Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Cited by (1,043)

Items 101–200 of 1,043

1. Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk
   Mitja Mitrovič, Nikolaos A. Patsopoulos, Ashley Harris Beecham, Theresa Dankowski, An Goris, Bénédicte Dubois, Marie Beatrice D'hooghe, Robin Lemmens, Philip Van Damme, Helle Bach Søndergaard et al. · 2018 · Cell
2. PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia
   Rustenhoven, Justin, Smith, Amy M., Smyth, Leon C., Jansson, Deidre, Scotter, Emma L., Swanson, Molly E. V., Aalderink, Miranda, Coppieters, Natacha, Narayan, Pritika, Handley, Renee et al. · 2018 · Molecular Neurodegeneration
3. Neuroimmune Connections in Aging and Neurodegenerative Diseases
   Scheiblich, Hannah, Trombly, Melanie, Ramirez, Alfredo, Heneka, Michael T. · 2020 · Trends in Immunology
4. The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans
   Xiang, Xianyuan, Piers, Thomas M., Wefers, Benedikt, Zhu, Kaichuan, Mallach, Anna, Brunner, Bettina, Kleinberger, Gernot, Song, Wilbur, Colonna, Marco, Herms, Jochen et al. · 2018 · Molecular Neurodegeneration
5. The new genetic landscape of Alzheimer’s disease: from amyloid cascade to genetically driven synaptic failure hypothesis?
   Dourlen, Pierre, Kilinc, Devrim, Malmanche, Nicolas, Chapuis, Julien, Lambert, Jean-Charles · 2019 · Acta Neuropathologica
6. Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation
   Castillo, Erika, Leon, Julio, Mazzei, Guianfranco, Abolhassani, Nona, Haruyama, Naoki, Saito, Takashi, Saido, Takaomi, Hokama, Masaaki, Iwaki, Toru, Ohara, Tomoyuki et al. · 2017 · Scientific Reports
7. Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease: Current Evidence and Future Perspectives
   Donovan Anthony McGrowder, Fabian G. Miller, Kurt Vaz, Chukwuemeka R. Nwokocha, Cameil F. Wilson-Clarke, Melisa Anderson, Jabari Brown, Lennox Anderson-Jackson, Lowen Williams, Lyndon Latore et al. · 2021 · Brain Sciences
8. Gene-environment interactions in Alzheimer's disease: A potential path to precision medicine
   Eid, Aseel, Mhatre, Isha, Richardson, Jason R. · 2019 · Pharmacology & Therapeutics
9. Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets
   Nizami, Sohaib, Hall‐Roberts, Hazel, Warrier, Sharat, Cowley, Sally A., Di Daniel, Elena · 2019 · British Journal of Pharmacology
10. Epigenome-wide meta-analysis of DNA methylation differences in prefrontal cortex implicates the immune processes in Alzheimer’s disease
    Zhang, Lanyu, Silva, Tiago C., Young, Juan I., Gomez, Lissette, Schmidt, Michael A., Hamilton-Nelson, Kara L., Kunkle, Brian W., Chen, Xi, Martin, Eden R., Wang, Lily · 2020 · Nature Communications
11. A global view of the genetic basis of Alzheimer disease
    C. Reitz, M. Pericak-Vance, T. Foroud, R. Mayeux · 2023 · Nature Reviews Neurology
12. Neuroinflammation represents a common theme amongst genetic and environmental risk factors for Alzheimer and Parkinson diseases
    Rachel J. Boyd, Dimitrios Avramopoulos, Lauren L. Jantzie, Andrew S. McCallion · 2022 · Journal of Neuroinflammation
13. Tumor Necrosis Factor (TNF) blocking agents are associated with lower risk for Alzheimer’s disease in patients with rheumatoid arthritis and psoriasis
    Zhou, Mengshi, Xu, Rong, Kaelber, David C., Gurney, Mark E. · 2020 · PLOS ONE
14. Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer’s disease
