Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

Moffitt, Richard A, Marayati, Raoud, Flate, Elizabeth L, Volmar, Keith E, Loeza, S Gabriela Herrera, Hoadley, Katherine A, Rashid, Naim U, Williams, Lindsay A +10 more·2015·Nature Genetics

Cited by (1,002)

Items 101–200 of 1,002

  1. Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis
    Cassandra Burdziak, Direna Alonso‐Curbelo, Thomas Walle, José Santos Reyes, Francisco M. Barriga, Doron Haviv, Yubin Xie, Zhen Zhao, Chujun Julia Zhao, Hsuan-An Chen et al. · 2023 · Science
  2. Altered Gene Expression along the Glycolysis–Cholesterol Synthesis Axis Is Associated with Outcome in Pancreatic Cancer
    Joanna M. Karasinska, James Thomas Topham, Steve E. Kalloger, Gun Ho Jang, Robert Edward Denroche, Luka Culibrk, Laura M. Williamson, Hui‐Li Wong, Michael K.C. Lee, Grainne Mary O'Kane et al. · 2019 · Clinical Cancer Research
  3. The pancreatic cancer genome revisited
    Hayashi, Akimasa, Hong, Jungeui, Iacobuzio-Donahue, Christine A. · 2021 · Nature Reviews Gastroenterology & Hepatology
  4. DNA damage repair as a target in pancreatic cancer: state-of-the-art and future perspectives
    Lukas Perkhofer, Johann Gout, Élodie Roger, Fernando Kude de Almeida, Carolina Simões, Lisa Wiesmüller, Thomas Theodor Werner Seufferlein, Alexander Kleger · 2020 · Gut
  5. Cell-type deconvolution in epigenome-wide association studies: a review and recommendations
    Andrew Erich Teschendorff, Shijie Zheng · 2017 · Epigenomics
  6. Context-Specific Determinants of the Immunosuppressive Tumor Microenvironment in Pancreatic Cancer
    Chiara Falcomatà, Stefanie Bärthel, Günter Schneider, Roland Rad, Marc Schmidt‐Supprian, Dieter Saur · 2023 · Cancer Discovery
  7. TGF-β Signaling in Liver, Pancreas, and Gastrointestinal Diseases and Cancer
    Nancy R. Gough, Xiyan Xiang, Lopa Mishra · 2021 · Gastroenterology
  8. Single cell transcriptomic analyses implicate an immunosuppressive tumor microenvironment in pancreatic cancer liver metastasis
    Shu Zhang, Wen Fang, Siqi Zhou, Dongming Zhu, Ruidong Chen, Xin Gao, Zhuojin Li, Yao Shi Fu, Yixuan Zhang, Fa Yang et al. · 2023 · Nature Communications
  9. Cell plasticity in epithelial homeostasis and tumorigenesis
    Júlia Varga, Florian R. Greten · 2017 · Nature Cell Biology
  10. A unifying paradigm for transcriptional heterogeneity and squamous features in pancreatic ductal adenocarcinoma
    Akimasa Hayashi, Jun Fan, Ruoyao Chen, Yu-Jui Ho, Alvin P. Makohon-Moore, Nicolas Lecomte, Yi Zhong, Jungeui Hong, Jinlong Huang, Hitomi Sakamoto et al. · 2020 · Nature Cancer
  11. Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer
    Linara Gabitova-Cornell, Aizhan Surumbayeva, Suraj Peri, Janusz Franco‐Barraza, Diana Restifo, Nicole Weitz, Charline Ogier, Aaron R. Goldman, Tiffiney R. Hartman, Ralph Francescone et al. · 2020 · Cancer Cell
  12. Prognostic relevance of molecular subtypes and master regulators in pancreatic ductal adenocarcinoma
    Rekin’s Janky, María Mercedes Binda, Joke Allemeersch, Anke Van den broeck, Olivier Govaere, Johannes V. Swinnen, Tania Roskams, Stein Aerts, Baki Topal · 2016 · BMC Cancer
  13. Multi-omics profiling of younger Asian breast cancers reveals distinctive molecular signatures
    Zhengyan Kan, Ying Ding, Jin-Ho Kim, Hae Hyun Jung, Woosung Chung, Samir Lal, Soonweng Cho, Julio Fernandez-Banet, Se Kyung Lee, Seok Won Kim et al. · 2018 · Nature Communications
  14. Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts
    Rémy Nicolle, Yuna Blum, Laëtitia Marisa, Céline Loncle, Odile Gayet, Vincent Moutardier, Olivıer Turrini, Marc F. Giovannini, Benjamin Bian, Martin Bigonnet et al. · 2017 · Cell Reports
  15. The Immune Subtypes and Landscape of Squamous Cell Carcinoma
    Bailiang Li, Yi Cui, Dhanya K. Nambiar, John B. Sunwoo, Ruijiang Li · 2019 · Clinical Cancer Research
