Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
Ernst, Thomas, Chase, Andrew J, Score, Joannah, Hidalgo-Curtis, Claire E, Bryant, Catherine, Jones, Amy V, Waghorn, Katherine, Zoi, Katerina +10 more·2010·Nature Genetics
DOI 10.1038/ng.621
Cited by (1,000)
Items 801–900 of 1,000
- Molecular pathology of myelodysplastic syndromes: new developments and implications for diagnosis and treatmentXiaohui Zhang, Jeffrey E. Lancet, Ling Zhang · 2015 · Leukemia & lymphoma/Leukemia and lymphoma
- Epigenetic deregulation in myeloid malignanciesKristen M. Meldi, María E. Figueroa · 2014 · Translational research
- Alterations of Histone Modifications in CancerCiro Mercurio, Simon Edward Plyte, Saverio Minucci · 2012 · Elsevier eBooks
- Identification of epigenetic modifications that contribute to pathogenesis in therapy-related AML: Effective integration of genome-wide histone modification with transcriptional profilesXinan Holly Yang, Bin Wang, John M. Cunningham · 2015 · BMC Medical Genomics
- The genomic landscape of myeloid neoplasms with myelodysplasia and its clinical implicationsLuca Malcovati, Ilaria Ambaglio, Chiara Elena · 2015 · Current Opinion in Oncology
- EZH2: a pleiotropic proteinThomas Burmeister · 2016 · Blood
- High expression of ABCG2 induced by EZH2 disruption has pivotal roles in MDS pathogenesisKimihito Cojin Kawabata, Yasutaka Hayashi, Daichi Inoue, H Meguro, Hiroko Sakurai, Tomofusa Fukuyama, Yosuke Tanaka, Shuhei Asada, T Fukushima, Reina Nagase et al. · 2017 · Leukemia
- Bioinformatics analysis of the network of histone H3 lysine 9 trimethylation in acute myeloid leukaemiaAishu Dong, Wen‐Bin Yang, He Feng Huang, Xiaohai Zhou, Zhewei He, Rongxing Yao, Wenjian Guo · 2020 · Oncology Reports
- From cellular morphology to molecular and epigenetic anomalies of myelodysplastic syndromesMacoura Gadji, Aline Rangel Pozzo · 2018 · Genes Chromosomes and Cancer
- Drug Discovery MethodsMarie Lopez, Maxime Leroy, Chantal Etiévant, Fréderic Ausseil, Alexandre Gagnon, Paola Barbara Arimondo · 2016 · Elsevier eBooks
- Genetic Determinants of Cancer SusceptibilityJoe M. Angel, Erika L. Abel, John DiGiovanni · 2010 · Elsevier eBooks
- A miniaturized mode-of-action profiling platform enables high throughput characterization of the molecular and cellular dynamics of EZH2 inhibitionLilia Falkenstern, Victoria Georgi, Stefanie Bunse, Volker Badock, Manfred Husemann, Ulrike Roehn, Timo Stellfeld, Mark E. Fitzgerald, Steven J. Ferrara, Detlef Stöckigt et al. · 2024 · Scientific Reports
- Myeloid sarcoma shows a high frequency of mutations activating the MAPK / ERK pathway and association with clonal hematopoiesisDominik Nann, Tim‐Colin Schade, Mathis Overkamp, Lejla Mahmutovic, Eyyub Bag, Stephan Forchhammer, Julia Slotta‐Huspenina, L Boudová, Karl Sotlar, Leticia Quintanilla‐Martínez et al. · 2025 · The Journal of Pathology Clinical Research
- Rare germline variants in regions of loss of heterozygosity may influence clinical course of hematological malignanciesAshot S. Harutyunyan, Bettina Gisslinger, Thorsten Klampfl, Tobias Berg, Klaudia Bagienski, Heinz Gisslinger, Róbert Královics · 2011 · Leukemia
- Recurrent Cytogenetic Abnormalities in Myelodysplastic SyndromesMeaghan Wall · 2016 · Methods in molecular biology
- EpigeneticsRosanna Weksberg, Darci T. Butcher, Daria Grafodatskaya, Sanaa Choufani, Benjamin Tycko · 2013 · Elsevier eBooks
