Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

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3. Current Insights into the Joint Genetic Basis of Type 2 Diabetes and Coronary Heart Disease
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5. Identification of shared genetic susceptibility locus for coronary artery disease, type 2 diabetes and obesity: a meta-analysis of genome-wide studies
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6. Filter Paper Blood Spot Enzyme Linked Immunoassay for Insulin and Application in the Evaluation of Determinants of Child Insulin Resistance
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7. Cross-Sectional and Longitudinal Replication Analyses of Genome-Wide Association Loci of Type 2 Diabetes in Han Chinese
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8. Admixture Mapping and Subsequent Fine-Mapping Suggests a Biologically Relevant and Novel Association on Chromosome 11 for Type 2 Diabetes in African Americans
   Janina M. Jeff, Loren L. Armstrong, Marylyn DeRiggi Ritchie, Joshua C. Denny, Abel Kho, Melissa Basford, Wendy A. Wolf, Jennifer A. Pacheco, Rongling Li, Rex L. Chisholm et al. · 2014 · PLoS ONE
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   Dotun Adeboye Ogunyemi, Jun Xu, Arnold M. Mahesan, Steve Rad, Eric H. Kim, Jacqueline Yano, Carolyn J. Alexander, Jerome I. Rotter, Yii‐Der Ida Chen · 2013 · Journal of Diabetes Mellitus
10. Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits
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11. Predictive network modeling in human induced pluripotent stem cells identifies key driver genes for insulin responsiveness
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12. Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes aetiology
    Anne Lundager Madsen, Sílvia Bonàs‐Guarch, S. Gheibi, Rashmi B. Prasad, Jagadish Vangipurapu, Vineet Ahuja, Luis Rodrigo Cataldo, Om Prakash Dwivedi, Gad Hatem, Goutham Atla et al. · 2024 · Nature Metabolism
13. Comparison of Transcriptome Profiles of the Fungus Botrytis cinerea and Insect Pest Bradysia odoriphaga in Response to Benzothiazole
    Kaidi Cui, Yunhe Zhao, Leiming He, Jinfeng Ding, Beixing Li, Wei Mu, Liu Feng · 2020 · Frontiers in Microbiology
14. Genome-wide association study for systemic lupus erythematosus in an egyptian population
    Ashraf Antar Elghzaly, Celi Sun, Loren L. Looger, Misa Hirose, Mohamed Salama, Noha M. Khalil, Mervat Essam Behiry, Mohamed Tharwat Hegazy, Mohamed Ahmed Hussein, Mohamad Nabil Salem et al. · 2022 · Frontiers in Genetics
15. Dorothy Hodgkin Lecture 2010^. From hype to hope? A journey through the genetics of Type 2 diabetes
    Mark I. McCarthy · 2010 · Diabetic Medicine
16. Predictive utility of a genetic risk score of common variants associated with type 2 diabetes in a black South African population
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17. A common variation of the PTEN gene is associated with peripheral insulin resistance
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18. IRS1 G972R Missense Polymorphism Is Associated With Failure to Oral Antidiabetes Drugs in White Patients With Type 2 Diabetes From Italy
    Sabrina Prudente, Eleonora Morini, Daniela Lucchesi, Olga Lamacchia, Diego Bailetti, Luana Mercuri, Federica Alberico, Massimiliano Copetti, Laura Pucci, Stefania Fariello et al. · 2014 · Diabetes
19. Phosphoinositide Signalling Pathways in Metabolic Regulation
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20. Type 2 diabetes-related variants influence the risk of developing multiple myeloma: results from the IMMEnSE consortium
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21. Associations between two single-nucleotide polymorphisms (rs1801278 and rs2943641) of insulin receptor substrate 1 gene and type 2 diabetes susceptibility: a meta-analysis
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22. Current state of the obesity research: genetic aspects, the role of microbiome, and susceptibility to COVID-19
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23. Genome-wide DNA methylation profiling in anorexia nervosa discordant identical twins
    Carmen Iranzo-Tatay, David Hervás, Luis Miguel Rojo-Bofill, Diana Garcia, Francisco J. Vaz Leal, Inés Calabria, Luis Beato‐Fernández, Silvestre Oltra, Juan Sandoval, Luis Rojo‐Moreno · 2022 · Translational Psychiatry
24. Metabolic Syndrome: An Overview on Its Genetic Associations and Gene–Diet Interactions
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25. Association study of a common variant near IRS1 with type 2 diabetes mellitus in Chinese Han population
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26. Genetic Association Study with Metabolic Syndrome and Metabolic-Related Traits in a Cross-Sectional Sample and a 10-Year Longitudinal Sample of Chinese Elderly Population
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27. Predictive performance of a genetic risk score using 11 susceptibility alleles for the incidence of Type 2 diabetes in a general Japanese population: a nested case–control study
    Atsushi Goto, Mitsuhiko Noda, Maki Goto, Kazuki Yasuda, Tetsuya Mizoue, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Manami Inoue, Shoichiro Tsugane et al. · 2018 · Diabetic Medicine
28. Joint Effect of Genetic and Lifestyle Risk Factors on Type 2 Diabetes Risk among Chinese Men and Women
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29. Differential aetiology and impact of phosphoinositide 3-kinase (PI3K) and Akt signalling in skeletal muscle on in vivo insulin action
    Martin Haljeta Friedrichsen, Pernille Poulsen, Erik Arne Richter, Bo F. Hansen, Jesper B. Birk, Rasmus Ribel‐Madsen, Kirstine L. Stender-Petersen, E. Nilsson, Henning Beck‐Nielsen, Allan Arthur Vaag et al. · 2010 · Diabetologia
30. Association of single nucleotide polymorphisms with insulin secretion, insulin sensitivity, and diabetes in women with a history of gestational diabetes mellitus
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31. Cumulative Effect and Predictive Value of Genetic Variants Associated with Type 2 Diabetes in Han Chinese: A Case-Control Study
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32. Genetics of Lipid Traits and Relationship to Coronary Artery Disease
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33. Genetic Determinants of Type 2 Diabetes in Asians
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34. Do Variants Associated with Susceptibility to Pancreatic Cancer and Type 2 Diabetes Reciprocally Affect Risk?
