Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

Moffitt, Richard A, Marayati, Raoud, Flate, Elizabeth L, Volmar, Keith E, Loeza, S Gabriela Herrera, Hoadley, Katherine A, Rashid, Naim U, Williams, Lindsay A +10 more·2015·Nature Genetics

DOI 10.1038/ng.3398

Cited by (1,002)

Items 701–800 of 1,002

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Dietrich Alexander Ruess, Claudia Kayser, Jakob Neubauer, Stefan Fichtner‐Feigl, Ulrich Theodor Hopt, Uwe A. Wittel · 2017 · Pancreas
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Kai Chen, Yongsu Ma, Xinxin Liu, Xiejian Zhong, Long Di, Xiaodong Tian, Lei Zheng, Yinmo Yang · 2023 · Cancer Letters
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James D. Byrne, Mohammad Raheel Jajja, Allison N. Schorzman, Amanda W. Keeler, J. Christopher Luft, William C. Zamboni, Joseph M. DeSimone, Jen Jen Yeh · 2016 · Proceedings of the National Academy of Sciences
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Lin Wang, Qiaomei Guo, Wenjun Yu, Lihua Qiao, Mingna Zhao, Chenzi Zhang, Xiaomeng Hu, Guohua Yang, Liwen Xiong, Jiatao Lou · 2017 · Lung Cancer
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Hassan A. Ali, Joanna M. Karasinska, James Thomas Topham, Danisha Johal, Steve E. Kalloger, Andrew Metcalfe, Cassia Warren, A. Miyagi, Lan Valerie Tao, Maya Kevorkova et al. · 2024 · Cancer & Metabolism
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Nelson Dusetti, Jean‐Baptiste Bachet, Brice Chanez, Cindy Neuzillet, Louis de Mestier, Nicolas Williet, Nicolas Frauhoffer, Rémy Nicolle, Alice Boilève, Anthony Turpin et al. · 2025 · Cancer Treatment Reviews
Advances in the Genetics and Biology of Pancreatic Cancer
Andrew J. Aguirre, Eric Andrew Collisson · 2017 · The Cancer Journal
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Tao Wei, Jian Zhang, Jin Li, Qi Chen, Xiao Zhi, Tao Wei, Jingjiao Ma, Jiaqi Yang, Yu Lou, Tao Ma et al. · 2020 · Molecular Oncology
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Luis F. Flores, Brooke R Tader, Ezequiel J. Tolosa, Ashley N. Sigafoos, David L. Marks, Martín E. Fernández-Zapico · 2021 · Cells
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Yifan Zhang, Qing Li, Pei-Qi Huang, Tong Su, Shu-Heng Jiang, Li-Peng Hu, Xueli Zhang, Yue Sun, Hong Pan, Xiao-Mei Yang et al. · 2022 · Oncogene
Predictive value of collagen in cancer
Peggi M. Angel, Stephen C. Zambrzycki · 2022 · Advances in cancer research
Post‐operative mortality and recurrence patterns in pancreatic cancer according to <i>KRAS</i> mutation and <scp>CDKN2A</scp> , p53, and <scp>SMAD4</scp> expression
Masugi, Yohei, Takamatsu, Manabu, Tanaka, Mariko, Hara, Kensuke, Inoue, Yosuke, Hamada, Tsuyoshi, Suzuki, Tatsunori, Arita, Junichi, Hirose, Yuki, Kawaguchi, Yoshikuni et al. · 2023 · The Journal of Pathology: Clinical Research
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Nicky A. Beelen, Merel R. Aberle, Virginia Bruno, Steven W.M. Olde Damink, Gerard M.J. Bos, Sander S. Rensen, Lotte Wieten · 2023 · Frontiers in Immunology
Detecting circulating tumor material and digital pathology imaging during pancreatic cancer progression
Radim Moravec, Rao L. Divi, Mukesh Verma · 2017 · World Journal of Gastrointestinal Oncology
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Neha Chopra, Sangeeta Choudhury, Seema Bhargava, Saima Wajid, Nirmal Kumar Ganguly · 2019 · Pancreatology
