The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Common variants at ten loci modulate the QT interval duration in the QTSCD Study
Open accessAbstract
The QT interval, a measure of cardiac repolarization, predisposes to ventricular arrhythmias and sudden cardiac death (SCD) when prolonged or shortened. A common variant in NOS1AP is known to influence repolarization. We analyze genome-wide data from five population-based cohorts (ARIC, KORA, SardiNIA, GenNOVA and HNR) with a total of 15,842 individuals of European ancestry, to confirm the NOS1AP association and identify nine additional loci at P < 5 × 10−8. Four loci map near the monogenic long-QT syndrome genes KCNQ1, KCNH2, SCN5A and KCNJ2. Two other loci include ATP1B1 and PLN, genes with established electrophysiological function, whereas three map to RNF207, near LITAF and within NDRG4-GINS3-SETD6-CNOT1, respectively, all of which have not previously been implicated in cardiac electrophysiology. These results, together with an accompanying paper from the QTGEN consortium, identify new candidate genes for ventricular arrhythmias and SCD.
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Genomic Control for Association Studies
Devlin, B., & Roeder, K. (1999) · Biometrics · doi:10.1111/j.0006-341x.1999.00997.x · Cited by 3,162 · cited 1×
“016, indicating that unmodeled relatedness and population structure had no appreciable impact on our result”
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Genome-wide association study of PR interval
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Self-citationSeveral common variants modulate heart rate, PR interval and QRS duration
Holm, H., Gudbjartsson, D. F., Arnar, D. O., Thorleifsson, G., Thorgeirsson, G., Stefansdottir, H., Gudjonsson, S. A., Jonasdottir, A., Mathiesen, E. B., Njølstad, I., et al. (2010) · Nature Genetics · doi:10.1038/ng.511 · Cited by 386
Genetic variation in SCN10A influences cardiac conduction
Chambers, J. C., Zhao, J., Terracciano, C. M. N., Bezzina, C. R., Zhang, W., Kaba, R., Navaratnarajah, M., Lotlikar, A., Sehmi, J. S., Kooner, M. K., et al. (2010) · Nature Genetics · doi:10.1038/ng.516 · Cited by 289
Metadata
- Authors
- Pfeufer, A., Sanna, S., Arking, D. E., Müller, M., Gateva, V., Fuchsberger, C., Ehret, G. B., Orrú, M., Pattaro, C., Köttgen, A., Perz, S., Usala, G., Barbalic, M., Li, M., Pütz, B., Scuteri, A., Prineas, R. J., Sinner, M. F., Gieger, C., Najjar, S. S., Kao, W. H. L., Mühleisen, T. W., Dei, M., Happle, C., Möhlenkamp, S., Crisponi, L., Erbel, R., Jöckel, K.-H., Naitza, S., Steinbeck, G., Marroni, F., Hicks, A. A., Lakatta, E., Müller-Myhsok, B., Pramstaller, P. P., Wichmann, H.-E., Schlessinger, D., Boerwinkle, E., Meitinger, T., Uda, M., Coresh, J., Kääb, S., Abecasis, G. R., & Chakravarti, A.
- Venue
- Nature Genetics
- Published
- 2009-03-22
- Volume
- 41
- Issue
- 4
- Pages
- 407-414
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2022617607
- Cited by
- 389
- References
- 3
- FWCI
- 30.25
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Common variants at ten loci modulate the QT interval duration in the QTSCD Study. https://app.cochat.ai/papers/10.1038/ng.362
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- Pfeufer, A., Sanna, S., Arking, D. E., Müller, M., Gateva, V., Fuchsberger, C., Ehret, G. B., Orrú, M., Pattaro, C., Köttgen, A., Perz, S., Usala, G., Barbalic, M., Li, M., Pütz, B., Scuteri, A., Prineas, R. J., Sinner, M. F., Gieger, C., . . . Chakravarti, A. (2009). Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nature Genetics. https://doi.org/10.1038/ng.362
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