FAK in cancer: mechanistic findings and clinical applications

Comprehensive molecular portraits of human breast tumours

The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11412 · Cited by 12,129 · see citing works

The protein kinase complement of the human genome

Manning, G., Whyte, D. B., Martinez, R., Hunter, T., & Sudarsanam, S. (2002) · Science · doi:10.1126/science.1075762 · Cited by 8,145 · see citing works

Integrated genomic analyses of ovarian carcinoma

Perou, C. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/hvp3-wg08 · Cited by 7,927 · see citing works

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101 · see citing works

Focal adhesion kinase: in command and control of cell motility

Mitra, S. K., Hanson, D. R., & Schlaepfer, D. D. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1549 · Cited by 2,586 · see citing works

Focal adhesion kinase: the first ten years

Parsons, J. T. (2003) · Journal of Cell Science · doi:10.1242/jcs.00373 · Cited by 1,364 · see citing works

The role of focal-adhesion kinase in cancer — a new therapeutic opportunity

McLean, G. W., Carragher, N. O., Avizienyte, E., EVANS, J., Brunton, V. G., & Frame, M. C. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1647 · Cited by 1,036 · see citing works

E-cadherin–integrin crosstalk in cancer invasion and metastasis

Canel, M., Serrels, A., Frame, M. C., & Brunton, V. G. (2013) · Journal of Cell Science · doi:10.1242/jcs.100115 · Cited by 624 · see citing works

Signal transduction by focal adhesion kinase in cancer

Zhao, J., & Guan, J. (2009) · Cancer and Metastasis Reviews · doi:10.1007/s10555-008-9165-4 · Cited by 606 · see citing works

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

Schaller, M. D. (2010) · Journal of Cell Science · doi:10.1242/jcs.045112 · Cited by 599 · see citing works

Cellular Characterization of a Novel Focal Adhesion Kinase Inhibitor

Slack‐Davis, J. K., Martin, K. H., Tilghman, R. W., Iwanicki, M., Ung, E. J., Autry, C. L., Luzzio, M. J., Cooper, B. A., Kath, J. C., Roberts, W. G., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m606695200 · Cited by 486 · see citing works

Structural Basis for the Autoinhibition of Focal Adhesion Kinase

Lietha, D., Cai, X., Ceccarelli, D. F. J., Li, Y., Schaller, M. D., & Eck, M. J. (2007) · Cell · doi:10.1016/j.cell.2007.05.041 · Cited by 485 · see citing works

Nuclear FAK Promotes Cell Proliferation and Survival through FERM-Enhanced p53 Degradation

Lim, S., Chen, X. L., Lim, Y., Hanson, D. A., Vo, T.-T. T., Howerton, K., Larocque, N., Fisher, S. J., Schlaepfer, D. D., & Ilić, D. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.11.031 · Cited by 483 · see citing works

Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271

Roberts, W. G., Ung, E. J., Whalen, P. M., Cooper, B. A., Hulford, C. A., Autry, C., Richter, D., Emerson, E., Lin, J., Kath, J. C., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5155 · Cited by 381 · see citing works

The FERM domain: organizing the structure and function of FAK

Frame, M. C., Patel, H., Serrels, B., Lietha, D., & Eck, M. J. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2996 · Cited by 372 · see citing works

Integrin β 1 -focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs

Shibue, T., & Weinberg, R. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904227106 · Cited by 365 · see citing works

Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling

Avizienyte, E., Wyke, A. W., Jones, R. J., McLean, G. W., Westhoff, M., Brunton, V. G., & Frame, M. C. (2002) · Nature Cell Biology · doi:10.1038/ncb829 · Cited by 359 · see citing works

VEGF-Induced Vascular Permeability Is Mediated by FAK

Chen, X. L., Nam, J., Jean, C., Lawson, C., Walsh, C. T., Goka, E. T., Lim, S., Tomar, A., Tancioni, I., Uryu, S. A., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.11.002 · Cited by 341 · see citing works

