The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
Open accessAbstract
Sebastien Gagneux and colleagues analyze a global collection of Mycobacterium tuberculosis clinical isolates to classify sublineages by phylogeography. They find globally distributed ‘generalist’ and geographically restricted ‘specialist’ sublineages of lineage 4, indicating that different evolutionary strategies were adopted to succeed in various ecological niches. Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.
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Metadata
- Authors
- Stucki, D., Brites, D., Jeljeli, L., Coscolla, M., Liu, Q., Trauner, A., Fenner, L., Rutaihwa, L., Borrell, S., Luo, T., Gao, Q., Kato-Maeda, M., Ballif, M., Egger, M., Macedo, R., Mardassi, H., Moreno, M., Vilanova, G. T., Fyfe, J., Globan, M., Thomas, J., Jamieson, F., Guthrie, J. L., Asante-Poku, A., Yeboah-Manu, D., Wampande, E., Ssengooba, W., Joloba, M., Boom, W. H., Basu, I., Bower, J., Saraiva, M., Vasconcellos, S. E. G., Suffys, P., Koch, A., Wilkinson, R., Gail-Bekker, L., Malla, B., Ley, S. D., Beck, H.-P., de Jong, B. C., Toit, K., Sanchez-Padilla, E., Bonnet, M., Gil-Brusola, A., Frank, M., Penlap Beng, V. N., Eisenach, K., Alani, I., Ndung'u, P. W., Revathi, G., Gehre, F., Akter, S., Ntoumi, F., Stewart-Isherwood, L., Ntinginya, N. E., Rachow, A., Hoelscher, M., Cirillo, D. M., Skenders, G., Hoffner, S., Bakonyte, D., Stakenas, P., Diel, R., Crudu, V., Moldovan, O., Al-Hajoj, S., Otero, L., Barletta, F., Carter, E. J., Diero, L., Supply, P., Comas, I., Niemann, S., & Gagneux, S.
- Venue
- Nature Genetics
- Published
- 2016-10-31
- Volume
- 48
- Issue
- 12
- Pages
- 1535-1543
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2544696205
- Cited by
- 423
- References
- 78
- FWCI
- 31.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Stucki, D., Brites, D., Jeljeli, L., Coscolla, M., Liu, Q., Trauner, A., Fenner, L., Rutaihwa, L., Borrell, S., Luo, T., Gao, Q., Kato-Maeda, M., Ballif, M., Egger, M., Macedo, R., Mardassi, H., Moreno, M., Vilanova, G. T., Fyfe, J., . . . Gagneux, S. (2016). Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages. Nature Genetics. https://doi.org/10.1038/ng.3704
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