The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells
Open accessAbstract
The discovery of interchromosomal interactions in higher eukaryotes points to a functional interplay between genome architecture and gene expression, challenging the view of transcription as a one-dimensional process. However, the extent of interchromosomal interactions and the underlying mechanisms are unknown. Here we present the first genome-wide analysis of transcriptional interactions using the mouse globin genes in erythroid tissues. Our results show that the active globin genes associate with hundreds of other transcribed genes, revealing extensive and preferential intra- and interchromosomal transcription interactomes. We show that the transcription factor Klf1 mediates preferential co-associations of Klf1-regulated genes at a limited number of specialized transcription factories. Our results establish a new gene expression paradigm, implying that active co-regulated genes and their regulatory factors cooperate to create specialized nuclear hot spots optimized for efficient and coordinated transcriptional control.
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Self-citationThe active spatial organization of the β-globin locus requires the transcription factor EKLF
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Self-citationSingle-cell Hi-C reveals cell-to-cell variability in chromosome structure
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Self-citationArchitectural protein subclasses shape 3D organization of genomes during lineage commitment
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Metadata
- Authors
- Schoenfelder, S., Sexton, T., Chakalova, L., Cope, N. F., Horton, A., Andrews, S., Kurukuti, S., Mitchell, J. A., Umlauf, D., Dimitrova, D. S., Eskiw, C. H., Luo, Y., Wei, C.-L., Ruan, Y., Bieker, J. J., & Fraser, P.
- Venue
- Nature Genetics
- Published
- 2009-12-13
- Volume
- 42
- Issue
- 1
- Pages
- 53-61
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2152531901
- Cited by
- 714
- References
- 9
- FWCI
- 26.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Schoenfelder, S., Sexton, T., Chakalova, L., Cope, N. F., Horton, A., Andrews, S., Kurukuti, S., Mitchell, J. A., Umlauf, D., Dimitrova, D. S., Eskiw, C. H., Luo, Y., Wei, C.-L., Ruan, Y., Bieker, J. J., & Fraser, P. (2010). Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells. Nature Genetics. https://doi.org/10.1038/ng.496
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