A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24

Goode, E. L., Cancer), T. A. C. S. (., The Australian Ovarian Cancer Study Group, Chenevix‐Trench, G., Song, H., Ramus, S. J., Notaridou, M., Lawrenson, K., Widschwendter, M., Vierkant, R. A., et al. (2010) · Nature Genetics · doi:10.1038/ng.668 · Cited by 338 · see citing works

Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis

Shen, T., Park, A. Y. J., Alcaraz, A., Peng, X., Jang, I. K., Koni, P. A., Flavell, R. A., Gu, H., & Guan, J. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200411155 · Cited by 305 · see citing works

Mechanisms that link the oncogenic epithelial–mesenchymal transition to suppression of anoikis

Frisch, S. M., Schaller, M. D., & Cieply, B. W. (2013) · Journal of Cell Science · doi:10.1242/jcs.120907 · Cited by 295 · see citing works

Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis

Sood, A. K., Armaiz-Pena, G. N., Halder, J., Nick, A. M., Stone, R. L., Hu, W., Carroll, A. R., Spannuth, W. A., Deavers, M. T., Allen, J. K., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40802 · Cited by 283 · see citing works

Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex

Serrels, B., Serrels, A., Brunton, V. G., Holt, M., McLean, G. W., Gray, C. H., Jones, G. E., & Frame, M. C. (2007) · Nature Cell Biology · doi:10.1038/ncb1626 · Cited by 269 · see citing works

Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling

Pylayeva, Y., Gillen, K. M., Gerald, W. L., Beggs, H. E., Reichardt, L. F., & Giancotti, F. G. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37160 · Cited by 261 · see citing works

FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion

Chan, K. T., Cortesio, C. L., & Huttenlocher, A. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200809110 · Cited by 258 · see citing works

Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics

Schöber, M., Raghavan, S., Nikolova, M., Polak, L., Pasolli, H. A., Beggs, H. E., Reichardt, L. F., & Fuchs, E. V. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200608010 · Cited by 253 · see citing works

Merlin Deficiency Predicts FAK Inhibitor Sensitivity: A Synthetic Lethal Relationship

Shapiro, I. M., Kolev, V. N., Vidal, C. M., Kadariya, Y., Ring, J. E., Wright, Q. G., Weaver, D. T., Menges, C. W., Padval, M. V., McClatchey, A. I., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008639 · Cited by 250 · see citing works

Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation

Braren, R., Hu, H., Kim, Y. H., Beggs, H. E., Reichardt, L. F., & Wang, R. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200506184 · Cited by 244 · see citing works

Safety, Pharmacokinetic, and Pharmacodynamic Phase I Dose-Escalation Trial of PF-00562271, an Inhibitor of Focal Adhesion Kinase, in Advanced Solid Tumors

Infante, J. R., Camidge, D. R., Mileshkin, L., Chen, E. X., Hicks, R. J., Rischin, D., Fingert, H. J., Pierce, K. J., Xu, H., Roberts, W. G., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.38.9346 · Cited by 244 · see citing works

TGFβ-induced EMT requires focal adhesion kinase (FAK) signaling

Cicchini, C., Laudadio, I., Citarella, F., Corazzari, M., Steindler, C., Conigliaro, A., Fantoni, A., Amicone, L., & Tripodi, M. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.09.005 · Cited by 240 · see citing works

Inhibition of Focal Adhesion Kinase by PF-562,271 Inhibits the Growth and Metastasis of Pancreatic Cancer Concomitant with Altering the Tumor Microenvironment

Stokes, J. B., Adair, S. J., Slack‐Davis, J. K., Walters, D. M., Tilghman, R. W., Hershey, E. D., Lowrey, B. T., Thomas, K. S., Bouton, A. H., Hwang, R. F., et al. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0261 · Cited by 233 · see citing works

Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK–p130Cas complex

Wang, Y., & McNiven, M. A. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201105153 · Cited by 223 · see citing works

Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progressionPreprint

McLean, G. W., Komiyama, N. H., Serrels, B., Asano, H., Reynolds, L. E., Conti, F. J. A., Hodivala‐Dilke, K., METZGER, D., Chambon, P., Grant, S. G. N., et al. (2004) · Genes & Development · doi:10.1101/gad.316304 · Cited by 223 · see citing works

β1 Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy

Eke, I., Deuse, Y., Hehlgans, S., Gurtner, K., Krause, M., Baumann, M. A., Shevchenko, A., Sandfort, V., & Cordes, N. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61350 · Cited by 220 · see citing works

FAK promotes recruitment of talin to nascent adhesions to control cell motility

Lawson, C., Lim, S., Uryu, S. A., Chen, X. L., Calderwood, D., & Schlaepfer, D. D. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201108078 · Cited by 218 · see citing works

PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility

Lim, Y., Lim, S., Tomar, A., Gardel, M. L., Bernard‐Trifilo, J. A., Chen, X. L., Uryu, S. A., Cañete-Soler, R., Zhai, J., Lin, H., et al. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200708194 · Cited by 215 · see citing works

A FAK-Cas-Rac-Lamellipodin Signaling Module Transduces Extracellular Matrix Stiffness into Mechanosensitive Cell Cycling

Bae, Y., Mui, K. L., Hsu, B. Y., Liu, S., Cretu, A., Razinia, Z., Xu, T., Puré, E., & Assoian, R. K. (2014) · Science Signaling · doi:10.1126/scisignal.2004838 · Cited by 213 · see citing works

The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions

Shibue, T., Brooks, M. W., Inan, M. F., Reinhardt, F., & Weinberg, R. A. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0239 · Cited by 212 · see citing works

Mammary Epithelial-Specific Ablation of the Focal Adhesion Kinase Suppresses Mammary Tumorigenesis by Affecting Mammary Cancer Stem/Progenitor Cells

Luo, M., Fan, H., Nagy, T., Wei, H., Wang, C., Liu, S., Wicha, M. S., & Guan, J. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3078 · Cited by 211 · see citing works

Therapeutic Efficacy of a Novel Focal Adhesion Kinase Inhibitor TAE226 in Ovarian Carcinoma

Halder, J., Lin, Y. G., Merritt, W. M., Spannuth, W. A., Nick, A. M., Honda, T., Kamat, A. A., Han, L. Y., Kim, T. J., Lü, C., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2667 · Cited by 207 · see citing works

Role of Focal Adhesion Kinase in Regulating YB–1–Mediated Paclitaxel Resistance in Ovarian Cancer

Kang, Y., Hu, W., Ivan, C., Dalton, H. J., Miyake, T. M., Pecot, C. V., Zand, B., Liu, T., Huang, J., Jennings, N. B., et al. (2013) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt210 · Cited by 206 · see citing works

The dual kinase complex FAK-Src as a promising therapeutic target in cancer

Bolós, V. (2010) · OncoTargets and Therapy · doi:10.2147/ott.s6909 · Cited by 203 · see citing works

Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation

Hiratsuka, S., Goel, S., Kamoun, W. S., Maru, Y., Fukumura, D., Duda, D. G., & Jain, R. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100446108 · Cited by 196 · see citing works

Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression

Lahlou, H., Sanguin‐Gendreau, V., Zuo, D., Cardiff, R. D., McLean, G. W., Frame, M. C., & Muller, W. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710091104 · Cited by 196 · see citing works

MicroRNA-7 Inhibits Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer Cells via Targeting FAK Expression

Kong, X., Li, G., Yuan, Y., He, Y., Wu, X., Zhang, W., Wu, Z., Chen, T., Wu, W., Lobie, P. E., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041523 · Cited by 195 · see citing works

Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins

Seong, J., Tajik, A., Sun, J., Guan, J., Humphries, M. J., Craig, S. E., Shekaran, A., Garcı́a, A. J., Lu, S., Lin, M. Z., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307405110 · Cited by 194 · see citing works

Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation

Lagares, D., Busnadiego, Ó., García-Fernández, R. A., Kapoor, M., Liu, S., Carter, D. E., Abraham, D., Shiwen, X., Carreira, P. E., Fontaine, B. A., et al. (2011) · Arthritis & Rheumatism · doi:10.1002/art.33482 · Cited by 192 · see citing works

