The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Genome-wide association study of PR interval
Open accessAbstract
The electrocardiographic PR interval (or PQ interval) reflects atrial and atrioventricular nodal conduction, disturbances of which increase risk of atrial fibrillation. We report a meta-analysis of genome-wide association studies for PR interval from seven population-based European studies in the CHARGE Consortium: AGES, ARIC, CHS, FHS, KORA, Rotterdam Study, and SardiNIA (N = 28,517). We identified nine loci associated with PR interval at P < 5 × 10−8. At the 3p22.2 locus, we observed two independent associations in voltage-gated sodium channel genes, SCN10A and SCN5A. Six of the loci were near cardiac developmental genes, including CAV1-CAV2, NKX2-5 (CSX1), SOX5, WNT11, MEIS1, and TBX5-TBX3, providing pathophysiologically interesting candidate genes. Five of the loci, SCN5A, SCN10A, NKX2-5, CAV1-CAV2, and SOX5, were also associated with atrial fibrillation (N = 5,741 cases, P < 0.0056). This suggests a role for common variation in ion channel and developmental genes in atrial and atrioventricular conduction as well as in susceptibility to atrial fibrillation.
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A haplotype map of the human genome
The International HapMap Consortium (2005) · Nature · doi:10.1038/nature04226 · Cited by 5,858
The Cardiovascular Health Study: design and rationale.
Fried, L. P., Borhani, N. O., Enright, P., Furberg, C. D., Gardin, J. M., Kronmal, R. A., Kuller, L. H., Manolio, T. A., Mittelmark, M. B., Newman, A., et al. (1991) · Annals of Epidemiology · doi:10.1016/1047-2797(91)90005-w · Cited by 3,652
Self-citationGenomic Control for Association Studies
Devlin, B., & Roeder, K. (1999) · Biometrics · doi:10.1111/j.0006-341x.1999.00997.x · Cited by 3,162 · cited 1×
“076 and report overall analysis results unadjusted for this λ value (25).”
Background(1989) · PubMed · Cited by 3,139
THE ATHEROSCLEROSIS RISK IN COMMUNIT (ARIC) STUDY: DESIGN AND OBJECTIVES
THE ARIC INVESTIGATORS (1989) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115184 · Cited by 2,924
Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study
Heeringa, J., van der Kuip, D. A. M., Hofman, A., Kors, J. A., van Herpen, G., Stricker, B. H. C., Stijnen, T., Lip, G. Y. H., & Witteman, J. C. M. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi825 · Cited by 1,939
Self-citationThe Rotterdam Study: objectives and design update
Hofman, A., Breteler, M. M. B., van Duijn, C. M., Krestin, G. P., Pols, H. A., Stricker, B. H. C., Tiemeier, H., Uitterlinden, A. G., Vingerling, J. R., & Witteman, J. C. M. (2007) · European Journal of Epidemiology · doi:10.1007/s10654-007-9199-x · Cited by 1,395
Self-citationChung, M. K., Martin, D. O., Sprecher, D., Wazni, O., Kanderian, A., Carnes, C. A., Bauer, J. A., Tchou, P. J., Niebauer, M. J., Natale, A., et al. (2001) · Circulation · doi:10.1161/hc4901.101760 · Cited by 1,375
Self-citationSchnabel, R. B., Sullivan, L. M., Levy, D., Pencina, M. J., Massaro, J. M., D'Agostino, R. B., Newton-Cheh, C., Yamamoto, J. F., Magnani, J. W., Tadros, T. M., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60443-8 · Cited by 1,041
Self-citationLi, Y., Willer, C., Sanna, S., & Abecasis, G. (2009) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164242 · Cited by 990
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Calkins, H., Kuck, K. H., Cappato, R., Brugada, J., Camm, A. J., Chen, S.-A., Crijns, H. J. G., Damiano, R. J., Davies, D. W., DiMarco, J., et al. (2012) · Heart Rhythm · doi:10.1016/j.hrthm.2011.12.016 · Cited by 1,456
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Hon, C.-C., Ramilowski, J. A., Harshbarger, J., Bertin, N., Rackham, O. J. L., Gough, J., Denisenko, E., Schmeier, S., Poulsen, T. M., Severin, J., et al. (2017) · Nature · doi:10.1038/nature21374 · Cited by 1,007
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Metadata
- Authors
- Pfeufer, A., van Noord, C., Marciante, K. D., Arking, D. E., Larson, M. G., Smith, A. V., Tarasov, K. V., Müller, M., Sotoodehnia, N., Sinner, M. F., Verwoert, G. C., Li, M., Kao, W. H. L., Köttgen, A., Coresh, J., Bis, J. C., Psaty, B. M., Rice, K., Rotter, J. I., Rivadeneira, F., Hofman, A., Kors, J. A., Stricker, B. H. C., Uitterlinden, A. G., van Duijn, C. M., Beckmann, B. M., Sauter, W., Gieger, C., Lubitz, S. A., Newton-Cheh, C., Wang, T. J., Magnani, J. W., Schnabel, R. B., Chung, M. K., Barnard, J., Smith, J. D., Van Wagoner, D. R., Vasan, R. S., Aspelund, T., Eiriksdottir, G., Harris, T. B., Launer, L. J., Najjar, S. S., Lakatta, E., Schlessinger, D., Uda, M., Abecasis, G. R., Müller-Myhsok, B., Ehret, G. B., Boerwinkle, E., Chakravarti, A., Soliman, E. Z., Lunetta, K. L., Perz, S., Wichmann, H.-E., Meitinger, T., Levy, D., Gudnason, V., Ellinor, P. T., Sanna, S., Kääb, S., Witteman, J. C. M., Alonso, A., Benjamin, E. J., & Heckbert, S. R.
- Venue
- Nature Genetics
- Published
- 2010-01-10
- Volume
- 42
- Issue
- 2
- Pages
- 153-159
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2066192569
- Cited by
- 438
- References
- 52
- FWCI
- 29.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Pfeufer, A., van Noord, C., Marciante, K. D., Arking, D. E., Larson, M. G., Smith, A. V., Tarasov, K. V., Müller, M., Sotoodehnia, N., Sinner, M. F., Verwoert, G. C., Li, M., Kao, W. H. L., Köttgen, A., Coresh, J., Bis, J. C., Psaty, B. M., Rice, K., Rotter, J. I., . . . Heckbert, S. R. (2010). Genome-wide association study of PR interval. Nature Genetics. https://doi.org/10.1038/ng.517
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