Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

Moffitt, Richard A, Marayati, Raoud, Flate, Elizabeth L, Volmar, Keith E, Loeza, S Gabriela Herrera, Hoadley, Katherine A, Rashid, Naim U, Williams, Lindsay A +10 more·2015·Nature Genetics

Cited by (1,002)

Items 301–400 of 1,002

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  2. Heterocellular gene signatures reveal luminal-A breast cancer heterogeneity and differential therapeutic responses
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  3. Splice variants as novel targets in pancreatic ductal adenocarcinoma
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  4. Different shades of pancreatic ductal adenocarcinoma, different paths towards precision therapeutic applications
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  5. An overview of genetic mutations and epigenetic signatures in the course of pancreatic cancer progression
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  6. Pan-Cancer Analysis of Ligand–Receptor Cross-talk in the Tumor Microenvironment
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  12. Immune response drives outcomes in prostate cancer: implications for immunotherapy
    Jialin Meng, Yujie Zhou, Xiaofan Lu, Zichen Bian, Yiding Chen, Song Fan, Jun Zhou, Li Zhang, 郝宗耀, Meng Zhang et al. · 2020 · Molecular Oncology
  13. Multifunctional Lipid Bilayer Nanocarriers for Cancer Immunotherapy in Heterogeneous Tumor Microenvironments, Combining Immunogenic Cell Death Stimuli with Immune Modulatory Drugs
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  14. The Desmoplastic Stroma of Pancreatic Cancer: Multilayered Levels of Heterogeneity, Clinical Significance, and Therapeutic Opportunities
    Yohei Masugi · 2022 · Cancers
  15. Pacpaint: a histology-based deep learning model uncovers the extensive intratumor molecular heterogeneity of pancreatic adenocarcinoma
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  16. Mapping functional to morphological variation reveals the basis of regional extracellular matrix subversion and nerve invasion in pancreatic cancer
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  17. Comprehensive analysis of the tumor immune micro-environment in non-small cell lung cancer for efficacy of checkpoint inhibitor
    Jeong‐Sun Seo, Ahreum Kim, Jong-Yeon Shin, Young Tae Kim · 2018 · Scientific Reports
  18. YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinoma
    Tu, Bo, Yao, Jun, Ferri-Borgogno, Sammy, Zhao, Jun, Chen, Shujuan, Wang, Qiuyun, Yan, Liang, Zhou, Xin, Zhu, Cihui, Bang, Seungmin et al. · 2019 · JCI Insight
  19. TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis
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  20. Metastasis in Pancreatic Ductal Adenocarcinoma: Current Standing and Methodologies
    Marina Ayres Pereira, Iok In Christine Chio · 2019 · Genes
  21. Transforming Growth Factor-β Blockade in Pancreatic Cancer Enhances Sensitivity to Combination Chemotherapy
    Qiang, Li, Hoffman, Megan T., Ali, Lestat R., Castillo, Jaime I., Kageler, Lauren, Temesgen, Ayantu, Lenehan, Patrick, Wang, S. Jennifer, Bello, Elisa, Cardot-Ruffino, Victoire et al. · 2023 · Gastroenterology
  22. Integrative analysis of spatial and single-cell transcriptome data from human pancreatic cancer reveals an intermediate cancer cell population associated with poor prognosis
    Seongryong Kim, Galam Leem, Junjeong Choi, Yongjun Koh, Suho Lee, Sanghee Nam, Jin Su Kim, Chan Hee Park, Ho Kyoung Hwang, Kyoung Il Min et al. · 2024 · Genome Medicine
  23. Colorectal Cancer Subtypes: Developmental Origin and Microenvironmental Regulation
    Evelyn Fessler, Jan Paul Medema · 2016 · Trends in cancer
  24. Immune Gene Signature Delineates a Subclass of Papillary Thyroid Cancer with Unfavorable Clinical Outcomes
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  25. ATM Dysfunction in Pancreatic Adenocarcinoma and Associated Therapeutic Implications
    Samantha Ann Armstrong, Christopher William Schultz, Ariana Azimi-Sadjadi, Jonathan Robert Brody, Michael Jon Pishvaian · 2019 · Molecular Cancer Therapeutics
  26. Pathology assessment of pancreatic cancer following neoadjuvant treatment: Time to move on
    Caroline Sophie Verbeke, Lena Häberle, Daniela M. Lenggenhager, Iréne Esposito · 2018 · Pancreatology
  27. HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties
    Ethan V. Abel, Masashi Goto, Brian Magnuson, Saji T. Abraham, Nikita Ramanathan, Emily Hotaling, Anthony A. Alaniz, Chandan Kumar‐Sinha, Michele L. Dziubinski, Sumithra Urs et al. · 2018 · eLife
  28. Immunogenomic landscape of hepatocellular carcinoma with immune cell stroma and EBV-positive tumor-infiltrating lymphocytes
    Hyo Jeong Kang, Ji‐Hye Oh, Sung‐Min Chun, Deokhoon Kim, Yeon‐Mi Ryu, Hee Sang Hwang, Sang‐Yeob Kim, Jihyun An, Eun Jeong Cho, Hyeonjin Lee et al. · 2019 · Journal of Hepatology
  29. Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis
    Michael P. H. Tyler, Itay Tirosh · 2021 · Nature Communications
  30. A comprehensive review of pancreatic cancer and its therapeutic challenges
    Shan Jiang, Johan Bourghardt Fagman, Yunyun Ma, Jian Liu, Caroline Vihav, Cecilia Engström, Beidong Liu, Changyan Chen · 2022 · Aging