A novel low‐molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth

Shi, Q., Hjelmeland, A. B., Keir, S. T., Song, L., Wickman, S., Jackson, D., Ohmori, O., Bigner, D. D., Friedman, H. S., & Rich, J. N. (2007) · Molecular Carcinogenesis · doi:10.1002/mc.20297 · Cited by 189 · see citing works

Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling

Ashton, G. H. S., Morton, J. P., Myant, K., Phesse, T. J., Ridgway, R. A., Marsh, V. L., Wilkins, J. A., Athineos, D., Muncan, V., Kemp, R., et al. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.07.015 · Cited by 189 · see citing works

Gene Alterations Identified by Expression Profiling in Tumor-Associated Endothelial Cells from Invasive Ovarian Carcinoma

Lü, C., Bonome, T., Li, Y., Kamat, A. A., Han, L. Y., Schmandt, R. E., Coleman, R. L., Gershenson, D. M., Jaffe, R. B., Birrer, M. J., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3700 · Cited by 185 · see citing works

Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase

Owen, K. A., Pixley, F. J., Thomas, K. S., Vicente‐Manzanares, M., Ray, B. J., Horwitz, A. F., Parsons, J. T., Beggs, H. E., Stanley, E. R., & Bouton, A. H. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200708093 · Cited by 178 · see citing works

Spatial and Temporal Regulation of Focal Adhesion Kinase Activity in Living Cells

Cai, X., Lietha, D., Ceccarelli, D. F. J., Karginov, A. V., Rajfur, Z., Jacobson, K., Hahn, K. M., Eck, M. J., & Schaller, M. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01324-07 · Cited by 177 · see citing works

Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function

Jean, C., Chen, X. L., Nam, J., Tancioni, I., Uryu, S. A., Lawson, C., Ward, K. K., Walsh, C. T., Miller, N. L. G., Ghassemian, M., et al. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201307067 · Cited by 177 · see citing works

Sonic hedgehog signaling pathway induces cell migration and invasion through focal adhesion kinase/AKT signaling-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9 in liver cancer

Chen, J., Huang, X., Wang, Q., Huang, J., Zhang, L., Chen, X., Lei, J., & Cheng, Z. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs274 · Cited by 172 · see citing works

Regulation of Focal Adhesion Kinase by Its Amino-Terminal Domain through an Autoinhibitory Interaction

Cooper, L. A., Shen, T., & Guan, J. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.8030-8041.2003 · Cited by 170 · see citing works

FAK promotes recruitment of talin to nascent adhesions to control cell motility

Lawson, C., Lim, S., Uryu, S. A., Chen, X. L., Calderwood, D., & Schlaepfer, D. D. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.2011080781963c · Cited by 170 · see citing works

PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments

Tanjoni, I., Walsh, C. T., Uryu, S. A., Tomar, A., Nam, J., Mielgo, A., Lim, S., Liang, C., Koenig, M., Patel, N., et al. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.9.10.11434 · Cited by 167 · see citing works

Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy

Tavora, B., Reynolds, L. E., Batista, S., Demircioglu, F., Fernandez, I., Lechertier, T., Lees, D. M., Wong, P.-P., Alexopoulou, A., Elia, G., et al. (2014) · Nature · doi:10.1038/nature13541 · Cited by 163 · see citing works

Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumors

Mitra, S. K., Mikolon, D., Molina, J. E., Hsia, D. A., Hanson, D. A., Chi, A., Lim, S.-T., Bernard‐Trifilo, J. A., Ilić, D., Stupack, D. G., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1209588 · Cited by 158 · see citing works

Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia

Joshi, I., Yoshida, T., Jena, N., Qi, X., Zhang, J., Etten, R. A. V., & Georgopoulos, K. (2014) · Nature Immunology · doi:10.1038/ni.2821 · Cited by 158 · see citing works

