Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

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A bivalent chromatin structure marks key developmental genes in embryonic stem cells

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Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing

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Detection of large-scale variation in the human genome

Iafrate, A. J., Feuk, L., Rivera, M. N., Listewnik, M. L., Donahoe, P. K., Qi, Y., Scherer, S. W., & Lee, C. (2004) · Nature Genetics · doi:10.1038/ng1416 · Cited by 2,892

The Polycomb group protein EZH2 directly controls DNA methylation

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Mutation in TET2 in Myeloid Cancers

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Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

Morin, R. D., Johnson, N. A., Severson, T., Mungall, A. J. J., An, J., Goya, R., Paul, J. E., Boyle, M., Woolcock, B. W., Kuchenbauer, F. C., et al. (2010) · Nature Genetics · doi:10.1038/ng.518 · Cited by 1,719

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

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Histone Methyltransferase Activity of a Drosophila Polycomb Group Repressor Complex

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Drosophila Enhancer of Zeste/ESC Complexes Have a Histone H3 Methyltransferase Activity that Marks Chromosomal Polycomb Sites

Czermin, B., Melfi, R., McCabe, D., Seitz, V., Imhof, A., & Pirrotta, V. (2002) · Cell · doi:10.1016/s0092-8674(02)00975-3 · Cited by 1,536

Update on the Biology of Myeloproliferative Neoplasms

Královics, R. (2011) · Springer eBooks · doi:10.1007/978-3-642-24989-1_1 · Cited by 3

A Novel Prognostic Scoring Model for Myelodysplastic Syndrome Patients With SF3B1 Mutation

Ma, L., Liang, B., Hu, H., Yang, W., Lin, S., Cao, L., Li, K., Kuang, Y., Shou, L., Jin, W., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.905490 · Cited by 3

Mutations in the histone methyltransferase Ezh2 drive context-dependent leukemia in Xenopus tropicalis

Tulkens, D., Boelens, M., Naert, T., Carron, M., Demuynck, S., Dewaele, S., Isterdael, G. V., Creytens, D., Pieters, T., Goossens, S., et al. (2023) · Leukemia · doi:10.1038/s41375-023-02052-2 · Cited by 3

Expressional changes of genes and miRNA in common megakaryocyte-erythroid progenitors from lower-risk myelodysplastic syndrome

Maki, K., Sasaki, K., Nagata, Y., Nagasawa, F., Nakamura, Y., Ogawa, S., & Mitani, K. (2014) · International Journal of Hematology · doi:10.1007/s12185-014-1639-2 · Cited by 3

Single nucleotide polymorphism array-based karyotyping shows sequential genomic changes from monosomy to copy-neutral loss of heterozygosity of chromosome 7 and 20q deletion within a balanced translocation t(14;20) in AML

Huh, J., Mun, Y., Seong, C. M., & Chung, W. S. (2011) · Cancer Genetics · doi:10.1016/j.cancergen.2011.11.003 · Cited by 3

Genomics of lymphoid malignancies reveal major activation pathways in lymphocytes

Knoechel, B., & Lohr, J. G. (2013) · Journal of Autoimmunity · doi:10.1016/j.jaut.2013.06.012 · Cited by 3

Epigenetics and Chemoresistance in Childhood Acute Lymphoblastic Leukemia

Newton, T. P., Cummings, C. T., Graham, D. K., & Bernt, K. M. (2014) · International Journal of Hematologic Oncology · doi:10.2217/ijh.13.68 · Cited by 3

The Current Molecular Site of the Myeloproliferative Neoplasms - TET-àtête with the JAKpot but no LNK so far to Resolve Complexity

Bock, O. (2013) · Journal of Leukemia · doi:10.4172/2329-6917.1000108 · Cited by 3

MYC amplification in multiple marker chromosomes and EZH2 microdeletion in a man with acute myeloid leukemia

Xiang, Z., Abdallah, A.-O. A., Govindarajan, R., Mehta, P., Emanuel, P. D., Papenhausen, P. R., & Schichman, S. A. (2015) · Cancer Genetics · doi:10.1016/j.cancergen.2015.01.010 · Cited by 3

Histone deacetylase inhibitors and epigenetic regulation in lymphoid malignancies