    Angela Jeong, Kiall F. Suazo, W. Gibson Wood, Mark Dewey Distefano, Ling Li · 2018 · Critical Reviews in Biochemistry and Molecular Biology
15. Omics sciences for systems biology in Alzheimer’s disease: State-of-the-art of the evidence
    Harald Juergen Hampel, Robert Nisticò, Nicholas T. Seyfried, Allan I. Levey, Erica S. Modeste, Pablo Lemercier, Filippo Baldacci, Nicola Toschi, Francesco Garaci, George L. Perry et al. · 2021 · Ageing Research Reviews
16. Retinal changes in Alzheimer's disease— integrated prospects of imaging, functional and molecular advances
    Veer Bala Gupta, Nitin Chitranshi, Jurre den Haan, Mehdi Mirzaei, Yuyi You, Jeremiah K. H. Lim, Devaraj K. Basavarajappa, Angela Godinez, Silvia Di Angelantonio, Perminder Singh Sachdev et al. · 2020 · Progress in Retinal and Eye Research
17. Protective genes and pathways in Alzheimer’s disease: moving towards precision interventions
    Seto, Mabel, Weiner, Rebecca L., Dumitrescu, Logan, Hohman, Timothy J. · 2021 · Molecular Neurodegeneration
18. Translating genetic risk of Alzheimer’s disease into mechanistic insight and drug targets
    Annerieke S. R. Sierksma, Valentina Escott‐Price, Bart De Strooper · 2020 · Science
19. Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models
    Sebastian Monasor, Laura, Müller, Stephan A, Colombo, Alessio Vittorio, Tanrioever, Gaye, König, Jasmin, Roth, Stefan, Liesz, Arthur, Berghofer, Anna, Piechotta, Anke, Prestel, Matthias et al. · 2020 · eLife
20. NEAT1 and paraspeckles in neurodegenerative diseases: A missing lnc found?
    Haiyan An, Non G. Williams, Tatyana A. Shelkovnikova · 2018 · Non-coding RNA Research
21. Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers
    Jansen, Iris E., van der Lee, Sven J., Gomez-Fonseca, Duber, de Rojas, Itziar, Dalmasso, Maria Carolina, Grenier-Boley, Benjamin, Zettergren, Anna, Mishra, Aniket, Ali, Muhammad, Andrade, Victor et al. · 2022 · Acta Neuropathologica
22. Human iPSC‐derived microglia: A growing toolset to study the brain's innate immune cells
    Hasselmann, Jonathan, Blurton‐Jones, Mathew · 2020 · Glia
23. Neuroinflammation and fractalkine signaling in Alzheimer’s disease
    Dylan J. Finneran, Kevin R. Nash · 2019 · Journal of Neuroinflammation
24. Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph
    Magno, Lorenza, Lessard, Christian B., Martins, Marta, Lang, Verena, Cruz, Pedro, Asi, Yasmine, Katan, Matilda, Bilsland, Jamie, Lashley, Tammaryn, Chakrabarty, Paramita et al. · 2019 · Alzheimer's Research & Therapy
25. Concomitant memantine and Lactobacillus plantarum treatment attenuates cognitive impairments in APP/PS1 mice
    Qiujun Wang, Yue’e Shen, Xin Wang, Shuang Fu, Xin Zhang, Yina Zhang, Ruitao Wang · 2020 · Aging
26. Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer’s disease
    Broce, Iris J., Tan, Chin Hong, Fan, Chun Chieh, Jansen, Iris, Savage, Jeanne E., Witoelar, Aree, Wen, Natalie, Hess, Christopher P., Dillon, William P., Glastonbury, Christine M. et al. · 2019 · Acta Neuropathologica
27. Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation
    Ewers, Michael, Biechele, Gloria, Suárez‐Calvet, Marc, Sacher, Christian, Blume, Tanja, Morenas‐Rodriguez, Estrella, Deming, Yuetiva, Piccio, Laura, Cruchaga, Carlos, Kleinberger, Gernot et al. · 2020 · EMBO Molecular Medicine
28. Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer’s disease-like neuroinflammation and cognitive impairment