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK

Weis, S. M., Lim, S., Lutu-Fuga, K. M., Barnes, L. A., Chen, X. L., Göthert, J. R., Shen, T., Guan, J., Schlaepfer, D. D., & Cheresh, D. A. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200710038 · Cited by 158 · see citing works

Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-β signaling and metastasis

Wendt, M. K., & Schiemann, W. P. (2009) · Breast Cancer Research · doi:10.1186/bcr2360 · Cited by 158 · see citing works

Endothelial FAK is required for tumour angiogenesis

Tavora, B., Batista, S., Reynolds, L. E., Jadeja, S., Robinson, S. D., Kostourou, V., Hart, I. R., Fruttiger, M., Parsons, M., & Hodivala‐Dilke, K. (2010) · EMBO Molecular Medicine · doi:10.1002/emmm.201000106 · Cited by 151 · see citing works

Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes

Goñi, G., Epifano, C., Boskovic, J., Camacho‐Artacho, M., Zhou, J., Bronowska, A. K., Martín, M. T., Eck, M. J., Kremer, L., Gräter, F., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1317022111 · Cited by 139 · see citing works

FAK dimerization controls its kinase‐dependent functions at focal adhesions

Brami‐Cherrier, K., Gervasi, N., Arsenieva, D., Walkiewicz, K. W., Boutterin, M., Ortega, Á., Leonard, P. G., Seantier, B., Gasmi, L., Bouceba, T., et al. (2014) · The EMBO Journal · doi:10.1002/embj.201386399 · Cited by 136 · see citing works

Quantitative In vivo Imaging of the Effects of Inhibiting Integrin Signaling via Src and FAK on Cancer Cell Movement: Effects on E-cadherin Dynamics

Canel, M., Serrels, A., Miller, D., Timpson, P., Serrels, B., Frame, M. C., & Brunton, V. G. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1454 · Cited by 136 · see citing works

Mammary Epithelial-Specific Disruption of Focal Adhesion Kinase Retards Tumor Formation and Metastasis in a Transgenic Mouse Model of Human Breast Cancer

Provenzano, P. P., Inman, D. R., Eliceiri, K. W., Beggs, H. E., & Keely, P. J. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080308 · Cited by 134 · see citing works

Caspase-8 Association with the Focal Adhesion Complex Promotes Tumor Cell Migration and Metastasis

Barbero, S., Mielgo, A., Torres, V. A., Teitz, T., Shields, D. J., Mikolon, D., Bogyo, M. S., Barilà, D., Lahti, J. M., Schlaepfer, D. D., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3937 · Cited by 134 · see citing works

Integrated genomic analyses of ovarian carcinoma

The Cancer Genome Atlas Research Network (2011) · Nature · doi:10.1038/nature10166 · Cited by 129 · see citing works

Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models

Walsh, C. T., Tanjoni, I., Uryu, S. A., Tomar, A., Nam, J., Luo, H., Phillips, A., Patel, N., Kwok, C., McMahon, G., et al. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.9.10.11433 · Cited by 124 · see citing works

An AMPK-Independent Signaling Pathway Downstream of the LKB1 Tumor Suppressor Controls Snail1 and Metastatic Potential

Goodwin, J. M., Svensson, R. U., Lou, H. J., Winslow, M. M., Turk, B. E., & Shaw, R. J. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.06.021 · Cited by 119 · see citing works

Tumor-Secreted LOXL2 Activates Fibroblasts through FAK Signaling

Barker, H. E., Bird, D., Lang, G., & Erler, J. T. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0033-t · Cited by 119 · see citing works

Knock-in Mutation Reveals an Essential Role for Focal Adhesion Kinase Activity in Blood Vessel Morphogenesis and Cell Motility-Polarity but Not Cell Proliferation

Lim, S., Chen, X. L., Tomar, A., Miller, N. L. G., Yoo, J., & Schlaepfer, D. D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.129999 · Cited by 118 · see citing works

Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development

Zhao, X., Peng, X., Sun, S., Park, A. Y. J., & Guan, J. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200912094 · Cited by 118 · see citing works