Markozashvili, D., Ribrag, V., & Vassetzky, Y. S. (2015) · Investigational New Drugs · doi:10.1007/s10637-015-0290-y · Cited by 3

Prise en charge des myélodysplasies

Duchmann, M., Fenaux, P., & Cluzeau, T. (2015) · Bulletin du Cancer · doi:10.1016/j.bulcan.2015.07.007 · Cited by 3

dBRWD3 Regulates Tissue Overgrowth and Ectopic Gene Expression Caused by Polycomb Group Mutations

Shih, H., Chen, W., Liu, K.-Y., Shih, Z., Chen, Y.-J., Hsieh, P.-C., Kuo, K.-L., Huang, K., Hsu, P., Liu, Y., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006262 · Cited by 3

Elevated expression of the EZH2 gene in CALR-mutated patients with primary myelofibrosis

Fan, N., Tang, Y., Wu, Z., Guan, M., Chen, B., Xu, X., Ma, W., Xu, X. L., & Zhang, X. (2018) · Annals of Hematology · doi:10.1007/s00277-018-3287-8 · Cited by 3

Fishing the targets of myeloid malignancies in the era of next generation sequencing

Shi, X. E., He, A. B.-L., Ma, A. C. H., & Leung, A. Y. H. (2015) · Blood Reviews · doi:10.1016/j.blre.2015.09.001 · Cited by 3

Advances in the Management of Myelofibrosis

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Epigenetics in Acute Myeloid Leukemia

Giorgio, C., Dell’Aversana, C., & Altucci, L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803239-8.00027-2 · Cited by 2

Activating Mutations of the EZH2 Histone Methyltransferase in Cancer

Kruger, R. G., Graves, A. P., & McCabe, M. T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809737-3.00011-8 · Cited by 2

Neoplastische Bildungsstörungen der Hämatopoiese mit erhaltener Ausreifung

Kreipe, H. H. (2018) · Springer eBooks · doi:10.1007/978-3-540-85184-4_4 · Cited by 2

Germline Abnormalities in DNA Methylation and Histone Modification and Associated Cancer Risk

Fernandez, J. A., & Patnaik, M. M. (2022) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-022-00665-5 · Cited by 2

Epigenetic Mediated Regulation of Cancer-Testis/Germline Antigen and Its Implication in Cancer Immunotherapy: A Treasure Map for Future Anticipatory Medicine

Gupta, R., Jit, B. P., & Sharma, A. K. (2022) · Cognitive systems monographs · doi:10.1007/978-3-031-17678-4_9 · Cited by 2

Polycomb Repressive Complex 2 in Oncology

Guo, Y., Yu, Y., & Wang, G. G. (2023) · Cancer treatment and research · doi:10.1007/978-3-031-45654-1_9 · Cited by 2

miR-217 Regulates Normal and Tumor Cell Fate Following Induction of Endoplasmic Reticulum Stress

Dey, N., Koumenis, C., Ruggero, D., Fuchs, S. Y., & Diehl, J. A. (2024) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-23-0676 · Cited by 2

Myelodysplastic Syndrome: Clinical Characteristics and Significance of Preclinically Detecting Biallelic Mutations in the TET2 Gene

Михайловна, Д. А., Chegodar, A. S., Бодунова, Н. А., Konovalov, F. A., Nefedova, M., Kremneva, N. V., Kurbanov, N. K., Bilyalov, A. I., Nikolaev, S., Khatkov, I. E., et al. (2024) · Life · doi:10.3390/life14050637 · Cited by 2

Exploring Epigenetic Complexity in Regulation of Hematopoietic Stem Cells Niche: A Mechanistic Journey from Normal to Malignant Hematopoiesis

Yusoff, N. A., Hamid, Z. A., Taib, I. S., Razak, S. R. A., & Budin, S. B. (2025) · Advances in experimental medicine and biology · doi:10.1007/5584_2024_846 · Cited by 2

Mutation dynamics from diagnosis to relapse in acute myeloid leukemia with chromosomal 7 deletions

Kugler, E., Dasdemir, E., Bataller, Á., Wang, B., Dinardo, C. D., Daver, N. G., Yilmaz, M. E., Short, N. J., Borthakur, G. M., Kadia, T. M., et al. (2025) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2025.2477723 · Cited by 3

