. X., Cuoco, M. S., Crowdis, J. P., Bosma-Moody, A., Zhang, Z., Bi, K., Kanodia, A., Su, M.-J., Ku, S., Garcia, M. M., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01244-6 · Cited by 180 · see citing works
Self-citationAmariuta, T., Ishigaki, K., Sugishita, H., Ohta, T., Koido, M., Dey, K. K., Matsuda, K., Murakami, Y., Price, A. L., Kawakami, E., et al. (2020) · Nature Genetics · doi:10.1038/s41588-020-00740-8 · Cited by 180 · see citing works
Carlsson, S., & Vickers, A. J. (2020) · Medical Clinics of North America · doi:10.1016/j.mcna.2020.08.007 · Cited by 176 · see citing works
Genetic associations for two biological age measures point to distinct aging phenotypes
Kuo, C., Pilling, L. C., Liu, Z., Atkins, J. L., & Levine, M. E. (2021) · Aging Cell · doi:10.1111/acel.13376 · Cited by 173 · see citing works
Prostate Cancer in Primary Care
Merriel, S. W., Funston, G., & Hamilton, W. T. (2018) · Advances in Therapy · doi:10.1007/s12325-018-0766-1 · Cited by 173 · see citing works
Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis
Bouras, E., Karhunen, V., Gill, D., Huang, J. V., Haycock, P., Gunter, M. J., Johansson, M., Brennan, P., Key, T. J., Lewis, S. J., et al. (2022) · BMC Medicine · doi:10.1186/s12916-021-02193-0 · Cited by 172 · see citing works
Self-citationZeng, J., Xue, A., Jiang, L., Lloyd-Jones, L. R., Wu, Y., Wang, H., Zheng, Z., Yengo, L., Kemper, K. E., Goddard, M. E., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21446-3 · Cited by 144 · see citing works
Gallagher, C. S., Mäkinen, N., Harris, H. R., Rahmioğlu, N., Uimari, O., Cook, J. P., Shigesi, N., Ferreira, T. C., Velez-Edwards, D. R., Edwards, T. L., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12536-4 · Cited by 169 · see citing works
A Review of Prostate Cancer Genome-Wide Association Studies (GWAS)
Benafif, S., Kote‐Jarai, Z., & Eeles, R. A. (2018) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-16-1046 · Cited by 161 · see citing works
Self-citationThe illusion of polygenic disease risk prediction
Wald, N., & Old, R. W. (2019) · Genetics in Medicine · doi:10.1038/s41436-018-0418-5 · Cited by 154 · see citing works
An epigenome-wide association study of sex-specific chronological ageing
McCartney, D. L., Zhang, F., Hillary, R. F., Zhang, Q., Stevenson, A. J., Walker, R. M., Bermingham, M. L., Boutin, T., Morris, S. W., Campbell, A., et al. (2020) · Genome Medicine · doi:10.1186/s13073-019-0693-z · Cited by 152 · see citing works
Large-scale transcriptome-wide association study identifies new prostate cancer risk regions
Mancuso, N., Gayther, S. A., Gusev, A., Zheng, W., Penney, K. L., Kote‐Jarai, Z., Eeles, R. A., Freedman, M. L., Haiman, C. A., Paşaniuc, B., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06302-1 · Cited by 151 · see citing works
Self-citationCellular and Molecular Mechanisms Underlying Prostate Cancer Development: Therapeutic Implications
Testa, U., Castelli, G., & Pelosi, E. (2019) · Medicines · doi:10.3390/medicines6030082 · Cited by 156 · see citing works
Wang, A., Shen, J., Rodriguez, A. A., Saunders, E. J., Chen, F., Janivara, R., Darst, B. F., Sheng, X., Xu, Y., Chou, A., et al. (2023) · Nature Genetics · doi:10.1038/s41588-023-01534-4 · Cited by 146 · see citing works
Self-citationYuan, S., Carter, P., Bruzelius, M., Vithayathil, M. K., Kar, S., Mason, A. M., Lin, A., Burgess, S., & Larsson, S. C. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102956 · Cited by 141 · see citing works
Zhang, Y., Hurson, A. N., Zhang, H., Choudhury, P. P., Easton, D. F., Milne, R. L., Simard, J., Hall, P. N., Michailidou, K., Dennis, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16483-3 · Cited by 134 · see citing works
Self-citationJia, G., Lu, Y., Wen, W., Long, J., Liu, Y., Tao, R., Li, B., Denny, J. C., Shu, X., & Zheng, W. (2020) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkaa021 · Cited by 136 · see citing works
