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Cited by 234

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Population genetic differentiation of height and body mass index across Europe

Open access
Robinson, Matthew R, Hemani, Gibran, Medina-Gomez, Carolina, Mezzavilla, Massimo, Esko, Tonu, Shakhbazov, Konstantin, Powell, Joseph E, Vinkhuyzen, Anna, Berndt, Sonja I, Gustafsson, Stefan, Justice, Anne E, Kahali, Bratati, Locke, Adam E, Pers, Tune H, Vedantam, Sailaja, Wood, Andrew R, van Rheenen, Wouter, Andreassen, Ole A, Gasparini, Paolo, Metspalu, Andres, Berg, Leonard H van den, Veldink, Jan H, Rivadeneira, Fernando, Werge, Thomas M, Abecasis, Goncalo R, Boomsma, Dorret I, Chasman, Daniel I, de Geus, Eco J C, Frayling, Timothy M, Hirschhorn, Joel N, Hottenga, Jouke Jan, Ingelsson, Erik, Loos, Ruth J F, Magnusson, Patrik K E, Martin, Nicholas G, Montgomery, Grant W, North, Kari E, Pedersen, Nancy L, Spector, Timothy D, Speliotes, Elizabeth K, Goddard, Michael E, Yang, Jian, Visscher, Peter M·2015·Nature Genetics
DOI 10.1038/ng.3401
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Abstract

Across-nation differences in the mean values for complex traits are common, but the reasons for these differences are unknown. Here we find that many independent loci contribute to population genetic differences in height and body mass index (BMI) in 9,416 individuals across 14 European countries. Using discovery data on over 250,000 individuals and unbiased effect size estimates from 17,500 sibling pairs, we estimate that 24% (95% credible interval (CI) = 9%, 41%) and 8% (95% CI = 4%, 16%) of the captured additive genetic variance for height and BMI, respectively, reflect population genetic differences. Population genetic divergence differed significantly from that in a null model (height, P < 3.94 × 10−8; BMI, P < 5.95 × 10−4), and we find an among-population genetic correlation for tall and slender individuals (r = −0.80, 95% CI = −0.95, −0.60), consistent with correlated selection for both phenotypes. Observed differences in height among populations reflected the predicted genetic means (r = 0.51; P < 0.001), but environmental differences across Europe masked genetic differentiation for BMI (P < 0.58).

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Metadata

Authors
Robinson, M. R., Hemani, G., Medina-Gomez, C., Mezzavilla, M., Esko, T., Shakhbazov, K., Powell, J. E., Vinkhuyzen, A., Berndt, S. I., Gustafsson, S., Justice, A. E., Kahali, B., Locke, A. E., Pers, T. H., Vedantam, S., Wood, A. R., van Rheenen, W., Andreassen, O. A., Gasparini, P., Metspalu, A., Berg, L. H. V. D., Veldink, J. H., Rivadeneira, F., Werge, T. M., Abecasis, G. R., Boomsma, D. I., Chasman, D. I., de Geus, E. J. C., Frayling, T. M., Hirschhorn, J. N., Hottenga, J. J., Ingelsson, E., Loos, R. J. F., Magnusson, P. K. E., Martin, N. G., Montgomery, G. W., North, K. E., Pedersen, N. L., Spector, T. D., Speliotes, E. K., Goddard, M. E., Yang, J., & Visscher, P. M.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2015-09-14
Volume
47
Issue
11
Pages
1357-1362
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng.3401
OpenAlex
W1868707796
Cited by
234
References
22
FWCI
15.42
Type
journal article
Language
en
Open access
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