Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
ARUK Consortium, Sims, Rebecca, GERAD/PERADES, CHARGE, ADGC, EADI, van der Lee, Sven J, Naj, Adam C, Bellenguez, Céline, Badarinarayan, Nandini, Jakobsdottir, Johanna +443 more·2017·Nature Genetics
DOI 10.1038/ng.3916
Cited by (1,043)
Items 801–900 of 1,043
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- Network Medicine and Alzheimer’s Disease Therapy2018
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- A comparative study of structural variant calling strategies using the Alzheimer’s Disease Sequencing Project’s whole genome family dataJohn Stephen Malamon, John J. Farrell, Li Charlie Xia, Beth A. Dombroski, Wan‐Ping Lee, Gautami Das, Badri Narayan Vardarajan, Jessica Way, Amanda B Kuzma, Otto Valladares et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
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- Immunogenetic mechanism driving neurological and neurodegenerative disordersYounis Ahmad Hajam, Premlata Premlata, Raksha Rani, Riya Sharma, Preeti Sharma, Rajesh Kumar · 2022 · Elsevier eBooks
- Leveraging gene co-regulation to identify gene sets enriched for disease heritability2021
- The TMEM106B rs1990621 protective variant is also associated with increased neuronal proportionZeran Li, Fabiana Geraldo Farias, Umber Dube, Jorge L. Del‐Aguila, Kathie A. Mihindukulasuriya, María Victoria Fernández, Laura Ibáñez, John Budde, Fengxian Wang, Allison M. Lake et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
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- Personalized single-cell transcriptomics reveals molecular diversity in Alzheimer’s diseasePramod Bharadwaj Chandrashekar, Sayali Anil Alatkar, Noah Cohen Kalafut, Ting Jin, Chirag Gupta, Ryan Conway Burczak, Huang Xiang, Shuang Liu, Athan Z. Li, Aram Hong et al. · 2026 · Nature Communications
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- Novel small molecules inhibit proteotoxicity and inflammation: Mechanistic and therapeutic implications for Alzheimer’s Disease, healthspan and lifespan- Aging as a consequence of glycolysisRachel R Litke, James M. Vicari, Bik Tzu Huang, Lila R. Shapiro, Kun-Hyung Roh, Aaron E. Silver, Pooja Talreja, Nicolle Palacios, Yonejung Yoon, Christopher Paul Kellner et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
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MiceBevan, Ryan J., Maguire, Emily, Mackinnon, Eilish, Salis, Elisa, Phillips, Thomas, Simonazzi, Elena, Vassileva, Marieta, Allen, Nicholas D., Williams, Julie, Taylor, Philip R. · 2026 · Glia
- Mechanisms of increased Alzheimer’s disease pathology with R47H and R62H TREM2 variantsNurun Nahar Fancy, Nanet Willumsen, Vicky M. N. Chau, Samuel L Boulger, Harry J. Whitwell, Wenhao Wang, Baptiste Avot, Michael Thomas, Jonathan Talbot-Martin, Stergios Tsartsalis et al. · 2026 · Acta Neuropathologica
- Evaluation of gene-based family-based methods to detect novel genes associated with familial late onset Alzheimer disease2018
- Integrative genomics and single-cell CRISPRi screening dissect Alzheimer GWAS non-coding variants regulating TSPAN14Shannon Laub, Natalia M. Tulina, Matthew Hoffman, Joe Faryean, Sandhya Ramachandran, Bao Khanh Trang, Stephanie M. Lewkiewicz, Alessandra Chesi · 2026 · The American Journal of Human Genetics
- A guide to selecting high-performing antibodies for PLC-gamma-2 for use in Western Blot, immunoprecipitation and immunofluorescenceRuíz Moleón, Vera, Fotouhi, Maryam, Alende, Charles, Ayoubi, Riham, Bedford, Logan M., Southern, Kathleen, Richardson, Timothy I., Laflamme, Carl, NeuroSGC/YCharOS/EDDU collaborative group, ABIF consortium · 2024 · F1000Research
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- Heterozygous expression of the Alzheimer’s disease protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses.Shiden Solomon, Nirmal Kumar Sampathkumar, Ivo Carre, Mrityunjoy Mondal, George Chennell, Anthony Christopher Vernon, Marc‐David Ruepp, Jacqueline C. Mitchell · 2022 · Research Square
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- Polygenic risk score analysis identifies deleterious protein-coding variants in novel immune pathway genes ATP8B4, FCGR1A , and LILRB1 that associate with Alzheimer’s diseaseJoseph S. Reddy, Xue Wang, Mariet Allen, Minerva M. Carrasquillo, Joanna M. Biernacka, Gregory D. Jenkins, Brandon J. Coombes, Olivia Belbin, Todd Eliot Golde, Nilüfer Ertekin‐Taner et al. · 2022 · medRxiv
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- Intelligent diagnostic technology in multi-party joint intervention to explore improvement of neurocognitive statusWei Baojian, Lang Yanmei, Chunyu Li · 2020 · Journal of Intelligent & Fuzzy Systems