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Raju Kandimalla, Tadanobu Shimura, Saurav Mallik, Fuminori Sonohara, Susan Tsai, Douglas B. Evans, Song Cheol Kim, Hideo Baba, Yasuhiro Kodera, Daniel D. Von Hoff et al. · 2020 · Annals of Surgery
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Rong Liu, Ya-Zhou Liao, Wei Zhang, Hong‐Hao Zhou · 2021 · Frontiers in Oncology
The transcriptional hallmarks of intra-tumor heterogeneity across a thousand tumors
Avishai Gavish, Michael P. H. Tyler, Dor Simkin, Daniel Kovarsky, L. Nicolas Gonzalez Castro, Debdatta Halder, Rony Chanoch-Myers, Julie Laffy, Michael Mints, Alissa Greenwald et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
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Ming Li, Sebastian R. Freeman, Janusz Franco‐Barraza, Kathy Qi Cai, Amy Kim, Sha Jin, Edna Cukierman, Kaiming Ye · 2024 · Biomaterials
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Zheng-Yan Kan, Ji Wen, V. Bonato, Jennifer Webster, Wen-Jing Yang, Vladimir Ivanov, K. Kim, W. Roh, Chaoting Liu, X. J. Mu et al. · 2025 · Nature Communications
Molecular landscape and sub-classification of gastrointestinal cancers: a review of literature.
B. Fakhri, K. Lim · 2017 · Journal of Gastrointestinal Oncology
Cancer‐associated fibroblasts show heterogeneous gene expression and induce vascular endothelial growth factor A (VEGFA) in response to environmental stimuli
Ken-ichi Inoue, Satoko Kishimoto, Kazumi Akimoto, Masashi Sakuma, Shigeru Toyoda, Teruo Inoue, Ken‐Ichiro Yoshida, Mitsugi Shimoda, Shuji Suzuki · 2019 · Annals of Gastroenterological Surgery
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So Mee Kwon, Young‐Kyoung Lee, Seongki Min, Hyun Goo Woo, Hee-Jung Wang, Gyesoon Yoon · 2020 · iScience
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Katharina Lankes, Zonera Hassan, Josefina Doffo, Christian Schneeweis, Svenja Lier, Rupert Öllinger, Roland Rad, Oliver Holger Krämer, Ulrich Bernd Keller, Dieter Saur et al. · 2020 · Molecular Oncology
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Swati Venkat, Abdulrahman A. Alahmari, Michael E. Feigin · 2021 · Trends in cancer
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Wiebke Lückstädt, S. Bub, T. Koudelka, E. Pavlenko, Florian Peters, P. Somasundaram, Christoph Becker-Pauly, R. Lucius, Friederike Zunke, P. Arnold · 2021 · Frontiers in Cell and Developmental Biology
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Hans Martin Singh, Mathias Felix Leber, Sascha Bossow, Christine E. Engeland, Jan Dessila, Christian Grossardt, Karim Zaoui, John Cameron Bell, Dirk Jäger, Christof V. Kalle et al. · 2021 · Molecular Therapy — Oncolytics
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Christopher M. Thompson, Andrew C. Cannon, Sean C. West, Dario Ghersi, Pranita Atri, Rakesh Bhatia, Lynette M. Smith, Satyayanarayana Rachagani, Christopher Wichman, Sushil Kumar et al. · 2021 · Clinical Cancer Research
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Hafiza Padinharayil, Vikrant Rai, Alex George · 2023 · Cancers
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Yuanzhuo Gu, Zhengkui Zhang, Marcel G M Camps, FERRY A. OSSENDORP, Ruud H. M. Wijdeven, Peter ten Dijke · 2023 · Science Advances
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Yanfen Zheng, Xingyang Li, Shuang Deng, Hongzhe Zhao, Ying Ye, Shaoping Zhang, Xudong Huang, Ruihong Bai, Lisha Zhuang, Quanbo Zhou et al. · 2023 · Nature Communications
Dendrimers as drug delivery systems for oncotherapy: Current status of promising applications