- Knockdown of NIR Suppresses Breast Cancer Cell Proliferation via Promoting FOXO3Bolin Chen, Chengcheng Dong, Fang Wang, Jiacai Wu · 2021 · OncoTargets and Therapy
- Oncogenic Roles of Polycomb Repressive Complex 2 in Bladder Cancer and Upper Tract Urothelial CarcinomaEric Yi‐Hsiu Huang, Yu-Kuang Chen, Chen-Pu Ou, Yi‐Ting Chen, Sung‐Fang Chen, William J. Huang, Kung‐Hao Liang · 2022 · Biomedicines
- Biological Functions of the KDM2 Family of Histone DemethylasesJaclyn Andricovich, Alexandros Tzatsos · 2023 · Advances in experimental medicine and biology
- Polycomb group proteins in hematopoietic stem cell aging and malignanciesKarin Klauke, Gerald de Haan · 2011 · International Journal of Hematology
- Heterogeneity of molecular markers in chronic myelomonocytic leukemia: a disease associated with several gene alterationsJean-Noël Bastie, Romain Aucagne, Nathalie M Droin, Éric Solary, Laurent Delva · 2012 · Cellular and Molecular Life Sciences
- Myelodysplastic syndromes: advantages of a combined cytogenetic and molecular diagnostic workupElena Ciabatti, Angelo Valetto, Veronica Bertini, Maria Immacolata Ferreri, Alice Guazzelli, Susanna Grassi, Francesca Guerrini, Iacopo Petrini, Maria Rita Metelli, Maria Adelaide Caligo et al. · 2017 · Oncotarget
- Mechanistic Insights of Aberrant Splicing with Splicing Factor Mutations Found in Myelodysplastic SyndromesNaoyuki Kataoka, Eri Matsumoto, So Masaki · 2021 · International Journal of Molecular Sciences
- One Omics Approach Does Not Rule Them All: The Metabolome and the Epigenome Join Forces in Haematological MalignanciesAntonia Kalushkova, Patrick Nylund, Alba Atienza Párraga, Andreas Lennartsson, Helena Jernberg‐Wiklund · 2021 · Epigenomes
- Antisense technology as a potential strategy for the treatment of coronaviruses infection: With focus on COVID‐19Seyedeh Hoda Alavizadeh, Maham Doagooyan, Fatemeh Zahedipour, Shima Yahoo Torghabe, Bahare Baharieh, Firooze Soleymani, Fatemeh Gheybi · 2022 · IET Nanobiotechnology
- Switch-Independent 3A: An Epigenetic Regulator in Cancer with New Implications for Pulmonary Arterial HypertensionKatherine Jankowski, Vineeta Jagana, Malik Bisserier, Lahouaria Hadri · 2023 · Biomedicines
- Histone profiles in cancerSimone Stefanie Riedel, Tobias Neff, Kathrin Maria Bernt · 2015 · Pharmacology & Therapeutics
- Epigenetic aberrations in myeloid malignancies (Review)Shinichiro Takahashi · 2013 · International Journal of Molecular Medicine
- Genotype-Phenotype Interactions in the Myeloproliferative NeoplasmsAnna L. Godfrey, Anthony Richard Green · 2012 · Hematology/Oncology Clinics of North America
- Molecular Genetics of Myelofibrosis and its associated Disease PhenotypesAli Tabarroki, Ramon Velasquez Tiu · 2014 · Europe PMC (PubMed Central)
- Insights into the Molecular Genetics of Myeloproliferative NeoplasmsHuong Nguyen, Jason R. Gotlib · 2012 · American Society of Clinical Oncology Educational Book
- Application of induced pluripotent stem cell technology for the investigation of hematological disordersHamid Dolatshad, Dharamveer Tatwavedi, Doaa Ahmed, Jana F. Tegethoff, Jacqueline Boultwood, Andrea Pellagatti · 2018 · Advances in Biological Regulation