Overexpression of Focal Adhesion Kinase in Head and Neck Squamous Cell Carcinoma Is Independent of fak Gene Copy Number

Canel, M., Secades, P., Rodrigo, J. P., Cabanillas, R., Herrero, A., Suarez, C. M., & Chiara, M. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1583 · Cited by 116 · see citing works

Focal Adhesion Kinase: Targeting Adhesion Signaling Pathways for Therapeutic Intervention

Parsons, J. T., Slack‐Davis, J. K., Tilghman, R. W., & Roberts, W. G. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-2220 · Cited by 115 · see citing works

RHOA-FAK is a required signaling axis for the maintenance of KRAS-driven lung adenocarcinomas

Konstantinidou, G., Ramadori, G., Torti, F., Kangasniemi, K., Ramirez, R. E., Cai, Y., Behrens, C., Dellinger, M. T., Brekken, R. A., Wistuba, I. I., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0388 · Cited by 114 · see citing works

Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression

Ward, K. K., Tancioni, I., Lawson, C., Miller, N. L. G., Jean, C., Chen, X. L., Uryu, S. A., Kim, J., Tarin, D., Stupack, D. G., et al. (2012) · Clinical & Experimental Metastasis · doi:10.1007/s10585-012-9562-5 · Cited by 109 · see citing works

Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation

Lietha, D., & Eck, M. J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003800 · Cited by 108 · see citing works

Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2

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Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression

Lim, S., Miller, N. L. G., Chen, X. L., Tancioni, I., Walsh, C. T., Lawson, C., Uryu, S. A., Weis, S. M., Cheresh, D. A., & Schlaepfer, D. D. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201109067 · Cited by 105 · see citing works

Intrinsic focal adhesion kinase activity controls orthotopic breast carcinoma metastasis via the regulation of urokinase plasminogen activator expression in a syngeneic tumor model

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A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl) -3, 5, 7-triaza-1-azoniatricyclo [3.3.1.13,7]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo

Golubovskaya, V., Figel, S. A., Ho, B. T., Johnson, C. P., Yemma, M., Huang, G., Zheng, M., Nyberg, C., Magis, A. T., Ostrov, D. A., et al. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs120 · Cited by 103 · see citing works

Focal Adhesion Kinase Versus p53: Apoptosis or Survival?

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Disrupting the Scaffold to Improve Focal Adhesion Kinase–Targeted Cancer Therapeutics

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Ovarian cancer ascites protects from TRAIL-induced cell death through αvβ5 integrin-mediated focal adhesion kinase and Akt activation

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pH sensing by FAK-His58 regulates focal adhesion remodeling

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FAK‐dependent regulation of myofibroblast differentiation

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Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer

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FAK Regulates Intestinal Epithelial Cell Survival and Proliferation during Mucosal Wound Healing

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Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage–specific FAK knockout

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Focal adhesion kinase inhibitors are potent anti‐angiogenic agents

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Pyk2 Inhibition of p53 as an Adaptive and Intrinsic Mechanism Facilitating Cell Proliferation and Survival

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Function of Focal Adhesion Kinase Scaffolding to Mediate Endophilin A2 Phosphorylation Promotes Epithelial-Mesenchymal Transition and Mammary Cancer Stem Cell Activities in Vivo

Fan, H., Zhao, X., Sun, S., Luo, M., & Guan, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.420497 · Cited by 80 · see citing works

Organization and post-transcriptional processing of focal adhesion kinase gene

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Fragment-Based Discovery of New Highly Substituted 1H-Pyrrolo[2,3-b]- and 3H-Imidazolo[4,5-b]-Pyridines as Focal Adhesion Kinase Inhibitors

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Nanog Increases Focal Adhesion Kinase (FAK) Promoter Activity and Expression and Directly Binds to FAK Protein to Be Phosphorylated

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Loss of Scar/WAVE Complex Promotes N-WASP- and FAK-Dependent Invasion

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Mammary Epithelial-specific Deletion of the Focal Adhesion Kinase Gene Leads to Severe Lobulo-Alveolar Hypoplasia and Secretory Immaturity of the Murine Mammary Gland

