Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Cited by (1,043)

Items 201–300 of 1,043

1. Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer’s Disease
   Mikael Marttinen, Mari Takalo, Teemu Natunen, Rebekka Wittrahm, Sami Gabbouj, Susanna Kemppainen, Ville Leinonen, Heikki Tanila, Annakaisa Haapasalo, Mikko O. Hiltunen · 2018 · Frontiers in Neuroscience
2. CARMA is a new Bayesian model for fine-mapping in genome-wide association meta-analyses
   Zi-Kun Yang, Chen Wang, Lin-Xi Liu, Atlas Khan, Annie J Lee, B. Vardarajan, R. Mayeux, Krzysztof Kiryluk, I. Ionita-Laza · 2023 · Nature Genetics
3. Amygdala and anterior cingulate transcriptomes from individuals with bipolar disorder reveal downregulated neuroimmune and synaptic pathways
   Peter P. Zandi, Andrew E. Jaffe, Fernando S. Goes, Emily E. Burke, Leonardo Collado‐Torres, Louise A. Huuki-Myers, Arta Seyedian, Yian Lin, Fayaz Seifuddin, Mehdi Pirooznia et al. · 2022 · Nature Neuroscience
4. Apolipoprotein E4 and meningeal lymphatics in Alzheimer disease: a conceptual framework
   Alexios‐Fotios A. Mentis, Efthimios Dardiotis, George Panagiotis Chrousos · 2020 · Molecular Psychiatry
5. APOE4 confers transcriptomic and functional alterations to primary mouse microglia
   Machlovi, Saima I., Neuner, Sarah M., Hemmer, Brittany M., Khan, Riana, Liu, Yiyuan, Huang, Min, Zhu, Jeffrey D., Castellano, Joseph M., Cai, Dongming, Marcora, Edoardo et al. · 2022 · Neurobiology of Disease
6. Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden
   Haure-Mirande, Jean-Vianney, Wang, Minghui, Audrain, Mickael, Fanutza, Tomas, Kim, Soong Ho, Heja, Szilvia, Readhead, Ben, Dudley, Joel T., Blitzer, Robert D., Schadt, Eric E. et al. · 2019 · Molecular Psychiatry
7. Role of Genetics and Epigenetics in the Pathogenesis of Alzheimer’s Disease and Frontotemporal Dementia
   Chiara Fenoglio, Elio Angelo Scarpini, María Serpente, Daniela Galimberti · 2018 · Journal of Alzheimer s Disease
8. The pericyte–glia interface at the blood–brain barrier
   Giannoni, Patrizia, Badaut, Jerome, Dargazanli, Cyril, De Maudave, Alexis Fayd’Herbe, Klement, Wendy, Costalat, Vincent, Marchi, Nicola · 2018 · Clinical Science
9. Artificial intelligence for drug discovery and development in Alzheimer's disease
   Qiu, Yunguang, Cheng, Feixiong · 2024 · Current Opinion in Structural Biology
10. The Dual Role of Amyloid Beta-Peptide in Oxidative Stress and Inflammation: Unveiling Their Connections in Alzheimer’s Disease Etiopathology
    Hugo Fanlo-Ucar, Pol Picón-Pagès, Víctor Herrera-Fernández, Gerard ILL‐Raga, Francisco J. Muñoz · 2024 · Antioxidants
11. Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis
    Luke A. Miles, Stefan J. Hermans, Gabriela A. N. Crespi, Jonathan H. Gooi, Larissa Doughty, Tracy L. Nero, Jasmina Markulić, Andreas Ebneth, Berthold Wroblowski, Daniel Oehlrich et al. · 2019 · iScience
12. The Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes immune functions
    Takalo, Mari, Wittrahm, Rebekka, Wefers, Benedikt, Parhizkar, Samira, Jokivarsi, Kimmo, Kuulasmaa, Teemu, Mäkinen, Petra, Martiskainen, Henna, Wurst, Wolfgang, Xiang, Xianyuan et al. · 2020 · Molecular Neurodegeneration
13. Toll-Like Receptor 4: A Promising Therapeutic Target for Alzheimer’s Disease
    Linyu Wu, Xiao‐Hui Xian, Guangyu Xu, Zixuan Tan, Fang Dong, Min Zhang, Feng Zhang · 2022 · Mediators of Inflammation
14. Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer’s disease in comparison with healthy aging
    Maria Conte, Jacopo Sabbatinelli, Antonio Chiariello, Morena Martucci, Aurelia Santoro, Daniela Monti, Marina Arcaro, Daniela Galimberti, Elio Angelo Scarpini, Anna Rita Bonfigli et al. · 2020 · GeroScience
15. MOSTWAS: Multi-Omic Strategies for Transcriptome-Wide Association Studies
    Arjun Bhattacharya, Yun Li, Michael I. Love · 2021 · PLoS Genetics
16. CNS Border-Associated Macrophages: Ontogeny and Potential Implication in Disease
    Iasonas Dermitzakis, Paschalis Theotokis, Paschalis Evangelidis, Efthymia Delilampou, Nikolaos Evangelidis, Anastasia Chatzisavvidou, Eleni Avramidou, Maria Eleni Μanthou · 2023 · Current Issues in Molecular Biology
17. Clinical pet imaging of microglial activation: Implications for microglial therapeutics in alzheimer’s disease
    Shen, Zhiwei, Bao, Xinjie, Wang, Renzhi · 2018 · Frontiers in Aging Neuroscience
18. The Role of Genetics in Advancing Precision Medicine for Alzheimer’s Disease—A Narrative Review
    Yun Freudenberg‐Hua, Wentian Li, Peter Davies · 2018 · Frontiers in Medicine
19. Tracking neuroinflammatory biomarkers in Alzheimer’s disease: a strategy for individualized therapeutic approaches?
    Lista, Simone, Imbimbo, Bruno P., Grasso, Margherita, Fidilio, Annamaria, Emanuele, Enzo, Minoretti, Piercarlo, López-Ortiz, Susana, Martín-Hernández, Juan, Gabelle, Audrey, Caruso, Giuseppe et al. · 2024 · Journal of Neuroinflammation
20. Proteomics of neurodegenerative diseases: analysis of human post‐mortem brain
    Ka Wan Li, Andrea B. Ganz, August Benjamin Smit · 2018 · Journal of Neurochemistry
21. Identification of conserved proteomic networks in neurodegenerative dementia
    Swarup, Vivek, Chang, Timothy S., Duong, Duc M., Dammer, Eric B., Lah, James J., Johnson, Erik E.C.B., Seyfried, Nicholas T., Levey, Allan I., Geschwind, Daniel H. · 2019
22. BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation
    Sartori, Maxime, Mendes, Tiago, Desai, Shruti, Lasorsa, Alessia, Herledan, Adrien, Malmanche, Nicolas, Mäkinen, Petra, Marttinen, Mikael, Malki, Idir, Chapuis, Julien et al. · 2019 · Acta Neuropathologica
23. Identification of Conserved Proteomic Networks in Neurodegenerative Dementia
    Swarup, Vivek, Chang, Timothy S., Duong, Duc M., Dammer, Eric B., Dai, Jingting, Lah, James J., Johnson, Erik C.B., Seyfried, Nicholas T., Levey, Allan I., Geschwind, Daniel H. · 2020 · Cell Reports
24. Gene variations in Autism Spectrum Disorder are associated with alternation of gut microbiota, metabolites and cytokines
    Zhi Liu, Xuhua Mao, Dan Zhou, Yang Pei, Rui Xu, Mengchen Guo, Kangjian Liu, Faming Zhang, Junyu Chen, Chuan Su et al. · 2021 · Gut Microbes
25. Neuroimmune contributions to Alzheimer’s disease: a focus on human data
    Haage, Verena, De Jager, Philip L. · 2022 · Molecular Psychiatry
26. Enriched environment enhances β‐adrenergic signaling to prevent microglia inflammation by amyloid‐β
    Huixin Xu, Molly M. Rajsombath, Pia Weikop, Dennis J. Selkoe · 2018 · EMBO Molecular Medicine
27. Exploring the genetics and non-cell autonomous mechanisms underlying ALS/FTLD
    Hongbo Chen, Mark W. Kankel, Susan C. Su, Steve Han, Dimitry Ofengeim · 2018 · Cell Death and Differentiation
28. The concept of resilience to Alzheimer’s Disease: current definitions and cellular and molecular mechanisms