- Age-Related Increase of EED Expression in Early Hematopoietic Progenitor Cells is Associated with Global Increase of the Histone Modification H3K27me3Nina Graffmann, Jens Brands, André Görgens, Symone Vitoriano da Conceição Castro, Simeon Santourlidis, Alexandra Reckert, Inga Michele, Stefanie Ritz‐Timme, Johannes Fischer, James Adjaye et al. · 2015 · Stem Cells and Development
- Polycomb protein RING1A limits hematopoietic differentiation in myelodysplastic syndromesAnna Palau, Anne-Kathrin Garz, Jeannine Diesch, Anabel Zwick, Roberto Malinverni, Vanesa Valero, Katrina M. Lappin, Raquel Casquero, Andreas Lennartsson, Johannes A. Zuber et al. · 2017 · Oncotarget
- Epigenetic TherapiesWallace Bourgeois, Scott A. Armstrong, Emily Heikamp · 2024 · Cold Spring Harbor Perspectives in Medicine
- Alternative splicing of EZH2 regulated by SNRPB mediates hepatocellular carcinoma progression via BMP2 signaling pathwayXingyu Wang, Weiyi Liu, Chunai Zhan, Yuanyuan Zhang, Xinyu Li, Yaoyun Wang, Mengfei Sheng, Madiha Maqsood, Hang Shen, An-Min Liang et al. · 2024 · iScience
- Research progress on gene mutations and drug resistance in leukemiaXiangyu Ma, Jiamin Xu, Yanan Wang, Joshua S. Fleishman, Hao Bing, Bin Yu, Yanming Li, Letao Bo, Shaolong Zhang, Zhe‐Sheng Chen et al. · 2024 · Drug Resistance Updates
- EZH2: An analysis of a potential new tumor marker in high-risk localization of cutaneous squamous cell carcinomasCristian-Viktor Valea, Maurice Klein, Christian Hallermann, Hans-Joachim Schulze, Jan-Dirk Raguse, Kai Wermker · 2025 · Frontiers in Oncology
- Genetic evolution of myeloproliferative neoplasms from chronic phase to blastic phase: An analysis of 46 paired samplesHsiao‐Wen Kao, Hung Chang, Ming‐Chung Kuo, Jin‐Hou Wu, Ying‐Jung Huang, Ting‐Yu Huang, Tung‐Liang Lin, Lee‐Yung Shih · 2025 · Cancer
- Emerging role of EZH2 in solid tumor metastasisAyushi Verma, Muqtada Ali Khan, Saumya Ranjan Satrusal, Dipak B. Datta · 2024 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Mining the epigenetic landscape in ALLLindsay M. LaFave, Ross L. Levine · 2013 · Nature Genetics
- Clinical characteristics and outcomes of EZH2-mutant myelodysplastic syndrome: A large single institution analysis of 1774 patientsSomedeb Ball, Luis E. E. Aguirre, Akriti Gupta Jain, Najla E. Al Ali, Sara Tinsley, Onyee Chan, Andrew Tucker Kuykendall, Kendra Lynn Sweet, Jeffrey E. Lancet, David Andrew Sallman et al. · 2022 · Leukemia Research
- Recurring mutations in myeloproliferative neoplasms alter epigenetic regulation of gene expression.Gary W. Reuther · 2011 · Europe PMC (PubMed Central)
- Alterations of polycomb gene BMI1 in human myeloproliferative neoplasmsMandy Brecqueville, José Adélaı̈de, François Bertucci, Pascal Finetti, Max Chaffanet, Daniel Birnbaum, Anne Murati · 2012 · Cell Cycle
- Genetic and molecular characterization of myelodysplastic syndromes and related myeloid neoplasmsBhumika J. Patel, Cassandra M. Hirsch, Michael J. Clemente, Mikkael Aaron Sekeres, Hideki Makishima, Jaroslaw Pawel Maciejewski · 2015 · International Journal of Hematology
- No increase of JAK2 46/1 haplotype frequency in essential thrombocythemia with CALR mutations: Functional effect of the haplotype limited to allele with JAK2V617F mutation but not CALR mutationJyh‐Pyng Gau, Chih‐Cheng Chen, Yi-Sheng Chou, Chia‐Jen Liu, Yuan‐Bin Yu, Liang‐Tsai Hsiao, Liu H, Hui‐Chi Hsu, Tzeon-Jye Chiou, Po‐Min Chen et al. · 2015 · Blood Cells Molecules and Diseases
