Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

Rung, Johan, Cauchi, Stéphane, Albrechtsen, Anders, Shen, Lishuang, Rocheleau, Ghislain, Cavalcanti-Proença, Christine, Bacot, François, Balkau, Beverley +32 more·2009·Nature Genetics

Cited by (480)

Items 101–200 of 480

  1. Etiology of type 2 diabetes and Alzheimer’s disease: Exploring the mitochondria
    Silzer, Talisa K., Phillips, Nicole R. · 2018 · Mitochondrion
  2. Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes
    Vesna Boraska Perica, Nigel William Rayner, Christopher J. Groves, Timothy M. Frayling, Mahamadou Diakité, Kirk A. Rockett, Dominic P. Kwiatkowski, Aaron Day-Williams, Mark I. McCarthy, Eleftheria Zeggini · 2010 · BMC Medical Genetics
  3. Genetic determinants of circulating GIP and GLP-1 concentrations
    Peter Almgren, Andreas Lindqvist, Ulrika Krus, Liisa Hakaste, Emilia Ottosson-Laakso, Olof Asplund, Emily Sonestedt, Rashmi B. Prasad, Esa Laurila, Marju Orho‐Melander et al. · 2017 · JCI Insight
  4. Consistent Directions of Effect for Established Type 2 Diabetes Risk Variants Across Populations
    Christopher A. Haiman, Megan Dann Fesinmeyer, Kylee L. Spencer, Petra Bůžková, Venkata Saroja Voruganti, Peggy C. Wan, Jeff Haessler, Nora Franceschini, Kristine R. Monroe, Barbara V. Howard et al. · 2012 · Diabetes
  5. The genetics of type 2 diabetes and its clinical relevance
    Aparna Pal, Mark I. McCarthy · 2012 · Clinical Genetics
  6. Emerging Applications of Metabolomic and Genomic Profiling in Diabetic Clinical Medicine
    Aine M. McKillop, Peter R. Flatt · 2011 · Diabetes Care
  7. The Genetic Basis of Obesity and Related Metabolic Diseases in Humans and Companion Animals
    Natalie Jessica Wallis, Eleanor Raffan · 2020 · Genes
  8. Replication Study for the Association of 9 East Asian GWAS-Derived Loci with Susceptibility to Type 2 Diabetes in a Japanese Population
    Kensuke Sakai, Minako Imamura, Yasushi Tanaka, Minoru Iwata, Hiroshi Hirose, Kohei Kaku, Hiroshi Maegawa, Hirotaka Watada, Kazuyuki Tobe, Atsunori Kashiwagi et al. · 2013 · PLoS ONE
  9. Literature-Based Genetic Risk Scores for Coronary Heart Disease
    Anika A. M. Vaarhorst, Yingchang Lu, Bastiaan T. Heijmans, Martijn E.T. Dollé, Stefan Böhringer, Hein Putter, Sandra Imholz, Audrey H. H. Merry, Marleen M. J. van Greevenbroek, J. Wouter Jukema et al. · 2012 · Circulation Cardiovascular Genetics
  10. Genetic and Physiological Effects of Insulin on Human Urate Homeostasis
    Asim K. Mandal, Megan Leask, Christopher Estiverne, Hyon K. Choi, Tony Raymond Merriman, David Bruce Mount · 2021 · Frontiers in Physiology
  11. The genetic interactions between non-alcoholic fatty liver disease and cardiovascular diseases
    Nicholas Chew, Bryan Chong, Cheng Han Ng, Gwyneth Kong, Yip Han Chin, Wang Xiao, Chang Jie Mick Lee, Yock Young Dan, Mark Dhinesh Muthiah, Roger Foo · 2022 · Frontiers in Genetics
  12. Protection from non-alcoholic steatohepatitis and liver tumourigenesis in high fat-fed insulin receptor substrate-1-knockout mice despite insulin resistance