New Approvals in Low- and Intermediate-Risk Myelodysplastic Syndromes

McMahon, C. M., Raddi, M. G., Mohan, S. R., & Santini, V. (2025) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk-25-473654 · Cited by 2

Nouveaux outils et traitements pour les syndromes myélodysplasiques

Cluzeau, T., & Fenaux, P. (2012) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2012.06.009 · Cited by 2

Bone marrow biopsies of patients with hematopoietic and lymphoid disorders – epidemiology, chromosomal aberrations and molecular pathology

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Novel therapeutic strategies in myelodysplastic syndromes

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Malignant Transformation and Epigenetics

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Acute Myeloid Leukemia with Myelodysplasia-Related Changes, Therapy-Related Myeloid Neoplasms, and Acute Myeloid Leukemia, Not Otherwise Specified

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Genetic, Hematologic and Psychological Aspects of Leukemia

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New Insights into the Molecular Mechanisms of Long Non-coding RNAs in Cancer Biology

Torsin, L. I., Dragomir, M. P., & Calin, G. A. (2019) · Springer eBooks · doi:10.1007/978-3-030-17086-8_4 · Cited by 2

Effect of enhancer of zeste homolog 2 mutations on the prognosis of patients with myelodysplastic syndrome

Huang, X., & Wang, X. (2020) · Medicine · doi:10.1097/md.0000000000021900 · Cited by 2

Mutational Analysis of EZH2 Gene in Patients with Colorectal Adenoma Reveals a Genetic Variant Associated with Risk of Malignant Transformation

Mahasneh, A., Alnegresh, F., & Alfaqih, M. A. (2021) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2021.22.12.4085 · Cited by 2

Epigenetic Control Using Small Molecules in Cancer

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Molecular Genetics of Myelodysplastic Syndromes

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Myeloproliferative Neoplasms

Méndez‐Ferrer, S., & Fang, Z. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00237-6 · Cited by 2

Myeloproliferative neoplasms

Randolph, T. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-53045-3.00041-6 · Cited by 1

Genomic Landscape and Risk Stratification of Acute Myeloid Leukemia

Hou, H. (2023) · Springer eBooks · doi:10.1007/978-981-99-3810-0_5 · Cited by 1

Observation of PICALM::MLLT10-rearrangement and coincidental EZH2 mutations in a patient with acute myeloid leukemia: A case report and review of the literature

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Induced pluripotent stem cell-based modelling of disease evolution in myeloid leukemia: MDS to AML

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Elucidating the risk factors and oncogene drivers of acute myeloid leukemia

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Nanopore Sequencing Reveals Novel Alternative Splice Variants of EZH2 in Pediatric Medulloblastoma

Ramírez-Chiquito, J. C., Rosete-Ambriz, S. A., Olguín-García, A. C., Eguía-Aguilar, M. D. P., Niembro-Zúñiga, A., Marhx-Bracho, A., Perezpeña-Diazconti, M., & Juárez-Méndez, S. (2025) · Biomedicines · doi:10.3390/biomedicines13102461 · Cited by 1

Transgenerational adaptation to hypoxia

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The molecular management of classic myeloproliferative neoplasm

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Dual inhibition of FACT and RRM2 suppresses the progression of pancreatic ductal adenocarcinoma driven by the oncohistone H2BG53D

Qin, T., Wan, Y. C. E., Hu, S., Chen, J., Zhu, X., Zhou, J., Chen, Y., Wang, X., Zheng, Z., Chan, L. L., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116596 · Cited by 1

The Role and Impact of Non-driver Gene Mutations in Myelofibrosis

Boldrini, V., Guglielmelli, P., & Vannucchi, A. M. (2026) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-026-00773-6 · Cited by 1

Nonsense-mediated mRNA decay: friend or foe in cancer biology?