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35. Joint Effects of Known Type 2 Diabetes Susceptibility Loci in Genome-Wide Association Study of Singapore Chinese: The Singapore Chinese Health Study
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36. World Congress on Insulin Resistance, Diabetes, and Cardiovascular Disease
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37. Understanding Genetic Heterogeneity in Type 2 Diabetes by Delineating Physiological Phenotypes: SIRT1 and its Gene Network in Impaired Insulin Secretion
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38. A Missense Mutation in IRS1 is Associated with the Development of Early-Onset Type 2 Diabetes
    Juyi Li, Shan Sun, Xiufang Wang, Yarong Li, Hong Yan Zhu, Hongmei Zhang, Aiping Deng · 2020 · International Journal of Endocrinology
39. Nutrigenetics: Bridging Two Worlds to Understand Type 2 Diabetes
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40. Genetic variants near the IRS1 gene, physical activity and type 2 diabetes in US men and women
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41. Filter Paper Blood Spot Enzyme Linked Immunoassay for Adiponectin and Application in the Evaluation of Determinants of Child Insulin Sensitivity
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42. The New Perspectives on Genetic Studies of Type 2 Diabetes and Thyroid Diseases
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43. Search for genetic determinants of sulfonylurea efficacy in type 2 diabetic patients from China
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44. GENETIC FACTORS INVOLVED IN THE PATHOGENESIS OF TYPE 2 DIABETES
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45. Impact of type 2 diabetes variants identified through genome-wide association studies in early-onset type 2 diabetes from South Indian population
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46. Studies of a genetic variant in HK1 in relation to quantitative metabolic traits and to the prevalence of type 2 diabetes
    Anette P. Gjesing, Aneta Aleksandra Nielsen, Ivan Brandslund, Cramer Christensen, Anneli Sandbæk, Torben Jørgensen, Daniel R. Witte, Amélie Bonnefond, Philippe Froguel, Torben F. Hansen et al. · 2011 · BMC Medical Genetics
47. Differential expression of insulin receptor substrate-1(IRS-1) in visceral and subcutaneous adipose depots of morbidly obese subjects undergoing bariatric surgery in a tertiary care center in north India; SNP analysis and correlation with metabolic profile
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48. Recent progress in the use of genetics to understand links between type 2 diabetes and related metabolic traits
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49. Common Variants Associated with Type 2 Diabetes in a Black South African Population of Setswana Descent: African Populations Diverge
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50. Association of IRS1 genetic variants with glucose control and insulin resistance in type 2 diabetic patients from Bosnia and Herzegovina
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51. Replication study for the association of a single-nucleotide polymorphism, rs3746876, within KCNJ15, with susceptibility to type 2 diabetes in a Japanese population
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52. Pharmacogenetics of oral antidiabetes drugs: evidence for diverse signals at the IRS1 locus
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53. The Role of Genetic Polymorphism in the Formation of Arterial Hypertension, Type 2 Diabetes and their Comorbidity
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54. Analysis of phosphatidylinositol 3-kinase activation in the adipose tissue of gestational diabetes mellitus patients and insulin resistance
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55. COBLL1 and IRS1 Gene Polymorphisms and Placental Expression in Women with Gestational Diabetes
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56. When diet and exercise are not enough, think immunomodulation
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57. Type 2 Diabetes-Related Variants Influence the Risk of Developing Prostate Cancer: A Population-Based Case-Control Study and Meta-Analysis
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58. Bridging the Gap Between Genetic Associations and Molecular Mechanisms for Type 2 Diabetes
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59. From genotype to human β cell phenotype and beyond
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60. A Multi-Cohort Study of Polymorphisms in the GH/IGF Axis and Physical Capability: The HALCyon Programme
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61. Integrating Common Risk Factors with Polygenic Scores Improves the Prediction of Type 2 Diabetes
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62. Insulin receptor substrate 1 (IRS1) variants confer risk of diabetes in the Boston Puerto Rican Health Study.