  16. Pancreatic cancer treatment: better, but a long way to go
    Robert J. Torphy, Yuki Fujiwara, Richard David Schulick · 2020 · Surgery Today
  17. Extracellular Matrices and Cancer-Associated Fibroblasts: Targets for Cancer Diagnosis and Therapy?
    Ismahane Belhabib, Sonia Zaghdoudi, Claire Lac, Corinne Bousquet, Christine Jean · 2021 · Cancers
  18. Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor
    Kevin D. Freeman‐Cook, Robert L. Hoffman, Nichol L. G. Miller, Jonathan Almaden, John Chionis, Qin Zhang, Koleen J. Eisele, Chaoting Liu, Cathy Zhang, Nanni H. Huser et al. · 2021 · Cancer Cell
  19. Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production in pancreatic cancer
    Marybeth Anderson, Raoud Marayati, Richard A. Moffitt, Jen Jen Yeh · 2016 · Oncotarget
  20. The impact of cancer-associated fibroblasts on major hallmarks of pancreatic cancer
    Qiqing Sun, Bo Zhang, Qiangsheng Hu, Yi Qin, Wenyan Xu, Wensheng Liu, Xianjun Yu, Jin Xu · 2018 · Theranostics
  21. Pathology of pancreatic cancer
    Lena Häberle, Iréne Esposito · 2019 · Translational Gastroenterology and Hepatology
  22. KRAS drives immune evasion in a genetic model of pancreatic cancer
    Irene Ischenko, Stephen D’Amico, Manisha Rao, Jinyu Li, Michael J. Hayman, Scott Powers, Oleksi Petrenko, Nancy C. Reich · 2021 · Nature Communications
  23. Immune Cell and Stromal Signature Associated With Progression-Free Survival of Patients With Resected Pancreatic Ductal Adenocarcinoma
    Ujjwal Mukund Mahajan, E Langhoff, Elisabetta Goni, Eithne Costello, William Greenhalf, Christopher Michael Halloran, Steffen Ormanns, Stephan Krüger, Stefan Hubert Boeck, Silvia Ribback et al. · 2018 · Gastroenterology
  24. Stratification of Pancreatic Ductal Adenocarcinoma: Combinatorial Genetic, Stromal, and Immunologic Markers
    Erik S. Knudsen, Paris J. Vail, Uthra Balaji, Hoai Ngo, Ihab W. Botros, Vladimir Makarov, Nadeem Riaz, Vinod P. Balachandran, Steven D. Leach, Debrah M. Thompson et al. · 2017 · Clinical Cancer Research
  25. Survival of pancreatic cancer cells lacking KRAS function
    Muzumdar, Mandar Deepak, Chen, Pan-Yu, Dorans, Kimberly Judith, Chung, Katherine Minjee, Bhutkar, Arjun, Hong, Erin, Noll, Elisa M., Sprick, Martin R., Trumpp, Andreas, Jacks, Tyler · 2017 · Nature Communications
  26. Molecular subtyping of colorectal cancer: Recent progress, new challenges and emerging opportunities
    Wei Wang, Raju Kandimalla, Hao Huang, Lina Zhu, Ying Li, Feng Gao, Ajay Goel, Xin Wang · 2018 · Seminars in Cancer Biology
  27. Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer
    Recouvreux, Maria Victoria, Moldenhauer, Matthew R., Galenkamp, Koen M.O., Jung, Michael, James, Brian, Zhang, Yijuan, Lowy, Andrew, Bagchi, Anindya, Commisso, Cosimo · 2020 · Journal of Experimental Medicine
  28. Chemotherapy induces dynamic immune responses in breast cancers that impact treatment outcome
    Yeon Hee Park, Samir Lal, Jeong Eon Lee, Yoon‐La Choi, Ji Wen, Sripad Ram, Ying Ding, Soo Hyun Lee, Eric L. Powell, Se Kyung Lee et al. · 2020 · Nature Communications
