The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity
Open accessAbstract
Microbial pathogenesis studies are typically performed with reference strains, thereby overlooking within-species heterogeneity in microbial virulence. Here we integrated human epidemiological and clinical data with bacterial population genomics to harness the biodiversity of the model foodborne pathogen Listeria monocytogenes and decipher the basis of its neural and placental tropisms. Taking advantage of the clonal structure of this bacterial species, we identify clones epidemiologically associated either with food or with human central nervous system (CNS) or maternal-neonatal (MN) listeriosis. The latter clones are also most prevalent in patients without immunosuppressive comorbidities. Strikingly, CNS- and MN-associated clones are hypervirulent in a humanized mouse model of listeriosis. By integrating epidemiological data and comparative genomics, we have uncovered multiple new putative virulence factors and demonstrate experimentally the contribution of the first gene cluster mediating L. monocytogenes neural and placental tropisms. This study illustrates the exceptional power in harnessing microbial biodiversity to identify clinically relevant microbial virulence attributes.
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Parkhill, J., Sebaihia, M., Preston, A., Murphy, L. D., Thomson, N., Harris, D. E., Holden, M. T. G., Churcher, C. M., Bentley, S. D., Mungall, K. L., et al. (2003) · Nature Genetics · doi:10.1038/ng1227 · Cited by 1,037
A transgenic model for listeriosis: role of internalin in crossing the intestinal barrier
Lecuit, M., Vandormael-Pournin, S., Lefort, J., Huerre, M., Gounon, P., Dupuy, C., Babinet, C., & Cossart, P. (2001) · Science · doi:10.1126/science.1059852 · Cited by 633
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Cited by
The European Union One Health 2018 Zoonoses Report
European Food Safety Authority and European Centre for Disease Prevention and Control (EFSA and ECDC) (2019) · EFSA Journal · doi:10.2903/j.efsa.2019.5926 · Cited by 874
Whole genome-based population biology and epidemiological surveillance of Listeria monocytogenes
Moura, A., Criscuolo, A., Pouseele, H., Maury, M. M., Leclercq, A., Tarr, C., Björkman, J. T., Dallman, T., Reimer, A., Enouf, V., et al. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.185 · Cited by 668
Self-citationListeria monocytogenes meningitis in the Netherlands, 1985–2014: a nationwide surveillance study
Koopmans, M. M., Bijlsma, M. W., Brouwer, M. C., van de Beek, D., & van der Ende, A. (2017) · Journal of Infection · doi:10.1016/j.jinf.2017.04.004 · Cited by 79
Besic, V., Habibolahi, F., Noël, B., Rupp, S., Genovesio, A., & Lebreton, A. (2020) · RNA Biology · doi:10.1080/15476286.2020.1777380 · Cited by 10
Metadata
- Authors
- Maury, M. M., Tsai, Y.-H., Charlier, C., Touchon, M., Chenal-Francisque, V., Leclercq, A., Criscuolo, A., Gaultier, C., Roussel, S., Brisabois, A., Disson, O., Rocha, E. P. C., Brisse, S., & Lecuit, M.
- Venue
- Nature Genetics
- Published
- 2016-02-01
- Volume
- 48
- Issue
- 3
- Pages
- 308-313
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2259709515
- Cited by
- 706
- References
- 2
- FWCI
- 50.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Maury, M. M., Tsai, Y.-H., Charlier, C., Touchon, M., Chenal-Francisque, V., Leclercq, A., Criscuolo, A., Gaultier, C., Roussel, S., Brisabois, A., Disson, O., Rocha, E. P. C., Brisse, S., & Lecuit, M. (2016). Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity. Nature Genetics. https://doi.org/10.1038/ng.3501
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