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Cited by 1,524

The DOI matches its Crossref record; 284 of the 284 references it cites were found in a registry or an index.

Epidemiology of ovarian cancer: a review

Open access
Brett M., Reid, Brett M., Reid, Jennifer B., Permuth, Thomas A., Sellers, Jennifer B., Permuth, Thomas A., Sellers·2017·Cancer Biology & Medicine

Abstract

Ovarian cancer (OC) is the seventh most commonly diagnosed cancer among women in the world and the tenth most common in China. Epithelial OC is the most predominant pathologic subtype, with five major histotypes that differ in origination, pathogenesis, molecular alterations, risk factors, and prognosis. Genetic susceptibility is manifested by rare inherited mutations with high to moderate penetrance. Genome-wide association studies have additionally identified 29 common susceptibility alleles for OC, including 14 subtype-specific alleles. Several reproductive and hormonal factors may lower risk, including parity, oral contraceptive use, and lactation, while others such as older age at menopause and hormone replacement therapy confer increased risks. These associations differ by histotype, especially for mucinous OC, likely reflecting differences in etiology. Endometrioid and clear cell OC share a similar, unique pattern of associations with increased risks among women with endometriosis and decreased risks associated with tubal ligation. OC risks associated with other gynecological conditions and procedures, such as hysterectomy, pelvic inflammatory disease, and polycystic ovarian syndrome, are less clear. Other possible risk factors include environmental and lifestyle factors such as asbestos and talc powder exposures, and cigarette smoking. The epidemiology provides clues on etiology, primary prevention, early detection, and possibly even therapeutic strategies.

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Crossref · 10.20892/j.issn.2095-3941.2016.0084

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Metadata

Authors
Brett M., R., Brett M., R., Jennifer B., P., Thomas A., S., Jennifer B., P., & Thomas A., S.
Venue
Cancer Biology & Medicine
Published
2017
Volume
14
Issue
1
Pages
9-32
ISSN
2095-3941 (ISSN-L)
OpenAlex
W2594404528
Cited by
1,524
References
284
FWCI
119.20
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Epidemiology of ovarian cancer: a review. https://app.cochat.ai/papers/10.20892/j.issn.2095-3941.2016.0084
The paper
Brett M., R., Brett M., R., Jennifer B., P., Thomas A., S., Jennifer B., P., & Thomas A., S. (2017). Epidemiology of ovarian cancer: a review. Cancer Biology & Medicine. https://doi.org/10.20892/j.issn.2095-3941.2016.0084

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.