A General Test of Association for Quantitative Traits in Nuclear Families

Introduction to Quantitative Genetics.

Edwards, A. W. F., & Falconer, D. S. (1982) · Biometrics · doi:10.2307/2529912 · Cited by 21,447 · see citing works

The Future of Genetic Studies of Complex Human Diseases

Risch, N., & Merikangas, K. (1996) · Science · doi:10.1126/science.273.5281.1516 · Cited by 5,355 · see citing works

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

Spielman, R. S., McGinnis, R. E., & Ewens, W. J. (1993) · PubMed · Cited by 3,679 · see citing works

Wiley Series in Probability and Mathematics Statistics

Huber, P. J. (1981) · Wiley series in probability and statistics · doi:10.1002/0471725250.scard · Cited by 2,257 · see citing works

Variance Components

Searle, S. R., Casella, G., & McCulloch, C. E. (1992) · Wiley Series in Probability and Statistics · doi:10.1002/9780470316856 · Cited by 1,926 · see citing works

The investigation of linkage between a quantitative trait and a marker locus

Haseman, J. K., & Elston, R. C. (1972) · Behavior Genetics · doi:10.1007/bf01066731 · Cited by 1,367 · see citing works

Variations on a Theme: Cataloging Human DNA Sequence Variation

Collins, F. S., Guyer, M. S., & Chakravarti, A. (1997) · Science · doi:10.1126/science.278.5343.1580 · Cited by 1,062 · see citing works

Introduction to Quantitative Genetics

P.B., S. (1963) · Poultry Science · doi:10.3382/ps.0420547 · Cited by 1,052 · see citing works

THE EVOLUTIONARY DYNAMICS OF COMPLEX POLYMORPHISMS,,

Lewontin, R. C., & Kojima, K. (1960) · Evolution · doi:10.1111/j.1558-5646.1960.tb03113.x · Cited by 769 · see citing works

Array of hope

Lander, E. S. (1999) · Nature Genetics · doi:10.1038/4427 · Cited by 556 · see citing works

Extensions to multivariate normal models for pedigree analysis

Hopper, J. L., & Mathews, J. D. (1982) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1982.tb01588.x · Cited by 511 · see citing works

The use of a genetic map of biallelic markers in linkage studies

Kruglyak, L. (1997) · Nature Genetics · doi:10.1038/ng0997-21 · Cited by 497 · see citing works

Combined Linkage and Association Sib-Pair Analysis for Quantitative Traits

Fulker, D. W., Cherny, S. S., Sham, P. C., & Hewitt, J. K. (1999) · The American Journal of Human Genetics · doi:10.1086/302193 · Cited by 443 · see citing works

A Log-Linear Approach to Case-Parent–Triad Data: Assessing Effects of Disease Genes That Act Either Directly or through Maternal Effects and That May Be Subject to Parental Imprinting

Weinberg, C. R., Wilcox, A. J., & Lie, R. T. (1998) · The American Journal of Human Genetics · doi:10.1086/301802 · Cited by 391 · see citing works

A Transmission Disequilibrium Test for Quantitative Trait Loci

Rabinowitz, D. (1997) · Human Heredity · doi:10.1159/000154433 · Cited by 230 · see citing works

Transmission-disequilibrium tests for quantitative traits.

Allison, D. B. (1997) · PubMed · Cited by 217 · see citing works

Tests for Linkage and Association in Nuclear Families

Martin, E. R., Kaplan, N. L., & Weir, B. S. (1997) · The American Journal of Human Genetics · doi:10.1086/514860 · Cited by 215 · see citing works

Use of siblings as controls in case‐control association studies

Curtis, D. (1997) · Annals of Human Genetics · doi:10.1046/j.1469-1809.1998.6210089.x · Cited by 189 · see citing works

A note on the application of the transmission disequilibrium test when a parent is missing.

Curtis, D., & Sham, P. C. (1995) · PubMed · Cited by 182 · see citing works

Transmission/disequilibrium tests for quantitative traits

Sun, F., Flanders, W. D., Yang, Q., & Zhao, H. (2000) · Annals of Human Genetics · doi:10.1046/j.1469-1809.2000.6460555.x · Cited by 172 · see citing works

Assessing genetic linkage and association with robust components of variance approaches

Amos, C. I., Zhu, D., & Boerwinkle, E. (1996) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1996.tb01184.x · Cited by 154 · see citing works

It's raining SNPs, hallelujah?