- Chronic lymphocytic leukemia - genomics lead the wayDaniel Mertens, Lars Bullinger, Stephan Stilgenbauer · 2011 · Haematologica
- Genetic Determinants of Cancer SusceptibilityJoe M. Angel, John DiGiovanni · 2017 · Elsevier eBooks
- Integrative Multi-Omics Analysis of Oncogenic EZH2 Mutants: From Epigenetic Reprogramming to Molecular SignaturesJulian Aldana, Miranda L. Gardner, Michael A. Freitas · 2023 · International Journal of Molecular Sciences
- The Etiology of Acute LeukemiaJessica N. Nichol, Sarit E. Assouline, Wilson H. Miller · 2012 · Springer eBooks
- Acute Myeloid LeukemiaRobert John Arceci, Jason N. Berman, Soheil Meshinchi · 2013 · Elsevier eBooks
- Mouse Models of Myeloid MalignanciesFaisal Basheer, George S. Vassiliou · 2020 · Cold Spring Harbor Perspectives in Medicine
- Dominant negative effects on H3K27 methylation by Weaver syndrome-associated EZH2 variantsOrla Deevy, Craig Monger, Francesca Matrà, Ellen Tuck, Eric Conway, Mihaly Badonyi, Darragh Nimmo, Simona Rodighiero, Qi Zhang, Chen Davidovich et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Polycomb repressive complexes as therapeutic targets in hematologic malignanciesMakoto Yamagishi, Atsushi Iwama, Issay Kitabayashi · 2025 · Experimental Hematology
- Somatic mutations and DNA methylation identify a subgroup of poor prognosis within lower‐risk myelodysplastic syndromesDavid Rombaut, Sarah Sandmann, Tobias Tekath, Simon Crouch, Aniek O. de Graaf, Alexandra G. Smith, Daniel Painter, Olivier Kosmider, Magnus Tobiasson, Andreas Lennartsson et al. · 2025 · HemaSphere
- Au cœur d’une complexité biologiqueMyriam Koubi, Christian Chabannon, Estelle Duprez · 2017 · médecine/sciences
- WITHDRAWN: Molecular genetics of thrombotic myeloproliferative neoplasms: Implications in precision oncologyYuh Cai Chia, Marini Ramli, Peng Yeong Woon, Muhammad Farid Johan, Rosline Hassan, Md Asiful Islam · 2021 · Genes & Diseases · Retracted
- Genetic Impairments of PRC2 Activity in Oncology: Problems and ProspectsDarya Chetverina, Д. В. Ломаев, Pavel G Georgiev, Maksim Erokhin · 2021 · Russian Journal of Genetics
- New Horizons in Myeloproliferative Neoplasms Treatment: A Review of Current and Future Therapeutic OptionsDomenico Penna · 2021 · Medicina
- Epigenetic vulnerabilities of leukemia harboring inactivating EZH2 mutationsMona Alqazzaz, Genna M. Luciani, Victoria Vu, Raquel A. C. Machado, Magdalena M. Szewczyk, Ella C. Adamson, Sehyun Cheon, Fengling Li, C.H. Arrowsmith, Mark David Minden et al. · 2023 · Experimental Hematology
- How I treat …Frank Moosig, Eva Reinhold‐Keller, Konstanze Holl‐Ulrich, Alfred Christian Feller, Thorsten Alexander Bley, Julia Ulrike Holle, Jochen Zwerina, Peter Lamprecht, Klaus Dalhoff, Nils Venhoff et al. · 2012 · Zeitschrift für Rheumatologie
- Clinical Predictors of Outcome in MPNFrancesco Passamonti, Margherita Maffioli, Michele Merli, Andrea Ferrario, Domenica Caramazza · 2012 · Hematology/Oncology Clinics of North America
- SNPs Array Karyotyping Reveals a Novel Recurrent 20p13 Amplification in Primary MyelofibrosisGiuseppe Visani, Maria Rosaria Sapienza, Alessandro Isidori, Claudio Tripodo, Maria Antonella Laginestra, Simona Righi, Carlo Alberto Sagramoso Sacchetti, Anna Gazzola, Claudia Mannu, Maura Rossi et al. · 2011 · PLoS ONE