  29. Tumor microbiome links cellular programs and immunity in pancreatic cancer
    Ghaddar, Bassel, Biswas, Antara, Harris, Chris, Omary, M. Bishr, Carpizo, Darren R., Blaser, Martin J., De, Subhajyoti · 2022 · Cancer Cell
  30. Immune Checkpoint Inhibition for Pancreatic Ductal Adenocarcinoma: Current Limitations and Future Options
    Derya Kabacaoğlu, Katrin J. Ciecielski, Dietrich Alexander Ruess, Hana Algül · 2018 · Frontiers in Immunology
  31. Arginase 1 is a key driver of immune suppression in pancreatic cancer
    Rosa Elena Menjivar, Zeribe C. Nwosu, Wenting Du, Katelyn L. Donahue, Hanna S. Hong, Carlos E. Espinoza, Kristee L. Brown, Ashley Velez-Delgado, Wei Yan, Fatima Lima et al. · 2023 · eLife
  32. Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors
    Magdolna Djurec, Osvaldo Graña‐Castro, Albert Lee, Kevin Troulé, Elisa Espinet, Lavinia Cabras, Carolina Navas, María Teresa Blasco, Laura Martín-Díaz, Miranda Burdiel et al. · 2018 · Proceedings of the National Academy of Sciences
  33. Detection of early stage pancreatic cancer using 5-hydroxymethylcytosine signatures in circulating cell free DNA
    Gulfem Dilek Guler, Yuhong Ning, Chin‐Jen Ku, Tierney C. Phillips, Erin McCarthy, Christopher K. Ellison, Anna Bergamaschi, François Collin, Paul Lloyd, Aaron Scott et al. · 2020 · Nature Communications
  34. NF-κB regulates GDF-15 to suppress macrophage surveillance during early tumor development
    Nivedita M. Ratnam, Jennifer M. Peterson, Erin E. Talbert, Katherine J. Ladner, Priyani V. Rajasekera, Carl Richard Schmidt, Mary E. Dillhoff, Benjamin J. Swanson, Ericka N. Haverick, Raleigh D. Kladney et al. · 2017 · Journal of Clinical Investigation
  35. Review of applications of high-throughput sequencing in personalized medicine: barriers and facilitators of future progress in research and clinical application
    Lightbody, Gaye, Haberland, Valeriia, Browne, Fiona, Taggart, Laura, Zheng, Huiru, Parkes, Eileen, Blayney, Jaine K · 2019 · Briefings in Bioinformatics
  36. EGFR-Pak signaling selectively regulates glutamine deprivation-induced macropinocytosis
    Lee, Szu-Wei, Zhang, Yijuan, Jung, Michael, Cruz, Nathalia, Alas, Basheer, Commisso, Cosimo · 2019 · Developmental Cell
  37. An Empirical Approach Leveraging Tumorgrafts to Dissect the Tumor Microenvironment in Renal Cell Carcinoma Identifies Missing Link to Prognostic Inflammatory Factors
    Tao Wang, Rong Lü, Payal Kapur, Bijay Shankar Jaiswal, Raquibul Hannan, Ze Zhang, Iván Pedrosa, Jason J. Luke, He Zhang, Leonard D. Goldstein et al. · 2018 · Cancer Discovery
  38. FOXA1 upregulation promotes enhancer and transcriptional reprogramming in endocrine-resistant breast cancer
    Xiaoyong Fu, Resel Pereira, Carmine De Angelis, Jamunarani Veeraraghavan, Sarmistha Nanda, Lanfang Qin, Maria Letizia Cataldo, Vidyalakshmi Sethunath, Sepideh Mehravaran, Carolina Gutiérrez et al. · 2019 · Proceedings of the National Academy of Sciences
  39. Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer
    Luisa F. Escobar‐Hoyos, Alex Penson, Ram Kannan, Hana Cho, Chun‐Hao Pan, Rohit Kumar Singh, Lisa Helene Apken, G. Aaron Hobbs, Renhe Luo, Nicolas Lecomte et al. · 2020 · Cancer Cell
  40. Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer
    Stephan B. Dreyer, Rosanna Upstill‐Goddard, Viola Paulus-Hock, Clara Paris, Eirini-Maria Lampraki, Eloise V. Dray, Bryan Serrels, Giuseppina Caligiuri, Selma Rebus, Dennis Plenker et al. · 2020 · Gastroenterology
  41. Pancreatic Cancer Genomes: Implications for Clinical Management and Therapeutic Development
    Stephan B. Dreyer, David Kuang-Fu Chang, Peter J. Bailey, Andrew Victor Biankin · 2017 · Clinical Cancer Research
  42. Patient-specific modeling of stroma-mediated chemoresistance of pancreatic cancer using a three-dimensional organoid-fibroblast co-culture system
    Sebastian Schuth, Solange Le Blanc, Teresa G. Krieger, Julia Jabs, Miriam Schenk, Nathalia A. Giese, Markus Wolfgang Büchler, Roland Eils, Christian Conrad, Oliver Strobel · 2022 · Journal of Experimental & Clinical Cancer Research
  43. Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types
    Katharine Yu, Bin Chen, Dvir Aran, Joseph K. Charalel, Christina S. F. Yau, Denise M. Wolf, Laura van ‘t Veer, Atul Janardhan Butte, Theodore C. Goldstein, Marina Sirota · 2019 · Nature Communications
  44. NRG1 Gene Fusions Are Recurrent, Clinically Actionable Gene Rearrangements in KRAS Wild-Type Pancreatic Ductal Adenocarcinoma
    Martin R. Jones, Laura Williamson, James Thomas Topham, Michael K.C. Lee, Angela Goytain, Julie Ho, Robert Edward Denroche, Gun-Ho Jang, Erin Pleasance, Yaoquing Shen et al. · 2019 · Clinical Cancer Research
  45. New Treatment Strategies for Metastatic Pancreatic Ductal Adenocarcinoma
    Ritu Singh, Eileen Mary O'Reilly · 2020 · Drugs
  46. Cancer associated fibroblast FAK regulates malignant cell metabolism
    Fevzi Demircioglu, Jun Wang, Juliana B. Candido, Ana S.H. Costa, Pedro Casado, Beatriz de Luxán‐Delgado, Louise E. Reynolds, Jesús Gómez-Escudero, Emma Newport, Vinothini Rajeeve et al. · 2020 · Nature Communications
  47. Molecular subtyping of cancer: current status and moving toward clinical applications
    Lan Zhao, Victor Ho-Fun Lee, Michael K. Ng, Hong Yan, Maarten F. Bijlsma · 2018 · Briefings in Bioinformatics
  48. Carcinogenesis of Pancreatic Ductal Adenocarcinoma
    Peter Störz, Howard C. Crawford · 2020 · Gastroenterology
  49. Novel microenvironment-based classification of intrahepatic cholangiocarcinoma with therapeutic implications
    Miguel A. Martín-Serrano, Benjamin Kepecs, Miguel Torres‐Martín, Emily R. Bramel, Philipp Konstantin Haber, Elliot Merritt, Alexander Rialdi, Nesteene Joy Param, Miho Maeda, Katherine E. Lindblad et al. · 2022 · Gut
  50. NFκB in Pancreatic Stellate Cells Reduces Infiltration of Tumors by Cytotoxic T Cells and Killing of Cancer Cells, via Up-regulation of CXCL12
    Bharti Garg, Bhuwan Giri, Shrey Modi, Vrishketan Sethi, Iris Castro, Oliver Umland, Yuguang J. Ban, Shweta Lavania, Rajinder Kumar Dawra, Sulagna Banerjee et al. · 2018 · Gastroenterology