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Emerging Epigenetic Therapies—Lysine Methyltransferase/PRC Complex Inhibitors

Pande, V., Pocalyko, D. J., & Dhanak, D. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800206-3.00019-7 · Cited by 1

Epigenomics – A Bird’s Eye Perspective on the Genome

Gall‐Tros̆elj, K., & Kujundžić, R. N. (2010) · University of Zagreb University Computing Centre (SRCE) · Cited by 1

Genetic changes of miR-182 G106A: rather a polymorphism than a somatic mutation

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Znaczenie modyfikacji epigenetycznych w patogenezie białaczek

Głowacki, S., & Błasiak, J. (2013) · Acta Haematologica Polonica · doi:10.1016/j.achaem.2013.02.002 · Cited by 1

Current Insights in the Cellular and Molecular Biology of Chronic Myelomonocytic Leukemia

Itzykson, R., Droin, N. M., & Solary, É. (2012) · International Journal of Hematologic Oncology · doi:10.2217/ijh.12.19 · Cited by 1

An Update on the Molecular Pathogenesis of Myelodysplastic Syndromes

Nimer, S. D. (2010) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2010.10.012 · Cited by 1

Polycomb-independent activity of EZH2 in castration resistant prostate cancer

Xu, K., Wu, Z. J., Groner, A. C., He, H. H., Cai, C., Stack, E. C., Loda, M. F., Liu, T., Morrissey, C. M., Vessella, R. L., et al. (2013) · Epigenetics & Chromatin · doi:10.1186/1756-8935-6-s1-o14 · Cited by 1

Trithorax and polycomb cooperation in MLL fusion acute leukemia

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Mechanistic insight into the aberrant silencing of the keratin 13 gene in oral squamous cell carcinoma cells

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Histone deacetylase inhibitors in myeloproliferative neoplasms: current roles and future prospects

Tedjaseputra, A., Galli, S., Ibrahim, M., Harrison, C. N., & McLornan, D. P. (2016) · Expert Opinion on Orphan Drugs · doi:10.1517/21678707.2016.1149467 · Cited by 1

Genetic Characteristics of Polycythemia Vera and Essential Thrombocythemia in Korean Patients

Yoo, E., Park, K.-J., Won, H., Park, J., Park, J., Lee, S., Kim, H., Bang, S., Chi, H., Jung, C. W., et al. (2016) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.21981 · Cited by 1

Impacts of Histone Lysine Methylation on Chromatin

Lanouette, S., Haddad, J. F., Zhang, P., & Couture, J.-F. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802389-1.00002-2 · Cited by 1

Identification of a novel KMT2A–SEPT14 fusion in acute myeloid leukemia

Nguyen, D. N., Haley, L. M., Pallavajjala, A., Gojo, I., & Ning, Y. (2017) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2017.1324163 · Cited by 1

Diagnosis and Prognosis: Molecular

Kulasekararaj, A. G., Kosmider, O., & Mufti, G. J. (2018) · Hematologic malignancies · doi:10.1007/978-3-319-76879-3_2 · Cited by 1

The Frequency of SF3B1 Mutations in Thai Patients with Myelodysplastic Syndrome

Rujirachaivej, P., Siriboonpiputtana, T., Rerkamnuaychoke, B., Magmuang, S., Chareonsirisuthigul, T., Boonsakan, P., Petvises, S., Sirirat, T., Niparuck, P., & Chuncharunee, S. (2018) · Europe PMC (PubMed Central) · doi:10.22034/apjcp.2018.19.7.1825 · Cited by 1

Genetic alterations in 47 patients with a novel myelodysplastic syndrome diagnosis at a single center

Zhao, P., Qin, J., Liu, W., Quan, R., Xiao, H., Liu, C., Li, L., Lv, Y., Zhu, Q.-Z., Wang, H., et al. (2019) · Oncology Letters · doi:10.3892/ol.2019.10853 · Cited by 1

Epigenetics

Weksberg, R., Butcher, D. T., Cytrynbaum, C. S., Siu, M. T., Choufani, S., & Tycko, B. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812537-3.00005-6 · Cited by 1

Epigenetic therapies—update on lysine methyltransferase/PRC complex inhibitors

Kim, S., Barkey, N. M., Atasoylu, O., & Dhanak, D. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91367-6.00011-8 · Cited by 1

Inhibition of Enhancer of Zeste Homolog 2 Induces Blast Differentiation, Impairs Engraftment and Prolongs Survival in Murine Models of Acute Myeloid Leukemia

Fobare, S., Elgamal, O. A., Wunderlich, M., Stahl, E. H., Mehmood, A., Furby, C., Lerma, J. R., Sesterhenn, T. M., Pan, J., Rai, J., et al. (2024) · Cancers · doi:10.3390/cancers16030569 · Cited by 1

Therapeutic index of targeting select chromatin complexes in human cancer patients