  31. Morphological heterogeneity in ductal adenocarcinoma of the pancreas – Does it matter?
    Caroline Sophie Verbeke · 2016 · Pancreatology
  32. Comprehensive pancancer genomic analysis reveals (RTK)-RAS-RAF-MEK as a key dysregulated pathway in cancer: Its clinical implications
    Robin John Lester Imperial, Omer M. Toor, Arif Hussain, Janakiraman Subramanian, Ashiq Masood · 2017 · Seminars in Cancer Biology
  33. Alternative polyadenylation drives oncogenic gene expression in pancreatic ductal adenocarcinoma
    Swati Venkat, Arwen A. Tisdale, Johann RE Schwarz, Abdulrahman A. Alahmari, H. Carlo Maurer, Kenneth P. Olive, Kevin Hasegawa Eng, Michael E. Feigin · 2020 · Genome Research
  34. Clinical and genomic characterisation of mismatch repair deficient pancreatic adenocarcinoma
    Robert C. Grant, Robert Edward Denroche, Gun Ho Jang, Klaudia M. Nowak, Amy Xin Wei Zhang, Ayelet Borgida, Spring Holter, James Thomas Topham, Julie M. Wilson, Anna Dodd et al. · 2020 · Gut
  35. Intratumoral injection of TLR9 agonist promotes an immunopermissive microenvironment transition and causes cooperative antitumor activity in combination with anti-PD1 in pancreatic cancer
    Carmine Carbone, Geny Piro, Antonio Agostini, Pietro Delfino, Francesco De Sanctis, Vincenzo Nasca, Francesco Spallotta, Claudio Sette, Maurizio Martini, Stefano Ugel et al. · 2021 · Journal for ImmunoTherapy of Cancer
  36. The Proteomic Landscape of Pancreatic Ductal Adenocarcinoma Liver Metastases Identifies Molecular Subtypes and Associations with Clinical Response
    Henry C.-H. Law, Dragana Lagundžin, Emalie J. Clement, Fangfang Qiao, Zachary S. Wagner, Kimiko L. Krieger, Diane L. Costanzo-Garvey, Thomas C. Caffrey, Jean L. Grem, Dominick J. DiMaio et al. · 2019 · Clinical Cancer Research
  37. Mechanisms of PDAC subtype heterogeneity and therapy response
    Elisa Espinet, Lukas Klein, Ellen Puré, Shiv K. Singh · 2022 · Trends in cancer
  38. Molecular profiling of ctDNA in pancreatic cancer: Opportunities and challenges for clinical application
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  39. High-resolution Hi-C maps highlight multiscale 3D epigenome reprogramming during pancreatic cancer metastasis
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  40. Patient-derived organoids (PDOs) and PDO-derived xenografts (PDOXs): New opportunities in establishing faithful pre-clinical cancer models
    Ergang Wang, Kun Xiang, Yun Zhang, Xiao‐Fan Wang · 2022 · Journal of the National Cancer Center
  41. PanIN and CAF transitions in pancreatic carcinogenesis revealed with spatial data integration
    Alexander T.F. Bell, Jacob T. Mitchell, Ashley L. Kiemen, Melissa R. Lyman, Kohei Fujikura, Jae Woo Lee, Erin M. Coyne, Sarah M. Shin, Sushma Nagaraj, Atul M. Deshpande et al. · 2024 · Cell Systems
  42. Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer
    Loretah Chibaya, Kelly D. DeMarco, Christina F. Lusi, Griffin I. Kane, Meghan L. Brassil, Chaitanya Naimesh Parikh, Katherine C. Murphy, Shreya R. Chowdhury, Junhui Li, Boyang Ma et al. · 2024 · Science Translational Medicine
  43. Immunotherapy and pancreatic cancer: unique challenges and potential opportunities
    Kate Young, Daniel Johnathan Hughes, David Cunningham, Naureen Starling · 2018 · Therapeutic Advances in Medical Oncology
  44. Reshaping preoperative treatment of pancreatic cancer in the era of precision medicine
    Raffaella Casolino, Chiara Braconi, Giuseppe Malleo, Salvatore Paiella, Claudio Bassi, Michèle Milella, Stephan B. Dreyer, Fieke E. M. Froeling, David Kuang-Fu Chang, Andrew Victor Biankin et al. · 2020 · Annals of Oncology
  45. Reprogramming of stromal fibroblasts by SNAI2 contributes to tumor desmoplasia and ovarian cancer progression
    Zongyuan Yang, Xin Yang, Sen Xu, Ping Jin, Xiaoting Li, Wei Xiao, Dan Liu, Kecheng Huang, Sixiang Long, Ya Wang et al. · 2017 · Molecular Cancer
  46. Notch activity characterizes a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features
    Changyu Zhu, Yu-Jui Ho, Marcela A. Salomao, Dianne H. Dapito, Alberto Bartolomé, Robert F. Schwabe, Ju‐Seog Lee, Scott W. Lowe, Utpal B. Pajvani · 2020 · Journal of Hepatology
  47. Precision Oncology in Surgery