    L. D. de Vries, I. Huitinga, Helmut W. Kessels, D. Swaab, J. Verhaagen · 2024 · Molecular Neurodegeneration
29. Molecular estimation of neurodegeneration pseudotime in older brains
    Sumit Mukherjee, Laura M. Heath, Christoph Preuß, Suman Jayadev, Gwenn A. Garden, Anna K. Greenwood, Solveig K. Sieberts, Philip L. De Jager, Nilüfer Ertekin‐Taner, Gregory W. Carter et al. · 2020 · Nature Communications
30. Genomics and Functional Genomics of Alzheimer's Disease
    Kamboh, M. Ilyas · 2022 · Neurotherapeutics
31. CX3CR1-deficient microglia shows impaired signalling of the transcription factor NRF2: Implications in tauopathies
    Castro-Sánchez, Sara, García-Yagüe, Ángel J., Kügler, Sebastian, Lastres-Becker, Isabel · 2019 · Redox Biology
32. Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo
    Daisuke Ogasawara, Taka-Aki Ichu, Vincent F. Vartabedian, Jacqueline R. Benthuysen, Hui Jing, Alex Reed, Olesya A. Ulanovskaya, Jonathan J. Hulce, Amanda J. Roberts, Steven J Brown et al. · 2018 · Nature Chemical Biology
33. Transcriptional signatures of tau and amyloid neuropathology
    Castanho, Isabel, Murray, Tracey K., Hannon, Eilis, Jeffries, Aaron, Walker, Emma, Laing, Emma, Baulf, Hedley, Harvey, Joshua, Bradshaw, Lauren, Randall, Andrew et al. · 2020 · Cell Reports
34. Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry
    Devanshi Patel, Jesse B Mez, Badri Narayan Vardarajan, Lyndsay A. Staley, Jaeyoon Chung, Xiaoling Zhang, John J. Farrell, Michael J. Rynkiewicz, Lisa Cannon‐Albright, Craig Carl Teerlink et al. · 2019 · JAMA Network Open
35. TREM2 Variants and Neurodegenerative Diseases: A Systematic Review and Meta-Analysis
    Sheng-Lan Zhou, Chen‐Chen Tan, Xiao‐He Hou, Xi‐Peng Cao, Lan Tan, Jin‐Tai Yu · 2019 · Journal of Alzheimer s Disease
36. Current views on meningeal lymphatics and immunity in aging and Alzheimer’s disease
    Shanon Rego, Guadalupe Sánchez, Sandro Dá Mesquita · 2023 · Molecular Neurodegeneration
37. PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment
    Alzheimer’s Disease Neuroimaging Initiative (ADNI), Kleineidam, Luca, Chouraki, Vincent, Próchnicki, Tomasz, van der Lee, Sven J., Madrid-Márquez, Laura, Wagner-Thelen, Holger, Karaca, Ilker, Weinhold, Leonie, Wolfsgruber, Steffen et al. · 2020 · Acta Neuropathologica
38. Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer’s disease
    Tsai, Andy P., Dong, Chuanpeng, Lin, Peter Bor-Chian, Oblak, Adrian L., Viana Di Prisco, Gonzalo, Wang, Nian, Hajicek, Nicole, Carr, Adam J., Lendy, Emma K., Hahn, Oliver et al. · 2023 · Immunity
39. Integrated lipidomics and proteomics network analysis highlights lipid and immunity pathways associated with Alzheimer’s disease
    Jin Xu, Giulia Bankov, Min Gyu Kim, Asger Wretlind, Jodie Lord, Rebecca Green, Angela Hodges, Abdul Hye, Dag Aarsland, Latha Velayudhan et al. · 2020 · Translational Neurodegeneration
40. TREM2 Alzheimer’s variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages
    Hall-Roberts, Hazel, Agarwal, Devika, Obst, Juliane, Smith, Thomas B., Monzón-Sandoval, Jimena, Di Daniel, Elena, Webber, Caleb, James, William S., Mead, Emma, Davis, John B. et al. · 2020 · Alzheimer's Research & Therapy
41. rAAV-based brain slice culture models of Alzheimer’s and Parkinson’s disease inclusion pathologies