Chakravarti, A. (1998) · Nature Genetics · doi:10.1038/885 · Cited by 138 · see citing works

Testing the association between polymorphic markers and quantitative traits in pedigrees

George, V. T., Elston, R. C., & Rao, D. C. (1987) · Genetic Epidemiology · doi:10.1002/gepi.1370040304 · Cited by 136 · see citing works

Sibling-Based Tests of Linkage and Association for Quantitative Traits

Allison, D. B., Heo, M., Kaplan, N. L., & Martin, E. R. (1999) · The American Journal of Human Genetics · doi:10.1086/302404 · Cited by 120 · see citing works

Wiley Series in Probability and Mathematical Statistics

Scott, D. W. (1992) · Wiley series in probability and statistics · doi:10.1002/9780470316849.oth1 · Cited by 116 · see citing works

Use of siblings as controls in case-control association studies

Curtis, D. (1997) · Annals of Human Genetics · doi:10.1017/s000348009700626x · Cited by 100 · see citing works

A permutation test for the robust sib-pair linkage method

WAN, Y., Cohen, J. C., & GUERRA, R. (1997) · Annals of Human Genetics · doi:10.1017/s0003480096005957 · Cited by 39 · see citing works

A Sib-Pair Regression Model of Linkage Disequilibrium for Quantitative Traits

Cardon, L. R. (2000) · Human Heredity · doi:10.1159/000022940 · Cited by 21 · see citing works

Finite-Sample Properties of Family-Based Association Tests

Whittaker, J. C., & Thompson, D. J. (1999) · The American Journal of Human Genetics · doi:10.1086/302277 · Cited by 5 · see citing works

Untitled work

(2000) · doi:10.1002/1098-2272(200101)20:1

PLINK: a tool set for whole-genome association and population-based linkage analyses.

Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089 · see citing works

Second-generation PLINK: rising to the challenge of larger and richer datasets

Chang, C. C., Chow, C. C., Tellier, L. C., Vattikuti, S., Purcell, S. M., & Lee, J. J. (2015) · Gigascience · doi:10.1186/s13742-015-0047-8 · Cited by 12,709 · see citing works

Genetics of Food Intake Self-Regulation in Childhood: Literature Review and Research Opportunities

Faith, M. S., Carnell, S., & Kral, T. V. E. (2013) · Human Heredity · doi:10.1159/000353879 · Cited by 7,628 · see citing works

A unified mixed-model method for association mapping that accounts for multiple levels of relatedness

Yu, J., Pressoir, G., Briggs, W. H., Bi, I. V., Yamasaki, M., Doebley, J., McMullen, M. D., Gaut, B. S., Nielsen, D. M., Holland, J. B., et al. (2005) · Nature Genetics · doi:10.1038/ng1702 · Cited by 4,155 · see citing works

Genome-wide association studies for common diseases and complex traits

Hirschhorn, J. N., & Daly, M. J. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1521 · Cited by 2,853 · see citing works

Mixed linear model approach adapted for genome-wide association studies

Zhang, Z., Ersoz, E. S., Lai, C., Todhunter, R. J., Tiwari, H. K., Gore, M. A., Bradbury, P. J., Yu, J., Arnett, D. K., Ordovás, J. M., et al. (2010) · Nature Genetics · doi:10.1038/ng.546 · Cited by 2,132 · see citing works

Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits

Purcell, S., Cherny, S. S., & Sham, P. C. (2003) · Bioinformatics · doi:10.1093/bioinformatics/19.1.149 · Cited by 2,057 · see citing works

Genome-wide association studies

Uffelmann, E., Huang, Q. Q., Munung, N. S., de Vries, J., Okada, Y., Martin, A. R., Martin, H. C., Lappalainen, T., & Posthuma, D. (2021) · Nature Reviews Methods Primers · doi:10.1038/s43586-021-00056-9 · Cited by 1,849 · see citing works

Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits

Scuteri, A., Sanna, S., Chen, W.-M., Uda, M., Albai, G., Strait, J., Najjar, S., Nagaraja, R., Orrú, M., Usala, G., et al. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030115 · Cited by 1,724 · see citing works

Carnitine—metabolism and functions

Bremer, J. (1983) · Physiological Reviews · doi:10.1152/physrev.1983.63.4.1420 · Cited by 1,666 · see citing works