    Shulan Qiu, Juan Pablo Palavicini, Jianing Wang, Nancy S. Gonzalez, Sijia He, Elizabeth Dustin, Cheng Zou, Lin Ding, Anindita Bhattacharjee, Candice E. Van Skike et al. · 2021 · Molecular Neurodegeneration
29. Plasma lipidome is dysregulated in Alzheimer’s disease and is associated with disease risk genes
    Yue Liu, Anbupalam Thalamuthu, Karen A. Mather, John D. Crawford, Marina Ulanova, Matthew Wai Kin Wong, Russell Pickford, Perminder Singh Sachdev, Nady Braidy · 2021 · Translational Psychiatry
30. Multimodal Data Analysis of Alzheimer's Disease Based on Clustering Evolutionary Random Forest
    Xia-an Bi, Xi Hu, Hao Wu, Yang Wang · 2020 · IEEE Journal of Biomedical and Health Informatics
31. SORL1 genetic variants and Alzheimer disease risk: a literature review and meta-analysis of sequencing data
    Campion, Dominique, Charbonnier, Camille, Nicolas, Gaël · 2019 · Acta Neuropathologica
32. The Sant Pau Initiative on Neurodegeneration (SPIN) cohort: A data set for biomarker discovery and validation in neurodegenerative disorders
    Daniel Andres Alcolea, Jordi Clarimón, María Carmona‐Iragui, Ignacio Illán‐Gala, Estrella Morenas‐Rodríguez, Isabel Barroeta, Roser Ribosa Nogué, Isabel Sala, María Belén Sánchez‐Saudinós, Laura Videla et al. · 2019 · Alzheimer s & Dementia Translational Research & Clinical Interventions
33. Diversity of transcriptomic microglial phenotypes in aging and Alzheimer's disease
    Delphine Boche, Marcia N. Gordon · 2021 · Alzheimer s & Dementia
34. Post-translational modifications: Regulators of neurodegenerative proteinopathies
    Rohan V. Gupta, Mehar Sahu, Devesh Srivastava, Swati Tiwari, Rashmi K. Ambasta, Pravir Kumar · 2021 · Ageing Research Reviews
35. A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity
    DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank), van der Lee, Sven J., EADB (Alzheimer Disease European DNA biobank), IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia), Netherlands Brain Bank (NBB), The GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, Conway, Olivia J., Jansen, Iris et al. · 2019 · Acta Neuropathologica
36. TLR4 Targeting as a Promising Therapeutic Strategy for Alzheimer Disease Treatment
    Yongji Zhou, Yanxing Chen, Congcong Xu, Hao Zhang, Caixiu Lin · 2020 · Frontiers in Neuroscience
37. Potential Bidirectional Relationship Between Periodontitis and Alzheimer’s Disease
    Daniela Liccardo, Federica Marzano, Federica Carraturo, Marco Guida, Grazia Daniela Femminella, Leonardo Bencivenga, Jacopo Agrimi, Armida Addonizio, Imma Melino, Alessandra Valletta et al. · 2020 · Frontiers in Physiology
38. Genetic and environmental factors in Alzheimer’s and Parkinson’s diseases and promising therapeutic intervention via fecal microbiota transplantation
    Hui Wang, Feng Yang, Shidong Zhang, Ruihua Xin, Yan Sun · 2021 · npj Parkinson s Disease
39. Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples
    Prokop, Stefan, Miller, Kelly R., Labra, Sergio R., Pitkin, Rose M., Hoxha, Kevt’her, Narasimhan, Sneha, Changolkar, Lakshmi, Rosenbloom, Alyssa, Lee, Virginia M.-Y., Trojanowski, John Q. · 2019 · Acta Neuropathologica
40. TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease
    Yueran Li, Huifang Xu, Huifang Wang, Kui Yang, Jiajie Luan, Sheng Wang · 2023 · Biomedicine & Pharmacotherapy
41. Differential Phagocytic Properties of CD45low Microglia and CD45high Brain Mononuclear Phagocytes—Activation and Age-Related Effects