    Cara L. Croft, Pedro E. Cruz, Daniel H. Ryu, Carolina Ceballos‐Diaz, Kevin H. Strang, Brittany M. Woody, Wen-Lang Lin, Michael A. Deture, Edgardo Rodríguez-Lebrón, Dennis W. Dickson et al. · 2019 · The Journal of Experimental Medicine
42. Peripheral and central neuroimmune mechanisms in Alzheimer’s disease pathogenesis
    Zhang, Shuo, Gao, Yue, Zhao, Yini, Huang, Timothy Y., Zheng, Qiuyang, Wang, Xin · 2025 · Molecular Neurodegeneration
43. Transcriptional landscape of human microglia implicates age, sex, and APOE‐related immunometabolic pathway perturbations
    Tulsi Patel, Troy Carnwath, Xue Wang, Mariet Allen, Sarah Lincoln, Laura J. Lewis‐Tuffin, Zachary Quicksall, Shu Lin, Frederick Q Tutor‐New, Charlotte C.G. Ho et al. · 2022 · Aging Cell
44. Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport
    Brian W. Kunkle, Badri Narayan Vardarajan, Adam Christian Naj, Patrice L. Whitehead, Sophie Rolati, Susan Slifer, Regina M. Carney, Michael L. Cuccaro, Jeffery M. Vance, John R. Gilbert et al. · 2017 · JAMA Neurology
45. Immune response and endocytosis pathways are associated with the resilience against Alzheimer’s disease
    Tesi, Niccolò, van der Lee, Sven J., Hulsman, Marc, Jansen, Iris E., Stringa, Najada, van Schoor, Natasja M., Scheltens, Philip, van der Flier, Wiesje M., Huisman, Martijn, Reinders, Marcel J. T. et al. · 2020 · Translational Psychiatry
46. Reassessment of Pioglitazone for Alzheimer’s Disease
    Ann M. Saunders, Daniel K. Burns, William Kirby Gottschalk · 2021 · Frontiers in Neuroscience
47. Network Medicine for Alzheimer’s Disease and Traditional Chinese Medicine
    Juliet T. Jarrell, Li Gao, David S. Cohen, Xudong Huang · 2018 · Molecules
48. Role of Neuron and Glia in Alzheimer’s Disease and Associated Vascular Dysfunction
    Sanghamitra Bandyopadhyay · 2021 · Frontiers in Aging Neuroscience
49. Metabolic Regulation of Glia and Their Neuroinflammatory Role in Alzheimer's Disease
    Preeti Kumari, Anika Sood, Valencia Fernandes · 2021 · Cellular and Molecular Neurobiology
50. TREM2 and sTREM2 in Alzheimer’s disease: from mechanisms to therapies
    Lianshuai Zhang, Xianyuan Xiang, Y. Li, Guojun Bu, Xiao‐Fen Chen · 2025 · Molecular Neurodegeneration
51. The Molecular and Neuropathological Consequences of Genetic Risk for Alzheimer's Dementia
    Shinya Tasaki, Chris Gaiteri, Sara Mostafavi, Philip L. De Jager, David Alan Bennett · 2018 · Frontiers in Neuroscience
52. Centenarian controls increase variant effect sizes by an average twofold in an extreme case–extreme control analysis of Alzheimer’s disease
    Tesi, Niccolò, van der Lee, Sven J., Hulsman, Marc, Jansen, Iris E., Stringa, Najada, van Schoor, Natasja, Meijers-Heijboer, Hanne, Huisman, Martijn, Scheltens, Philip, Reinders, Marcel J. T. et al. · 2019 · European Journal of Human Genetics
53. Microglia: Friend and foe in tauopathy
    Odfalk, Kristian F., Bieniek, Kevin F., Hopp, Sarah C. · 2022 · Progress in Neurobiology
54. Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
    Dong Won Kim, Kevin J. Tu, Alice Wei, Ashley Lau, Anabel Gonzalez-Gil, Tianyu Cao, Kerstin E. Braunstein, Jonathan P. Ling, Juan Carlos Troncoso, Philip C. Wong et al. · 2022 · Molecular Neurodegeneration
55. Atlas of RNA editing events affecting protein expression in aged and Alzheimer’s disease human brain tissue