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

Willer, C. J., Sanna, S., Jackson, A. U., Scuteri, A., Bonnycastle, L. L., Clarke, R., Heath, S. C., Timpson, N. J., Najjar, S. S., Stringham, H. M., et al. (2008) · Nature Genetics · doi:10.1038/ng.76 · Cited by 1,585 · see citing works

Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS

Nicolae, D. L., Gamazon, E., Zhang, W., Duan, S., Dolan, M. E., & Cox, N. J. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000888 · Cited by 1,292 · see citing works

Association study designs for complex diseases

Cardon, L. R., & Bell, J. I. (2001) · Nature Reviews Genetics · doi:10.1038/35052543 · Cited by 1,380 · see citing works

Status and Prospects of Association Mapping in Plants

Zhu, C., Gore, M. A., Buckler, E. S., & Yu, J. (2008) · The Plant Genome · doi:10.3835/plantgenome2008.02.0089 · Cited by 1,344 · see citing works

A tutorial on statistical methods for population association studies

Balding, D. J. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1916 · Cited by 1,328 · see citing works

DNA methylation age of blood predicts all-cause mortality in later life

Marioni, R. E., Shah, S., McRae, A. F., Chen, B. H., Colicino, E., Harris, S. E., Gibson, J., Henders, A. K., Redmond, P., Cox, S. R., et al. (2015) · Genome Biology · doi:10.1186/s13059-015-0584-6 · Cited by 1,261 · see citing works

New approaches to population stratification in genome-wide association studies

Price, A. L., Zaitlen, N., Reich, D., & Patterson, N. J. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2813 · Cited by 1,181 · see citing works

Genetic analysis of genome-wide variation in human gene expression

Morley, M. P., Molony, C. M., Weber, T. M., Devlin, J. L., Ewens, K. G., Spielman, R. S., & Cheung, V. G. (2004) · Nature · doi:10.1038/nature02797 · Cited by 1,207 · see citing works

Pedigree disequilibrium tests for multilocus haplotypes.

Dudbridge, F. (2003) · Genetic Epidemiology · doi:10.1002/gepi.10252 · Cited by 1,135 · see citing works

Methods of integrating data to uncover genotype-phenotype interactions

Ritchie, M. D., Holzinger, E. R., Li, R., Pendergrass, S. A., & Kim, D. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3868 · Cited by 1,085 · see citing works

Are Political Orientations Genetically Transmitted?

Alford, J. R., Funk, C. L., & Hibbing, J. R. (2005) · American Political Science Review · doi:10.1017/s0003055405051579 · Cited by 976 · see citing works

Genotype Imputation

Li, Y., Willer, C., Sanna, S., & Abecasis, G. (2009) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164242 · Cited by 990 · see citing works

Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset

The U.S.–Venezuela Collaborative Research Project*, & Wexler, N. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308679101 · Cited by 761 · see citing works

A functional genetic link between distinct developmental language disorders

Vernes, S. C., Newbury, D. F., Abrahams, B. S., Winchester, L., Nicod, J., Groszer, M., Alarcón, M., Oliver, P. L., Davies, K. E., Geschwind, D. H., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802828 · Cited by 676 · see citing works

Linkage disequilibrium and association studies in higher plants: Present status and future prospects

Gupta, P. K., Rustgi, S., & Kulwal, P. L. (2005) · Plant Molecular Biology · doi:10.1007/s11103-005-0257-z · Cited by 670 · see citing works

Likelihood-Based Association Analysis for Nuclear Families and Unrelated Subjects with Missing Genotype Data

Dudbridge, F. (2008) · Human Heredity · doi:10.1159/000119108 · Cited by 607 · see citing works

Genetic association studies

Cordell, H. J., & Clayton, D. G. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67424-7 · Cited by 587 · see citing works

Interleukin 7 receptor α chain ( IL7R ) shows allelic and functional association with multiple sclerosis

for the Multiple Sclerosis Genetics Group, Gregory, S. G., Schmidt, S., Seth, P., Oksenberg, J. R., Hart, J., Prokop, A., Caillier, S. J., Ban, M., Goris, A., et al. (2007) · Nature Genetics · doi:10.1038/ng2103 · Cited by 657 · see citing works