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Sunitinib and PF-562,271 (FAK/Pyk2 inhibitor) effectively block growth and recovery of human hepatocellular carcinoma in a rat xenograft model

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Argonaute2 promotes tumor metastasis by way of up-regulating focal adhesion kinase expression in hepatocellular carcinoma

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miRNA Expression Profiling in Migrating Glioblastoma Cells: Regulation of Cell Migration and Invasion by miR-23b via Targeting of Pyk2

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IGFBP2/FAK Pathway Is Causally Associated with Dasatinib Resistance in Non–Small Cell Lung Cancer Cells

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Cortactin as a Target for FAK in the Regulation of Focal Adhesion Dynamics

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KLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancer

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Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT

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Focal Adhesion Kinase (FAK) Binds RET Kinase via Its FERM Domain, Priming a Direct and Reciprocal RET-FAK Transactivation Mechanism

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Conditional Deletion of the Focal Adhesion Kinase FAK Alters Remodeling of the Blood–Brain Barrier in Glioma

Lee, J., Borboa, A. K., Chun, H. B., Baird, A., & Eliceiri, B. P. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2740 · Cited by 63 · see citing works

Compensatory Function of Pyk2 Protein in the Promotion of Focal Adhesion Kinase (FAK)-null Mammary Cancer Stem Cell Tumorigenicity and Metastatic Activity

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High-Throughput Tyrosine Kinase Activity Profiling Identifies FAK as a Candidate Therapeutic Target in Ewing Sarcoma

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Conditional deletion of FAK in mice endothelium disrupts lung vascular barrier function due to destabilization of RhoA and Rac1 activities

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Endothelial FAK as a therapeutic target in disease

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Snail1 controls epithelial–mesenchymal lineage commitment in focal adhesion kinase–null embryonic cells

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p190RhoGEF (Rgnef) Promotes Colon Carcinoma Tumor Progression via Interaction with Focal Adhesion Kinase

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Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth

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Mitsugumin 53 (MG53) Ligase Ubiquitinates Focal Adhesion Kinase during Skeletal Myogenesis

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Distinct FAK Activities Determine Progenitor and Mammary Stem Cell Characteristics

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FAK Inhibition Disrupts a β5 Integrin Signaling Axis Controlling Anchorage-Independent Ovarian Carcinoma Growth

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Structure-based discovery of cellular-active allosteric inhibitors of FAK

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The role of focal adhesion kinase catalytic activity on the proliferation and migration of squamous cell carcinoma cells

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Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer

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Autophosphorylation-independent and -dependent Functions of Focal Adhesion Kinase during Development

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Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells

Jung, O., Choi, S., Jang, S., Lee, S.-A., Lim, S., Choi, Y.-J., Kim, H., Kim, D., Kwak, T., Kim, H., et al. (2012) · Journal of Cell Science · doi:10.1242/jcs.100586 · Cited by 51 · see citing works

Proline-rich tyrosine kinase 2 and its phosphorylated form pY881 are novel prognostic markers for non-small-cell lung cancer progression and patients’ overall survival

Kuang, B.-H., Zhang, M.-Q., Xu, L.-H., Hu, L.-J., Wang, H.-B., Zhao, W.-F., Du, Y., & Zhang, X. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.439 · Cited by 50 · see citing works

FAK-heterozygous mice display enhanced tumour angiogenesis

Kostourou, V., Lechertier, T., Reynolds, L. E., Lees, D. M., Baker, M., Jones, D. T., Tavora, B., Ramjaun, A. R., Birdsey, G. M., Robinson, S. D., et al. (2013) · Nature Communications · doi:10.1038/ncomms3020 · Cited by 49 · see citing works

Focal Adhesion Kinase Regulates Pathogen-Killing Capability and Life Span of Neutrophils via Mediating Both Adhesion-Dependent and -Independent Cellular Signals

Kasorn, A., Alcaide, P., Jia, Y., Subramanian, K. K., Sarraj, B., Li, Y., Loison, F., Hattori, H., Silberstein, L. E., Luscinskas, F. W., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802984 · Cited by 48 · see citing works

Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model

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Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2

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Visualizing and Manipulating Focal Adhesion Kinase Regulation in Live Cells

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Proteomic Profiling of Endothelial Invasion Revealed Receptor for Activated C Kinase 1 (RACK1) Complexed with Vimentin to Regulate Focal Adhesion Kinase (FAK)

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Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition

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Essential role for focal adhesion kinase in regulating stress hematopoiesis

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Rgnef (p190RhoGEF) Knockout Inhibits RhoA Activity, Focal Adhesion Establishment, and Cell Motility Downstream of Integrins

Miller, N. L. G., Lawson, C., Chen, X. L., Lim, S., & Schlaepfer, D. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037830 · Cited by 33 · see citing works

Targeting Vascular Cell Migration as a Strategy for Blocking Angiogenesis: The Central Role of Focal Adhesion Protein Tyrosine Kinase Family

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FAK Deletion Promotes p53-Mediated Induction of p21, DNA-Damage Responses and Radio-Resistance in Advanced Squamous Cancer Cells

Graham, K., Moran‐Jones, K., Sansom, O. J., Brunton, V. G., & Frame, M. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027806 · Cited by 31 · see citing works

A non-canonical role for Rgnef (p190RhoGEF) in promoting integrin-stimulated focal adhesion kinase activation

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Loss of Focal Adhesion Kinase Enhances Endothelial Barrier Function and Increases Focal Adhesions

Arnold, K. M., Goeckeler, Z. M., & Wysolmerski, R. B. (2013) · Microcirculation · doi:10.1111/micc.12063 · Cited by 28 · see citing works

Critical features of FAK-expressing AML bone marrow microenvironment through leukemia stem cell hijacking of mesenchymal stromal cells

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Somatic mutational analysis of FAK in breast cancer: A novel gain-of-function mutation due to deletion of exon 33

Fang, X., Liu, X., Yao, L., Chen, C.-Q., Gu, Z., Ni, P., Zheng, X., & Fan, Q. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.11.134 · Cited by 25 · see citing works

Requirement of PEA3 for Transcriptional Activation of FAK Gene in Tumor Metastasis

Li, S., Huang, X., Zhang, D., Huang, Q., Pei, G., Wang, L., Jiang, W., Hu, Q., Tan, R. X., & Hua, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079336 · Cited by 22 · see citing works

Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion

Lu, J., Sun, Y., Nombela‐Arrieta, C., Du, K., Park, S., Chai, L., Walkley, C. R., Luo, H. R., & Silberstein, L. E. (2011) · Experimental Hematology · doi:10.1016/j.exphem.2011.11.010 · Cited by 22 · see citing works

An aberrant spliced transcript of focal adhesion kinase is exclusively expressed in human breast cancer

Yao, L., Li, K., Peng, W., Lin, Q., Li, S., Hu, X., Zheng, X., & Shao, Z. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-136 · Cited by 21 · see citing works

Off‐targets effects underlie the inhibitory effect of FAK inhibitors on platelet activation: studies using Fak‐deficient mice

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Macrophages as regulators of tumour immunity and immunotherapy

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Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

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Physical traits of cancer

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The delivery of therapeutic oligonucleotides

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FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling

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Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies

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Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions

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Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin β1/FAK Signaling

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Targeting extracellular matrix stiffness to attenuate disease: from molecular mechanisms to clinical trials

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FAK signaling in human cancer as a target for therapeutics

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Tumor Microenvironment and Differential Responses to Therapy

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Targeting FAK in anticancer combination therapies

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From state-of-the-art treatments to novel therapies for advanced-stage pancreatic cancer

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Alteration of the Antitumor Immune Response by Cancer-Associated Fibroblasts

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Proteolysis-targeting chimeras (PROTACs) in cancer therapy

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Epithelial–mesenchymal transition: a new target in anticancer drug discovery

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Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice

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Cancer cell behaviors mediated by dysregulated pH dynamics at a glance

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