    Yiyi Ma, Eric B. Dammer, Daniel Felsky, Duc M. Duong, Hans‐Ulrich Klein, Charles C. White, Maotian Zhou, Benjamin A. Logsdon, Cristin Aubin, Jishu Xu et al. · 2021 · Nature Communications
56. Age-dependent effect of APOE and polygenic component on Alzheimer's disease
    Eftychia Bellou, Emily Ann Baker, Ganna Leonenko, Matthew Bracher‐Smith, Paula Daunt, Georgina Elizabeth Menzies, Julie H. Williams, Valentina Escott‐Price · 2020 · Neurobiology of Aging
57. Cell type-specific changes identified by single-cell transcriptomics in Alzheimer’s disease
    Tain Luquez, Pallavi Gaur, Ivy M Kosater, Matti Lam, Dylan I. Lee, Jason A. Mares, Fahad Paryani, Archana Yadav, Vilas Menon · 2022 · Genome Medicine
58. TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation
    Magno, Lorenza, Bunney, Tom D., Mead, Emma, Svensson, Fredrik, Bictash, Magda N. · 2021 · Molecular Neurodegeneration
59. Single-cell peripheral immunoprofiling of Alzheimer’s and Parkinson’s diseases
    Thanaphong Phongpreecha, Rosemary Fernandez, Dunja Mrdjen, Anthony Culos, Chandresh R. Gajera, Adam M. Wawro, Natalie Stanley, Brice L Gaudilliere, Kathleen L. Poston, Nima Aghaeepour et al. · 2020 · Science Advances
60. PLCG2-associated immune dysregulation (PLAID) comprises broad and distinct clinical presentations related to functional classes of genetic variants
    Baysac, Kathleen, Sun, Guangping, Nakano, Hiroto, Schmitz, Elizabeth G., Cruz, Anthony C., Fisher, Charles, Bailey, Alexis C., Abbott, Jordan K., Aldave Becerra, Juan Carlos, Allenspach, Eric J. et al. · 2024 · Journal of Allergy and Clinical Immunology
61. Lipidome disruption in Alzheimer’s disease brain: detection, pathological mechanisms, and therapeutic implications
    He, Sijia, Xu, Ziying, Han, Xianlin · 2025 · Molecular Neurodegeneration
62. A multi-omic atlas of the human frontal cortex for aging and Alzheimer's disease research
    2018
63. Exploring the Impact of TREM2 in Tumor-Associated Macrophages
    Darya Khantakova, Simone Brioschi, Martina Molgora · 2022 · Vaccines
64. The role of CD2AP in the Pathogenesis of Alzheimer's Disease
    Tao, Qing-Qing, Chen, Yu-Chao, Wu, Zhi-Ying · 2019 · Aging and disease
65. Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain
    Guillermo Carbajosa, Karim Malki, Nathan Lawless, Hong Wang, John W. Ryder, Eva Wozniak, Kristie Wood, Charles A. Mein, Richard Dobson, David Andrew Collier et al. · 2018 · Neurobiology of Aging
66. Functional and Phenotypic Diversity of Microglia: Implication for Microglia-Based Therapies for Alzheimer’s Disease
    Yijun Xu, Ngan Pan Bennett Au, Chi Him Eddie Ma · 2022 · Frontiers in Aging Neuroscience
67. WASP family proteins: Molecular mechanisms and implications in human disease
    Kramer, Daniel A., Piper, Hannah K., Chen, Baoyu · 2022 · European Journal of Cell Biology
68. Cerebrospinal fluid proteomics and biological heterogeneity in Alzheimer’s disease: A literature review
    Kirsten E. J. Wesenhagen, Charlotte Elisabeth Teunissen, Pieter Jelle Visser, Betty Marije Tijms · 2019 · Critical Reviews in Clinical Laboratory Sciences
69. Causal effects of gut microbiota on sepsis and sepsis-related death: insights from genome-wide Mendelian randomization, single-cell RNA, bulk RNA sequencing, and network pharmacology
    Sha Yang, Jing Guo, Zhuo Kong, Mei Deng, Jingjing Da, Xin Lin, Shuo Peng, Junwu Fu, Tao Luo, Jun Ma et al. · 2024 · Journal of Translational Medicine
