The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Inactivation of Capicua drives cancer metastasis
Open accessAbstract
Metastasis is the leading cause of death in people with lung cancer, yet the molecular effectors underlying tumor dissemination remain poorly defined. Through the development of an in vivo spontaneous lung cancer metastasis model, we show that the developmentally regulated transcriptional repressor Capicua (CIC) suppresses invasion and metastasis. Inactivation of CIC relieves repression of its effector ETV4, driving ETV4-mediated upregulation of MMP24, which is necessary and sufficient for metastasis. Loss of CIC, or an increase in levels of its effectors ETV4 and MMP24, is a biomarker of tumor progression and worse outcomes in people with lung and/or gastric cancer. Our findings reveal CIC as a conserved metastasis suppressor, highlighting new anti-metastatic strategies that could potentially improve patient outcomes.
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Cites
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Cited by
Blakely, C. M., Watkins, T. B. K., Wu, W., Gini, B., Chabon, J. J., McCoach, C. E., McGranahan, N., Wilson, G. A., Birkbak, N. J., Olivas, V. R., et al. (2017) · Nature Genetics · doi:10.1038/ng.3990 · Cited by 571
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Genome-wide CRISPR/Cas9 Screen Identifies Host Factors Essential for Influenza Virus Replication
Han, J., Perez, J. T., Chen, C., Li, Y., Benitez, A., Kandasamy, M., Lee, Y., Andrade, J., tenOever, B., & Manicassamy, B. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.045 · Cited by 266
Matrix Metalloproteinases as New Targets in Alzheimer’s Disease: Opportunities and Challenges
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Metadata
- Authors
- Okimoto, R. A., Breitenbuecher, F., Olivas, V. R., Wu, W., Gini, B., Hofree, M., Asthana, S., Hrustanovic, G., Flanagan, J., Tulpule, A., Blakely, C. M., Haringsma, H. J., Simmons, A. D., Gowen, K., Suh, J., Miller, V. A., Ali, S., Schuler, M., & Bivona, T. G.
- Venue
- Nature Genetics
- Published
- 2016-11-21
- Volume
- 49
- Issue
- 1
- Pages
- 87-96
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2553574746
- Cited by
- 160
- References
- 10
- FWCI
- 8.13
- Type
- journal article
- Language
- en
- Open access
- green
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- Okimoto, R. A., Breitenbuecher, F., Olivas, V. R., Wu, W., Gini, B., Hofree, M., Asthana, S., Hrustanovic, G., Flanagan, J., Tulpule, A., Blakely, C. M., Haringsma, H. J., Simmons, A. D., Gowen, K., Suh, J., Miller, V. A., Ali, S., Schuler, M., & Bivona, T. G. (2017). Inactivation of Capicua drives cancer metastasis. Nature Genetics. https://doi.org/10.1038/ng.3728
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