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Cited by 455

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Common variants at 5q22 associate with pediatric eosinophilic esophagitis

Open access
Rothenberg, Marc E, Spergel, Jonathan M, Sherrill, Joseph D, Annaiah, Kiran, Martin, Lisa J, Cianferoni, Antonella, Gober, Laura, Kim, Cecilia, Glessner, Joseph, Frackelton, Edward, Thomas, Kelly, Blanchard, Carine, Liacouras, Chris, Verma, Ritu, Aceves, Seema, Collins, Margaret H, Brown-Whitehorn, Terri, Putnam, Phil E, Franciosi, James P, Chiavacci, Rosetta M, Grant, Struan F A, Abonia, J Pablo, Sleiman, Patrick M A, Hakonarson, Hakon·2010·Nature Genetics

Abstract

Eosinophilic esophagitis (EoE) is an allergic disorder characterized by the accumulation of eosinophils in the esophagus. We report association of EoE with variants at chromosome 5q22 encompassing TSLP and WDR36 (rs3806932, combined P = 3.19 × 10−9). TSLP is overexpressed in esophageal biopsies from individuals with EoE compared with unaffected individuals, whereas WDR36 expression is unaltered between the two groups. These data implicate the 5q22 locus in the pathogenesis of EoE and identify TSLP as the most likely candidate gene in the region.

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Metadata

Authors
Rothenberg, M. E., Spergel, J. M., Sherrill, J. D., Annaiah, K., Martin, L. J., Cianferoni, A., Gober, L., Kim, C., Glessner, J., Frackelton, E., Thomas, K., Blanchard, C., Liacouras, C., Verma, R., Aceves, S., Collins, M. H., Brown-Whitehorn, T., Putnam, P. E., Franciosi, J. P., Chiavacci, R. M., Grant, S. F. A., Abonia, J. P., Sleiman, P. M. A., & Hakonarson, H.
Venue
Nature Genetics
Published
2010-03-07
Volume
42
Issue
4
Pages
289-291
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
OpenAlex
W2116575182
Cited by
455
References
15
FWCI
36.33
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Common variants at 5q22 associate with pediatric eosinophilic esophagitis. https://app.cochat.ai/papers/10.1038/ng.547
The paper
Rothenberg, M. E., Spergel, J. M., Sherrill, J. D., Annaiah, K., Martin, L. J., Cianferoni, A., Gober, L., Kim, C., Glessner, J., Frackelton, E., Thomas, K., Blanchard, C., Liacouras, C., Verma, R., Aceves, S., Collins, M. H., Brown-Whitehorn, T., Putnam, P. E., Franciosi, J. P., . . . Hakonarson, H. (2010). Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nature Genetics. https://doi.org/10.1038/ng.547

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.