  51. The role of hypoxia in pancreatic cancer: a potential therapeutic target?
    Mert Erkan, Metin Kurtoğlu, Jorg H. Kleeff · 2015 · Expert Review of Gastroenterology & Hepatology
  52. Basal‐like and classical cells coexist in pancreatic cancer revealed by single‐cell analysis on biopsy‐derived pancreatic cancer organoids from the classical subtype
    Natalia Anahi Juiz, Abdessamad El Kaoutari, Martin Bigonnet, Odile Gayet, Julie Roques, Rémy Nicolle, Juan Iovanna, Nelson Dusetti · 2020 · The FASEB Journal
  53. Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions
    Eileen S. Carpenter, Ahmed M. Elhossiny, Padma Kadiyala, Jay Li, Jake J. McGue, Brian D. Griffith, Yaqing Zhang, Jacob Edwards, Sarah Nelson, Fatima Lima et al. · 2023 · Cancer Discovery
  54. Cell of origin affects tumour development and phenotype in pancreatic ductal adenocarcinoma
    Lee, Alex Y L, Dubois, Claire L, Sarai, Karnjit, Zarei, Soheila, Schaeffer, David F, Sander, Maike, Kopp, Janel L · 2019 · Gut
  55. Tumor microbiome contributes to an aggressive phenotype in the basal-like subtype of pancreatic cancer
    Wei Guo, Yuchao Zhang, Shiwei Guo, Zi Mei, Huiping Liao, Hang Ying Dong, Kaichun Wu, Haocheng Ye, Yuhang Zhang, Yufei Zhu et al. · 2021 · Communications Biology
  56. A Four-Chemokine Signature Is Associated with a T-cell–Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer
    Romero, Joan M., Grünwald, Barbara, Jang, Gun-Ho, Bavi, Prashant P., Jhaveri, Aaditeya, Masoomian, Mehdi, Fischer, Sandra E., Zhang, Amy, Denroche, Robert E., Lungu, Ilinca M. et al. · 2020 · Clinical Cancer Research
  57. The PDAC extracellular matrix: a review of the ECM protein composition, tumor cell interaction, and therapeutic strategies
    Perez, Vincent M., Kearney, Joseph F., Yeh, Jen Jen · 2021 · Frontiers in Oncology
  58. Generation of an in vitro 3D PDAC stroma rich spheroid model
    Matthew J. Ware, Vazrik Keshishian, Justin J. Law, Jason C. Ho, Carlos A. Favela, Paul C. T. Rees, Billie Smith, Mohammad Sayeeduddin, Rosa F. Hwang, Kimal Rajapakshe et al. · 2016 · Biomaterials
  59. Schwann cells regulate tumor cells and cancer-associated fibroblasts in the pancreatic ductal adenocarcinoma microenvironment
    Meilin Xue, Youwei Zhu, Yongsheng Jiang, Lijie Han, Minmin Shi, Rui Jun Su, Liwen Wang, Cheng Xiong, Chaofu Wang, Ting Wang et al. · 2023 · Nature Communications
  60. circFARP1 enables cancer-associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF/STAT3 axis
    Chonghui Hu, Renpeng Xia, Xiang Zhang, Tingting Li, Yuancheng Ye, Guolin Li, Rihua He, Zhihua Li, Qing Lin, Shangyou Zheng et al. · 2022 · Molecular Cancer
  61. Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix
    Jiang, Honglin, Torphy, Robert J., Steiger, Katja, Hongo, Henry, Ritchie, Alexa J., Kriegsmann, Mark, Horst, David, Umetsu, Sarah E., Joseph, Nancy M., McGregor, Kimberly et al. · 2020 · Journal of Clinical Investigation
  62. Artificial intelligence in early drug discovery enabling precision medicine
    Fabio Boniolo, Emilio Dorigatti, Alexander J. Ohnmacht, Dieter Saur, Benjamin Schubert, Michael P. Menden · 2021 · Expert Opinion on Drug Discovery
  63. Pancreatic Ductal Adenocarcinoma: A Strong Imbalance of Good and Bad Immunological Cops in the Tumor Microenvironment
    Etienne D. Foucher, Clément Ghigo, Salem Chouaı̈b, Jérôme Galon, Juan Iovanna, Daniel Olive · 2018 · Frontiers in Immunology
  64. Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis
    Xu Wang, Li-Peng Hu, Weiting Qin, Qin Yang, Deyu Chen, Qing Li, Kaixia Zhou, Pei-Qi Huang, Chunjie Xu, Jun Li et al. · 2021 · Nature Communications
  65. TIMP1 Triggers Neutrophil Extracellular Trap Formation in Pancreatic Cancer
    Benjamin Schoeps, Celina Eckfeld, Olga Prokopchuk, Jan P. Böttcher, Daniel Häußler, Katja Steiger, İhsan Ekin Demir, Percy Alexander Knolle, Oliver Soehnlein, Dieter E. Jenne et al. · 2021 · Cancer Research
