The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis
Open accessAbstract
The TMPRSS2-ERG fusion, present in approximately 50% of prostate cancers, is less common in prostatic intraepithelial neoplasia (PIN), raising questions about whether TMPRSS2-ERG contributes to disease initiation. We identified the translational start site of a common TMPRSS2-ERG fusion and showed that transgenic TMPRSS2-ERG mice develop PIN, but only in the context of PI3-kinase pathway activation. TMPRSS2-ERG–positive human tumors are also enriched for PTEN loss, suggesting cooperation in prostate tumorigenesis.
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Cites
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Self-citationRole of the TMPRSS2-ERG Gene Fusion in Prostate Cancer
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Self-citationDuplication of the fusion of TMPRSS2 to ERG sequences identifies fatal human prostate cancer
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Self-citationTMPRSS2-ERG Fusion Prostate Cancer: An Early Molecular Event Associated With Invasion
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Cited by
The functions and regulation of the PTEN tumour suppressor
Song, M. S., Salmena, L., & Pandolfi, P. P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3330 · Cited by 1,926
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Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements
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Self-citationIdentification of a Cell of Origin for Human Prostate Cancer
Goldstein, A. S., Huang, J., Guo, C., Garraway, I. P., & Witte, O. N. (2010) · Science · doi:10.1126/science.1189992 · Cited by 554
Androgen Signaling in Prostate Cancer
Dai, C., Heemers, H., & Sharifi, N. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a030452 · Cited by 406
Metadata
- Authors
- King, J. C., Xu, J., Wongvipat, J., Hieronymus, H., Carver, B. S., Leung, D. H., Taylor, B. S., Sander, C., Cardiff, R. D., Couto, S. S., Gerald, W. L., & Sawyers, C. L.
- Venue
- Nature Genetics
- Published
- 2009-04-26
- Volume
- 41
- Issue
- 5
- Pages
- 524-526
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2049205984
- Cited by
- 477
- References
- 15
- FWCI
- 38.37
- Type
- journal article
- Language
- en
- Open access
- green
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