Self-citationAssessing the causal association of glycine with risk of cardio-metabolic diseases
Wittemans, L. B. L., Lotta, L. A., Oliver‐Williams, C., Stewart, I. D., Surendran, P., Karthikeyan, S., Day, F. R., Koulman, A., Imamura, F., Zeng, L., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08936-1 · Cited by 134 · see citing works
Self-citationFinnGen, Sakaue, S., Kanai, M., Karjalainen, J. M., Akiyama, M., Kurki, M., Matoba, N., Takahashi, A., Hirata, M., Kubo, M., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0785-8 · Cited by 119 · see citing works
Geographic Variation and Bias in the Polygenic Scores of Complex Diseases and Traits in Finland
Kerminen, S., Martin, A. R., Koskela, J. T., Ruotsalainen, S., Havulinna, A. S., Surakka, I. L., Palotie, A. V., Perola, M., Salomaa, V. V., Daly, M. J., et al. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.05.001 · Cited by 108 · see citing works
Yuan, J., Kensler, K. H., Hu, Z., Zhang, Y., Zhang, T., Jiang, J., Xu, M., Pan, Y., Long, M., Montone, K. T., et al. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008641 · Cited by 116 · see citing works
Merging new-age biomarkers and nanodiagnostics for precision prostate cancer management
Koo, K. M., Mainwaring, P. N., Tomlins, S. A., & Trau, M. (2019) · Nature Reviews Urology · doi:10.1038/s41585-019-0178-2 · Cited by 111 · see citing works
Gusev, A., Lawrenson, K., Lin, X., Junior, P. C. M. L., Kar, S., Vavra, K. C., Segato, F., Fonseca, M. A., Lee, J. M., Pejovic, T., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0395-x · Cited by 111 · see citing works
Self-citationShared heritability and functional enrichment across six solid cancers
Jiang, X., Finucane, H. K., Schumacher, F. R., Schmit, S. L., Tyrer, J. P., Han, Y., Michailidou, K., Lesseur, C., Kuchenbaecker, K. B., Dennis, J., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-08054-4 · Cited by 107 · see citing works
Self-citationAssessment of a Polygenic Risk Score in Screening for Prostate Cancer
McHugh, J. K., Bancroft, E. K., Saunders, E. J., Brook, M. N., McGrowder, E. H., Wakerell, S., James, D., Rageevakumar, R., Benton, B. E., Taylor, N., et al. (2025) · New England Journal of Medicine · doi:10.1056/nejmoa2407934 · Cited by 110 · see citing works
Self-citationPost-GWAS in prostate cancer: from genetic association to biological contribution
Farashi, S., Kryza, T., Clements, J., & Batra, J. (2018) · Nature Reviews. Cancer · doi:10.1038/s41568-018-0087-3 · Cited by 88 · see citing works
Self-citationDadaev, T., Saunders, E. J., Newcombe, P. J., Anokian, E., Leongamornlert, D. A., Brook, M. N., Cieza-Borrella, C., Mijušković, M., Wakerell, S., Olama, A. A. A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04109-8 · Cited by 104 · see citing works
Self-citationKerns, S. L., Fachal, L., Dorling, L., Barnett, G. C., Baran, A., Peterson, D. R., Hollenberg, M., Hao, K., Narzo, A. D., Ahsen, M. E., et al. (2020) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djz075 · Cited by 117 · see citing works
Self-citationDissecting polygenic signals from genome-wide association studies on human behaviour
Abdellaoui, A., & Verweij, K. J. H. (2021) · Nature Human Behaviour · doi:10.1038/s41562-021-01110-y · Cited by 95 · see citing works
Germline Pathogenic Variants in 7636 Japanese Patients With Prostate Cancer and 12 366 Controls
Momozawa, Y., Iwasaki, Y., Hirata, M., Liu, X., Kamatani, Y., Takahashi, A., Sugano, K., Yoshida, T., Murakami, Y., Matsuda, K., et al. (2019) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djz124 · Cited by 100 · see citing works
Fritsche, L. G., Patil, S. B., Beesley, L. J., VandeHaar, P., Salvatore, M., Ma, Y., Peng, R. B., Taliun, D., Zhou, X., & Mukherjee, B. (2020) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2020.08.025 · Cited by 92 · see citing works
Pesticide exposure and risk of aggressive prostate cancer among private pesticide applicators