    Rangaraju, Srikant, Raza, Syed Ali, Li, Noel Xiang’An, Betarbet, Ranjita, Dammer, Eric B., Duong, Duc, Lah, James J., Seyfried, Nicholas T., Levey, Allan I. · 2018 · Frontiers in Immunology
42. Genetic risk for alzheimer disease is distinct from genetic risk for amyloid deposition
    Leonenko, Ganna, Shoai, Maryam, Bellou, Eftychia, Sims, Rebecca, Williams, Julie, Hardy, John, Escott‐Price, Valentina, the Alzheimer's Disease Neuroimaging Initiative · 2019 · Annals of Neurology
43. Genetic architecture of Alzheimer's disease
    Neuner, Sarah M., TCW, Julia, Goate, Alison M. · 2020 · Neurobiology of Disease
44. Leveraging preclinical models for the development of Alzheimer disease therapeutics
    Kimberly A. Scearce-Levie, Pascal E. Sanchez, Joseph W. Lewcock · 2020 · Nature Reviews Drug Discovery
45. Disease-Modifying Therapies for Alzheimer’s Disease: More Questions than Answers
    Golde, Todd E. · 2022 · Neurotherapeutics
46. Pharmacokinetics and pharmacodynamics of a single dose Nilotinib in individuals with Parkinson's disease
    Fernando Pagán, Michaeline L. Hebron, Barbara Wilmarth, Yasar A. Torres-Yaghi, Abigail Lawler, Elizabeth E. Mundel, Nadia Yusuf, Nathan J. Starr, Joy Arellano, Helen H. Howard et al. · 2019 · Pharmacology Research & Perspectives
47. Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery
    Zane Jaunmuktane, Annelies Quaegebeur, Ricardo Jorge Ferreira Taipa, Miguel Viana Baptista, Raquel Pinheiro Barbosa, Carolin Koriath, Raf Sciot, Simon Mead, Sebastian Brandner · 2018 · Acta Neuropathologica
48. Decreased levels of circulating trimethylamine N-oxide alleviate cognitive and pathological deterioration in transgenic mice: a potential therapeutic approach for Alzheimer’s disease
    Qiang Gao, Yuan Wang, Xin Wang, Shuang Fu, Xin Zhang, Ruitao Wang, Xin Zhang · 2019 · Aging
49. Stimulation of TREM2 with agonistic antibodies—an emerging therapeutic option for Alzheimer's disease
    Kai Schlepckow, Estrella Morenas‐Rodríguez, Soyon Youngae Hong, Christian Haass · 2023 · The Lancet Neurology
50. PHOSPHOLIPASE C
    C. Bill, C. Vines · 2019 · Advances in Experimental Medicine and Biology
51. Genetic variability in response to amyloid beta deposition influences Alzheimer’s disease risk
    Salih, Dervis A, Bayram, Sevinc, Guelfi, Sebastian, Reynolds, Regina H, Shoai, Maryam, Ryten, Mina, Brenton, Jonathan W, Zhang, David, Matarin, Mar, Botia, Juan A et al. · 2019 · Brain Communications
52. Osteoarthritis year in review 2019: genetics, genomics and epigenetics
    Louise N. Reynard, Matt J. Barter · 2019 · Osteoarthritis and Cartilage
53. A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the <i>OAS1</i> gene
    Magusali, Naciye, Graham, Andrew C, Piers, Thomas M, Panichnantakul, Pantila, Yaman, Umran, Shoai, Maryam, Reynolds, Regina H, Botia, Juan A, Brookes, Keeley J, Guetta-Baranes, Tamar et al. · 2021 · Brain
54. New tricks for an ancient system: Physiological and pathological roles of complement in the CNS
    Andrea J. Tenner, Beth Stevens, Trent M. Woodruff · 2018 · Molecular Immunology
55. Organotypic brain slice cultures to model neurodegenerative proteinopathies
    Cara L. Croft, Hunter S. Futch, Brenda D. Moore, Todd Eliot Golde · 2019 · Molecular Neurodegeneration
56. Interpretable deep learning translation of GWAS and multi-omics findings to identify pathobiology and drug repurposing in Alzheimer’s disease
