The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24
Open accessAbstract
Ovarian cancer accounts for more deaths than all other gynecological cancers combined. To identify common low-penetrance ovarian cancer susceptibility genes, we conducted a genome-wide association study of 507,094 SNPs in 1,768 individuals with ovarian cancer (cases) and 2,354 controls, with follow up of 21,955 SNPs in 4,162 cases and 4,810 controls, leading to the identification of a confirmed susceptibility locus at 9p22 (in BNC2). Here, we report on nine additional candidate loci (defined as having P ≤ 10−4) identified after stratifying cases by histology, which we genotyped in an additional 4,353 cases and 6,021 controls. We confirmed two new susceptibility loci with P ≤ 5 × 10−8 (8q24, P = 8.0 × 10−15 and 2q31, P = 3.8 × 10−14) and identified two additional loci that approached genome-wide significance (3q25, P = 7.1 × 10−8 and 17q21, P = 1.4 × 10−7). The associations of these loci with serous ovarian cancer were generally stronger than with other cancer subtypes. Analysis of HOXD1, MYC, TIPARP and SKAP1 at these loci and of BNC2 at 9p22 supports a functional role for these genes in ovarian cancer development.
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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
Self-citationTargeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
Farmer, H., McCabe, N., Lord, C. J., Tutt, A. N. J., Johnson, D. A., Richardson, T. B., Santarosa, M., Dillon, K. J., Hickson, I., Knights, C., et al. (2005) · Nature · doi:10.1038/nature03445 · Cited by 6,683
Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers
Fong, P. C., Boss, D. S., Yap, T. A., Tutt, A., Wu, P., Mergui-Roelvink, M., Mortimer, P., Swaisland, H., Lau, A., O'Connor, M. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0900212 · Cited by 3,634
The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer
Pomerantz, M. M., Ahmadiyeh, N., Jia, L., Herman, P., Verzi, M. P., Doddapaneni, H., Beckwith, C. A., Chan, J. A., Hills, A., Davis, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.403 · Cited by 663
Cited by
Epidemiology of ovarian cancer: a review
Brett M., R., Brett M., R., Jennifer B., P., Thomas A., S., Jennifer B., P., & Thomas A., S. (2017) · Cancer Biology & Medicine · doi:10.20892/j.issn.2095-3941.2016.0084 · Cited by 1,524
FAK in cancer: mechanistic findings and clinical applications
Sulzmaier, F. J., Jean, C., & Schlaepfer, D. D. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3792 · Cited by 1,381
Mutations in BRIP1 confer high risk of ovarian cancer
Rafnar, T., Gudbjartsson, D. F., Sulem, P., Jonasdottir, A., Sigurdsson, A., Jonasdottir, A., Besenbacher, S., Lundin, P., Stacey, S. N., Gudmundsson, J., et al. (2011) · Nature Genetics · doi:10.1038/ng.955 · Cited by 406
Self-citationCouch, F. J., Wang, X., McGuffog, L., Lee, A., Olswold, C., Kuchenbaecker, K. B., Soucy, P., Fredericksen, Z., Barrowdale, D., Dennis, J., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003212 · Cited by 371
Self-citationChong, C., Müller, M., Pak, H., Harnett, D., Huber, F., Grun, D., Leleu, M., Auger, A., Arnaud, M., Stevenson, B. J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14968-9 · Cited by 346
Metadata
- Authors
- The Wellcome Trust Case-Control Consortium, Goode, E. L., Cancer), T. A. C. S. (., The Australian Ovarian Cancer Study Group, the Ovarian Cancer Association Consortium (OCAC), Chenevix-Trench, G., Song, H., Ramus, S. J., Notaridou, M., Lawrenson, K., Widschwendter, M., Vierkant, R. A., Larson, M. C., Kjaer, S. K., Birrer, M. J., Berchuck, A., Schildkraut, J., Tomlinson, I., Kiemeney, L. A., Cook, L. S., Gronwald, J., Garcia-Closas, M., Gore, M. E., Campbell, I., Whittemore, A. S., Sutphen, R., Phelan, C., Anton-Culver, H., Pearce, C. L., Lambrechts, D., Rossing, M. A., Chang-Claude, J., Moysich, K. B., Goodman, M. T., Dörk, T., Nevanlinna, H., Ness, R. B., Rafnar, T., Hogdall, C., Hogdall, E., Fridley, B. L., Cunningham, J. M., Sieh, W., McGuire, V., Godwin, A. K., Cramer, D. W., Hernandez, D., Levine, D., Lu, K., Iversen, E. S., Palmieri, R. T., Houlston, R., van Altena, A. M., Aben, K. K. H., Massuger, L. F. A. G., Brooks-Wilson, A., Kelemen, L. E., Le, N. D., Jakubowska, A., Lubinski, J., Medrek, K., Stafford, A., Easton, D. F., Tyrer, J., Bolton, K. L., Harrington, P., Eccles, D., Chen, A., Molina, A. N., Davila, B. N., Arango, H., Tsai, Y.-Y., Chen, Z., Risch, H. A., McLaughlin, J., Narod, S. A., Ziogas, A., Brewster, W., Gentry-Maharaj, A., Menon, U., Wu, A. H., Stram, D. O., Pike, M. C., Beesley, J., & Webb, P. M.
- Venue
- Nature Genetics
- Published
- 2010-09-19
- Volume
- 42
- Issue
- 10
- Pages
- 874-879
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2148512375
- Cited by
- 344
- References
- 4
- FWCI
- 34.82
- Type
- journal article
- Language
- en
- Open access
- green
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