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63. Genetic Architecture of Type 2 Diabetes
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64. Influence of polymorphisms in candidate genes on carcass and meat quality traits in rabbits
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65. Common variants in and near IRS1 and subclinical cardiovascular disease in the Framingham Heart Study
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66. MYH9 gene polymorphisms may be associated with cerebrovascular blood flow in patients with type 2 diabetes
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67. Association of Type 2 Diabetes Mellitus related SNP genotypes with altered serum adipokine levels and metabolic syndrome phenotypes.
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68. Role of Zinc Finger Transcription Factor Zfp69 in Body Fat Storage and Diabetes Susceptibility of Mice
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69. The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies
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70. Associations of Haplotypes Upstream ofIRS1with Insulin Resistance, Type 2 Diabetes, Dyslipidemia, Preclinical Atherosclerosis, and Skeletal MuscleLOC646736mRNA Levels
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71. Quality control metrics improve repeatability and reproducibility of single-nucleotide variants derived from whole-genome sequencing
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72. Genetic Associations with Metabolic Syndrome and Its Quantitative Traits by Race/Ethnicity in the United States
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73. Utilizing Genetic Predisposition Score in Predicting Risk of Type 2 Diabetes Mellitus Incidence: A Community-based Cohort Study on Middle-aged Koreans
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74. Nanoparticle-mediated in vitro delivery of E4orf1 to preadipocytes is a clinically relevant delivery system to improve glucose uptake
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75. IRS-1 gene polymorphism and DNA damage in pregnant women with diabetes or mild gestational hyperglycemia
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76. Genetic influences on the association between fetal growth and susceptibility to type 2 diabetes
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77. Pitfall of genome-wide association studies: Sources of inconsistency in genotypes and their effects
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78. Metabolomics study on the association between nicotinamide N-methyltransferase gene polymorphisms and type 2 diabetes
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79. The Genetic Determinants of Common Obesity-Susceptibility
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80. A Rare Co-Segregation-Mutation in the Insulin Receptor Substrate 1 Gene in One Chinese Family with Ankylosing Spondylitis
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81. Type 2 diabetes genes – Present status and data from Norwegian studies
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82. Evidence of selection at insulin receptor substrate-1 gene loci
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83. De novo RNA sequence assembly during in vivo inflammatory stress reveals hundreds of unannotated lincRNAs in human blood CD14+monocytes and in adipose tissue
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84. A novel test by combining the maximum and minimum values among a large number of dependent Z‐scores with application to genome wide association study
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85. Interaction of Insulin Resistance and Related Genetic Variants With Triglyceride-Associated Genetic Variants
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86. Identification of Interactive Genetic Loci Linked to Insulin Resistance in Metabolic Syndrome—An Update
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87. TheIRS1rs2943641 Variant and Risk of Future Cancer Among Morbidly Obese Individuals
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88. Different Associations Between CDKAL1 Variants and Type 2 Diabetes Mellitus Susceptibility: A Meta-analysis
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89. No evidence for association of insulin receptor substrate-1 Gly972Arg variant with type 2 diabetes mellitus in a mixed-ancestry population of South Africa
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90. The SH2B1 obesity locus and abnormal glucose homeostasis: Lack of evidence for association from a meta-analysis in individuals of European ancestry
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91. Diabetes and Renin-Angiotensin-Aldosterone System: Pathophysiology and Genetics
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92. Epidemiology and genetic determinants of progressive deterioration of glycaemia in American Indians: the Strong Heart Family Study
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93. Genetic variation near IRS1 is associated with adiposity and a favorable metabolic profile in US Hispanics/Latinos
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94. Risk assessment of type 2 diabetes in northern China based on the logistic regression model
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95. Physical activity attenuates the association between the IRS1 genotype and childhood obesity in Chinese children
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96. Genetic Variants of HNF4A, WFS1, DUSP9, FTO, and ZFAND6 Genes Are Associated with Prediabetes Susceptibility and Inflammatory Markers in the Saudi Arabian Population
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97. Determining Genetic Risk Factors for Pediatric Type 2 Diabetes
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98. Common variation in oxidative phosphorylation genes is not a major cause of insulin resistance or type 2 diabetes
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99. Association between the TRAIL single nucleotide polymorphism rs1131580 and type 2 diabetes mellitus in a Han Chinese population
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100. Genome-Wide Association Studies of Type 2 Diabetes
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