Heritability of Cardiovascular and Personality Traits in 6,148 Sardinians

Pilia, G., Chen, W., Scuteri, A., Orrù, M., Albai, G., Dei, M., Lai, S., Usala, G., Lai, M., Loi, P., et al. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020132 · Cited by 543 · see citing works

A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15

Menzel, S., Garner, C., Gut, I., Matsuda, F., Yamaguchi, M., Heath, S., Foglio, M., Zelenika, D., Boland, A., Rooks, H., et al. (2007) · Nature Genetics · doi:10.1038/ng2108 · Cited by 529 · see citing works

Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians

Vasseur, F. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.21.2607 · Cited by 494 · see citing works

Family-based designs in the age of large-scale gene-association studies

Laird, N., & Lange, C. (2006) · Nature reviews genetics · doi:10.1038/nrg1839 · Cited by 477 · see citing works

Genomewide Rapid Association Using Mixed Model and Regression: A Fast and Simple Method For Genomewide Pedigree-Based Quantitative Trait Loci Association Analysis

Aulchenko, Y., de Koning, D., & Haley, C. (2007) · Genetics · doi:10.1534/genetics.107.075614 · Cited by 460 · see citing works

Demonstrating stratification in a European American population

Campbell, C. D., Ogburn, E. L., Lunetta, K. L., Lyon, H. N., Freedman, M. L., Groop, L. C., Altshuler, D., Ardlie, K. G., & Hirschhorn, J. N. (2005) · Nature Genetics · doi:10.1038/ng1607 · Cited by 444 · see citing works

Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses

Brumpton, B., Sanderson, E., Heilbron, K., Hartwig, F. P., Harrison, S., Vie, G. Å., Cho, Y., Howe, L. D., Hughes, A., Boomsma, D. I., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17117-4 · Cited by 402 · see citing works

Theory and practice in quantitative genetics

Posthuma, D., Beem, A. L., de Geus, E. J. C., van Baal, G. C. M., von Hjelmborg, J. B., Iachine, I., & Boomsma, D. I. (2003) · Twin Research · doi:10.1375/136905203770326367 · Cited by 416 · see citing works

Endophenotypes in the Genetic Analyses of Mental Disorders

Cannon, T. D., & Keller, M. C. (2006) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.2.022305.095232 · Cited by 399 · see citing works

PEDSTATS: descriptive statistics, graphics and quality assessment for gene mapping data

Wigginton, J. E., & Abecasis, G. R. (2005) · Computer applications in the biosciences · doi:10.1093/bioinformatics/bti529 · Cited by 408 · see citing works

Linkage disequilibrium and the search for complex disease genes.Preprint

Jorde, L. (2000) · Genome Research · doi:10.1101/gr.144500 · Cited by 422 · see citing works

Family-Based Association Tests for Genomewide Association Scans

Chen, W., & Abecasis, G. R. (2007) · The American Journal of Human Genetics · doi:10.1086/521580 · Cited by 398 · see citing works

GRR: graphical representation of relationship errors

Abecasis, G. R., Cherny, S. S., Cookson, W., & Cardon, L. R. (2001) · Bioinformatics · doi:10.1093/bioinformatics/17.8.742 · Cited by 383 · see citing works

Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

Howe, L. J., Nivard, M. G., Morris, T. T., Hansen, A. F., Rasheed, H., Cho, Y., Chittoor, G., Ahlskog, R., Lind, P. A., Palviainen, T., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01062-7 · Cited by 377 · see citing works

Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans

Timmons, J. A., Knudsen, S., Rankinen, T., Koch, L. G., Sarzynski, M., Jensen, T., Keller, P., Scheele, C., Vollaard, N. B. J., Nielsen, S., et al. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01295.2009 · Cited by 358 · see citing works

Reduced signal for polygenic adaptation of height in UK Biobank

Berg, J. J., Harpak, A., Sinnott-Armstrong, N., Joergensen, A. M., Mostafavi, H., Field, Y., Boyle, E. A., Zhang, X., Racimo, F., Pritchard, J. K., et al. (2019) · eLife · doi:10.7554/elife.39725 · Cited by 339 · see citing works

Association of DISC1/TRAX Haplotypes With Schizophrenia, Reduced Prefrontal Gray Matter, and Impaired Short- and Long-term Memory