    Stephan B. Dreyer, Mark Pinese, Nigel Balfour Jamieson, Christopher James Scarlett, Emily K. Colvin, Marina Pajic, Amber L. Johns, Jeremy L. Humphris, Jianmin Wu, Mark J. Cowley et al. · 2018 · Annals of Surgery
  48. Hypoxia promotes the metastasis of pancreatic cancer through regulating NOX4/KDM5A-mediated histone methylation modification changes in a HIF1A-independent manner
    Hongzhen Li, Chunyan Peng, Chenhui Zhu, Shuang Nie, Xuetian Qian, Zhao Shi, Mengyue Shi, Liang Yan, Xiwei Ding, Shu Zhang et al. · 2021 · Clinical Epigenetics
  49. Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer
    Adam C. Mueller, Miles Piper, Andrew E. Goodspeed, Shiv Bhuvane, Jason S. Williams, Shilpa Bhatia, Andy V. Phan, Benjamin Van Court, Kathryn L. Zolman, Brisa Peña et al. · 2021 · Cancer Research
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  52. MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC
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  53. Improving outcomes of patients with pancreatic cancer
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  54. Molecular Events in the Natural History of Pancreatic Cancer
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  57. Oncogenic enhancers drive esophageal squamous cell carcinogenesis and metastasis
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  58. The roles of intratumour heterogeneity in the biology and treatment of pancreatic ductal adenocarcinoma
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  62. Organoid Models for Cancer Research
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  63. Current perspectives of cancer-associated fibroblast in therapeutic resistance: potential mechanism and future strategy
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  64. Pancreatic Cancer Heterogeneity Can Be Explained Beyond the Genome
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  67. Cancer-Associated Fibroblasts as a Common Orchestrator of Therapy Resistance in Lung and Pancreatic Cancer
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  69. Interplays of glucose metabolism and KRAS mutation in pancreatic ductal adenocarcinoma
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  70. Culture media composition influences patient-derived organoid ability to predict therapeutic responses in gastrointestinal cancers
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  71. An in vivo multiplexed small-molecule screening platform
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  72. Identification and Validation of a Diagnostic and Prognostic Multi-Gene Biomarker Panel for Pancreatic Ductal Adenocarcinoma
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  73. Survival of patients with borderline resectable pancreatic cancer who received neoadjuvant therapy and surgery
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  74. Inflammatory IFIT3 renders chemotherapy resistance by regulating post-translational modification of VDAC2 in pancreatic cancer
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  76. From Machine Learning to Patient Outcomes: A Comprehensive Review of AI in Pancreatic Cancer
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  78. The prognostic significance of cancer-associated fibroblasts in pancreatic ductal adenocarcinoma
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  79. Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma
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  80. Pancreatic cancer chemo-resistance is driven by tumor phenotype rather than tumor genotype
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  81. Microdissected pancreatic cancer proteomes reveal tumor heterogeneity and therapeutic targets
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  82. Liquid biopsies for management of pancreatic cancer
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  85. Liquid biopsy in pancreatic cancer: the beginning of a new era
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  93. Proteomic and genomic profiling of pancreatic cancer
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  97. UEG position paper on pancreatic cancer. Bringing pancreatic cancer to the 21st century: Prevent, detect, and treat the disease earlier and better
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