- Distinct Gene Mutations, their Prognostic Relevance and Molecularly Targeted Therapies in Acute Myeloid Leukemia (AML)Muhammad Tayyab · 2014 · Journal of Cancer Science & Therapy
- Preparation, Biochemical Analysis, and Structure Determination of SET Domain Histone MethyltransferasesElisa Bergamin, J.F. Couture · 2016 · Methods in enzymology on CD-ROM/Methods in enzymology
- Five Important Advances in HematopathologyMin Shi, Ruobing Xiao, Bruce A. Woda, Hongbo Yu · 2014 · Archives of Pathology & Laboratory Medicine
- Retinoic acid-incorporated glycol chitosan nanoparticles inhibit the expression of Ezh2 in U118 and U138 human glioma cellsHuchen Lu, Jun Ma, Zong Zhuang, Yao Zhang, Huilin Cheng, Ji‐Xin Shi · 2015 · Molecular Medicine Reports · Retracted
- EVI1-Positive Leukemias and Myelodysplastic Syndromes: Theoretical and Clinical Aspects (Literature Review)Mamaev Nn, Alena Igorevna Shakirova, Еlena V. Morozova, Tatiana Gindina · 2021 · Clinical oncohematology
- Myelodysplastic SyndromesChristopher James Gibson, Benjamin L. Ebert, David P. Steensma · 2017 · Elsevier eBooks
- Tumor suppressor function of the polycomb group genesMakiko Mochizuki‐Kashio, George Russel Wendt, Atsushi Iwama · 2012 · Cell Cycle
- The role of epigenetic modifications in hematological cancersJovana Ilic, Anna Bold, Stefan Tobias Knop · 2026 · Frontiers in Oncology
- Bahcc1 is critical for the aberrant epigenetic program in a mouse model of MLL-ENL–mediated leukemiaAkihide Nakamura, Masahiro Masuya, Makoto Shinmei, Isao Tawara, Tetsuya Nosaka, Ryoichi Ono · 2024 · Blood Advances
- How we diagnose Myelodysplastic syndromesHoward S. Oster, Moshe Mittelman · 2024 · Frontiers in Oncology
- A novel insight of Asp193His mutation on epigenetic methyltransferase activity of human EZH2 protein: An in-silico approachNisha Gautam, Satbir Kaur, Kamaljeet Kaur, Neeraj Kumar · 2019 · Meta Gene
- Polycomb Alterations in Acute Myeloid Leukaemia: From Structure to FunctionTeerna Bhattacharyya, Jonathan Bond · 2023 · Cancers
- The Heightened Importance of EZH2 in Cancer ImmunotherapyXiaohu Lin, Wenkai Zhou, Chengzhong Lin, Wei Cao · 2023 · Cancer Screening and Prevention
- Progress in the research of epigenetic regulators in cancer therapyLongjiang Di, Jun ZHANG, Wei‐Guo Zhu · 2023 · Scientia Sinica Vitae
- Mature T-cell leukemias: Molecular and Clinical AspectsNathanael G. Bailey, Kojo S.J. Elenitoba‐Johnson · 2015 · Current Hematologic Malignancy Reports
- Retinoic acid-incorporated glycol chitosan nanoparticles inhibit the expression of Ezh2 in U118 and U138 human glioma cellsHuchen Lu, Jun Ma, Zong Zhuang, Yao Zhang, Huilin Cheng, Ji‐Xin Shi · 2016 · Molecular Medicine Reports · Retracted
- Attenuated Acceleration to Leukemia after Ezh2 Loss in Nup98‐HoxD13 (NHD13) Myelodysplastic SyndromeVictoria Ling, Jesslyn Saw, Cedric Stevens Tremblay, Stefan Sonderegger, Emma Toulmin, Jacqueline Anne Boyle, Sung Kai Chiu, Steven Lane, Stephen B. Ting, David J. Curtis · 2019 · HemaSphere
- Effect of L-Leucine Therapy on Hematopoietic Function in Elderly Myelodysplastic Syndrome PatientsKaori Ito, Takahiro Hayashi, Yoko Inaguma, Tomohiko Terazawa, Maiko Ando, Yosuke Ando, Masahiro Tsuge, Azusa Kato, Akane Shimato, Shinji Suzuki et al. · 2019 · Biological and Pharmaceutical Bulletin
- An “EZ” Epigenetic Road to Leukemia Stem Cell Metabolic Reprogramming?Meng Li, Ari M. Melnick · 2019 · Cancer Discovery