    Akinobu Nakamura, Kazuki Tajima, Khadbaatar Zolzaya, Koichiro Sato, R. Inoue, Masato Yoneda, Koji Fujita, Yuichi Nozaki, K. C. Kubota, Hironori Haga et al. · 2012 · Diabetologia
  13. Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study
    Cécile M Povel, Jolanda M.A. Boer, N. Charlotte Onland‐Moret, Martijn E.T. Dollé, Edith J. M. Feskens, Yvonne T. van der Schouw · 2012 · Cardiovascular Diabetology
  14. Assessing the Clinical Utility of a Genetic Risk Score Constructed Using 49 Susceptibility Alleles for Type 2 Diabetes in a Japanese Population
    Minako Imamura, Daichi Shigemizu, Tatsuhiko Tsunoda, Minoru Iwata, Hiroshi Maegawa, Hirotaka Watada, Hiroshi Hirose, Yasushi Tanaka, Kazuyuki Tobe, Kohei Kaku et al. · 2013 · The Journal of Clinical Endocrinology & Metabolism
  15. The Architecture of Risk for Type 2 Diabetes: Understanding Asia in the Context of Global Findings
    Noraidatulakma Abdullah, John Attia, Christopher J. Oldmeadow, Rodney J. Scott, Elizabeth G. Holliday · 2014 · International Journal of Endocrinology
  16. A comparison of type 2 diabetes risk allele load between African Americans and European Americans
    Jacob M. Keaton, Jessica N. Cooke Bailey, Nicholette D. Palmer, Barry I. Freedman, Carl D. Langefeld, Maggie C.Y. Ng, Donald W. Bowden · 2014 · Human Genetics
  17. Type 2 Diabetes Mellitus
    Kenneth S. Polonsky, Charles Burant · 2016 · Elsevier eBooks
  18. A Single Nucleotide Polymorphism within DUSP9 Is Associated with Susceptibility to Type 2 Diabetes in a Japanese Population
    Hisashi Fukuda, Minako Imamura, Yasushi Tanaka, Minoru Iwata, Hiroshi Hirose, Kohei Kaku, Hiroshi Maegawa, Hirotaka Watada, Kazuyuki Tobe, Atsunori Kashiwagi et al. · 2012 · PLoS ONE
  19. Genotype Prediction of Adult Type 2 Diabetes From Adolescence in a Multiracial Population
    Jason L. Vassy, Pronabesh DasMahapatra, James B. Meigs, Nicholas J. Schork, Costan G. Magnussen, Wei Chen, Olli Tuomas Raitakari, Michael J. Pencina, Seema M. Jamal, Gerald S. Berenson et al. · 2012 · PEDIATRICS
  20. Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus
    Hemang M. Parikh, Valeriya Lyssenko, Leif Groop · 2009 · BMC Medical Genomics
  21. Identification of a splicing variant that regulates type 2 diabetes risk factor CDKAL1 level by a coding-independent mechanism in human
    Bo Zhou, Fan‐Yan Wei, Narumi Kanai, Atsushi Fujimura, Taku Kaitsuka, Kazuhito Tomizawa · 2014 · Human Molecular Genetics
  22. Depression and obesity: Focus on factors and mechanistic links
    Ashley Selman, Jean Dai, Jackson Driskill, Arubala P. Reddy, P. Hemachandra Reddy · 2024 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  23. Assessing the contribution of 38 genetic loci to the risk of type 2 diabetes in the S audi A rabian P opulation
    Nasser M. Al‐Daghri, Khalid M. Alkharfy, Majed Saleh Alokail, Amal Majed H. Alenad, Omar Salem Al-Attas, Abdul Khader Mohammed, Shaun Sabico, Omar Albagha · 2013 · Clinical Endocrinology