Cannon, T. D., Hennah, W., van Erp, T. G. M., Thompson, P. M., Lonnqvist, J., Huttunen, M., Gasperoni, T., Tuulio-Henriksson, A., Pirkola, T., Toga, A. W., et al. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.11.1205 · Cited by 337 · see citing works

A BDNF Coding Variant is Associated with the NEO Personality Inventory Domain Neuroticism, a Risk Factor for Depression

Sen, S., Nesse, R. M., Stoltenberg, S. F., Li, S., Gleiberman, L., Chakravarti, A., Weder, A. B., & Burmeister, M. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300053 · Cited by 331 · see citing works

Positional cloning of a novel gene influencing asthma from Chromosome 2q14

Allen, M., Heinzmann, A., Noguchi, E., Abecasis, G. R., Broxholme, J., Ponting, C. P., Bhattacharyya, S., Tinsley, J. M., Zhang, Y., Holt, R., et al. (2003) · Nature Genetics · doi:10.1038/ng1256 · Cited by 326 · see citing works

Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma

Zhang, Y., Leaves, N. I., Anderson, G. G., Ponting, C. P., Broxholme, J., Holt, R., Edser, P. A. H., Bhattacharyya, S., Dunham, A., Adcock, I. M., et al. (2003) · Nature Genetics · doi:10.1038/ng1166 · Cited by 320 · see citing works

Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults

Thein, S. L., Menzel, S., Xu, P., Best, S., Jiang, J., Close, J. P., Silver, N., Gerovassili, A., Chen, P., Yamaguchi, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611393104 · Cited by 313 · see citing works

Pedigree tests of transmission disequilibrium

Abecasis, G. R., Cookson, W., & Cardon, L. R. (2000) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200494 · Cited by 294 · see citing works

Genome‐Wide Association Study of Alcohol Dependence Implicates a Region on Chromosome 11

Edenberg, H. J., Koller, D. L., Xuei, X., Wetherill, L., McClintick, J. N., Almasy, L., Bierut, L. J., Bucholz, K. K., Goate, A., Aliev, F., et al. (2010) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01156.x · Cited by 293 · see citing works

Application of Association Mapping to Understanding the Genetic Diversity of Plant Germplasm Resources

Abdurakhmonov, I. Y., & Abdukarimov, A. (2008) · International Journal of Plant Genomics · doi:10.1155/2008/574927 · Cited by 293 · see citing works

Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness

Levy, D. A., Larson, M. G., Benjamin, E. J., Newton‐Cheh, C., Wang, T. J., Hwang, S., Vasan, R. S., & Mitchell, G. F. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-s1-s3 · Cited by 290 · see citing works

Genome-wide association scan for five major dimensions of personality

Terracciano, A., Sanna, S., Uda, M., Deiana, B., Usala, G., Busonero, F., Maschio, A., Scally, M., Patriciu, N. S., Chen, W.-M., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.113 · Cited by 286 · see citing works

Genetic predisposition to external apical root resorption

Al-Qawasmi, R. A., Hartsfield, J. K., Everett, E. T., Wetherill, L. F., Liu, L., Foroud, T., Macri, J. V., & Roberts, W. E. (2003) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1067/mod.2003.42 · Cited by 280 · see citing works

Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression

Straub, R. E., Lipska, B. K., Egan, M. F., Goldberg, T. E., Callicott, J. H., Mayhew, M. B., Vakkalanka, R., Kolachana, B. S., Kleinman, J. E., & Weinberger, D. R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001988 · Cited by 275 · see citing works

Contribution of genetic variation to transgenerational inheritance of DNA methylation

McRae, A. F., Powell, J. E., Henders, A. K., Bowdler, L. M., Hemani, G., Shah, S. H., Painter, J. N., Martin, N. G., Visscher, P. M., & Montgomery, G. W. (2014) · Genome biology · doi:10.1186/gb-2014-15-5-r73 · Cited by 270 · see citing works

PBAT: tools for family-based association studies.

