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Cited by 720

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

Open access
SpiroMeta Consortium, McKay, James D, Hung, Rayjean J, Han, Younghun, Zong, Xuchen, Carreras-Torres, Robert, Christiani, David C, Caporaso, Neil E, Johansson, Mattias, Xiao, Xiangjun, Li, Yafang, Byun, Jinyoung, Dunning, Alison, Pooley, Karen A, Qian, David C, Ji, Xuemei, Liu, Geoffrey, Timofeeva, Maria N, Bojesen, Stig E, Wu, Xifeng, Le Marchand, Loic, Albanes, Demetrios, Bickeböller, Heike, Aldrich, Melinda C, Bush, William S, Tardon, Adonina, Rennert, Gad, Teare, M Dawn, Field, John K, Kiemeney, Lambertus A, Lazarus, Philip, Haugen, Aage, Lam, Stephen, Schabath, Matthew B, Andrew, Angeline S, Shen, Hongbing, Hong, Yun-Chul, Yuan, Jian-Min, Bertazzi, Pier Alberto, Pesatori, Angela C, Ye, Yuanqing, Diao, Nancy, Su, Li, Zhang, Ruyang, Brhane, Yonathan, Leighl, Natasha, Johansen, Jakob S, Mellemgaard, Anders, Saliba, Walid, Haiman, Christopher A, Wilkens, Lynne R, Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, van der Heijden, Henricus F M, Kim, Jin Hee, Dai, Juncheng, Hu, Zhibin, Davies, Michael P A, Marcus, Michael W, Brunnström, Hans, Manjer, Jonas, Melander, Olle, Muller, David C, Overvad, Kim, Trichopoulou, Antonia, Tumino, Rosario, Doherty, Jennifer A, Barnett, Matt P, Chen, Chu, Goodman, Gary E, Cox, Angela, Taylor, Fiona, Woll, Penella, Brüske, Irene, Wichmann, H-Erich, Manz, Judith, Muley, Thomas R, Risch, Angela, Rosenberger, Albert, Grankvist, Kjell, Johansson, Mikael, Shepherd, Frances A, Tsao, Ming-Sound, Arnold, Susanne M, Haura, Eric B, Bolca, Ciprian, Holcatova, Ivana, Janout, Vladimir, Kontic, Milica, Lissowska, Jolanta, Mukeria, Anush, Ognjanovic, Simona, Orlowski, Tadeusz M, Scelo, Ghislaine, Swiatkowska, Beata, Zaridze, David, Bakke, Per, Skaug, Vidar, Zienolddiny, Shanbeh, Duell, Eric J, Butler, Lesley M, Koh, Woon-Puay, Gao, Yu-Tang, Houlston, Richard S, McLaughlin, John, Stevens, Victoria L, Joubert, Philippe, Lamontagne, Maxime, Nickle, David C, Obeidat, Ma'en, Timens, Wim, Zhu, Bin, Song, Lei, Kachuri, Linda, Artigas, María Soler, Tobin, Martin D, Wain, Louise V, Rafnar, Thorunn, Thorgeirsson, Thorgeir E, Reginsson, Gunnar W, Stefansson, Kari, Hancock, Dana B, Bierut, Laura J, Spitz, Margaret R, Gaddis, Nathan C, Lutz, Sharon M, Gu, Fangyi, Johnson, Eric O, Kamal, Ahsan, Pikielny, Claudio, Zhu, Dakai, Lindströem, Sara, Jiang, Xia, Tyndale, Rachel F, Chenevix-Trench, Georgia, Beesley, Jonathan, Bossé, Yohan, Chanock, Stephen, Brennan, Paul, Landi, Maria Teresa, Amos, Christopher I·2017·Nature Genetics
DOI 10.1038/ng.3892
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Abstract

Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genome-wide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer.

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Metadata

Authors
SpiroMeta Consortium, McKay, J. D., Hung, R. J., Han, Y., Zong, X., Carreras-Torres, R., Christiani, D. C., Caporaso, N. E., Johansson, M., Xiao, X., Li, Y., Byun, J., Dunning, A., Pooley, K. A., Qian, D. C., Ji, X., Liu, G., Timofeeva, M. N., Bojesen, S. E., Wu, X., Le Marchand, L., Albanes, D., Bickeböller, H., Aldrich, M. C., Bush, W. S., Tardon, A., Rennert, G., Teare, M. D., Field, J. K., Kiemeney, L. A., Lazarus, P., Haugen, A., Lam, S., Schabath, M. B., Andrew, A. S., Shen, H., Hong, Y.-C., Yuan, J.-M., Bertazzi, P. A., Pesatori, A. C., Ye, Y., Diao, N., Su, L., Zhang, R., Brhane, Y., Leighl, N., Johansen, J. S., Mellemgaard, A., Saliba, W., Haiman, C. A., Wilkens, L. R., Fernandez-Somoano, A., Fernandez-Tardon, G., van der Heijden, H. F. M., Kim, J. H., Dai, J., Hu, Z., Davies, M. P. A., Marcus, M. W., Brunnström, H., Manjer, J., Melander, O., Muller, D. C., Overvad, K., Trichopoulou, A., Tumino, R., Doherty, J. A., Barnett, M. P., Chen, C., Goodman, G. E., Cox, A., Taylor, F., Woll, P., Brüske, I., Wichmann, H.-E., Manz, J., Muley, T. R., Risch, A., Rosenberger, A., Grankvist, K., Johansson, M., Shepherd, F. A., Tsao, M.-S., Arnold, S. M., Haura, E. B., Bolca, C., Holcatova, I., Janout, V., Kontic, M., Lissowska, J., Mukeria, A., Ognjanovic, S., Orlowski, T. M., Scelo, G., Swiatkowska, B., Zaridze, D., Bakke, P., Skaug, V., Zienolddiny, S., Duell, E. J., Butler, L. M., Koh, W.-P., Gao, Y.-T., Houlston, R. S., McLaughlin, J., Stevens, V. L., Joubert, P., Lamontagne, M., Nickle, D. C., Obeidat, M., Timens, W., Zhu, B., Song, L., Kachuri, L., Artigas, M. S., Tobin, M. D., Wain, L. V., Rafnar, T., Thorgeirsson, T. E., Reginsson, G. W., Stefansson, K., Hancock, D. B., Bierut, L. J., Spitz, M. R., Gaddis, N. C., Lutz, S. M., Gu, F., Johnson, E. O., Kamal, A., Pikielny, C., Zhu, D., Lindströem, S., Jiang, X., Tyndale, R. F., Chenevix-Trench, G., Beesley, J., Bossé, Y., Chanock, S., Brennan, P., Landi, M. T., & Amos, C. I.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2017-06-12
Volume
49
Issue
7
Pages
1126-1132
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng.3892
OpenAlex
W2612427157
Cited by
720
References
42
FWCI
27.33
Type
journal article
Language
en
Open access
green

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The paper
SpiroMeta Consortium, McKay, J. D., Hung, R. J., Han, Y., Zong, X., Carreras-Torres, R., Christiani, D. C., Caporaso, N. E., Johansson, M., Xiao, X., Li, Y., Byun, J., Dunning, A., Pooley, K. A., Qian, D. C., Ji, X., Liu, G., Timofeeva, M. N., Bojesen, S. E., . . . Amos, C. I. (2017). Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Nature Genetics. https://doi.org/10.1038/ng.3892

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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