  24. Overlap of Genetic Susceptibility to Type 1 Diabetes, Type 2 Diabetes, and Latent Autoimmune Diabetes in Adults
    Kevin J. Basile, Vanessa C. Guy, Stanley S. Schwartz, Struan F.A. Grant · 2014 · Current Diabetes Reports
  25. Novel biological insights emerging from genetic studies of type 2 diabetes and related metabolic traits
    N Maneka G De Silva, Timothy M. Frayling · 2010 · Current Opinion in Lipidology
  26. Targeting type 2 diabetes: lessons from a knockout model of insulin receptor substrate 2
    Joana Moitinho Oliveira, Sandra A. Rebuffat, Rosa Gasa, Ramón Gomis · 2014 · Canadian Journal of Physiology and Pharmacology
  27. Manipulation of intestinal microbiome as potential treatment for insulin resistance and type 2 diabetes
    Yasaman Ghorbani, Katherine J. P. Schwenger, Johane P. Allard · 2021 · European Journal of Nutrition
  28. Genome-Wide Association Scan Allowing for Epistasis in Type 2 Diabetes
    Jordana T. Bell, Nicholas John Timpson, Nigel William Rayner, Eleftheria Zeggini, Timothy M. Frayling, Andrew Tym Hattersley, Andrew P. Morris, Mark I. McCarthy · 2010 · Annals of Human Genetics
  29. Insulin Resistance Associated Genes and miRNAs
    Maryam Honardoost, Mohammad Reza Sarookhani, Ehsan Arefian, Masoud Soleimani · 2014 · Applied Biochemistry and Biotechnology
  30. Association between type 2 diabetes mellitus-related SNP variants and obesity traits in a Saudi population
    Nasser M. Al‐Daghri, Khalid M. Alkharfy, Omar Salem Al-Attas, Soundararajan Krishnaswamy, Abdul Khader Mohammed, Omar Albagha, Amal Majed H. Alenad, George Panagiotis Chrousos, Majed Saleh Alokail · 2014 · Molecular Biology Reports
  31. Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study
    Nurgul S. Sikhayeva, Aisha N. Iskakova, Núria Saigí-Morgui, Elena V. Zholdybayeva, Chin B. Eap, Erlan M. Ramanculov · 2017 · BMC Medical Genetics
  32. Genetic variants in<i>MTNR1B</i>affecting insulin secretion
    Müssig, Karsten, Staiger, Harald, Machicao, Fausto, Häring, Hans-Ulrich, Fritsche, Andreas · 2010 · Annals of Medicine
  33. Two common genetic variants near nuclear-encoded OXPHOS genes are associated with insulin secretion in vivo
    Anders H. Olsson, Tina Rönn, Claes Ladenvall, Hemang M. Parikh, Bo Isomaa, Leif Groop, Charlotte Ling · 2011 · European Journal of Endocrinology
  34. Evidence of genetic predisposition for metabolically healthy obesity and metabolically obese normal weight
    Lam Opal Huang, Ruth J. F. Loos, Tuomas O. Kilpeläinen · 2018 · Physiological Genomics
  35. Posttranscriptional Regulation of Insulin Resistance: Implications for Metabolic Diseases
    Ana Pérez-García, Marta Torrecilla-Parra, Mario Fernández-de Frutos, Yolanda Martín-Martín, Virginia Pardo, Cristina M. Ramírez · 2022 · Biomolecules
  36. Genetics of type 2 diabetes in European populations
    Qibin Qi, Frank B. Hu · 2012 · Journal of Diabetes
  37. Type 2 diabetes mellitus and risk of malignancy: is there a strategy to identify a subphenotype of patients with increased susceptibility to endogenous and exogenous hyperinsulinism?