Pardo, L. A., Freeman, L. E. B., Lerro, C. C., Andreotti, G., Hofmann, J. N., Parks, C. G., Sandler, D. P., Lubin, J. H., Blair, A. E., & Koutros, S. (2020) · Environmental Health · doi:10.1186/s12940-020-00583-0 · Cited by 97 · see citing works
Self-citationHujoel, M. L. A., Gazal, S., Loh, P., Patterson, N. J., & Price, A. L. (2020) · Nature Genetics · doi:10.1038/s41588-020-0613-6 · Cited by 95 · see citing works
Sex-specific genetic effects across biomarkers
Flynn, E., Tanigawa, Y., Rodríguez, F., Altman, R. B., Sinnott-Armstrong, N., & Rivas, M. A. (2020) · European Journal of Human Genetics · doi:10.1038/s41431-020-00712-w · Cited by 87 · see citing works
A Multiple-Testing Procedure for High-Dimensional Mediation Hypotheses
Dai, J. Y., Stanford, J. L., & LeBlanc, M. L. (2020) · Journal of the American Statistical Association · doi:10.1080/01621459.2020.1765785 · Cited by 92 · see citing works
Self-citationAssessing Lung Cancer Absolute Risk Trajectory Based on a Polygenic Risk Model
Hung, R. J., Warkentin, M. T., Brhane, Y., Chatterjee, N., Christiani, D. C., Landi, M. T., Caporaso, N. E., Liu, G., Johansson, M., Albanes, D., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-1237 · Cited by 91 · see citing works
Self-citationRecurrent repeat expansions in human cancer genomes
Erwin, G. S., Gürsoy, G., Al-Abri, R., Suriyaprakash, A., Dolzhenko, E., Zhu, K., Hoerner, C. R., White, S. M., Ramirez, L., Vadlakonda, A., et al. (2022) · Nature · doi:10.1038/s41586-022-05515-1 · Cited by 85 · see citing works
Self-citationInferring disease architecture and predictive ability with LDpred2-auto
Privé, F., Albiñana, C., Arbel, J., Paşaniuc, B., & Vilhjálmsson, B. J. (2023) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2023.10.010 · Cited by 89 · see citing works
Causal inference for heritable phenotypic risk factors using heterogeneous genetic instruments
Wang, J., Zhao, Q., Bowden, J., Hemani, G., Smith, G. D., Small, D. S., & Zhang, N. R. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009575 · Cited by 82 · see citing works
Identifying and correcting for misspecifications in GWAS summary statistics and polygenic scores
Privé, F., Arbel, J., Aschard, H., & Vilhjálmsson, B. J. (2022) · Human Genetics and Genomics Advances · doi:10.1016/j.xhgg.2022.100136 · Cited by 83 · see citing works
Berstein, F. M., McCartney, D. L., Lu, A. T., Tsilidis, K. K., Bouras, E., Haycock, P., Burrows, K., Phipps, A. I., Buchanan, D. D., Cheng, I. C., et al. (2022) · eLife · doi:10.7554/elife.75374 · Cited by 86 · see citing works
Self-citationGenome-wide risk prediction of common diseases across ancestries in one million people
Mars, N., Kerminen, S., Feng, Y. A., Kanai, M., Läll, K., Thomas, L. F., Skogholt, A. H., Parolo, P. D. B., Neale, B. M., Smoller, J. W., et al. (2022) · Cell Genomics · doi:10.1016/j.xgen.2022.100118 · Cited by 78 · see citing works
Wei, Z., Yang, B., Tang, T., Xiao, Z., Ye, F., Li, X., Wu, S., Huang, J., & Jiang, S. (2023) · Cancer Medicine · doi:10.1002/cam4.5772 · Cited by 79 · see citing works
Germline Sequencing DNA Repair Genes in 5545 Men With Aggressive and Nonaggressive Prostate Cancer
Darst, B. F., Dadaev, T., Saunders, E. J., Sheng, X., Wan, P. C., Pooler, L., Xia, L. Y., Chanock, S. J., Berndt, S. I., Gapstur, S. M., et al. (2020) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djaa132 · Cited by 81 · see citing works
Self-citationRare Germline Variants in ATM Predispose to Prostate Cancer: A PRACTICAL Consortium Study
Karlsson, Q., Brook, M. N., Dadaev, T., Wakerell, S., Saunders, E. J., Muir, K. R., Neal, D. E., Giles, G. G., MacInnis, R. J., Thibodeau, S. N., et al. (2021) · European Urology Oncology · doi:10.1016/j.euo.2020.12.001 · Cited by 81 · see citing works
Self-citationCombined Effect of a Polygenic Risk Score and Rare Genetic Variants on Prostate Cancer Risk
Darst, B. F., Sheng, X., Eeles, R. A., Kote‐Jarai, Z., Conti, D. V., & Haiman, C. A. (2021) · European Urology · doi:10.1016/j.eururo.2021.04.013 · Cited by 80 · see citing works