  66. Epigenetic treatment of pancreatic cancer: is there a therapeutic perspective on the horizon?
    Elisabeth Heßmann, Steven A. Johnsen, Jens Thomas Siveke, Volker Ellenrieder · 2016 · Gut
  67. Fibroblasts in Pancreatic Ductal Adenocarcinoma: Biological Mechanisms and Therapeutic Targets
    Martin C. Whittle, Sunil R. Hingorani · 2019 · Gastroenterology
  68. ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity
    Sonia Alcalá, Patricia Sancho, Paola Martinelli, Diego Navarro, Coral Pedrero, Laura Martín-Hijano, Sandra Valle, Julie Earl, Macarena Rodríguez‐Serrano, Laura Ruíz-Cañas et al. · 2020 · Nature Communications
  69. The biological underpinnings of therapeutic resistance in pancreatic cancer
    Gregory Lawrence Beatty, Gregor Werba, Costas Andreas Lyssiotis, Diane M. Simeone · 2021 · Genes & Development
  70. Morphological classification of pancreatic ductal adenocarcinoma that predicts molecular subtypes and correlates with clinical outcome
    Sangeetha N. Kalimuthu, Gavin W. Wilson, Robert C. Grant, Matthew Seto, Grainne Mary O'Kane, Rajkumar Vajpeyi, Faiyaz Notta, Steve Gallinger, Runjan Chetty · 2019 · Gut
  71. DNMT1 as a therapeutic target in pancreatic cancer: mechanisms and clinical implications
    Kah Keng Wong · 2020 · Cellular Oncology
  72. Endoscopic ultrasonography‐guided biopsy using a Franseen needle design: Initial assessment
    Ji Young Bang, Shantel Hébert‐Magee, Muhammad Khalid Hasan, Udayakumar Navaneethan, Robert H. Hawes, Shyam Varadarajulu · 2016 · Digestive Endoscopy
  73. Epithelial to mesenchymal plasticity and differential response to therapies in pancreatic ductal adenocarcinoma
    Porter, Rebecca L., Magnus, Neelima K. C., Thapar, Vishal, Morris, Robert, Szabolcs, Annamaria, Neyaz, Azfar, Kulkarni, Anupriya S., Tai, Eric, Chougule, Abhijit, Hillis, Alessandra et al. · 2019 · Proceedings of the National Academy of Sciences
  74. Spatial transcriptomic analysis of primary and metastatic pancreatic cancers highlights tumor microenvironmental heterogeneity
    Ateeq Muhammed Khaliq, Meenakshi Rajamohan, Omer Abdelaziz Mohammed Saeed, Kimia Mansouri, Asif Adil, Chi Zhang, Anita Ahmed Turk, Julienne L. Carstens, Michael Garrett House, Sikander Hayat et al. · 2024 · Nature Genetics
  75. Surgical and molecular pathology of pancreatic neoplasms
    Wenzel M. Hackeng, Ralph H. Hruban, G. Johan A. Offerhaus, Lodewijk A.A. Brosens · 2016 · Diagnostic Pathology
  76. A COL11A1-correlated pan-cancer gene signature of activated fibroblasts for the prioritization of therapeutic targets
    Dongyu Jia, Zhenqiu Liu, Nan Deng, Tuan Zea Tan, Ruby Yun‐Ju Huang, Barbie Taylor‐Harding, Dong‐Joo Cheon, Kate Lawrenson, Wolf Ruprecht Wiedemeyer, Ann E. Walts et al. · 2016 · Cancer Letters
  77. Molecular subtypes in cancers of the gastrointestinal tract
    Maarten F. Bijlsma, Anguraj Sadanandam, Patrick B. O. Tan, Louis Vermeulen · 2017 · Nature Reviews Gastroenterology & Hepatology