    Karsten Müssig, Harald Staiger, Kοnstantinos Kantartzis, Andreas Fritsche, Lothar Kanz, Hans‐Ulrich Häring · 2010 · Diabetic Medicine
  38. Association of the genetic variants of insulin receptor substrate 1 (IRS-1) with type 2 diabetes mellitus in a Saudi population
    Khalid Khalaf Alharbi, Imran Ali Khan, Anjana Munshi, Fawiziah Khalaf Alharbi, Yazeed A. Al‐Sheikh, May Salem Al-Nbaheen · 2014 · Endocrine
  39. The Genetics of Insulin Resistance: Where’s Waldo?
    Richard M. Watanabe · 2010 · Current Diabetes Reports
  40. Dissection of type 2 diabetes: a genetic perspective
    Amélie Bonnefond, José C. Florez, Ruth J. F. Loos, Philippe Froguel · 2025 · The Lancet Diabetes & Endocrinology
  41. Personal History of Diabetes, Genetic Susceptibility to Diabetes, and Risk of Brain Glioma: A Pooled Analysis of Observational Studies
    Cari Meinhold Kitahara, Martha S. Linet, Alina V. Brenner, SOPHIA S WANG, Beatrice S. Melin, Zhaoming Wang, Peter D. Inskip, Laura E. Beane Freeman, Melissa Z. Braganza, Tania Carreón et al. · 2013 · Cancer Epidemiology Biomarkers & Prevention
  42. Keratoconus-susceptibility gene identification by corneal thickness genome-wide association study and artificial intelligence IBM Watson
    Yoshikatsu Hosoda, Masahiro Miyake, Akira Meguro, Yasuharu Tabara, Sachiko Iwai, Naoko Ueda‐Arakawa, Eri Nakano, Yuki Mori, Munemitsu Yoshikawa, Hideo Nakanishi et al. · 2020 · Communications Biology
  43. Phase separation of insulin receptor substrate 1 drives the formation of insulin/IGF-1 signalosomes
    Xiu Kui Gao, Xi Sheng Rao, Xiao Xia Cong, Zu Kang Sheng, Yu Ting Sun, Shui Bo Xu, Jian Feng Wang, Yongheng Liang, Linrong Lu, Hongwei Ouyang et al. · 2022 · Cell Discovery
  44. Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test
    Anette P. Gjesing, Lise Kjems, Marie Aare Vestmar, Niels Grarup, Allan R Linneberg, Carolyn Fiona Deacon, Jens Juul Holst, Oluf Borbye Pedersen, Torben F. Hansen · 2010 · Diabetologia
  45. Future Challenges and Present Ethical Considerations in the Use of Personalized Nutrition Based on Genetic Advice
    Rodrigo San-Cristóbal, Fermin Ignacio Milagro, José Alfredo Martínez · 2013 · Journal of the Academy of Nutrition and Dietetics
  46. A Comparative Perspective on Wnt/β-Catenin Signalling in Cell Fate Determination
    Clare L. Garcin, Shukry James Habib · 2017 · Results and problems in cell differentiation
  47. Investigation on Cardiovascular Risk Prediction Using Genetic Information
    Lina Pu, Ze Zhao, Yuan‐Ting Zhang · 2012 · IEEE Transactions on Information Technology in Biomedicine
  48. Hepatic Expression of Adenovirus 36 E4ORF1 Improves Glycemic Control and Promotes Glucose Metabolism Through AKT Activation
    Travis B. McMurphy, Wei Huang, Run Xiao, Xianglan Liu, Nikhil V. Dhurandhar, Lei Cao · 2016 · Diabetes
  49. IRS-1 genetic polymorphism (r.2963G>A) in type 2 diabetes mellitus patients associated with insulin resistance
    Anas Yousef, Eman Gamal Behiry, Wafaa Abd Allah, Hussien AM, Abdelmoneam Abdelmoneam, Mahmoud Hamada Imam, Hikal DM · 2018 · The Application of Clinical Genetics
  50. Sex-specific interactions between the IRS1 polymorphism and intakes of carbohydrates and fat on incident type 2 diabetes