Self-citationVithayathil, M. K., Carter, P., Kar, S., Mason, A. M., Burgess, S., & Larsson, S. C. (2021) · PLoS Medicine · doi:10.1371/journal.pmed.1003706 · Cited by 78 · see citing works
Mazrooei, P., Kron, K. J., Zhu, Y., Zhou, S., Grillo, G., Mehdi, T., Ahmed, M., Severson, T., Guilhamon, P., Armstrong, N. S., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.10.005 · Cited by 73 · see citing works
Self-citationSlenders, L., Landsmeer, L. P. L., Cui, K., Depuydt, M. A. C., Verwer, M. C., Mekke, J. M., Timmerman, N., van den Dungen, N. A. M., Kuiper, J., de Winther, M. P. J., et al. (2021) · European Heart Journal Open · doi:10.1093/ehjopen/oeab043 · Cited by 76 · see citing works
African-specific molecular taxonomy of prostate cancer
Jaratlerdsiri, W., Jiang, J., Gong, T., Patrick, S. M., Willet, C. E., Chew, T., Lyons, R. J., Haynes, A., Pasqualim, G., Louw, M., et al. (2022) · Nature · doi:10.1038/s41586-022-05154-6 · Cited by 76 · see citing works
Self-citationPolygenic hazard score is associated with prostate cancer in multi-ethnic populations
Huynh‐Le, M., Fan, C. C., Karunamuni, R. A., Thompson, W. K., Martı́nez, M. E., Eeles, R. A., Kote‐Jarai, Z., Muir, K. R., collaborators, U., Schleutker, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21287-0 · Cited by 75 · see citing works
Self-citationGuo, Y., Perez, A. A., Hazelett, D. J., Coetzee, G. A., Rhie, S. K., & Farnham, P. (2018) · Genome biology · doi:10.1186/s13059-018-1531-0 · Cited by 73 · see citing works
Polygenic risk modeling for prediction of epithelial ovarian cancer risk
Dareng, E., Tyrer, J. P., Barnes, D. R., Jones, M. R., Yang, X., Aben, K. K. H., Adank, M. A., Agata, S., Andrulis, I. L., Anton‐Culver, H., et al. (2022) · European Journal of Human Genetics · doi:10.1038/s41431-021-00987-7 · Cited by 73 · see citing works
Self-citationYuan, S., Wang, L., Zhang, H., Xu, F., Zhou, X., Yu, L., Sun, J., Chen, J., Ying, H., Xu, X., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104488 · Cited by 73 · see citing works
Self-citationClinical utility of polygenic risk scores: a critical 2023 appraisal
Koch, S., Schmidtke, J., Krawczak, M., & Caliebe, A. (2023) · Journal of Community Genetics · doi:10.1007/s12687-023-00645-z · Cited by 73 · see citing works
Genome Sequencing during a Patient’s Journey through Cancer
Nangalia, J., & Campbell, P. J. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1910138 · Cited by 66 · see citing works
Vitamin D and overall cancer risk and cancer mortality: a Mendelian randomization study
Ong, J., Gharahkhani, P., An, J., Law, M. H., Whiteman, D. C., Neale, R. Ε., & MacGregor, S. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy307 · Cited by 72 · see citing works
Hollis, B., Day, F. R., Busch, A. S., Thompson, D. J., Soares, A. G., Timmers, P. R. H. J., Kwong, A. S. F., Easton, D. F., Joshi, P. K., Timpson, N. J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14451-5 · Cited by 75 · see citing works
Self-citationRozet, F., Mongiat-Artus, P., Hennequin, C., Beauval, J., Beuzeboc, P., Cormier, L., Fromont, G., Mathiéu, R., Ploussard, G., Renard‐Penna, R., et al. (2020) · The French Journal of Urology · doi:10.1016/s1166-7087(20)30752-1 · Cited by 73 · see citing works
Self-citationHereditary Predisposition to Prostate Cancer: From Genetics to Clinical Implications
Brandão, A., Paulo, P., & Teixeira, M. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145036 · Cited by 70 · see citing works
Self-citationCirculating vitamin C concentration and risk of cancers: a Mendelian randomization study
Fu, Y., Xu, F., Jiang, L., Miao, Z., Liang, X., Yang, J., Larsson, S. C., & Zheng, J. (2021) · BMC Medicine · doi:10.1186/s12916-021-02041-1 · Cited by 70 · see citing works
Yarmolinsky, J., Díez‐Obrero, V., Richardson, T. G., Pigeyre, M., Sjaarda, J., Paré, G., Walker, V. M., Vincent, E. E., Tan, V. Y., Obón‐Santacana, M., et al. (2022) · PLoS Medicine · doi:10.1371/journal.pmed.1003897 · Cited by 70 · see citing works