  78. EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance
    Loretah Chibaya, Katherine C. Murphy, Kelly D. DeMarco, Sneha Gopalan, Haibo Liu, Chaitanya Naimesh Parikh, Yvette Lopez-Diaz, Melissa Faulkner, Junhui Li, John P. Morris et al. · 2023 · Nature Cancer
  79. Integrated single-cell and spatial transcriptomics uncover distinct cellular subtypes involved in neural invasion in pancreatic cancer
    Minmin Chen, Qinhang Gao, Huiheng Ning, Kang Chen, Yang Gao, Min Yu, Chaoqun Liu, Wei Zhou, Jieying Pan, Lusheng Wei et al. · 2025 · Cancer Cell
  80. Elucidation of tumor-stromal heterogeneity and the ligand-receptor interactome by single-cell transcriptomics in Real-world pancreatic cancer biopsies
    Lee, Jaewon J., Bernard, Vincent, Semaan, Alexander, Monberg, Maria E., Huang, Jonathan, Stephens, Bret M., Lin, Daniel, Rajapakshe, Kimal I., Weston, Brian R., Bhutani, Manoop S. et al. · 2021 · Clinical Cancer Research
  81. Machete identifies interferon-encompassing chromosome 9p21.3 deletions as mediators of immune evasion and metastasis
    Barriga, Francisco M., Tsanov, Kaloyan M., Ho, Yu-Jui, Sohail, Noor, Zhang, Amy, Baslan, Timour, Wuest, Alexandra N., Del Priore, Isabella, Meškauskaitė, Brigita, Livshits, Geulah et al. · 2022 · Nature Cancer
  82. Recent advances in organoid development and applications in disease modeling
    Sanchita Rauth, Saswati Karmakar, Surinder K. Batra, Moorthy Palanimuthu Ponnusamy · 2021 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  83. Organoid Sensitivity Correlates with Therapeutic Response in Patients with Pancreatic Cancer
    Joseph Elan Grossman, Lakshmi B. Muthuswamy, Ling Huang, Dipikaa Akshinthala, Sofia Perea, Raul S. González, Leo L. Tsai, Jonah Cohen, Bruno Bockorny, Andrea J. Bullock et al. · 2021 · Clinical Cancer Research
  84. Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy
    Teresa G. Krieger, Solange Le Blanc, Julia Jabs, Foo Wei Ten, Naveed Ishaque, Katharina Jechow, Olivia Debnath, Carl-Stephan Leonhardt, Anamika Giri, Roland Eils et al. · 2021 · Nature Communications
  85. Recent insights into the biology of pancreatic cancer
    Wantong Yao, Anirban Maitra, Haoqiang Ying · 2020 · EBioMedicine
  86. Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes
    Koji Miyabayashi, Lindsey A. Baker, Astrid Deschênes, Benno Traub, Giuseppina Caligiuri, Dennis Plenker, Brinda Alagesan, Pascal Belleau, Siran Li, Jude Kendall et al. · 2020 · Cancer Discovery
  87. Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
    Jeffrey A. Klomp, Jennifer E. Klomp, Clint A. Stalnecker, Kirsten L. Bryant, A. Cole Edwards, Kristina Drizyte‐Miller, Priya S. Hibshman, J. Nathaniel Diehl, Ye S. Lee, Alexis Jean Morales et al. · 2024 · Science
  88. Pancreatic Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells
    Elvira Pelosi, Germana Castelli, Ugo Testa · 2017 · Biomedicines
  89. HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer
    Holly Brunton, Giuseppina Caligiuri, Richard Cunningham, Rosanna Upstill‐Goddard, Ulla‐Maja Bailey, Ian Garner, Craig Nourse, Stephan B. Dreyer, Marc D. Jones, Kim Moran‐Jones et al. · 2020 · Cell Reports
  90. Senescent Carcinoma-Associated Fibroblasts Upregulate IL8 to Enhance Prometastatic Phenotypes
    Wang, Tao, Notta, Faiyaz, Navab, Roya, Joseph, Joella, Ibrahimov, Emin, Xu, Jing, Zhu, Chang-Qi, Borgida, Ayelet, Gallinger, Steven, Tsao, Ming-Sound · 2017 · Molecular Cancer Research
  91. Defining the molecular pathology of pancreatic body and tail adenocarcinoma
    Australian Pancreatic Cancer Genome Initiative, Stephan B. Dreyer, Nigel Balfour Jamieson, Rosanna Upstill‐Goddard, Peter J. Bailey, C. J. McKay, Andrew Victor Biankin, David Kuang-Fu Chang · 2018 · British journal of surgery
  92. Glucose Metabolism in Pancreatic Cancer
    Yan Liang, P. Shalem Raj, Wantong Yao, Haoqiang Ying · 2019 · Cancers
  93. Aggressive PDACs Show Hypomethylation of Repetitive Elements and the Execution of an Intrinsic IFN Program Linked to a Ductal Cell of Origin
    Elisa Espinet, Zuguang Gu, Charles David Imbusch, Nathalia A. Giese, Magdalena Büscher, Mariam Safavi, Silke Weisenburger, Corinna Klein, Vanessa Vogel, Mattia Falcone et al. · 2020 · Cancer Discovery
  94. Immune therapies in pancreatic ductal adenocarcinoma: Where are we now?
    Marc Hilmi, Laurent Bartholin, Cindy Neuzillet · 2018 · World Journal of Gastroenterology
  95. Desmoplasia in pancreatic ductal adenocarcinoma: insight into pathological function and therapeutic potential
    Andrew C. Cannon, Christopher M. Thompson, Bradley R. Hall, Maneesh Jain, Sushil Kumar K, Surinder K. Batra · 2018 · Genes & Cancer
  96. The Evolutionary Origins of Recurrent Pancreatic Cancer
    Hitomi Sakamoto, Marc A. Attiyeh, Jeffrey M. Gerold, Alvin P. Makohon-Moore, Akimasa Hayashi, Jungeui Hong, Rajya L. Kappagantula, Lance Zhang, Jerry P. Melchor, Johannes G. Reiter et al. · 2020 · Cancer Discovery
  97. Emerging roles for the IL-6 family of cytokines in pancreatic cancer
    Gemma van Duijneveldt, Michael D. W. Griffin, Tracy L. Putoczki · 2020 · Clinical Science
  98. Cell of origin influences pancreatic cancer subtype
    Flowers, Brittany M., Xu, Hang, Mulligan, Abigail S., Hanson, Kathryn J., Seoane, Jose A., Vogel, Hannes, Curtis, Christina, Wood, Laura D., Attardi, Laura D. · 2021 · Cancer Discovery
  99. Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer
    Toni T. Seppälä, Jacquelyn W. Zimmerman, Elisabetta Sereni, Dennis Plenker, Reecha Suri, Noah Rozich, Alex B. Blair, Dwayne L. Thomas, Jonathan A. Teinor, Ammar A. Javed et al. · 2020 · Annals of Surgery
  100. Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells
    Mahsa Zarei, Shruti Lal, Seth J. Parker, Avinoam Nevler, Ali Vaziri Gohar, Katerina Dukleska, Nicole Caroline Mambelli-Lisboa, Cynthia Moffat, Fernando F. Blanco, Saswati N. Chand et al. · 2017 · Cancer Research