    Ulrika Ericson, Gull Rukh, Ivana Stojkovic, Emily Sonestedt, Bo Gullberg, Elisabet Wirfält, Peter Wallström, Marju Orho‐Melander · 2012 · American Journal of Clinical Nutrition
  51. Perspectives on genetic studies of type 2 diabetes from the genome‐wide association studies era to precision medicine
    Minako Imamura, Shiro Maeda · 2024 · Journal of Diabetes Investigation
  52. A novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis
    Victoria DeMambro, Masanobu Kawai, Thomas L. Clemens, Keertik S. Fulzele, Jane A Maynard, Caralina Marín de Evsikova, Kenneth R. Johnson, ERNESTO M. CANALIS, Wesley G. Beamer, Clifford james Rosen et al. · 2009 · Journal of Endocrinology
  53. Genome‐wide association studies (GWAS): impact on elucidating the aetiology of diabetes
    Hakon H. Hakonarson, Struan F.A. Grant · 2011 · Diabetes/Metabolism Research and Reviews
  54. Treatment factors rather than genetic variation determine metabolic syndrome in childhood cancer survivors
    Marjolein van Waas, Sebastian J.C.M.M. Neggers, André Gerardus Uitterlinden, Karin Blijdorp, Ivana M.M. van der Geest, Rob Pieters, Marry M. van den Heuvel‐Eibrink · 2012 · European Journal of Cancer
  55. Type 2 Diabetes Mellitus and Glucagon Like Peptide-1 Receptor Signalling
    Kanamarlapudi Aiysha Thompson · 2013 · Clinical and Experimental Pharmacology
  56. Quantitative trait locus mapping and analysis of heritable variation in affiliative social behavior and co‐occurring traits
    Allison T. Knoll, K. Jiang, Pat R. Levitt · 2017 · Genes Brain & Behavior
  57. Genetic Risk Factors for Type 2 Diabetes: A Trans-Regulatory Genetic Architecture?
    Steven C. Elbein, Eric R. Gamazon, Swapan K. Das, Neda Rasouli, Philip A. Kern, Nancy Jean Cox · 2012 · The American Journal of Human Genetics
  58. Use of Net Reclassification Improvement (NRI) Method Confirms The Utility of Combined Genetic Risk Score to Predict Type 2 Diabetes
    Claudia H.T. Tam, Janice S. K. Ho, Ying Wang, Vincent Kwok Lim Lam, Heung Man Lee, Guozhi Jiang, Eric S. H. Lau, Alice P.S. Kong, Xiaodan Fan, Jean Woo et al. · 2013 · PLoS ONE
  59. Trans-ethnic fine mapping identifies a novel independent locus at the 3′ end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population
    Jane Zea-Chin Kuo, Wayne Huey‐Herng Sheu, Themistocles L. Assimes, Yi‐Jen Hung, Devin Absher, Yen‐Feng Chiu, Jordan T. Mak, Jun‐Sing Wang, Soonil Kwon, Chih‐Cheng Hsu et al. · 2013 · Diabetologia
  60. From Genetic Association to Molecular Mechanism
    Martijn van de Bunt, Anna L. Gloyn · 2010 · Current Diabetes Reports
  61. Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk
    Henning Jansen, Christina Loley, Wolfgang Lieb, Michael J. Pencina, Christopher P. Nelson, Sekar Kathiresan, Gina Marie Peloso, Benjamin F. Voight, Muredach P. Reilly, Themistocles L. Assimes et al. · 2015 · Atherosclerosis
  62. Genome-wide association studies: the good, the bad and the ugly
    TM Frayling · 2014 · Clinical Medicine
  63. IRS1 Genotype Modulates Metabolic Syndrome Reversion in Response to 2-Year Weight-Loss Diet Intervention
    Qibin Qi, Min Xu, Hongyu Wu, Liming Liang, Catherine M. Champagne, George A. Bray, Frank M. Sacks, Lu Qi · 2013 · Diabetes Care
  64. Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome
    Kathryn G. Ewens, Michelle R. Jones, Wendy Ankener, Douglas R. Stewart, Margrit Urbanek, Andrea Elizabeth Dunaif, Richard S. Legro, Angela K. Chua, Ricardo Azziz, Richard S. Spielman et al. · 2011 · Fertility and Sterility
  65. The type 2 diabetes and insulin-resistance locus near IRS1 is a determinant of HDL cholesterol and triglycerides levels among diabetic subjects
    Rajani Sharma, Sabrina Prudente, Francesco Andreozzi, Christine M. Powers, Gaia Chiara Mannino, Simonetta Bacci, Ernest V. Gervino, Thomas H. Hauser, Elena Succurro, Luana Mercuri et al. · 2011 · Atherosclerosis
  66. Proliferator-activated receptor gamma Pro12Ala interacts with the insulin receptor substrate 1 Gly972Arg and increase the risk of insulin resistance and diabetes in the mixed ancestry population from South Africa
    Zelda Vergotine, Yandiswa Yolanda Yako, André Pascal Kengne, Rajiv Timothy Erasmus, Tandi Edith Matsha · 2014 · BMC Genetics
  67. IRS1 DNA promoter methylation and expression in human adipose tissue are related to fat distribution and metabolic traits
    Kerstin Rohde, Matthias Klös, Lydia Hopp, Xuanshi Liu, Maria Keller, Michael Stümvoll, Arne Dietrich, Michael R. Schön, Daniel Gärtner, Tobias Lohmann et al. · 2017 · Scientific Reports
  68. AKT1 polymorphisms are associated with risk for metabolic syndrome
    Joseph M. Devaney, Heather Gordish‐Dressman, Brennan T. Harmon, Margaret K. Bradbury, Stephanie A. Devaney, Tamara B. Harris, Paul D. Thompson, Priscilla M. Clarkson, Thomas B. Price, Theodore J. Angelopoulos et al. · 2010 · Human Genetics
  69. Genetic Risk Factors for Type 2 Diabetes: Insights from the Emerging Genomic Evidence
    Evangelia Ntzani, Fotini K. Kavvoura · 2012 · Current Vascular Pharmacology
  70. An epigenetic map of age-associated autosomal loci in northern European families at high risk for the metabolic syndrome
    Omar Ali, Diana Cerjak, Jack W. Kent, Roland G. James, John Blangero, Melanie A. Carless, Yi Zhang · 2015 · Clinical Epigenetics
  71. Circulating 25-Hydroxyvitamin D, IRS1 Variant rs2943641, and Insulin Resistance: Replication of a Gene–Nutrient Interaction in 4 Populations of Different Ancestries
    Ju‐Sheng Zheng, Laurence D. Parnell, Caren E. Smith, Yu‐Chi Lee, Aziza Jamal‐Allial, Yiyi Ma, Duo Li, Katherine L. Tucker, José María Ordovás, Chao‐Qiang Lai · 2013 · Clinical Chemistry
  72. Modulation by Dietary Fat and Carbohydrate ofIRS1Association With Type 2 Diabetes Traits in Two Populations of Different Ancestries
    Ju‐Sheng Zheng, Donna K. Arnett, Laurence D. Parnell, Caren E. Smith, Duo Li, Ingrid B. Borecki, Katherine L. Tucker, José María Ordovás, Chao‐Qiang Lai · 2013 · Diabetes Care
  73. IRS1 gene polymorphisms Gly972Arg and Ala513Pro are not associated with insulin resistance and type 2 diabetes risk in non-obese Turkish population
    Hilal Arıkoğlu, Melda Aksoy Hepdogru, Dudu Erkoç Kaya, Aycan Aşık, Süleyman Hilmi İpekçi, Funda İşçioğlu · 2014 · Meta Gene
  74. Transcription factor AP-2β: A negative regulator of IRS-1 gene expression
    Xiangning Meng, Motoyuki Kondo, Katsutaro Morino, Tomoya Fuke, Toshiyuki Obata, Takeshi Yoshizaki, Satoshi Ugi, Yoshihiko Nishio, Shiro Maeda, Eiichi Araki et al. · 2010 · Biochemical and Biophysical Research Communications