Self-citationXin, J., Jiang, X., Ben, S., Yuan, Q., Su, L., Zhang, Z., Christiani, D. C., Du, M., & Wang, M. (2022) · BMC Medicine · doi:10.1186/s12916-022-02366-5 · Cited by 70 · see citing works
Genome-wide germline correlates of the epigenetic landscape of prostate cancer
Houlahan, K. E., Shiah, Y.-J., Gusev, A., Yuan, J., Ahmed, M., Shetty, A. H., Ramanand, S. G., Yao, C. Q., Bell, C. A., O’Connor, E. P., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0579-z · Cited by 69 · see citing works
Self-citationPolygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans
Shams, H., Shao, X., Santaniello, A., Kirkish, G., Harroud, A., Ma, Q., Isobe, N., Alexander, J., Bove, R. M., Baranzini, S. E., et al. (2022) · Brain · doi:10.1093/brain/awac092 · Cited by 70 · see citing works
- Authors
- Study, T. P., Schumacher, F. R., (APCB), A. P. C. B., Study, T. I., Canary PASS Investigators, Breast and Prostate Cancer Cohort Consortium (BPC3), The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, (CAPS), C. O. T. P. I. S., Prostate Cancer Genome-wide Association Study of Uncommon Susceptibility Loci (PEGASUS), The Genetic Associations and Mechanisms in Oncology (GAME-ON)/Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium, Al Olama, A. A., Berndt, S. I., Benlloch, S., Ahmed, M., Saunders, E. J., Dadaev, T., Leongamornlert, D., Anokian, E., Cieza-Borrella, C., Goh, C., Brook, M. N., Sheng, X., Fachal, L., Dennis, J., Tyrer, J., Muir, K., Lophatananon, A., Stevens, V. L., Gapstur, S. M., Carter, B. D., Tangen, C. M., Goodman, P. J., Thompson, I. M., Batra, J., Chambers, S., Moya, L., Clements, J., Horvath, L., Tilley, W., Risbridger, G. P., Gronberg, H., Aly, M., Nordström, T., Pharoah, P., Pashayan, N., Schleutker, J., Tammela, T. L. J., Sipeky, C., Auvinen, A., Albanes, D., Weinstein, S., Wolk, A., Håkansson, N., West, C. M. L., Dunning, A. M., Burnet, N., Mucci, L. A., Giovannucci, E., Andriole, G. L., Cussenot, O., Cancel-Tassin, G., Koutros, S., Beane Freeman, L. E., Sorensen, K. D., Orntoft, T. F., Borre, M., Maehle, L., Grindedal, E. M., Neal, D. E., Donovan, J. L., Hamdy, F. C., Martin, R. M., Travis, R. C., Key, T. J., Hamilton, R. J., Fleshner, N. E., Finelli, A., Ingles, S. A., Stern, M. C., Rosenstein, B. S., Kerns, S. L., Ostrer, H., Lu, Y.-J., Zhang, H.-W., Feng, N., Mao, X., Guo, X., Wang, G., Sun, Z., Giles, G. G., Southey, M. C., MacInnis, R. J., FitzGerald, L. M., Kibel, A. S., Drake, B. F., Vega, A., Gómez-Caamaño, A., Szulkin, R., Eklund, M., Kogevinas, M., Llorca, J., Castaño-Vinyals, G., Penney, K. L., Stampfer, M., Park, J. Y., Sellers, T. A., Lin, H.-Y., Stanford, J. L., Cybulski, C., Wokolorczyk, D., Lubinski, J., Ostrander, E. A., Geybels, M. S., Nordestgaard, B. G., Nielsen, S. F., Weischer, M., Bisbjerg, R., Røder, M. A., Iversen, P., Brenner, H., Cuk, K., Holleczek, B., Maier, C., Luedeke, M., Schnoeller, T., Kim, J., Logothetis, C. J., John, E. M., Teixeira, M. R., Paulo, P., Cardoso, M., Neuhausen, S. L., Steele, L., Ding, Y. C., De Ruyck, K., De Meerleer, G., Ost, P., Razack, A., Lim, J., Teo, S.-H., Lin, D. W., Newcomb, L. F., Lessel, D., Gamulin, M., Kulis, T., Kaneva, R., Usmani, N., Singhal, S., Slavov, C., Mitev, V., Parliament, M., Claessens, F., Joniau, S., Van den Broeck, T., Larkin, S., Townsend, P. A., Aukim-Hastie, C., Gago-Dominguez, M., Castelao, J. E., Martinez, M. E., Roobol, M. J., Jenster, G., van Schaik, R. H. N., Menegaux, F., Truong, T., Koudou, Y. A., Xu, J., Khaw, K.-T., Cannon-Albright, L., Pandha, H., Michael, A., Thibodeau, S. N., McDonnell, S. K., Schaid, D. J., Lindstrom, S., Turman, C., Ma, J., Hunter, D. J., Riboli, E., Siddiq, A., Canzian, F., Kolonel, L. N., Le Marchand, L., Hoover, R. N., Machiela, M. J., Cui, Z., Kraft, P., Amos, C. I., Conti, D. V., Easton, D. F., Wiklund, F., Chanock, S. J., Henderson, B. E., Kote-Jarai, Z., Haiman, C. A., & Eeles, R. A.