    Xu, Jielin, Mao, Chengsheng, Hou, Yuan, Luo, Yuan, Binder, Jessica L., Zhou, Yadi, Bekris, Lynn M., Shin, Jiyoung, Hu, Ming, Wang, Fei et al. · 2022 · Cell Reports
57. The role of the immune system in Alzheimer’s disease
    Kaimin Wu, Ya-Ru Zhang, Yuyuan Huang, Qiang Dong, Lan Tan, Jin‐Tai Yu · 2021 · Ageing Research Reviews
58. TREM2 ectodomain and its soluble form in Alzheimer’s disease
    Yang, Jiaolong, Fu, Zhihui, Zhang, Xingyu, Xiong, Min, Meng, Lanxia, Zhang, Zhentao · 2020 · Journal of Neuroinflammation
59. INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia
    Tsai, Andy P., Lin, Peter Bor-Chian, Dong, Chuanpeng, Moutinho, Miguel, Casali, Brad T., Liu, Yunlong, Lamb, Bruce T., Landreth, Gary E., Oblak, Adrian L., Nho, Kwangsik · 2021 · Neurobiology of Disease
60. The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration
    Jackson, Jacob T., Mulazzani, Elisabeth, Nutt, Stephen L., Masters, Seth L. · 2021 · Journal of Biological Chemistry
61. Microglial efferocytosis: Diving into the Alzheimer’s disease gene pool
    Romero-Molina, Carmen, Garretti, Francesca, Andrews, Shea J., Marcora, Edoardo, Goate, Alison M. · 2022 · Neuron
62. Association between metabolic syndrome and risk of incident dementia in UK Biobank
    Danial Qureshi, Jennifer A. Collister, Naomi E. Allen, Elżbieta Kuźma, Thomas J. Littlejohns · 2023 · Alzheimer s & Dementia
63. ABI3 and PLCG2 missense variants as risk factors for neurodegenerative diseases in Caucasians and African Americans
    Conway, Olivia J, Carrasquillo, Minerva M, Wang, Xue, Bredenberg, Jenny M, Reddy, Joseph S, Strickland, Samantha L, Younkin, Curtis S, Burgess, Jeremy D, Allen, Mariet, Lincoln, Sarah J et al. · 2018 · Molecular Neurodegeneration
64. Whole-genome sequencing reveals new Alzheimer’s disease–associated rare variants in loci related to synaptic function and neuronal development
    Prokopenko, Dmitry, Morgan, Sarah L., Mullin, Kristina, Hofmann, Oliver, Chapman, Brad, Kirchner, Rory, Alzheimer's Disease Neuroimaging Initiative (ADNI), Amberkar, Sandeep, Wohlers, Inken, Lange, Christoph et al. · 2021 · Alzheimer's &amp; Dementia
65. Systemic and CNS Inflammation Crosstalk: Implications for Alzheimer’s Disease
    Evi Paouri, Spiros Georgopoulos · 2019 · Current Alzheimer Research
66. Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation
    Anna Vilalta, Ye Zhou, Jean Sévalle, Jennifer K. Griffin, Kanayo Satoh, David H. Allendorf, Suman De, Mar Puigdellívol, Arturas Bruzas, Miguel Ángel Burguillos et al. · 2021 · Journal of Biological Chemistry
67. Complement-Mediated Events in Alzheimer’s Disease: Mechanisms and Potential Therapeutic Targets
    Andrea J. Tenner · 2020 · The Journal of Immunology
68. Insight into the genetic etiology of Alzheimer's disease: A comprehensive review of the role of rare variants
    Julie Hoogmartens, Rita Cacace, Christine Van Broeckhoven · 2021 · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
69. Piezo1 channel‐mediated C a2+ signaling inhibits lipopolysaccharide‐induced activation of the NF‐κB inflammatory signaling pathway and generation of TNF ‐α and IL ‐6 in microglial cells
    Philippa Malko, Xiaoling Jia, Ian Wood, Lin‐Hua Jiang · 2022 · Glia
70. Unsupervised excitation: GABAergic dysfunctions in Alzheimer’s disease
    Eleonora Ambrad Giovannetti, Martin Fuhrmann · 2018 · Brain Research