Lange, C., DeMeo, D., Silverman, E. K., Weiss, S. T., & Laird, N. M. (2004) · The American Journal of Human Genetics · doi:10.1086/381563 · Cited by 268 · see citing works

NOD1 variation, immunoglobulin E and asthma

Hysi, P. G., Kabesch, M., Moffatt, M. F., Schedel, M., Carr, D., Zhang, Y., Boardman, B., von Mutius, E., Weiland, S. K., Leupold, W., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi087 · Cited by 266 · see citing works

A Genomic Background Based Method for Association Analysis in Related Individuals

Amin, N., van Duijn, C. M., & Aulchenko, Y. S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001274 · Cited by 259 · see citing works

Mapping Genetic Loci That Determine Leukocyte Telomere Length in a Large Sample of Unselected Female Sibling Pairs

Andrew, T., Aviv, A., Falchi, M., Surdulescu, G. L., Gardner, J. P., Lu, X., Kimura, M., Kato, B. S., Valdes, A. M., & Spector, T. D. (2006) · The American Journal of Human Genetics · doi:10.1086/500052 · Cited by 252 · see citing works

Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein

Vickers, M. A. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00534-x · Cited by 252 · see citing works

A Powerful and Flexible Multilocus Association Test for Quantitative Traits

Kwee, L. C., Liu, D., Lin, X., Ghosh, D., & Epstein, M. P. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.10.010 · Cited by 227 · see citing works

Strong Genetic Evidence of DCDC2 as a Susceptibility Gene for Dyslexia

Schumacher, J., Anthoni, H., Dahdouh, F., König, I. R., Hillmer, A. M., Kluck, N., Manthey, M., Plume, E., Warnke, A., Remschmidt, H., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/498992 · Cited by 236 · see citing works

Genetics of human gene expression: mapping DNA variants that influence gene expression

Cheung, V. G., & Spielman, R. S. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2630 · Cited by 233 · see citing works

Population genetic differentiation of height and body mass index across Europe

Robinson, M. R., Hemani, G., Medina‐Gómez, C., Mezzavilla, M., Esko, T., Shakhbazov, K., Powell, J. E., Vinkhuyzen, A. A. E., Berndt, S. I., Gustafsson, S., et al. (2015) · Nature Genetics · doi:10.1038/ng.3401 · Cited by 225 · see citing works

A 77-Kilobase Region of Chromosome 6p22.2 Is Associated with Dyslexia in Families From the United Kingdom and From the United States

Francks, C., Paracchini, S., Smith, S. D., Richardson, A. J., Scerri, T. S., Cardon, L. R., Marlow, A. J., MacPhie, I. L., Walter, J., Pennington, B. F., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/426404 · Cited by 233 · see citing works

Glutathione S-transferase omega-1 modifiesage-at-onset of Alzheimer disease and Parkinson disease

Li, Y. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg357 · Cited by 234 · see citing works

SCAN: SNP and copy number annotation

Gamazon, E. R., Zhang, W., Konkashbaev, A. I., Duan, S., Kistner, E. O., Nicolae, D. L., Dolan, M. E., & Cox, N. J. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp644 · Cited by 230 · see citing works

Investigation of Dyslexia and SLI Risk Variants in Reading- and Language-Impaired Subjects

Newbury, D. F., Paracchini, S., Scerri, T. S., Winchester, L. M., Addis, L., Richardson, A. J., Walter, J., Stein, J. F., Talcott, J. B., & Monaco, A. P. (2010) · Behavior Genetics · doi:10.1007/s10519-010-9424-3 · Cited by 224 · see citing works

Case/pseudocontrol analysis in genetic association studies: A unified framework for detection of genotype and haplotype associations, gene‐gene and gene‐environment interactions, and parent‐of‐origin effects

Cordell, H. J., Barratt, B. J., & Clayton, D. G. (2004) · Genetic Epidemiology · doi:10.1002/gepi.10307 · Cited by 223 · see citing works

Filaggrin Mutations in Children with Severe Atopic Dermatitis

Morar, N., Cookson, W., Harper, J. I., & Moffatt, M. F. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700739 · Cited by 222 · see citing works

Genetic Advances in the Study of Speech and Language Disorders

Newbury, D. F., & Monaco, A. P. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.001 · Cited by 218 · see citing works

Genetic analysis of radiation-induced changes in human gene expression

Smirnov, D., Morley, M., Shin, E., Spielman, R., & Cheung, V. (2009) · Nature · doi:10.1038/nature07940 · Cited by 221 · see citing works

FOXP2 Is Not a Major Susceptibility Gene for Autism or Specific Language Impairment

Newbury, D. F., Bonora, E., Lamb, J. A., Fisher, S. E., Lai, C. S. L., Baird, G., Jannoun, L., Slonims, V., Stott, C., Merricks, M. J., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/339931 · Cited by 218 · see citing works