- Immunotherapy and Immunomodulation in Myeloproliferative NeoplasmsNaveen Pemmaraju, Natalie C. Chen, Srđan Verstovšek · 2021 · Hematology/Oncology Clinics of North America
- Targeting EZH2 prevents the occurrence and mitigates the development of Sjögren's syndrome in miceShicong Zhu, Mei Liu, Fenglin Zhu, Xi Yu, Junsong Wen, Chengyin Li · 2022 · International Immunopharmacology
- In Pursuit of Genetic Prognostic Factors and Treatment Approaches in Secondary Acute Myeloid Leukemia—A Narrative Review of Current KnowledgePaulina Stefaniuk, Agnieszka Szymczyk, Monika Podhorecka · 2022 · Journal of Clinical Medicine
- Role of Gene Mutations in Acute Myeloid Leukemia: A Review ArticleHimanshu Singh, Magesh Kumar, Himanshu Kanungo · 2023 · Global Medical Genetics
- Histone H3 mutations and their impact on genome stability maintenanceLucas D. Caeiro, Ramiro E. Verdún, Lluís Morey · 2024 · Biochemical Society Transactions
- Non-t(6;9) and Non-Inv(3) Balanced Chromosomal Rearrangements Are Associated With Poor Survival Outcomes in Myelodysplastic SyndromesJing Ai, Valeria Visconte, Ali Tabarroki, Edy Hasrouni, Betty K. Hamilton, Sudipto Mukherjee, Matt E Kalaycio, Ronald M. Sobecks, Anjali S. Advani, Mikkael Aaron Sekeres et al. · 2015 · Clinical Lymphoma Myeloma & Leukemia
- Inhibition of EZH2 degradation as a novel approach to overcome drug resistance in acute myeloid leukemiaStefanie Göllner, Carsten Müller‐Tidow · 2017 · Molecular & Cellular Oncology
- CD133 Marks a Stem Cell Population That Drives Human Primary MyelofibrosisIoanna Triviai, Thomas Stübig, Birte Niebuhr, Kais Hussein, Asterios S. Tsiftsoglou, Boris Fehse, Carol Stocking, Nicolaus Martin Kröger · 2013 · Blood
- Mutational Determinants of Epigenetic Instablity in Myeloid MalignanciesAnna Maria Jankowska, Hadrian Szpurka · 2012 · Seminars in Oncology
- Absence of mutations of the histone methyltransferase gene EZH2 in splenic b-cell marginal zone lymphomaMarta Salido, Luz Maria Martinez-Aviles, Vera Ademà, Ana Ferrer, Blanca Espinet, Mar Garcia, Antonio Salar, Carlos Besses, Lourdes Florensa, Sergi Serrano et al. · 2010 · Leukemia Research
- Collaboration between PcG Proteins and MLL Fusions in Leukemogenesis: An Emerging ParadigmBernd B. Zeisig, Mari-Francis Arteaga, Cécile Thirant, Chi Wai Eric So · 2011 · Cancer Cell
- Second-Generation Sequencing for Cancer Genome AnalysisHye-Jung E. Chun, Jaswinder S. Khattra, Martin I. Krzywinski, Samuel A. J. R. Aparicio, Marco A. Marra · 2013 · Elsevier eBooks
- Genetically altered cancer epigenomeMing Tang, Huacheng Luo, Jianrong Lu · 2015 · Elsevier eBooks
- The Etiology of Acute LeukemiaJessica N. Nichol, Mena Kinal, Wilson H. Miller · 2017 · Springer eBooks
- BCR-ABL1 -Negative Chronic Myeloid Neoplasms: An Update on Management TechniquesAlessandro Maria Vannucchi, Lisa Pieri, Maria Chiara Susini, Paola Guglielmelli · 2012 · Future Oncology
- Imatinib and Beyond – Targeting Activated Tyrosine Kinases in Myeloproliferative DisordersAndreas Hochhaus, Andreas Reiter, Thomas Ernst, Paul Graf La Rosée · 2012 · Onkologie
- Update on JAK2 inhibitors in myeloproliferative neoplasmDaniel Chan, Maya Koren‐Michowitz · 2011 · Therapeutic Advances in Hematology
- Recent Advances in Molecular Diagnostics and Targeted Therapy of Myeloproliferative NeoplasmsSimona Stivala, Sara C. Meyer · 2021 · Cancers