  75. Is FTO a type 2 diabetes susceptibility gene?
    David Meyre · 2012 · Diabetologia
  76. Inherited destiny? Genetics and gestational diabetes mellitus
    R. Watanabe · 2011 · Genome Medicine
  77. Changes in selective pressures associated with human population expansion may explain metabolic and immune related pathways enriched for signatures of positive selection
    Alexandra I. Vatsiou, Éric Bazin, Oscar E. Gaggiotti · 2016 · BMC Genomics
  78. Pathophysiology and Prevention of Heart Disease in Diabetes Mellitus
    Ahmet Afşin Oktay, Halis Kaan Aktürk, Kerim Esenboğa, Fahad Javed, Nichole M. Polin, Eiman Jahangir · 2017 · Current Problems in Cardiology
  79. Nutrigenetic variants and response to diet/lifestyle intervention in obese subjects: a pilot study
    Marica Franzago, Marta Di Nicola, Federica Fraticelli, Michele Marchioni, Liborio Stuppia, Ester Vitacolonna · 2021 · Acta Diabetologica
  80. Involvement of Cdkal1 in the etiology of type 2 diabetes mellitus and microvascular diabetic complications: a review
    Chandrachur Ghosh, Neeladrisingha Das, Sarama Saha, Tathagata Kundu, Debabrata Sircar, Partha Roy · 2022 · Journal of Diabetes & Metabolic Disorders
  81. Genomics and Genetics in the Biology of Adaptation to Exercise
    Claude Bouchard, Tuomo Rankinen, James A. Timmons · 2011 · Comprehensive physiology
  82. The Gly(972)Arg Variant of Human IRS1 Gene Is Associated With Variation in Glomerular Filtration Rate Likely Through Impaired Insulin Receptor Signaling
    Farook Thameem, Sobha Puppala, Jennifer L. Schneider, Basant Bhandari, Rector Arya, Nedal H. Arar, Tetyana L. Vasylyeva, Vidya S. Farook, Sharon P. Fowler, Laura A. Almasy et al. · 2012 · Diabetes
  83. Type 2 Diabetes Mellitus
    John B. Buse, Kenneth S. Polonsky, Charles Burant · 2011 · Elsevier eBooks
  84. Genetics, genomics, and diet interactions in obesity in the Latin American environment
    Patricia Guevara‐Ramírez, Santiago Cadena-Ullauri, Viviana A. Ruiz‐Pozo, Rafael Tamayo‐Trujillo, Elius Paz‐Cruz, Daniel Simancas‐Racines, Ana Karina Zambrano · 2022 · Frontiers in Nutrition
  85. Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic β cell insufficiency
    Damaris N. Lorenzo, Jane Anne Healy, Janell Hostettler, Jonathan Q. Davis, Jiayu Yang, Chao Wang, Hans E. Hohmeier, Mingjie Zhang, Vann Bennett · 2015 · Journal of Clinical Investigation
  86. Association of Type 2 Diabetes Susceptibility Loci With One‐Year Weight Loss in the Look AHEAD Clinical Trial
    Inga Peter, Jeanne M. McCaffery, Alyson Kelley-Hedgepeth, Hakon H. Hakonarson, Steven E. Reís, Lynne E. Wagenknecht, Alan S. Kopin, Gondon S. Huggins, For the Genetics Subgroup of the Look AHEAD Study · 2012 · Obesity
  87. Obesity-Induced Insulin Resistance in Human Skeletal Muscle Is Characterised by Defective Activation of p42/p44 MAP Kinase
    Antonio J. Ruiz‐Alcaraz, Christopher Lipina, John R. Petrie, Michael J. Murphy, Andrew D. Morris, Calum D. Sutherland, Daniel James Cuthbertson · 2013 · PLoS ONE
  88. Replication study of novel risk variants in six genes with type 2 diabetes and related quantitative traits in the Han Chinese lean individuals