The Serotonin Transporter Length Polymorphism, Neuroticism, and Depression: A Comprehensive Assessment of Association

Willis‐Owen, S. A. G., Turri, M. G., Munafo, M. R., Surtees, P. G., Wainwright, N. W. J., Brixey, R. D., & Jonathan Flint, C. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.050 · Cited by 210 · see citing works

Methods for Handling Multiple Testing

Rice, T., Schork, N. J., & Rao, D. C. (2008) · Advances in genetics · doi:10.1016/s0065-2660(07)00412-9 · Cited by 202 · see citing works

GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD67), is associated with childhood-onset schizophrenia and cortical gray matter volume loss

Addington, A. M., Gornick, M., Duckworth, J., Sporn, A. L., Gogtay, N., Bobb, A., GREENSTEIN, D. K., Lenane, M., Gochman, P., Baker, N., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001599 · Cited by 207 · see citing works

GWAS of epigenetic aging rates in blood reveals a critical role for TERT

Lu, A. T.-H., Xue, L., Salfati, E., Chen, B. H., Ferrucci, L., Levy, D. A., Joehanes, R., Murabito, J. M., Kiel, D. P., Tsai, P.-C., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02697-5 · Cited by 206 · see citing works

A Susceptibility Locus for Myopia in the Normal Population Is Linked to the PAX6 Gene Region on Chromosome 11: A Genomewide Scan of Dizygotic Twins

Hammond, C. J., Andrew, T., Mak, Y. T., & Spector, T. D. (2004) · The American Journal of Human Genetics · doi:10.1086/423148 · Cited by 202 · see citing works

Multipoint Estimation of Identity-by-Descent Probabilities at Arbitrary Positions among Marker Loci on General Pedigrees

Sobel, E. M., Sengul, H., & Weeks, D. E. (2001) · Human Heredity · doi:10.1159/000053366 · Cited by 201 · see citing works

Genetic variation in the 22q11 locus and susceptibility to schizophrenia

Liu, H., Abecasis, G. R., Heath, S. C., Knowles, A., Demars, S., Chen, Y., Roos, J. L., Rapoport, J. L., Gogos, J. A., & Karayiorgou, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232186099 · Cited by 201 · see citing works

Evaluation of Genetic Variation Contributing to Differences in Gene Expression between Populations

Zhang, W., Duan, S., Kistner, E. O., Bleibel, W. K., Huang, R. S., Clark, T. A., Chen, T. X., Schweitzer, A. C., Blume, J. E., Cox, N. J., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.12.015 · Cited by 200 · see citing works

Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham study

Seshadri, S. S., DeStefano, A. L., Au, R., Massaro, J. M., Beiser, A., Kelly‐Hayes, M., Kase, C. S., D’Agostino, R. B., DeCarli, C. S., Atwood, L. D., et al. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-s1-s15 · Cited by 199 · see citing works

A multivariate family-based association test using generalized estimating equations: FBAT-GEE

Lange, C. (2003) · Biostatistics · doi:10.1093/biostatistics/4.2.195 · Cited by 198 · see citing works

A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity

Huang, R. S., Duan, S., Bleibel, W. K., Kistner, E. O., Zhang, W., Clark, T. A., Chen, T. X., Schweitzer, A. C., Blume, J. E., Cox, N. J., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703736104 · Cited by 197 · see citing works

Support for involvement of neuregulin 1 in schizophrenia pathophysiology

Petryshen, T. L., Middleton, F. A., Kirby, A. W., Aldinger, K. A., Purcell, S., Tahl, A. R., Morley, C. P., McGann, L., Gentile, K. L., Rockwell, G. N., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001608 · Cited by 195 · see citing works

Variation in the Bitter‐taste Receptor Gene TAS2R38, and Adiposity in a Genetically Isolated Population in Southern Italy

Tepper, B. J., Koelliker, Y., Zhao, L., Ullrich, N. V., Lanzara, C., D’Adamo, P., Ferrara, A., Ulivi, S., Esposito, L., & Gasparini, P. (2008) · Obesity · doi:10.1038/oby.2008.357 · Cited by 194 · see citing works

Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis

MacGregor, S., Lind, P. A., Bucholz, K. K., Hansell, N. K., Madden, P. A. F., Richter, M. M., Montgomery, G. W., Martin, N. G., Heath, A. C., & Whitfield, J. B. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn372 · Cited by 194 · see citing works