Gao, Y., & Vakoc, C. R. (2024) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2024.102162 · Cited by 1

PRC2‐mediated apoptosis evasion is a therapeutic target of MDS/AML harboring inv(3)/t(3;3) and monosomy 7

Kunimoto, H., Miura, A., Sagisaka, M., Ito, M., Maenosono, R., Yamauchi, H., Nishimura, K., Honma, D., Tsutsumi, S., Adachi, A., et al. (2025) · HemaSphere · doi:10.1002/hem3.70149 · Cited by 1

Histone Methylation Modifiers in Medical Therapeutics

Trojer, P. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803239-8.00037-5 · Cited by 1

SIMULTANEOUS INHIBITION OF DRIVER AND EFFECTOR KINASES PROMOTES POTENT GROWTH ARREST OF AML CELLS IN VITRO AND IN VIVO

Weir, M. C. (2016) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 1

Leukemia-propagating cells demonstrate distinctive gene expression profiles compared with other cell fractions from patients with de novo Philadelphia chromosome-positive ALL

Zhao, H., Song, Y., Cao, X.-N., Qin, Y., Lai, Y., Jiang, H., Jiang, Q., Huang, X., & Kong, Y. (2018) · Annals of Hematology · doi:10.1007/s00277-018-3253-5 · Cited by 1

Genetic Aspects of Hematopoietic Malignancies

Kelley, T. W., & Patel, J. L. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-816061-9.00008-4 · Cited by 1

Polycomb Repressive Complex 2: Modulator Development for Functional Regulation of a Multiprotein Complex by Using Structural Information

Tokodai, Y., & Yakushiji, F. (2019) · ChemBioChem · doi:10.1002/cbic.201900212 · Cited by 1

Molecular mechanisms in cancer susceptibility—lessons from inherited cancers

Hodgson, S. V. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-809356-6.00024-1 · Cited by 1

Cryptic aberrations may allow more accurate prognostic classification of patients with myelodysplastic syndromes and clonal evolution

Svobodová, K., Lhotská, H., Hodanova, L., Pavlištová, L., Vesela, D., Beličková, M., Veselá, J., Březinová, J., Šárová, I., Izáková, S., et al. (2020) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22841 · Cited by 1

Untangling the Epigenetic Imbalance in B cell Lymphoma

Wu, R. (2020) · Current Pharmacology Reports · doi:10.1007/s40495-020-00214-9 · Cited by 1

EZH2-activating mutation: no reliable indicator for efficacy of methyltransferase inhibitors

Quentmeier, H., Pommerenke, C., Hauer, V., Uphoff, C. C., Zaborski, M., & Drexler, H. G. (2020) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2020.1795155 · Cited by 1

Cytogenetic Diagnosis of Myelodysplastic Syndromes

Olney, H. J., & Beau, M. M. L. (2013) · Springer eBooks · doi:10.1007/978-3-642-36229-3_3 · Cited by 1

Regulation of Amino Acid Metabolism in Hematological Malignancies: Advances from Transcriptomics and Metabolomics

Bajia, D., Ambe, G. N. N. N., & Derwich, K. (2022) · Journal of Biomedical Research & Environmental Sciences · doi:10.37871/jbres1622

A Review on the Role of Molecular Genetics in the Diagnostic Workup of BCR::ABL1-Negative Myeloproliferative Neoplasms

Maddali, M., Arunachalam, A. K., Kapadia, A. B., Kulkarni, U. P., & Balasubramanian, P. (2023) · Indian Journal of Medical and Paediatric Oncology · doi:10.1055/s-0043-1766138 · Cited by 1

A case of MDS / MPN overlap syndrome with ring sideroblasts and thrombocytosis: Tackling the quandary of thrombosis versus hemorrhage

Cherniawsky, H. M., & Razavi, H. M. (2023) · Clinical Case Reports · doi:10.1002/ccr3.7409 · Cited by 1

Modulation of Developmentally Regulated Gene Expression Programs through Targeting of Polycomb and Trithorax Group Proteins

Brand, M., & Dilworth, F. J. (2012) · Wiley eBooks · doi:10.1002/9781118349045.ch26 · Cited by 1

NSD 1 , EZH 2 and DNMT 3 A Overgrowth Genes and Their Associated Overgrowth Syndromes

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The myelodysplastic syndromes

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