    Xiao Yun Bao, Bin Peng, Mao Sheng Yang · 2011 · Molecular Biology Reports
  89. H19 inhibition increases HDAC6 and regulates IRS1 levels and insulin signaling in the skeletal muscle during diabetes
    Amit Kumar, Malabika Datta · 2022 · Molecular Medicine
  90. An update of the consensus statement on insulin resistance in children 2010
    V. Tagi, Sona Samvelyan, F. Chiarelli · 2022 · Frontiers in Endocrinology
  91. Polycystic ovary syndrome is not associated with genetic variants that mark risk of type 2 diabetes
    Richa Saxena, Corrine Kolka Welt · 2012 · Acta Diabetologica
  92. IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk
    Nikos Yiannakouris, Jackie A. Cooper, Sonia H Shah, Fotios Drenos, H. Ireland, Jeffrey Wayne Stephens, KaWah Li, Robert S Elkeles, Ian F. Godsland, Mika Kivimaki B et al. · 2011 · Nutrition Metabolism and Cardiovascular Diseases
  93. Recent advances and perspectives in next generation sequencing application to the genetic research of type 2 diabetes
    Yulia A. Nasykhova, Yury A. Barbitoff, Elena A. Serebryakova, Dmitriy Katserov, Andrey Sergeyevich Glotov · 2019 · World Journal of Diabetes
  94. Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL-cholesterol ratio as a proxy
    Natalie DeForest, Yuqi Wang, Zhiyi Zhu, Jacqueline S. Dron, Ryan Koesterer, Pradeep Natarajan, Jason A. Flannick, Tiffany Amariuta, Gina Marie Peloso, Amit R. Majithia · 2024 · Nature Communications
  95. Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia ofCordyceps militarisin High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice
    Sung-Hsun Yu, Szu-Yu Tina Chen, Wei-Shan Li, Navneet Kumar Dubey, Wei-Hong Chen, Jiunn‐Jye Chuu, Sy‐Jye Leu, Win‐Ping Deng · 2015 · Journal of Diabetes Research
  96. Quantitative candidate gene association studies of metabolic traits in Han Chinese type 2 diabetes patients
    Fanchao Wei, C. Y. Cai, Pei Yu, J. Lv, Chao Ling, Wentao Shi, Hongxiao Jiao, Baocheng Chang, F.H. Yang, Y. Tian et al. · 2015 · Genetics and Molecular Research
  97. A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: Results from the IMMEnSE consortium and meta-analysis
    Rafael Ríos, Carmen B. Lupiañez, Daniele Campa, Thomas Hielscher, Niels Weinhold, Joaquín Martínez‐López, Andrés Jerez, Stefano Landi, Krzysztof Jamroziak, Charles Dumontet et al. · 2016 · Oncotarget
  98. The Transcriptional Coactivators p/CIP and SRC-1 Control Insulin Resistance through IRS1 in Obesity Models
    Zhiyong Wang, O. Jameel Shah, Tony Hunter · 2012 · PLoS ONE
  99. Transferability and fine-mapping of glucose and insulin quantitative trait loci across populations: CARe, the Candidate Gene Association Resource
    C.-T. Liu, M. Ng, D. Rybin, A. Adeyemo, S. Bielinski, E. Boerwinkle, I. Borecki, B. Cade, Y.-D.-I. Chen, L. Djoussé et al. · 2012 · Diabetologia
  100. Hyperinsulinemia or Insulin Resistance: What Impacts the Progression of Alzheimer’s Disease?
    Vijay K. Hegde, Nikhil V. Dhurandhar, P. Hemachandra Reddy · 2019 · Journal of Alzheimer s Disease