Correlated genotypes in friendship networks

Fowler, J. H., Settle, J. E., & Christakis, N. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011687108 · Cited by 188 · see citing works

Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans

Edmondson, A. C., Brown, R., Kathiresan, S., Cupples, L. A., Demissie, S., Manning, A. K., Jensen, M. K., Rimm, E. B., Wang, J., Rodrigues, A., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37176 · Cited by 193 · see citing works

Genomics and Genetics in the Biology of Adaptation to Exercise

Bouchard, C., Rankinen, T., & Timmons, J. A. (2011) · Comprehensive physiology · doi:10.1002/cphy.c100059 · Cited by 211 · see citing works

CMIP and ATP2C2 Modulate Phonological Short-Term Memory in Language Impairment

Newbury, D. F., Winchester, L. M., Addis, L., Paracchini, S., Buckingham, L.-L., Clark, A., Cohen, W., Cowie, H., Dworzynski, K., Everitt, A., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.07.004 · Cited by 182 · see citing works

Somatic instability of the expanded CTG triplet repeat in myotonic dystrophy type 1 is a heritable quantitative trait and modifier of disease severity

Morales, F., Couto, J. M., Higham, C. F., Hogg, G., Cuenca, P., Braida, C., Wilson, R. H., Adam, B., Valle, G. D., Brian, R., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds185 · Cited by 181 · see citing works

G enetic F actors in E xternal A pical R oot R esorption and O rthodontic T reatment

Hartsfield, J. K., Everett, E. T., & Al-Qawasmi, R. A. (2004) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130401500205 · Cited by 177 · see citing works

An association study of asthma and total serum immunoglobin E levels for Toll‐like receptor polymorphisms in a Japanese population

Noguchi, E., Nishimura, F., Fukai, H., Kim, J. K., Ichikawa, K., Shibasaki, M., & Arinami, T. (2004) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2004.01839.x · Cited by 176 · see citing works

Genetic Predisposition to External Apical Root Resorption in Orthodontic Patients: Linkage of Chromosome-18 Marker

Al-Qawasmi, R. A., Hartsfield, J. K., Everett, E. T., Wetherill, L. F., Liu, L., Foroud, T., Macri, J. V., & Roberts, W. E. (2003) · Journal of Dental Research · doi:10.1177/154405910308200506 · Cited by 172 · see citing works

RNA-Seq Identifies SNP Markers for Growth Traits in Rainbow Trout

Salem, M., Vallejo, R. L., Leeds, T. D., Palti, Y., Liu, S., Sabbagh, A., Rexroad, C. E., & Yao, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036264 · Cited by 170 · see citing works

Variants in TF and HFE Explain ∼40% of Genetic Variation in Serum-Transferrin Levels

Benyamin, B., McRae, A. F., Zhu, G., Gordon, S. D., Henders, A. K., Palotie, A. V., Peltonen, L., Martin, N. G., Montgomery, G. W., Whitfield, J. B., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.11.011 · Cited by 169 · see citing works

5′ Flanking Variants of Resistin Are Associated With Obesity

Engert, J. C., Vohl, M., Williams, S. M., Lepage, P., Loredo‐Osti, J., Faith, J., Doré, C., Renaud, Y., Burtt, N. P., Villeneuve, A., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.5.1629 · Cited by 169 · see citing works

Am. J. Hum. Genet. 66:279–292, 2000 A General Test of Association for Quantitative Traits in Nuclear Families

Abecasis, G. R., Cardon, L. R., & Cookson, W. O. C. M. (1999)

ARTICLE Pedigree tests of transmission disequilibrium

Abecasis, G. R., Cookson, W. O., & Cardon, L. R. (2014)

Pedigree tests of transmission disequilibrium

Abecasis, G. R., Cookson, W., & Cardon, L. R. (2000) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200494 · Cited by 294 · see citing works

Testing Quantitative Traits for Association and Linkage in the Presence or Absence of Parental Data

Zhu, X., Elston, R. C., & Cooper, R. (2001) · Human Heredity · doi:10.1159/000053341 · Cited by 7 · see citing works

Family-based methods which rely on association for the mapping of genes in human populations.

Monks, S. A. (1999) · NCSU Libraries Repository (North Carolina State University Libraries)