- Affiliations
- Case Western Reserve University (US)
- University of Cambridge (GB)
- Division of Cancer Epidemiology and Genetics (US)
- Institute of Cancer Research (GB)
- University of Manchester (GB)
- American Cancer Society (US)
- Griffith University (AU)
- Translational Research Institute (AU)
- Garvan Institute of Medical Research (AU)
- Karolinska University Hospital (SE)
- University of Turku (FI)
- Tampere University (FI)
- Karolinska Institutet (SE)
- Uppsala University (SE)
- Harvard University (US)
- Washington University in St. Louis (US)
- Aarhus University Hospital (DK)
- Oslo University Hospital (NO)
- Aarhus University (DK)
- Princess Margaret Cancer Centre (CA)
- University of Oxford (GB)
- Albert Einstein College of Medicine (US)
- Queen Mary University of London (GB)
- Second Military Medical University (CN)
- Nanjing Medical University (CN)
- Shanghai Medical College of Fudan University (CN)
- Cancer Council Victoria (AU)
- Brigham and Women's Hospital (US)
- The University of Melbourne (AU)
- Monash Health (AU)
- University of Tasmania (AU)
- Universitat Pompeu Fabra (ES)
- Fundación Pública Galega de Medicina Xenómica (ES)
- Universidad de Cantabria (ES)
- Moffitt Cancer Center (US)
- National Institutes of Health (US)
- University of Washington (US)
- University of Copenhagen (DK)
- Copenhagen University Hospital (DK)
- German Cancer Research Center (DE)
- Herlev Hospital (DK)
- The University of Texas MD Anderson Cancer Center (US)
- Cancer Prevention Institute of California (US)
- Universidade do Porto (PT)
- Instituto Português de Oncologia Francisco Gentil (PT)
- Ghent University (BE)
- Ghent University Hospital (BE)
- University of Malaya (MY)
- University Hospital Centre Zagreb (HR)
- University of Alberta (CA)
- Alexandrovska Hospital (BG)
- Southampton General Hospital (GB)
- University of Surrey (GB)
- Universitair Ziekenhuis Leuven (BE)
- Manchester Academic Health Science Centre (GB)
- Inserm (FR)
- Endeavor Health (US)
- Mayo Clinic (US)
- USC Norris Comprehensive Cancer Center (US)
- Dartmouth College (US)
- Royal Marsden NHS Foundation Trust (GB)
- Corresponding author
- Schumacher, Fredrick R.
- Eeles, Rosalind A.
- ORCID
- Schumacher, Fredrick R.
- Berndt, Sonja I.
- Ahmed, Mahbubl
- Saunders, Edward J.
- Dadaev, Tokhir
- Leongamornlert, Daniel
- Anokian, Ezequiel
- Cieza-Borrella, Clara
- Goh, Chee
- Brook, Mark N.
- Sheng, Xin
- Fachal, Laura
- Dennis, Joe
- Tyrer, Jonathan
- Muir, Kenneth
- Lophatananon, Artitaya
- Stevens, Victoria L.
- Gapstur, Susan M.
- Carter, Brian D.
- Tangen, Catherine M.
- Goodman, Phyllis J.
- Thompson, Ian M.
- Batra, Jyotsna
- Chambers, Suzanne
- Moya, Leire
- Clements, Judith
- Horvath, Lisa
- Tilley, Wayne
- Risbridger, Gail P.
- Aly, Markus
- Nordström, Tobias
- Pharoah, Paul
- Pashayan, Nora
- Schleutker, Johanna
- Tammela, Teuvo L. J.
- Sipeky, Csilla
- Auvinen, Anssi
- Albanes, Demetrius
- Weinstein, Stephanie
- Wolk, Alicja
- Håkansson, Niclas
- West, Catharine M. L.
- Dunning, Alison M.
- Burnet, Neil
- Mucci, Lorelei A.
- Giovannucci, Edward
- Andriole, Gerald L.
- Cussenot, Olivier
- Koutros, Stella
- Borre, Michael
- Grindedal, Eli Marie
- Neal, David E.
- Donovan, Jenny L.
- Hamdy, Freddie C.
- Martin, Richard M.
- Travis, Ruth C.
- Hamilton, Robert J.
- Fleshner, Neil E.
- Finelli, Antonio
- Ingles, Sue Ann
- Stern, Mariana C.
- Rosenstein, Barry S.
- Kerns, Sarah L.