71. Polygenic regression uncovers trait-relevant cellular contexts through pathway activation transformation of single-cell RNA sequencing data
    Yunlong Ma, Chunyu Deng, Yijun Zhou, Yaru Zhang, Fei Qiu, Dingping Jiang, Gongwei Zheng, Jingjing Li, Jianwei Shuai, Yan Zhang et al. · 2023 · Cell Genomics
72. The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease
    Moutinho, Miguel, Puntambekar, Shweta S., Tsai, Andy P., Coronel, Israel, Lin, Peter B., Casali, Brad T., Martinez, Pablo, Oblak, Adrian L., Lasagna-Reeves, Cristian A., Lamb, Bruce T. et al. · 2022 · Science Translational Medicine
73. Measuring heritable contributions to Alzheimer’s disease: polygenic risk score analysis with twins
    Ida Karlsson, Valentina Escott‐Price, Margaret Gatz, John Hardy, Nancy L. Pedersen, Maryam Shoai, Chandra A. Reynolds · 2021 · Brain Communications
74. Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics
    Yogatheesan Varatharajah, Vijay K. Ramanan, Ravishankar K. Iyer, Prashanthi Vemuri, Alzheimer’s Disease Neuroimaging Initiative, Michael Walter Weiner, Paul Aisen, Ronald Carl Petersen, Clifford R. Jack, Andrew J. Saykin et al. · 2019 · Scientific Reports
75. Linking mechanisms of periodontitis to Alzheimer's disease
    Mahtab Sadrameli, Praveen Bathini, Lavinia Auber Alberi · 2020 · Current Opinion in Neurology
76. Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer’s disease
    Tracy L. Young‐Pearse, Hyo Lee, Yi‐Chen Hsieh, Vicky Chou, Dennis J. Selkoe · 2023 · Trends in Neurosciences
77. Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis
    Zhou, Xiaopu, Chen, Yu, Mok, Kin Y., Zhao, Qianhua, Chen, Keliang, Chen, Yuewen, Hardy, John, Li, Yun, Fu, Amy K. Y., Guo, Qihao et al. · 2018 · Proceedings of the National Academy of Sciences
78. Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers
    Logan Brase, Shih‐Feng You, Ricardo D’Oliveira Albanus, Jorge L. Del‐Aguila, Yaoyi Dai, Brenna C. Novotny, Carolina Soriano‐Tárraga, Taitea Dykstra, María Victoria Fernández, John Budde et al. · 2023 · Nature Communications
79. Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations
    Hajicek, Nicole, Keith, Nicholas C, Siraliev-Perez, Edhriz, Temple, Brenda RS, Huang, Weigang, Zhang, Qisheng, Harden, T Kendall, Sondek, John · 2019 · eLife
80. Inflammatory Cascade in Alzheimer’s Disease Pathogenesis: A Review of Experimental Findings
    Jade de Oliveira, Ewa Kucharska, Michelle Lima Garcez, Matheus Scarpatto Rodrigues, João Quevedo, Inés Moreno‐González, Josiane Budni · 2021 · Cells
81. Genomics of Alzheimer’s disease implicates the innate and adaptive immune systems
    Yihan Li, Simon Matthew Laws, Luke A. Miles, James S. Wiley, Xin Huang, Colin Louis Masters, Ben J. Gu · 2021 · Cellular and Molecular Life Sciences
82. Inhibition of Bruton's Tyrosine Kinase Modulates Microglial Phagocytosis: Therapeutic Implications for Alzheimer's Disease
    Keaney, James, Gasser, Julien, Gillet, Gaëlle, Scholz, Diana, Kadiu, Irena · 2019 · Journal of Neuroimmune Pharmacology
83. Alzheimer’s disease polygenic risk score as a predictor of conversion from mild-cognitive impairment
    Sultan Raja Chaudhury, Keeley J. Brookes, Tulsi Patel, Abigail Fallows, Tamar Guetta‐Baranes, James C. Turton, Rita João Guerreiro, José Brás, John Hardy, Paul T. Francis et al. · 2019 · Translational Psychiatry
84. Phospholipase C families: Common themes and versatility in physiology and pathology