Sophia Sueyoshi, João Vitor Silva, Felipe Guizze, Jeanine Giarolla · 2024 · International Journal of Pharmaceutics
Impact of SPARC expression on outcome in patients with advanced pancreatic cancer not receiving nab-paclitaxel: a pooled analysis from prospective clinical and translational trials
Steffen Ormanns, Michael Haas, Sibylle Baechmann, A. Altendorf-Hofmann, Anna Remold, Detlef Quietzsch, Michael Clemens, Martin Bentz, Michael Geißler, Helmut Lambertz et al. · 2016 · British Journal of Cancer
Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development
Enrique Rozengurt, Guido Eibl · 2019 · World Journal of Gastroenterology
Modeling Between-Study Heterogeneity for Improved Replicability in Gene Signature Selection and Clinical Prediction
Naim U. Rashid, Quefeng Li, Jen Jen Yeh, Joseph G. Ibrahim · 2019 · Journal of the American Statistical Association
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Koichiro Kumano, Hiromitsu Nakahashi, Pakavarin Louphrasitthiphol, Yukihito Kuroda, Yoshihiro Miyazaki, Osamu Shimomura, Shinji Hashimoto, Yoshimasa Akashi, Bryan James Mathis, Jaejeong Kim et al. · 2024 · Frontiers in Cell and Developmental Biology
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Wen-Chao Xu, Jia Xu, Jian-Zhou Liu, Nanzhou Wang, Li Zhou, Jun-Chao Guo · 2025 · MedComm
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Xianfeng Hui, Xiaowei Tian, Shihuan Ding, Aiping Sun, Tiesuo Zhao, Hui Wang · 2025 · Frontiers in Immunology
Landscape of transcriptomic interactions between breast cancer and its microenvironment
Natalie S. Fox, Syed Aleem Haider, Adrian Llewellyn Harris, Paul Christopher Boutros · 2019 · Nature Communications
Unsupervised Hierarchical Clustering of Pancreatic Adenocarcinoma Dataset from TCGA Defines a Mucin Expression Profile that Impacts Overall Survival
Nicolas Jonckheere, Julie Auwercx, Elsa Hadj Bachir, Lucie Coppin, Nihad Boukrout, Audrey Vincent, Bernadette P. NEVE, Mathieu Gautier, Víctor Treviño, Isabelle VAN SEUNINGEN · 2020 · Cancers
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Jérôme Raffenne, Fernando Ariel Martin, Rémy Nicolle, Marina Konta, Yuna Blum, Jérôme Torrisani, Francesco Puleo, Jean‐Baptiste Bachet, Magali Svrcek, Armelle Bardier–Dupas et al. · 2021 · Cancers
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Wenjing Song, Xin He, Pengju Gong, Yan T. Yang, Sirui Huang, Yifan Zeng, Lei Wei, Jingwei Zhang · 2021 · Frontiers in Genetics
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Ujjwal Mukund Mahajan, Ahmed Alnatsha, Qi Li, Bettina Oehrle, Frank Ulrich Weiß, Matthias Sendler, Marius Distler, Waldemar H. Uhl, Tim Fahlbusch, Elisabetta Goni et al. · 2021 · Cells
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Stephan B. Dreyer, Sarah Rae, Kirsty Bisset, Rosanna Upstill‐Goddard, Georgios Gemenetzis, Amber L. Johns, Australian Pancreatic Cancer Genome Initiative, Euan J. Dickson, Anubhav Mittal, Anthony James Gill et al. · 2021 · Annals of Surgery
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Rüdiger Braun, Monika Klinkhammer‐Schalke, Sylke Ruth Zeißig, K. Kleihues van Tol, Louisa Bolm, Kim C. Honselmann, Ekaterina Petrova, Hryhoriy V. Lapshyn, Steffen Deichmann, Thaer S. A. Abdalla et al. · 2022 · Cancers
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Raphaël Rapetti‐Mauss, Jérémy Nigri, Camille Berenguier, Pascal Finetti, Sarah-Simha Tubiana, Bonnie Labrum, Benoit Allegrini, Bernard Pellissier, Georgios Efthymiou, Zainab Hussain et al. · 2022 · Gut