- Lu, Yong-Jie
- Zhang, Hong-Wei
- Feng, Ninghan
- Mao, Xueying
- Wang, Guomin
- Giles, Graham G.
- Southey, Melissa C.
- MacInnis, Robert J.
- FitzGerald, Liesel M.
- Kibel, Adam S.
- Drake, Bettina F.
- Vega, Ana
- Szulkin, Robert
- Eklund, Martin
- Kogevinas, Manolis
- Llorca, Javier
- Penney, Kathryn L.
- Stampfer, Meir
- Park, Jong Y.
- Sellers, Thomas A.
- Lin, Hui-Yi
- Stanford, Janet L.
- Cybulski, Cezary
- Ostrander, Elaine A.
- Nordestgaard, Børge G.
- Nielsen, Sune F.
- Weischer, Maren
- Bisbjerg, Rasmus
- Røder, Martin Andreas
- Iversen, Peter
- Brenner, Hermann
- Holleczek, Bernd
- Kim, Jeri
- Logothetis, Christopher J.
- John, Esther M.
- Teixeira, Manuel R.
- Paulo, Paula
- Cardoso, Marta
- Neuhausen, Susan L.
- Steele, Linda
- Ding, Yuan Chun
- Ost, Piet
- Razack, Azad
- Lim, Jasmine
- Teo, Soo-Hwang
- Lin, Daniel W.
- Lessel, Davor
- Gamulin, Marija
- Kaneva, Radka
- Usmani, Nawaid
- Singhal, Sandeep
- Slavov, Chavdar
- Mitev, Vanio
- Parliament, Matthew
- Claessens, Frank
- Joniau, Steven
- Townsend, Paul A.
- Castelao, Jose Esteban
- Roobol, Monique J.
- Jenster, Guido
- Truong, Thérèse
- Xu, Jianfeng
- Khaw, Kay-Tee
- Pandha, Hardev
- Michael, Agnieszka
- Thibodeau, Stephen N.
- McDonnell, Shannon K.
- Schaid, Daniel J.
- Turman, Constance
- Ma, Jing
- Siddiq, Afshan
- Canzian, Federico
- Kolonel, Laurence N.
- Hoover, Robert N.
- Machiela, Mitchell J.
- Cui, Zuxi
- Kraft, Peter
- Amos, Christopher I.
- Conti, David V.
- Easton, Douglas F.
- Wiklund, Fredrik
- Chanock, Stephen J.
- Haiman, Christopher A.
- Eeles, Rosalind A.
- Venue
- Nature Genetics
- Published
- 2018-06-11
- Volume
- 50
- Issue
- 7
- Pages
- 928-936
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- PMC
- PMC6568012
- OpenAlex
- W2806504012
- Cited by
- 902
- References
- 65
- Citations by year
- 2026: 53 · 2025: 96 · 2024: 133 · 2023: 123 · 2022: 151 · 2021: 132 · 2020: 104 · 2019: 79 · 2018: 30
- FWCI
- 52.93
- Type
- journal article
- Language
- en
- Update notices
- correction (2019-01-08)
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- St George's Online Research Archive (St George's University of London) (acceptedVersion)
- QUT ePrints (Queensland University of Technology) (submittedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Civil War Book Review (submittedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- UTAS Research Repository (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- HAL (submittedVersion, other-oa)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Figshare (submittedVersion)
- Lirias (submittedVersion)
- UTS ePRESS (University of Technology Sydney) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Bristol Research (University of Bristol) (submittedVersion, other-oa)
- Griffith Research Online (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion)
- Apollo
- Funders
- U.S. Department of Defense (C5047/A10692, C1287/A10118, C5047/A7357, W81XWH, C1287/A16563, C8197/A16565, C1281/A12014, C5047/A8384, C12292/A11174, C5047/A15007, CA128978, W81XWH1010341, 223175)
- Cancer Research Institute
- Prostate Cancer Foundation
- Breast Cancer Research Foundation (C5047/A10692, C5047/A15007, C1287/A10118, CA128978, 209057, C1287/A16563, W81XWH-10-1-0341, C8197/A16565, C5047/A8384, C1281/A12014, 396414, C12292/A11174, HEALTH-F2-2009-223175)
- Ovarian Cancer Research Fund (W81XWH-10-1-0341, C1281/A12014, C1287/A10118, C8197/A16565, C12292/A11174, CA128978, C5047/A10692, C5047/A15007, C1287/A16563, C5047/A8384, HEALTH-F2-2009-223175)
- University of Southern California (C1281/A12014, C5047/A10692, C8197/A16565, C1287/A10118, C12292/A11174, C5047/A8384, W81XWH-10-1-0341, C5047/A15007, CA128978, C1287/A16563, HEALTH-F2-2009-223175)
- Aarhus Universitet
- Aarhus Universitetshospital