70. Harnessing Immunoproteostasis to Treat Neurodegenerative Disorders
    Golde, Todd E. · 2019 · Neuron
71. Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations
    Nicole Hajicek, John Sondek · 2019 · Worldwide Protein Data Bank
72. Inflammation and dementia: Using rheumatoid arthritis as a model to develop treatments?
    Alice Mason, Clive Holmes, Christopher John Edwards · 2018 · Autoimmunity Reviews
73. Hypothesis review: Alzheimer's overture guidelines
    Isidró Ferrer · 2022 · Brain Pathology
74. Alzheimer’s Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia
    Marvin Reich, Iñaki Paris, Martin Ebeling, Nadine Dahm, Christophe Schweitzer, Dieter Reinhardt, Roland Schmucki, Megana K. Prasad, Fabian Köchl, Marcel Leist et al. · 2021 · Frontiers in Immunology
75. Genome‐wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways
    Sherva, Richard, Gross, Alden, Mukherjee, Shubhabrata, Koesterer, Ryan, Amouyel, Philippe, Bellenguez, Celine, Dufouil, Carole, Bennett, David A., Chibnik, Lori, Cruchaga, Carlos et al. · 2020 · Alzheimer's & Dementia
76. Deletion of <i>Abi3</i> gene locus exacerbates neuropathological features of Alzheimer’s disease in a mouse model of Aβ amyloidosis
    Karahan, Hande, Smith, Daniel C., Kim, Byungwook, Dabin, Luke C., Al-Amin, Md Mamun, Wijeratne, H. R. Sagara, Pennington, Taylor, Viana di Prisco, Gonzalo, McCord, Brianne, Lin, Peter Bor-chian et al. · 2021 · Science Advances
77. Genome-wide profiling of DNA methylation and gene expression identifies candidate genes for human diabetic neuropathy
    Kai Guo, Stéphanie Eid, Sarah E. Elzinga, Crystal M. Pacut, Eva L. Feldman, Junguk Hur · 2020 · Clinical Epigenetics
78. Massively parallel techniques for cataloguing the regulome of the human brain
    Kayla G. Townsley, Kristen Brennand, Laura M. Huckins · 2020 · Nature Neuroscience
79. A rare missense variant of CASP7 is associated with familial late‐onset Alzheimer's disease
    Xiaoling Zhang, Congcong Zhu, Gary W. Beecham, Badri Narayan Vardarajan, Yiyi Ma, Daniel Lancour, John J. Farrell, Jaeyoon Chung, Alzheimer's Disease Sequencing Project, Richard P Mayeux et al. · 2018 · Alzheimer s & Dementia
80. T Cells: A Growing Universe of Roles in Neurodegenerative Diseases
    Dallin Dressman, Wassim Elyaman · 2021 · The Neuroscientist
81. Iron and Alzheimer’s Disease: From Pathology to Imaging
    Dean Q. Tran, Phillip DiGiacomo, Donald E. Born, Marios Georgiadis, Michael Zeineh · 2022 · Frontiers in Human Neuroscience
82. Microglial innate memory and epigenetic reprogramming in neurological disorders
    Ricardo Martins-Ferreira, Bárbara Leal, Paulo Costa, Esteban Ballestar · 2020 · Progress in Neurobiology
83. Rare genetic coding variants associated with human longevity and protection against age-related diseases
    Jhih-Rong Lin, Patrick Sin‐Chan, Valerio Napolioni, Guillermo G. Torres, Joydeep Mitra, Quanwei Zhang, Mohammad Reza Jabalameli, Zhen Wang, Nha Nguyen, Tina Gao et al. · 2021 · Nature Aging
84. Genome-wide epistasis analysis for Alzheimer’s disease and implications for genetic risk prediction
    Hui Wang, David A. A Bennett, Philip L. De Jager, Qingye Zhang, Hongyu Zhang · 2021 · Alzheimer s Research & Therapy
85. Microglia express ABI3 in the brains of Alzheimer's disease and Nasu-Hakola disease
    Satoh, Jun-ichi, Kino, Yoshihiro, Yanaizu, Motoaki, Tosaki, Youhei, Sakai, Kenji, Ishida, Tsuyoshi, Saito, Yuko · 2017 · Intractable &amp; Rare Diseases Research
86. Effect of APOE alleles on the glial transcriptome in normal aging and Alzheimer’s disease
    Serrano-Pozo, Alberto, Li, Zhaozhi, Noori, Ayush, Nguyen, Huong N., Mezlini, Aziz, Li, Liang, Hudry, Eloise, Jackson, Rosemary J., Hyman, Bradley T., Das, Sudeshna · 2021 · Nature Aging
87. Meta-analysis of the human brain transcriptome identifies heterogeneity across human AD coexpression modules robust to sample collection and methodological approach
    Benjamin A. Logsdon, Thanneer Malai Perumal, Vivek Swarup, Minghui Wang, Cory C. Funk, Chris Gaiteri, Mariet Allen, Xue Bing Wang, Eric B. Dammer, Gyan Prakash Srivastava et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