Scalable, compressed phenotypic screening using pooled perturbations
Nuo Liu, Walaa E. Kattan, Benjamin E. Mead, Conner Kummerlowe, Thomas Cheng, Sarah Ingabire, Jaime H. Cheah, Christian K. Soule, Anita Vrcic, Jane K. McIninch et al. · 2024 · Nature Biotechnology
Histological variants of pancreatic ductal adenocarcinoma: a survival analysis
Axel Bengtsson, Roland E. Andersson, Daniel Ansari · 2024 · Langenbeck s Archives of Surgery
Alpha-1-acid glycoprotein 1 is upregulated in pancreatic ductal adenocarcinoma and confers a poor prognosis
Qimin Zhou, Roland E. Andersson, Dingyuan Hu, Monika Posaric Bauden, Agata Sasor, Thomas Bygott, Krzysztof Pawłowski, Indira Plá, György Marko‐Varga, Daniel Ansari · 2019 · Translational research
The impact of metastatic sites in advanced pancreatic adenocarcinoma, systematic review and meta-analysis of prospective randomized studies
Pedro Luiz Serrano Usón, Fernanda Davila Sampaio Tolentino, Vanessa Montes Santos, Edna Terezinha Rother, Fernando Cotait Maluf · 2020 · PLoS ONE
Immune profiling and immunotherapeutic targets in pancreatic cancer
Felicia L. Lenzo, Shumei Kato, Sarabjot Pabla, Paul DePietro, Mary Nesline, Jeffrey M. Conroy, Blake Burgher, Sean T. Glenn, Boris W. Kuvshinoff, Razelle Kurzrock et al. · 2021 · Annals of Translational Medicine
Immunotherapy for pancreatic cancer: chasing the light at the end of the tunnel
Thomas P. Brouwer, Alexander L. Vahrmeijer, Noel F.C.C. de Miranda · 2021 · Cellular Oncology
Developmental and MAPK-responsive transcription factors drive distinct malignant subtypes and genetic dependencies in pancreatic cancer
Pasquale Laise, Mikko M. Turunen, Alvaro Curiel Garcia, Lorenzo Tomassoni, H. Carlo Maurer, Ela Elyada, Bernhard Schmierer, Jeremy Worley, Jordan S. Kesner, Xiangtian Tan et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
Phenotypic heterogeneity and tumor immune microenvironment directed therapeutic strategies in pancreatic ductal adenocarcinoma
Remya P. G. Ramesh, Hadida Yasmin, Pretty Ponnachan, Basel K. al-Ramadi, Uday Kishore, Ann Mary Joseph · 2025 · Frontiers in Immunology
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Kamila Krupa, Marta Magdalena Fudalej, Emilia Włoszek, Hanna Miski, Anna Maria Badowska-Kozakiewicz, Dominika Mękal, Michał Piotr Budzik, Aleksandra Izabela Czerw, Andrzej Deptała · 2025 · Cancers
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Lennart Versemann, Elisabeth Heßmann, Maria Ulisse · 2021 · Visceral Medicine
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Gehan Botrus, Pedro Luiz Serrano Usón, Puneet Raman, Adrienne E. Kaufman, Heidi Kosiorek, Jun Yin, Yu Fu, Umair Majeed, Mohamad Bassam Sonbol, Daniel H. Ahn et al. · 2022 · Frontiers in Oncology
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Catherine Davidson, David Taggart, Andrew H. Sims, David W. Lonergan, Marta Canel, Alan Serrels · 2022 · British Journal of Cancer
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Zhaoqi Shu, Minghe Fan, Bo Tu, Zhiheng Tang, Haojie Wang, Haimeng Li, Hengchao Li, Meng Yuan, Jingru Bai, Sihan Huo et al. · 2023 · Nature Communications
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Abdulrahman A. Alahmari, Aditi H. Chaubey, Venkata Soumith Jonnakuti, Arwen A. Tisdale, Carla D. Schwarz, Abigail C. Cornwell, Kathryn E. Maraszek, Emily J. Paterson, Minsuh Kim, Swati Venkat et al. · 2024 · RNA