- Case Western Reserve University
- Harvard T.H. Chan School of Public Health
- Institut for Klinisk Medicin, Aarhus Universitet
- National Cancer Research Institute
- Royal Marsden NHS Foundation Trust
- Australian Prostate Cancer Research
- Cancer Research UK (C8197/A16565’, 223175, C1281/A12014, 10119, C5047/A7357, C5047/A15007’, C1287‐A10118, 12014, HEALTHF2-2009-223175, C5047/A3354, 21332, 16561, 16565, C12292/A11174, ‘C5047/A10692, 15007, C1287, C5047/A8384, 10118, 14136, 16563, 18504, 16491, 17528, C16913-A6135, CA128978, A16563, 19169, C1287-A10710, W81XWH-10-1-0341, C1287‐A16563, C1281)
- National Institute for Health and Care Research (C5047/A15007, W81XWH-10-1-0341, NF-SI-0510-10096, C8197/A16565, HEALTH-F2-2009-223175, NF-SI-0509-10242, CA128978, C1287/A10118, C1281/A12014, NF-SI-0512-10114, C5047/A10692, NF-SI-0513-10121, C1287/A16563, C12292/A11174, C5047/A8384)
- University of Cambridge
- University of Warwick
- University College London
- University of Oxford
- European Commission (C1287/A10118, W81XWH-10-1-0341, C1281/A12014, C1287/A16563, C5047/A10692, C5047/A8384, C12292/A11174, C5047/A15007, C8197/A16565, CA128978, 223175)
- University of Bristol
- Prostate Cancer Foundation of Australia
- Monash University
- Griffith University
- Queensland University of Technology
- Cambridge University Hospitals
- Karolinska Institutet (W81XWH-10-1-0341, C1281/A12014, C1287/A10118, HEALTH-F2-2009-223175, C1287/A16563, CA128978, C5047/A8384, C5047/A10692, C12292/A11174, C8197/A16565, C5047/A15007)
- Peter MacCallum Cancer Centre
- Tampereen Yliopisto
- Turun Yliopisto
- Uppsala Universitet
- Tays
- Turun Yliopistollinen Keskussairaala
- National Institutes of Health (C1281/A12014, 223175, W81XWH-10-1-0341, C8197/A16565, C5047/A7357, C12292/A11174, C1287/A16563, W81XWH, C1287/A10118, HHSN268201200008I, C5047/A10692, HEALTH-F2-2009-223175, C5047/A15007, C5047/A8384, X01HG007492)
- Canadian Institutes of Health Research (C5047/A8384, C5047/A15007, C5047/A10692, C1287/A10118, C1287/A16563, CA128978, C8197/A16565, C1281/A12014, C12292/A11174, W81XWH-10-1-0341, HEALTH-F2-2009-223175, 223175)
- Medical Research Council (C12292/A11174, C1281/A12014, CA128978, C5047/A8384, HEALTH-F2-2009-223175, C8197/A16565, W81XWH-10-1-0341, C1287/A16563, C5047/A10692, MR/N003284/1, C1287/A10118, C5047/A15007)
- National Health and Medical Research Council (623204, 504702, 126402, 614296, 251533, 504700, 504715)
- Cancer Council Victoria (C1287/A16563, C1287/A10118, C8197/A16565, HEALTH-F2-2009-223175, C1281/A12014, C5047/A15007, C12292/A11174, W81XWH-10-1-0341, CA128978, C5047/A10692, C5047/A8384)
- Cancer Council Queensland
- Warwick Medical School
- Servicio Gallego de Salud
- Monash Biomedicine Discovery Institute, Monash University
- National Heart, Lung, and Blood Institute (HHSN268201200008I, HHSN268201200008C)
- National Cancer Institute (R01CA128978, U01CA188392, C5047/A15007, C5047/A10692, C5047/A8384, U19CA148065, HEALTH-F2-2009-223175, W81XWH-10-1-0341, UM1CA182883, UG1CA189974, U01CA098710, U19CA148537, K05CA175147, CA148065, U01CA098216, C1281/A12014, C12292/A11174, U01CA098758, U19CA148112, (CA128978, C1287/A16563, K07CA187546, C1287/A10118, C8197/A16565, U01CA098233, U10CA037429)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- DOD Prostate Cancer Research Program
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Diagnosis and Treatment
- Keywords
- prostate cancer, cancer susceptibility loci, genetic association, early-onset prostate cancer, polygenic risk score, ATM, p27, European ancestry, risk prediction, fine mapping
- MeSH terms
- Genotype, Humans, Male, Prostatic Neoplasms, Risk, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Genetic Loci
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