88. Human iPSC‐Derived Blood‐Brain Barrier Models: Valuable Tools for Preclinical Drug Discovery and Development?
    Antje Appelt‐Menzel, Sabrina Oerter, Sanjana Mathew, Undine Haferkamp, Carla Hartmann, Matthias Jung, Winfried Neuhaus, Ole Pleß · 2020 · Current Protocols in Stem Cell Biology
89. Lipid transporter Spns2 promotes microglia pro‐inflammatory activation in response to amyloid‐beta peptide
    Liansheng Zhong, Xue Jiang, Zhihui Zhu, Haiyan Qin, Michael B. Dinkins, Ji‐Na Kong, Silvia Leanhart, Rebecca Wang, Ahmed M. Elsherbini, Erhard Bieberich et al. · 2018 · Glia
90. Tipping points in neurodegeneration
    Mikael Simons, Johannes Levin, Martin Dichgans · 2023 · Neuron
91. Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype
    Yiyi Ma, Gyungah Jun, Xiaoling Zhang, Jaeyoon Chung, Adam Christian Naj, Yuning Chen, Céline Bellenguez, Kara L. Hamilton‐Nelson, Eden R. Martin, Brian W. Kunkle et al. · 2019 · JAMA Neurology
92. Applications of CRISPR-Cas9 in Alzheimer’s Disease and Related Disorders
    Laura Maria De Plano, Giovanna Calabrese, Sabrina Conoci A, Salvatore P. P. Guglielmino, Salvatore Oddo, Antonella Caccamo · 2022 · International Journal of Molecular Sciences
93. Modeling the complex genetic architectures of brain disease
    Michael B. Fernando, Tim Ahfeldt, Kristen Brennand · 2020 · Nature Genetics
94. Polygenic Risk Scores in Alzheimer’s Disease Genetics: Methodology, Applications, Inclusion, and Diversity
    Kaylyn Clark, Yuk Yee Leung, Wan‐Ping Lee, Benjamin F. Voight, Li‐San Wang · 2022 · Journal of Alzheimer s Disease
95. The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model
    Claes, Christel, England, Whitney E., Danhash, Emma P., Kiani Shabestari, Sepideh, Jairaman, Amit, Chadarevian, Jean Paul, Hasselmann, Jonathan, Tsai, Andy P., Coburn, Morgan A., Sanchez, Jessica et al. · 2022 · Alzheimer's &amp; Dementia
96. Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer’s disease
    Dalmasso, Maria Carolina, Brusco, Luis Ignacio, Olivar, Natividad, Muchnik, Carolina, Hanses, Claudia, Milz, Esther, Becker, Julian, Heilmann-Heimbach, Stefanie, Hoffmann, Per, Prestia, Federico A. et al. · 2019 · Translational Psychiatry
97. Association of <i>APOE</i> With Primary Open-Angle Glaucoma Suggests a Protective Effect for <i>APOE ε4</i>
    Margeta, Milica A., Letcher, Sophia M., Igo, Robert P., Cooke Bailey, Jessica N., Pasquale, Louis R., Haines, Jonathan L., Butovsky, Oleg, Wiggs, Janey L., for the NEIGHBORHOOD consortium · 2020 · Investigative Opthalmology &amp; Visual Science
98. Microglial Senescence and Activation in Healthy Aging and Alzheimer’s Disease: Systematic Review and Neuropathological Scoring
    Antonio Malvaso, Alberto Gatti, Giulia Negro, Chiara Calatozzolo, Valentina Medici, Tino Emanuele Poloni · 2023 · Cells
99. Genetic architecture of common non-Alzheimer’s disease dementias
    Rita João Guerreiro, Elizabeth Gibbons, Miguel Tábuas‐Pereira, Célia Kun‐Rodrigues, Gustavo Cordeiro, José Brás · 2020 · Neurobiology of Disease
100. Prospects for strain-specific immunotherapy in Alzheimer’s disease and tauopathies
     Bittar, Alice, Sengupta, Urmi, Kayed, Rakez · 2018 · npj Vaccines