    Katan, Matilda, Cockcroft, Shamshad · 2020 · Progress in Lipid Research
85. Microglia and astrocyte involvement in neurodegeneration and brain cancer
    Arthur A. Vandenbark, Halina Offner, Szymon Matejuk, Agata Matejuk · 2021 · Journal of Neuroinflammation
86. Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease
    Terzioglu, Gizem, Young-Pearse, Tracy L. · 2023 · Molecular Neurodegeneration
87. TREM2 in Alzheimer’s Disease: Microglial Survival and Energy Metabolism
    Zheng, Honghua, Cheng, Baoying, Li, Yanfang, Li, Xin, Chen, Xiaofen, Zhang, Yun-wu · 2018 · Frontiers in Aging Neuroscience
88. Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults
    Yang, Hyun‐Sik, Zhang, Can, Carlyle, Becky C., Zhen, Sherri Y., Trombetta, Bianca A., Schultz, Aaron P., Pruzin, Jeremy J., Fitzpatrick, Colleen D., Yau, Wai‐Ying W., Kirn, Dylan R. et al. · 2022 · Alzheimer's &amp; Dementia
89. Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance
    Singh, Neeraj, Das, Brati, Zhou, John, Hu, Xiangyou, Yan, Riqiang · 2022 · Science Advances
90. Blood will out: vascular contributions to Alzheimer’s disease
    Sidney Strickland · 2018 · Journal of Clinical Investigation
91. Step by step: towards a better understanding of the genetic architecture of Alzheimer’s disease
    Lambert, Jean-Charles, Ramirez, Alfredo, Grenier-Boley, Benjamin, Bellenguez, Céline · 2023 · Molecular Psychiatry
92. Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease
    Rathore, Nisha, Ramani, Sree Ranjani, Pantua, Homer, Payandeh, Jian, Bhangale, Tushar, Wuster, Arthur, Kapoor, Manav, Sun, Yonglian, Kapadia, Sharookh B., Gonzalez, Lino et al. · 2018 · PLOS Genetics
93. PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer’s disease
    Tsai, Andy P., Dong, Chuanpeng, Lin, Peter Bor-Chian, Messenger, Evan J., Casali, Brad T., Moutinho, Miguel, Liu, Yunlong, Oblak, Adrian L., Lamb, Bruce T., Landreth, Gary E. et al. · 2022 · Genome Medicine
94. Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model
    Wang, Hong, Li, Yupeng, Ryder, John W., Hole, Justin T., Ebert, Philip J., Airey, David C., Qian, Hui-Rong, Logsdon, Benjamin, Fisher, Alice, Ahmed, Zeshan et al. · 2018 · Molecular Neurodegeneration
95. Alzheimer’s disease – the journey of a healthy brain into organ failure
    Todd Eliot Golde · 2022 · Molecular Neurodegeneration
96. New insights on the genetic etiology of Alzheimer’s and related dementia
    2020
97. Tau at the interface between neurodegeneration and neuroinflammation
    Didonna, Alessandro · 2020 · Genes &amp; Immunity
98. Sex-specific effects of microglial activation on Alzheimer’s disease proteinopathy in older adults
    Kaitlin Blackstone Casaletto, Emma L. Nichols, Vahan Aslanyan, Stephanie M. Simone, Jennifer S. Rabin, Renaud La Joie, Adam M. Brickman, Kristen Dams-O’Connor, Priya Palta, Raj G. Kumar et al. · 2022 · Brain
99. Complement C7is a novel risk gene for Alzheimer's disease in Han Chinese
    Dengfeng Zhang, Yu Fan, Min Xu, Guihong Wang, Dong Wang, Jin Li, Lili Kong, Hejiang Zhou, Rongcan Luo, Rui Bi et al. · 2018 · National Science Review
100. Classification Methods Based on Complexity and Synchronization of Electroencephalography Signals in Alzheimer’s Disease
     Nobukawa, Sou, Yamanishi, Teruya, Kasakawa, Shinya, Nishimura, Haruhiko, Kikuchi, Mitsuru, Takahashi, Tetsuya · 2020 · Frontiers in Psychiatry